TOP2A Human (+)-catechin decreases expression EXP 6480464 Catechin results in decreased expression of TOP2A mRNA CTD PMID:15465739 TOP2A Human (+)-dexrazoxane decreases activity EXP 6480464 Dexrazoxane analog results in decreased activity of TOP2A protein and Dexrazoxane results in decreased activity of TOP2A protein CTD PMID:28941780 TOP2A Human (+)-epicatechin-3-O-gallate decreases activity EXP 6480464 epicatechin gallate results in decreased activity of TOP2A protein CTD PMID:16536579 TOP2A Human (-)-demecolcine decreases expression EXP 6480464 Demecolcine results in decreased expression of TOP2A mRNA CTD PMID:23649840 TOP2A Human (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of TOP2A mRNA CTD PMID:18851785 TOP2A Human (1->4)-beta-D-glucan multiple interactions ISO Top2a (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TOP2A mRNA CTD PMID:36331819 TOP2A Human 1,1-dichloroethene increases expression ISO Top2a (Mus musculus) 6480464 vinylidene chloride results in increased expression of TOP2A mRNA CTD PMID:26682919 TOP2A Human 1,2-dimethylhydrazine increases expression ISO Top2a (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of TOP2A mRNA CTD PMID:22206623 TOP2A Human 1,2-naphthoquinone multiple interactions EXP 6480464 1 and 2-naphthoquinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 and PMID:33760604 TOP2A Human 1,2-naphthoquinone affects activity EXP 6480464 1 and 2-naphthoquinone affects the activity of TOP2A protein CTD PMID:33760604 TOP2A Human 1,4-benzoquinone multiple interactions EXP 6480464 MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA] more ... CTD PMID:15935817 more ... TOP2A Human 1,4-benzoquinone decreases activity ISO Top2a (Mus musculus) 6480464 quinone results in decreased activity of TOP2A protein CTD PMID:31340051 TOP2A Human 1,4-benzoquinone increases activity EXP 6480464 quinone results in increased activity of TOP2A protein CTD PMID:15833037 TOP2A Human 1,4-benzoquinone affects activity EXP 6480464 quinone affects the activity of TOP2A protein and quinone metabolite affects the activity of TOP2A protein CTD PMID:16906772 and PMID:33760604 TOP2A Human 1,4-benzoquinone decreases activity EXP 6480464 quinone results in decreased activity of TOP2A protein CTD PMID:11468185 more ... TOP2A Human 1,4-benzoquinone increases expression EXP 6480464 quinone results in increased expression of TOP2A mRNA CTD PMID:18778717 TOP2A Human 1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 TOP2A Human 1,4-naphthoquinone multiple interactions EXP 6480464 1 and 4-naphthoquinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 TOP2A Human 1-naphthyl isothiocyanate affects expression ISO Top2a (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate affects the expression of TOP2A protein CTD PMID:26011634 TOP2A Human 1-naphthyl isothiocyanate increases expression ISO Top2a (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of TOP2A mRNA CTD PMID:30723492 TOP2A Human 17alpha-ethynylestradiol multiple interactions ISO Top2a (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA CTD PMID:17942748 TOP2A Human 17alpha-ethynylestradiol decreases expression ISO Top2a (Rattus norvegicus) 6480464 Ethinyl Estradiol results in decreased expression of TOP2A mRNA CTD PMID:12655037 TOP2A Human 17alpha-ethynylestradiol increases expression ISO Top2a (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of TOP2A mRNA CTD PMID:17942748 TOP2A Human 17alpha-ethynylestradiol affects expression ISO Top2a (Rattus norvegicus) 6480464 Ethinyl Estradiol affects the expression of TOP2A mRNA CTD PMID:17351261 TOP2A Human 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:16474171 more ... TOP2A Human 17beta-estradiol decreases expression ISO Top2a (Rattus norvegicus) 6480464 Estradiol results in decreased expression of TOP2A mRNA CTD PMID:32145629 TOP2A Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin and [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Doxorubicin CTD PMID:28323900 TOP2A Human 17beta-estradiol multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA and Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:26372666 and PMID:32741896 TOP2A Human 17beta-estradiol increases expression ISO Top2a (Rattus norvegicus) 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:26372666 TOP2A Human 17beta-estradiol multiple interactions ISO Top2a (Mus musculus) 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:25210133 TOP2A Human 17beta-estradiol increases expression ISO Top2a (Mus musculus) 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:19484750 more ... TOP2A Human 17beta-estradiol 3-benzoate multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA CTD PMID:32741896 TOP2A Human 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Top2a (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 TOP2A Human 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO Top2a (Rattus norvegicus) 6480464 2 more ... CTD PMID:20566336 TOP2A Human 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Top2a (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Top2a (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of TOP2A mRNA CTD PMID:21570461 more ... TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Top2a (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of TOP2A mRNA CTD PMID:34747641 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Top2a (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:32109520 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Top2a (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:25975270 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Top2a (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of TOP2A mRNA CTD PMID:15667827 and PMID:21846477 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:21802500 TOP2A Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Top2a (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA and Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of TOP2A protein] CTD PMID:17942748 and PMID:21846477 TOP2A Human 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO Top2a (Rattus norvegicus) 6480464 2 more ... CTD PMID:32109520 TOP2A Human 2,4-diaminotoluene increases expression ISO Top2a (Mus musculus) 6480464 2 and 4-diaminotoluene results in increased expression of TOP2A mRNA CTD PMID:20713471 TOP2A Human 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Top2a (Mus musculus) 6480464 2 more ... CTD PMID:38648751 TOP2A Human 2-acetamidofluorene increases expression ISO Top2a (Rattus norvegicus) 6480464 2-Acetylaminofluorene results in increased expression of TOP2A mRNA CTD PMID:22584684 TOP2A Human 2-amino-2-deoxy-D-glucopyranose decreases expression ISO Top2a (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 TOP2A Human 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of TOP2A mRNA CTD PMID:21179406 TOP2A Human 2-nitrofluorene increases expression ISO Top2a (Rattus norvegicus) 6480464 2-nitrofluorene results in increased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human 2-palmitoylglycerol increases expression EXP 6480464 2-palmitoylglycerol results in increased expression of TOP2A mRNA CTD PMID:37199045 TOP2A Human 3-chloropropane-1,2-diol increases expression ISO Top2a (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of TOP2A mRNA CTD PMID:38301995 TOP2A Human 3-methylcholanthrene increases expression ISO Top2a (Mus musculus) 6480464 Methylcholanthrene results in increased expression of TOP2A mRNA CTD PMID:20713471 TOP2A Human 3-methylcholanthrene multiple interactions ISO Top2a (Rattus norvegicus) 6480464 Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:26372666 TOP2A Human 3H-1,2-dithiole-3-thione increases expression ISO Top2a (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in increased expression of TOP2A mRNA CTD PMID:19162173 TOP2A Human 4'-epidoxorubicin multiple interactions EXP 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] and TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 and PMID:18465341 TOP2A Human 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO Top2a (Rattus norvegicus) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human 4-hydroxynon-2-enal increases expression ISO Top2a (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA CTD PMID:19191707 TOP2A Human 4-hydroxynon-2-enal decreases expression EXP 6480464 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA CTD PMID:12419474 TOP2A Human 4-hydroxynon-2-enal decreases expression ISO Top2a (Mus musculus) 6480464 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA CTD PMID:19191707 TOP2A Human 4-hydroxyphenyl retinamide increases expression ISO Top2a (Mus musculus) 6480464 Fenretinide results in increased expression of TOP2A mRNA CTD PMID:28973697 TOP2A Human 5-aza-2'-deoxycytidine affects expression EXP 6480464 Decitabine affects the expression of TOP2A mRNA CTD PMID:23300844 TOP2A Human 5-azacytidine multiple interactions EXP 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA and [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA CTD PMID:18348204 and PMID:18720364 TOP2A Human 5-fluorouracil decreases expression EXP 6480464 Fluorouracil results in decreased expression of TOP2A mRNA CTD PMID:15205334 and PMID:16557594 TOP2A Human 5-fluorouracil decreases expression ISO Top2a (Mus musculus) 6480464 Fluorouracil results in decreased expression of TOP2A mRNA CTD PMID:19272435 TOP2A Human 5-fluorouracil multiple interactions EXP 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] more ... CTD PMID:15016801 more ... TOP2A Human 6-propyl-2-thiouracil increases expression ISO Top2a (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of TOP2A mRNA CTD PMID:24780913 TOP2A Human 6-propyl-2-thiouracil decreases expression ISO Top2a (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of TOP2A mRNA CTD PMID:25825206 TOP2A Human 9,10-phenanthroquinone multiple interactions EXP 6480464 9 and 10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 TOP2A Human 9-hydroxyellipticine affects response to substance EXP 6480464 TOP2A protein affects the susceptibility to 9-hydroxyellipticine CTD PMID:23293027 TOP2A Human acetamide increases expression ISO Top2a (Rattus norvegicus) 6480464 acetamide results in increased expression of TOP2A mRNA CTD PMID:31881176 TOP2A Human acetamiprid decreases expression ISO Top2a (Mus musculus) 6480464 acetamiprid results in decreased expression of TOP2A mRNA CTD PMID:30103633 TOP2A Human acrylamide increases expression ISO Top2a (Rattus norvegicus) 6480464 Acrylamide results in increased expression of TOP2A mRNA CTD PMID:28959563 TOP2A Human acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of TOP2A mRNA CTD PMID:32763439 TOP2A Human acrylamide decreases expression ISO Top2a (Rattus norvegicus) 6480464 Acrylamide results in decreased expression of TOP2A mRNA CTD PMID:28606764 TOP2A Human aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of TOP2A protein CTD PMID:20106945 TOP2A Human aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of TOP2A gene CTD PMID:27153756 TOP2A Human aflatoxin B1 increases expression ISO Top2a (Rattus norvegicus) 6480464 Aflatoxin B1 results in increased expression of TOP2A mRNA CTD PMID:23630614 and PMID:25378103 TOP2A Human aflatoxin B1 decreases expression ISO Top2a (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of TOP2A mRNA CTD PMID:19770486 TOP2A Human aflatoxin B1 decreases expression ISO Top2a (Rattus norvegicus) 6480464 Aflatoxin B1 results in decreased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human alachlor increases expression ISO Top2a (Rattus norvegicus) 6480464 alachlor results in increased expression of TOP2A mRNA CTD PMID:12419858 TOP2A Human aldehydo-D-glucosamine decreases expression ISO Top2a (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 TOP2A Human aldehydo-D-glucose multiple interactions ISO Top2a (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of TOP2A mRNA CTD PMID:37567420 TOP2A Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of TOP2A protein CTD PMID:15059897 TOP2A Human all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of TOP2A mRNA CTD PMID:15498508 more ... TOP2A Human altenusin decreases activity EXP 6480464 altenusin results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human alternariol decreases activity EXP 6480464 alternariol metabolite results in decreased activity of TOP2A protein and alternariol results in decreased activity of TOP2A protein CTD PMID:27422292 and PMID:27682608 TOP2A Human Altertoxin I decreases activity EXP 6480464 altertoxin I results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human Altertoxin II decreases activity EXP 6480464 altertoxin II results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human amsacrine decreases response to substance EXP 6480464 TOP2A gene mutant form results in decreased susceptibility to Amsacrine and TOP2A protein mutant form results in decreased susceptibility to Amsacrine CTD PMID:10727526 more ... TOP2A Human amsacrine affects response to substance EXP 6480464 TOP2A protein modified form affects the susceptibility to Amsacrine CTD PMID:12569090 TOP2A Human amsacrine multiple interactions EXP 6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine more ... CTD PMID:16969495 and PMID:21878638 TOP2A Human anthracenes decreases activity EXP 6480464 Anthracenes results in decreased activity of TOP2A protein CTD PMID:20561793 TOP2A Human antimycin A increases expression EXP 6480464 Antimycin A results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human arachidonic acid decreases expression EXP 6480464 Arachidonic Acid results in decreased expression of TOP2A mRNA CTD PMID:16704987 TOP2A Human aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of TOP2A mRNA CTD PMID:33212167 TOP2A Human arsane increases expression EXP 6480464 Arsenic results in increased expression of TOP2A mRNA CTD PMID:11134558 TOP2A Human arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of TOP2A mRNA CTD PMID:11134558 TOP2A Human arsenite(3-) multiple interactions EXP 6480464 arsenite inhibits the reaction [G3BP1 protein binds to TOP2A mRNA] CTD PMID:32406909 TOP2A Human arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of TOP2A mRNA CTD PMID:34425169 TOP2A Human arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of TOP2A protein CTD PMID:16884364 TOP2A Human ATP increases hydrolysis EXP 6480464 TOP2A protein results in increased hydrolysis of Adenosine Triphosphate and TOP2A results in increased hydrolysis of Adenosine Triphosphate CTD PMID:20855424 more ... TOP2A Human ATP multiple interactions EXP 6480464 Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] more ... CTD PMID:20855424 more ... TOP2A Human atrazine affects methylation ISO Top2a (Rattus norvegicus) 6480464 Atrazine affects the methylation of TOP2A gene CTD PMID:35440735 TOP2A Human aurofusarin decreases activity EXP 6480464 aurofusarin results in decreased activity of TOP2A protein CTD PMID:29248571 TOP2A Human azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of TOP2A mRNA CTD PMID:22623647 TOP2A Human barium sulfate increases expression ISO Top2a (Rattus norvegicus) 6480464 Barium Sulfate results in increased expression of TOP2A mRNA CTD PMID:29463257 TOP2A Human benzene decreases expression EXP 6480464 Benzene results in decreased expression of TOP2A mRNA and Benzene results in decreased expression of TOP2A protein CTD PMID:21382456 TOP2A Human benzene-1,2,4-triol decreases activity EXP 6480464 hydroxyhydroquinone results in decreased activity of TOP2A protein CTD PMID:7586126 TOP2A Human benzimidazoles decreases activity EXP 6480464 Benzimidazoles results in decreased activity of TOP2A protein CTD PMID:20884089 TOP2A Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TOP2A mRNA CTD PMID:20106945 TOP2A Human benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:20064835 and PMID:21802500 TOP2A Human benzo[a]pyrene decreases expression ISO Top2a (Rattus norvegicus) 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:21839799 TOP2A Human benzo[a]pyrene decreases expression ISO Top2a (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:19770486 TOP2A Human benzo[a]pyrene increases expression ISO Top2a (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of TOP2A mRNA CTD PMID:20713471 and PMID:32417428 TOP2A Human benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20018196 more ... TOP2A Human benzo[b]fluoranthene increases expression ISO Top2a (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of TOP2A mRNA CTD PMID:26377693 TOP2A Human berberine multiple interactions EXP 6480464 TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form] CTD PMID:23747414 TOP2A Human berberine affects response to substance EXP 6480464 TOP2A protein affects the susceptibility to Berberine CTD PMID:23747414 TOP2A Human beta-D-glucosamine decreases expression ISO Top2a (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 TOP2A Human beta-lapachone decreases expression EXP 6480464 beta-lapachone results in decreased expression of TOP2A mRNA CTD PMID:38218311 TOP2A Human beta-naphthoflavone multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA CTD PMID:18164116 TOP2A Human beta-naphthoflavone decreases expression EXP 6480464 beta-Naphthoflavone results in decreased expression of TOP2A mRNA CTD PMID:32858204 TOP2A Human betulinic acid decreases activity EXP 6480464 Betulinic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 TOP2A Human bis(2-chloroethyl) sulfide affects expression ISO Top2a (Rattus norvegicus) 6480464 Mustard Gas affects the expression of TOP2A mRNA CTD PMID:15651846 TOP2A Human bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of TOP2A mRNA CTD PMID:25102026 TOP2A Human bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of TOP2A protein CTD PMID:31163220 TOP2A Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TOP2A mRNA CTD PMID:16474171 TOP2A Human bisphenol A increases expression ISO Top2a (Mus musculus) 6480464 bisphenol A results in increased expression of TOP2A mRNA CTD PMID:38701888 TOP2A Human bisphenol A affects expression ISO Top2a (Rattus norvegicus) 6480464 bisphenol A affects the expression of TOP2A mRNA CTD PMID:32145629 TOP2A Human bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of TOP2A mRNA CTD PMID:30903817 TOP2A Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TOP2A mRNA and bisphenol A results in decreased expression of TOP2A protein CTD PMID:29275510 and PMID:37567409 TOP2A Human bisphenol A decreases expression ISO Top2a (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of TOP2A mRNA CTD PMID:25181051 more ... TOP2A Human Boswellic acid multiple interactions EXP 6480464 boswellic acid analog binds to and results in decreased activity of TOP2A protein CTD PMID:10860928 TOP2A Human buta-1,3-diene increases expression ISO Top2a (Mus musculus) 6480464 1 and 3-butadiene results in increased expression of TOP2A mRNA CTD PMID:29038090 TOP2A Human butanal decreases expression EXP 6480464 butyraldehyde results in decreased expression of TOP2A mRNA CTD PMID:26079696 TOP2A Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOP2A mRNA CTD PMID:35301059 TOP2A Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOP2A mRNA and Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 and PMID:35301059 TOP2A Human cadmium dichloride decreases expression ISO Top2a (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of TOP2A mRNA CTD PMID:25993096 TOP2A Human cadmium dichloride multiple interactions ISO Top2a (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA CTD PMID:19840844 TOP2A Human cadmium dichloride decreases activity EXP 6480464 Cadmium Chloride results in decreased activity of TOP2A protein CTD PMID:21497582 TOP2A Human caffeine decreases phosphorylation EXP 6480464 Caffeine results in decreased phosphorylation of TOP2A protein CTD PMID:35688186 TOP2A Human calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of TOP2A mRNA CTD PMID:21592394 TOP2A Human calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA CTD PMID:21592394 TOP2A Human cannabidiol decreases activity EXP 6480464 Cannabidiol metabolite results in decreased activity of TOP2A protein CTD PMID:29272108 TOP2A Human cannabidiol multiple interactions EXP 6480464 Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] and Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 TOP2A Human captafol decreases activity ISO Top2a (Mus musculus) 6480464 captafol results in decreased activity of TOP2A protein CTD PMID:12113771 TOP2A Human captan decreases activity ISO Top2a (Mus musculus) 6480464 Captan results in decreased activity of TOP2A protein CTD PMID:12113771 TOP2A Human Carbadox decreases expression ISO Top2a (Rattus norvegicus) 6480464 Carbadox results in decreased expression of TOP2A protein CTD PMID:26558467 TOP2A Human carbon nanotube affects expression ISO Top2a (Mus musculus) 6480464 Nanotubes and Carbon affects the expression of TOP2A mRNA CTD PMID:25554681 TOP2A Human carbon nanotube increases expression ISO Top2a (Mus musculus) 6480464 Nanotubes and Carbon analog results in increased expression of TOP2A mRNA CTD PMID:25554681 TOP2A Human carboplatin multiple interactions EXP 6480464 TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 TOP2A Human cefaloridine decreases expression ISO Top2a (Rattus norvegicus) 6480464 Cephaloridine results in decreased expression of TOP2A mRNA CTD PMID:18500788 TOP2A Human CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to TOP2A gene] CTD PMID:28238834 TOP2A Human chlorendic acid increases expression ISO Top2a (Rattus norvegicus) 6480464 chlorendic acid results in increased expression of TOP2A mRNA CTD PMID:22584684 TOP2A Human chloroacetaldehyde increases activity EXP 6480464 chloroacetaldehyde results in increased activity of TOP2A protein CTD PMID:15751973 TOP2A Human chloroethene increases activity EXP 6480464 Vinyl Chloride metabolite results in increased activity of TOP2A protein CTD PMID:15751973 TOP2A Human chlorpyrifos decreases activity EXP 6480464 Chlorpyrifos results in decreased activity of TOP2A protein CTD PMID:26198043 TOP2A Human ciprofloxacin affects binding EXP 6480464 Ciprofloxacin binds to TOP2A protein CTD PMID:21413765 TOP2A Human ciprofloxacin multiple interactions EXP 6480464 [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein] and [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein] CTD PMID:21413765 TOP2A Human cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of TOP2A mRNA CTD PMID:27594783 TOP2A Human cisplatin affects expression EXP 6480464 Cisplatin affects the expression of TOP2A mRNA CTD PMID:23300844 TOP2A Human cisplatin increases expression ISO Top2a (Mus musculus) 6480464 Cisplatin results in increased expression of TOP2A mRNA CTD PMID:21151649 TOP2A Human cisplatin decreases expression ISO Top2a (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of TOP2A mRNA CTD PMID:22023808 TOP2A Human cisplatin multiple interactions EXP 6480464 [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin more ... CTD PMID:11325482 and PMID:28323900 TOP2A Human clofibrate increases expression ISO Top2a (Rattus norvegicus) 6480464 Clofibrate results in increased expression of TOP2A mRNA CTD PMID:32741897 TOP2A Human cobalt dichloride decreases expression ISO Top2a (Rattus norvegicus) 6480464 cobaltous chloride results in decreased expression of TOP2A mRNA CTD PMID:24386269 TOP2A Human cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of TOP2A mRNA CTD PMID:19320972 and PMID:19376846 TOP2A Human copper atom multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA CTD PMID:20971185 TOP2A Human copper atom increases expression ISO Top2a (Rattus norvegicus) 6480464 Copper results in increased expression of TOP2A mRNA CTD PMID:30556269 TOP2A Human copper(0) multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA CTD PMID:20971185 TOP2A Human copper(0) increases expression ISO Top2a (Rattus norvegicus) 6480464 Copper results in increased expression of TOP2A mRNA CTD PMID:30556269 TOP2A Human copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of TOP2A mRNA CTD PMID:19549813 TOP2A Human corosolic acid decreases expression EXP 6480464 corosolic acid results in decreased expression of TOP2A mRNA and corosolic acid results in decreased expression of TOP2A protein CTD PMID:37939859 TOP2A Human corticosterone decreases expression ISO Top2a (Rattus norvegicus) 6480464 Corticosterone results in decreased expression of TOP2A mRNA CTD PMID:15755911 TOP2A Human coumarin increases phosphorylation EXP 6480464 coumarin results in increased phosphorylation of TOP2A protein CTD PMID:35688186 TOP2A Human coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:18310284 and PMID:19167446 TOP2A Human Cryptotanshinone decreases expression EXP 6480464 cryptotanshinone results in decreased expression of TOP2A mRNA CTD PMID:28716507 TOP2A Human Cryptotanshinone multiple interactions EXP 6480464 cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein CTD PMID:28716507 TOP2A Human CU-O LINKAGE decreases expression EXP 6480464 cupric oxide results in decreased expression of TOP2A mRNA CTD PMID:22077320 TOP2A Human Cuprizon increases expression ISO Top2a (Rattus norvegicus) 6480464 Cuprizone results in increased expression of TOP2A mRNA CTD PMID:26577399 TOP2A Human curcumin multiple interactions EXP 6480464 [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA and [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA CTD PMID:18348204 and PMID:18414057 TOP2A Human curcumin decreases expression EXP 6480464 Curcumin analog results in decreased expression of TOP2A mRNA and Curcumin results in decreased expression of TOP2A mRNA CTD PMID:18348204 more ... TOP2A Human cyclophosphamide multiple interactions EXP 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] and TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 and PMID:18465341 TOP2A Human cyclophosphamide increases expression ISO Top2a (Rattus norvegicus) 6480464 Cyclophosphamide results in increased expression of TOP2A mRNA CTD PMID:11599041 TOP2A Human cyclosporin A decreases expression ISO Top2a (Rattus norvegicus) 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:19224547 TOP2A Human cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:20106945 more ... TOP2A Human cyclosporin A decreases expression ISO Top2a (Mus musculus) 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:19770486 TOP2A Human D-glucose multiple interactions ISO Top2a (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of TOP2A mRNA CTD PMID:37567420 TOP2A Human DDE increases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of TOP2A mRNA CTD PMID:38568856 TOP2A Human deguelin increases expression EXP 6480464 deguelin results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human delphinidin decreases activity EXP 6480464 delphinidin results in decreased activity of TOP2A protein CTD PMID:19182879 TOP2A Human delphinidin multiple interactions EXP 6480464 delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein] and delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein] CTD PMID:19182879 TOP2A Human dexamethasone affects expression ISO Top2a (Rattus norvegicus) 6480464 Dexamethasone affects the expression of TOP2A mRNA CTD PMID:15102944 TOP2A Human dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of TOP2A mRNA CTD PMID:23137833 TOP2A Human diallyl trisulfide decreases expression EXP 6480464 diallyl trisulfide results in decreased expression of TOP2A mRNA CTD PMID:34995734 TOP2A Human diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of TOP2A protein CTD PMID:16884364 TOP2A Human dibenzofuran decreases expression ISO Top2a (Rattus norvegicus) 6480464 dibenzofuran analog results in decreased expression of TOP2A mRNA CTD PMID:20566336 TOP2A Human dibutyl phthalate decreases expression ISO Top2a (Rattus norvegicus) 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:21266533 TOP2A Human dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of TOP2A mRNA CTD PMID:36828243 TOP2A Human dibutyl phthalate multiple interactions EXP 6480464 N-methyl-delta-3 more ... CTD PMID:36828243 TOP2A Human dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:28973377 TOP2A Human dibutyl phthalate decreases expression ISO Top2a (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:17361019 and PMID:21266533 TOP2A Human dichlorine multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA CTD PMID:18636392 TOP2A Human dichloroacetic acid increases expression ISO Top2a (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of TOP2A mRNA CTD PMID:28962523 TOP2A Human dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of TOP2A mRNA CTD PMID:28302478 TOP2A Human diethylstilbestrol increases expression ISO Top2a (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human dimethylarsinic acid increases expression ISO Top2a (Mus musculus) 6480464 Cacodylic Acid results in increased expression of TOP2A mRNA CTD PMID:17441966 TOP2A Human dimethylarsinic acid increases expression ISO Top2a (Rattus norvegicus) 6480464 Cacodylic Acid results in increased expression of TOP2A mRNA CTD PMID:37567419 TOP2A Human dimethylarsinic acid decreases expression ISO Top2a (Rattus norvegicus) 6480464 Cacodylic Acid results in decreased expression of TOP2A mRNA CTD PMID:17720352 TOP2A Human dioxygen increases expression ISO Top2a (Rattus norvegicus) 6480464 Oxygen deficiency results in increased expression of TOP2A mRNA CTD PMID:26476374 TOP2A Human dioxygen multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of TOP2A mRNA] more ... CTD PMID:26476374 and PMID:33729688 TOP2A Human diquat decreases expression ISO Top2a (Mus musculus) 6480464 Diquat results in decreased expression of TOP2A mRNA CTD PMID:36851058 TOP2A Human disodium selenite decreases expression EXP 6480464 Sodium Selenite results in decreased expression of TOP2A mRNA CTD PMID:24383545 TOP2A Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA CTD PMID:27188386 TOP2A Human doxorubicin multiple interactions EXP 6480464 [Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter] more ... CTD PMID:15486187 more ... TOP2A Human doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of TOP2A protein CTD PMID:17351394 and PMID:22751436 TOP2A Human doxorubicin decreases expression ISO Top2a (Mus musculus) 6480464 Doxorubicin results in decreased expression of TOP2A mRNA CTD PMID:25896364 TOP2A Human doxorubicin increases expression ISO Top2a (Mus musculus) 6480464 Doxorubicin results in increased expression of TOP2A mRNA CTD PMID:22712078 and PMID:36227756 TOP2A Human doxorubicin multiple interactions ISO Top2a (Mus musculus) 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 TOP2A Human doxorubicin affects activity EXP 6480464 Doxorubicin affects the activity of TOP2A protein CTD PMID:19182879 TOP2A Human doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of TOP2A mRNA CTD PMID:15205334 more ... TOP2A Human doxorubicin decreases response to substance EXP 6480464 TOP2A mRNA results in decreased susceptibility to Doxorubicin more ... CTD PMID:11470519 and PMID:15765123 TOP2A Human doxorubicin affects response to substance EXP 6480464 TOP2A protein affects the susceptibility to Doxorubicin CTD PMID:16217747 TOP2A Human doxorubicin increases response to substance EXP 6480464 TOP2A mRNA results in increased susceptibility to Doxorubicin and TOP2A results in increased susceptibility to Doxorubicin CTD PMID:15239142 and PMID:9862568 TOP2A Human dronedarone decreases expression EXP 6480464 dronedarone results in decreased expression of TOP2A mRNA and dronedarone results in decreased expression of TOP2A protein CTD PMID:29616291 TOP2A Human dronedarone multiple interactions EXP 6480464 CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein] more ... CTD PMID:29616291 TOP2A Human emodin multiple interactions EXP 6480464 Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate] and TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] CTD PMID:20855424 TOP2A Human emodin increases activity EXP 6480464 Emodin results in increased activity of TOP2A protein CTD PMID:20855424 TOP2A Human Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOP2A mRNA CTD PMID:19167446 TOP2A Human ethylbenzene increases methylation EXP 6480464 ethylbenzene results in increased methylation of TOP2A promoter CTD PMID:29217486 TOP2A Human etoposide affects binding EXP 6480464 Etoposide binds to TOP2A protein CTD PMID:21413765 TOP2A Human etoposide multiple interactions EXP 6480464 [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein] more ... CTD PMID:11325482 more ... TOP2A Human etoposide decreases activity EXP 6480464 Etoposide analog results in decreased activity of TOP2A protein more ... CTD PMID:21056033 more ... TOP2A Human etoposide affects activity EXP 6480464 Etoposide affects the activity of TOP2A protein CTD PMID:19182879 more ... TOP2A Human etoposide decreases expression ISO Top2a (Mus musculus) 6480464 Etoposide results in decreased expression of TOP2A protein CTD PMID:10856430 TOP2A Human etoposide decreases activity ISO Top2a (Mus musculus) 6480464 Etoposide results in decreased activity of TOP2A protein CTD PMID:15211611 TOP2A Human etoposide increases response to substance EXP 6480464 TOP2A protein results in increased susceptibility to Etoposide CTD PMID:11531262 TOP2A Human etoposide affects response to substance EXP 6480464 TOP2A protein modified form affects the susceptibility to Etoposide CTD PMID:12569090 TOP2A Human etoposide decreases response to substance EXP 6480464 TOP2A gene mutant form results in decreased susceptibility to Etoposide and TOP2A protein mutant form results in decreased susceptibility to Etoposide CTD PMID:11470519 and PMID:11676865 TOP2A Human fenofibrate increases expression ISO Top2a (Rattus norvegicus) 6480464 Fenofibrate results in increased expression of TOP2A mRNA CTD PMID:32741897 TOP2A Human fenpyroximate increases expression EXP 6480464 fenpyroximate results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of TOP2A mRNA CTD PMID:15465739 TOP2A Human folic acid multiple interactions EXP 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA CTD PMID:24657277 TOP2A Human FR900359 affects phosphorylation EXP 6480464 FR900359 affects the phosphorylation of TOP2A protein CTD PMID:37730182 TOP2A Human fructose multiple interactions ISO Top2a (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of TOP2A mRNA CTD PMID:37567420 TOP2A Human fulvestrant increases expression EXP 6480464 fulvestrant results in increased expression of TOP2A mRNA CTD PMID:12154049 TOP2A Human furan increases expression ISO Top2a (Rattus norvegicus) 6480464 furan results in increased expression of TOP2A mRNA CTD PMID:25539665 TOP2A Human genistein increases expression EXP 6480464 Genistein results in increased expression of TOP2A mRNA CTD PMID:16474171 TOP2A Human genistein affects activity ISO Top2a (Rattus norvegicus) 6480464 Genistein affects the activity of TOP2A protein CTD PMID:26723871 TOP2A Human glucose multiple interactions ISO Top2a (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of TOP2A mRNA CTD PMID:37567420 TOP2A Human glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 TOP2A Human glycidol decreases expression ISO Top2a (Rattus norvegicus) 6480464 glycidol results in decreased expression of TOP2A mRNA CTD PMID:24395379 TOP2A Human glyphosate multiple interactions ISO Top2a (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of TOP2A mRNA CTD PMID:37567420 TOP2A Human Heliotrine increases expression ISO Top2a (Rattus norvegicus) 6480464 heliotrine results in increased expression of TOP2A mRNA CTD PMID:32419051 TOP2A Human hexadecanoic acid affects phosphorylation EXP 6480464 Palmitic Acid affects the phosphorylation of TOP2A protein CTD PMID:28073184 TOP2A Human hydrogen peroxide multiple interactions EXP 6480464 [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] CTD PMID:15935818 TOP2A Human hydroquinone affects activity EXP 6480464 hydroquinone affects the activity of TOP2A protein CTD PMID:15833037 TOP2A Human hydroquinone decreases activity EXP 6480464 hydroquinone results in decreased activity of TOP2A protein CTD PMID:11468185 more ... TOP2A Human hydroquinone multiple interactions EXP 6480464 [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] CTD PMID:15935818 TOP2A Human hydroquinone decreases activity ISO Top2a (Mus musculus) 6480464 hydroquinone results in decreased activity of TOP2A protein CTD PMID:15211611 TOP2A Human hypericin decreases activity EXP 6480464 hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 TOP2A Human ifosfamide multiple interactions EXP 6480464 TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 TOP2A Human indirubin decreases expression EXP 6480464 indirubin results in decreased expression of TOP2A mRNA CTD PMID:15056799 TOP2A Human indole-3-methanol multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA CTD PMID:22129741 TOP2A Human irinotecan decreases expression EXP 6480464 Irinotecan metabolite results in decreased expression of TOP2A mRNA and Irinotecan results in decreased expression of TOP2A mRNA CTD PMID:15956246 TOP2A Human irinotecan increases response to substance EXP 6480464 TOP2A mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 TOP2A Human isoflavones decreases expression EXP 6480464 Isoflavones results in decreased expression of TOP2A mRNA CTD PMID:17374662 TOP2A Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of TOP2A protein CTD PMID:32959892 TOP2A Human L-1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 TOP2A Human lapatinib decreases expression EXP 6480464 Lapatinib results in decreased expression of TOP2A protein CTD PMID:37788138 TOP2A Human Lasiocarpine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 TOP2A Human lead diacetate decreases expression ISO Top2a (Mus musculus) 6480464 lead acetate results in decreased expression of TOP2A mRNA CTD PMID:22613225 TOP2A Human leflunomide decreases expression ISO Top2a (Rattus norvegicus) 6480464 leflunomide results in decreased expression of TOP2A mRNA CTD PMID:24136188 TOP2A Human leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of TOP2A mRNA CTD PMID:28988120 TOP2A Human lipopolysaccharide affects expression EXP 6480464 Lipopolysaccharides affects the expression of TOP2A mRNA CTD PMID:28070326 TOP2A Human lipopolysaccharide increases expression ISO Top2a (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of TOP2A mRNA CTD PMID:10975854 TOP2A Human lipopolysaccharide multiple interactions EXP 6480464 Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TOP2A mRNA] CTD PMID:28070326 TOP2A Human lithium atom increases expression ISO Top2a (Rattus norvegicus) 6480464 Lithium results in increased expression of TOP2A mRNA CTD PMID:21711903 TOP2A Human lithium hydride increases expression ISO Top2a (Rattus norvegicus) 6480464 Lithium results in increased expression of TOP2A mRNA CTD PMID:21711903 TOP2A Human lovastatin multiple interactions ISO Top2a (Mus musculus) 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 TOP2A Human lucanthone decreases expression EXP 6480464 Lucanthone results in decreased expression of TOP2A mRNA CTD PMID:21148553 TOP2A Human Macrosporin decreases activity EXP 6480464 macrosporin results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human MeIQx increases expression EXP 6480464 2-amino-3 more ... CTD PMID:20816883 TOP2A Human menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of TOP2A mRNA CTD PMID:20044591 TOP2A Human methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of TOP2A mRNA CTD PMID:25290377 TOP2A Human methamphetamine decreases expression ISO Top2a (Rattus norvegicus) 6480464 Methamphetamine results in decreased expression of TOP2A mRNA and Methamphetamine results in decreased expression of TOP2A protein CTD PMID:28341135 TOP2A Human methapyrilene increases expression ISO Top2a (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of TOP2A mRNA and Methapyrilene results in increased expression of TOP2A protein CTD PMID:15890375 more ... TOP2A Human methotrexate multiple interactions EXP 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA CTD PMID:24657277 TOP2A Human methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of TOP2A mRNA CTD PMID:24657277 TOP2A Human methylmercury chloride decreases expression ISO Top2a (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of TOP2A mRNA CTD PMID:20061341 TOP2A Human methylparaben decreases expression EXP 6480464 methylparaben results in decreased expression of TOP2A mRNA CTD PMID:31745603 TOP2A Human methylseleninic acid affects expression EXP 6480464 methylselenic acid affects the expression of TOP2A mRNA CTD PMID:14617803 TOP2A Human mycotoxin multiple interactions EXP 6480464 [Mycotoxins co-treated with Oxidants] results in decreased activity of TOP2A protein CTD PMID:26894873 TOP2A Human mycotoxin decreases activity EXP 6480464 Mycotoxins results in decreased activity of TOP2A protein CTD PMID:26894873 TOP2A Human myricetin decreases activity EXP 6480464 myricetin results in decreased activity of TOP2A protein CTD PMID:16536579 TOP2A Human N(4)-hydroxycytidine decreases expression ISO Top2a (Mus musculus) 6480464 N(4)-hydroxycytidine results in decreased expression of TOP2A mRNA CTD PMID:37748715 TOP2A Human N-acetyl-1,4-benzoquinone imine decreases activity EXP 6480464 N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 TOP2A Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 TOP2A Human N-butyl-N-(4-hydroxybutyl)nitrosamine multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [Butylhydroxybutylnitrosamine co-treated with Propolis analog] results in increased expression of TOP2A mRNA CTD PMID:26111810 TOP2A Human N-methyl-4-phenylpyridinium increases expression ISO Top2a (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TOP2A protein CTD PMID:26558463 TOP2A Human N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TOP2A mRNA CTD PMID:24810058 TOP2A Human N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Top2a (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA more ... CTD PMID:19840844 TOP2A Human N-methyl-N-nitrosourea increases expression ISO Top2a (Mus musculus) 6480464 Methylnitrosourea results in increased expression of TOP2A mRNA CTD PMID:25270620 TOP2A Human N-nitrosodiethylamine increases expression ISO Top2a (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:17854601 TOP2A Human N-nitrosodiethylamine increases expression ISO Top2a (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:25242409 TOP2A Human N-nitrosodiethylamine multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA and [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA CTD PMID:18164116 and PMID:22129741 TOP2A Human N-nitrosodiethylamine multiple interactions ISO Top2a (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA and RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOP2A mRNA] CTD PMID:17854601 and PMID:24535843 TOP2A Human N-nitrosodimethylamine increases expression ISO Top2a (Rattus norvegicus) 6480464 Dimethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human N-Nitrosopyrrolidine decreases expression EXP 6480464 N-Nitrosopyrrolidine results in decreased expression of TOP2A mRNA CTD PMID:32234424 TOP2A Human naphthalene-1,2-diol affects activity EXP 6480464 1 and 2-dihydroxynaphthalene affects the activity of TOP2A protein CTD PMID:33760604 TOP2A Human nevadensin decreases activity EXP 6480464 nevadensin results in decreased activity of TOP2A protein CTD PMID:34635930 TOP2A Human nickel subsulfide increases expression ISO Top2a (Rattus norvegicus) 6480464 nickel subsulfide results in increased expression of TOP2A mRNA CTD PMID:24952340 TOP2A Human niclosamide affects binding EXP 6480464 Niclosamide binds to TOP2A protein CTD PMID:36870549 TOP2A Human Nitidine decreases expression EXP 6480464 nitidine results in decreased expression of TOP2A mRNA and nitidine results in decreased expression of TOP2A protein CTD PMID:30132517 TOP2A Human O-methyleugenol affects expression ISO Top2a (Rattus norvegicus) 6480464 methyleugenol affects the expression of TOP2A protein CTD PMID:26011634 TOP2A Human ochratoxin A increases expression ISO Top2a (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of TOP2A mRNA and ochratoxin A results in increased expression of TOP2A protein CTD PMID:19237604 and PMID:38301995 TOP2A Human okadaic acid multiple interactions ISO Top2a (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA CTD PMID:19840844 TOP2A Human oleanolic acid decreases activity EXP 6480464 Oleanolic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 TOP2A Human oleanolic acid decreases expression EXP 6480464 Oleanolic Acid analog results in decreased expression of TOP2A protein CTD PMID:26612655 TOP2A Human orotic acid increases expression ISO Top2a (Rattus norvegicus) 6480464 Orotic Acid results in increased expression of TOP2A mRNA CTD PMID:17203948 TOP2A Human oxaliplatin multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA CTD PMID:25729387 TOP2A Human oxaliplatin decreases expression ISO Top2a (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of TOP2A mRNA CTD PMID:25729387 TOP2A Human oxfendazole decreases expression ISO Top2a (Rattus norvegicus) 6480464 oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 TOP2A Human ozone increases expression ISO Top2a (Mus musculus) 6480464 Ozone results in increased expression of TOP2A mRNA CTD PMID:12763052 TOP2A Human ozone multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA CTD PMID:18636392 TOP2A Human ozone multiple interactions ISO Top2a (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TOP2A mRNA more ... CTD PMID:19555225 more ... TOP2A Human p-menthan-3-ol decreases activity EXP 6480464 Menthol results in decreased activity of TOP2A protein CTD PMID:16158947 TOP2A Human p-menthan-3-ol increases expression EXP 6480464 Menthol results in increased expression of TOP2A mRNA CTD PMID:26760959 TOP2A Human paclitaxel increases response to substance EXP 6480464 TOP2A mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 TOP2A Human paclitaxel multiple interactions EXP 6480464 TOP2A results in decreased susceptibility to [Cisplatin co-treated with Paclitaxel] CTD PMID:11325482 TOP2A Human palbociclib decreases expression EXP 6480464 palbociclib analog results in decreased expression of TOP2A mRNA more ... CTD PMID:15542782 more ... TOP2A Human palbociclib multiple interactions EXP 6480464 palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein] and RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]] CTD PMID:22751436 TOP2A Human paracetamol affects expression ISO Top2a (Mus musculus) 6480464 Acetaminophen affects the expression of TOP2A mRNA CTD PMID:17562736 TOP2A Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of TOP2A mRNA CTD PMID:29067470 TOP2A Human paracetamol decreases expression ISO Top2a (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of TOP2A protein CTD PMID:26011634 TOP2A Human paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of TOP2A mRNA CTD PMID:22230336 TOP2A Human paraquat multiple interactions EXP 6480464 [Paraquat co-treated with Antigens and Dermatophagoides] results in decreased expression of TOP2A mRNA CTD PMID:34097952 TOP2A Human PCB138 multiple interactions ISO Top2a (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 TOP2A Human pectolinarigenin multiple interactions EXP 6480464 pectolinarigenin binds to and results in increased expression of TOP2A protein more ... CTD PMID:37393350 TOP2A Human perfluorooctane-1-sulfonic acid multiple interactions ISO Top2a (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TOP2A mRNA CTD PMID:36331819 TOP2A Human perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of TOP2A mRNA CTD PMID:25868421 and PMID:36326898 TOP2A Human phenformin decreases expression ISO Top2a (Rattus norvegicus) 6480464 Phenformin results in decreased expression of TOP2A mRNA CTD PMID:31324951 TOP2A Human phenobarbital multiple interactions ISO Top2a (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TOP2A mRNA] CTD PMID:19482888 and PMID:24535843 TOP2A Human phenobarbital increases expression ISO Top2a (Mus musculus) 6480464 Phenobarbital results in increased expression of TOP2A mRNA CTD PMID:19363144 more ... TOP2A Human phenobarbital increases expression ISO Top2a (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of TOP2A mRNA CTD PMID:19162173 TOP2A Human phenylmercury acetate decreases expression EXP 6480464 Phenylmercuric Acetate results in decreased expression of TOP2A mRNA CTD PMID:26272509 TOP2A Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA CTD PMID:27188386 TOP2A Human PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of TOP2A mRNA CTD PMID:20816883 TOP2A Human PhIP increases expression ISO Top2a (Rattus norvegicus) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of TOP2A mRNA CTD PMID:29877212 TOP2A Human phorbol 13-acetate 12-myristate multiple interactions ISO Top2a (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA CTD PMID:19840844 TOP2A Human phytoestrogen increases expression EXP 6480464 Phytoestrogens results in increased expression of TOP2A mRNA CTD PMID:18310284 TOP2A Human picoxystrobin increases expression EXP 6480464 picoxystrobin results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human piperonyl butoxide increases expression ISO Top2a (Rattus norvegicus) 6480464 Piperonyl Butoxide results in increased expression of TOP2A mRNA CTD PMID:15890375 TOP2A Human pirinixic acid increases expression ISO Top2a (Mus musculus) 6480464 pirinixic acid results in increased expression of TOP2A mRNA CTD PMID:18301758 TOP2A Human pirinixic acid increases expression ISO Top2a (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of TOP2A mRNA CTD PMID:12832660 more ... TOP2A Human pirinixic acid decreases expression ISO Top2a (Mus musculus) 6480464 pirinixic acid results in decreased expression of TOP2A mRNA CTD PMID:17426115 TOP2A Human pregnenolone 16alpha-carbonitrile increases expression ISO Top2a (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in increased expression of TOP2A mRNA CTD PMID:19162173 TOP2A Human procyanidin B2 decreases activity EXP 6480464 procyanidin B2 results in decreased activity of TOP2A protein CTD PMID:16536579 TOP2A Human progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of TOP2A mRNA CTD PMID:21795739 TOP2A Human progesterone decreases expression ISO Top2a (Rattus norvegicus) 6480464 Progesterone results in decreased expression of TOP2A mRNA CTD PMID:20726854 TOP2A Human progesterone increases expression EXP 6480464 Progesterone results in increased expression of TOP2A mRNA CTD PMID:18070364 and PMID:21540246 TOP2A Human promethazine affects expression ISO Top2a (Rattus norvegicus) 6480464 Promethazine affects the expression of TOP2A protein CTD PMID:26011634 TOP2A Human propanal decreases expression EXP 6480464 propionaldehyde results in decreased expression of TOP2A mRNA CTD PMID:26079696 TOP2A Human propiconazole increases expression ISO Top2a (Mus musculus) 6480464 propiconazole results in increased expression of TOP2A mRNA CTD PMID:21278054 TOP2A Human Pyrenophorol decreases activity EXP 6480464 pyrenophorol results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human quercetin multiple interactions ISO Top2a (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2A mRNA] CTD PMID:26476374 TOP2A Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of TOP2A mRNA CTD PMID:21632981 TOP2A Human raloxifene increases expression EXP 6480464 Raloxifene Hydrochloride results in increased expression of TOP2A mRNA CTD PMID:12154049 TOP2A Human razoxane affects binding EXP 6480464 Razoxane binds to TOP2A protein CTD PMID:17875725 TOP2A Human Rebamipide increases expression ISO Top2a (Rattus norvegicus) 6480464 rebamipide results in increased expression of TOP2A mRNA CTD PMID:18299717 TOP2A Human resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of TOP2A protein CTD PMID:16536579 TOP2A Human resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of TOP2A mRNA CTD PMID:15767336 and PMID:23137833 TOP2A Human resveratrol decreases expression ISO Top2a (Mus musculus) 6480464 resveratrol results in decreased expression of TOP2A protein CTD PMID:25505154 TOP2A Human resveratrol increases expression ISO Top2a (Rattus norvegicus) 6480464 resveratrol results in increased expression of TOP2A mRNA CTD PMID:19228061 TOP2A Human riddelliine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 TOP2A Human rotenone decreases expression ISO Top2a (Rattus norvegicus) 6480464 Rotenone results in decreased expression of TOP2A mRNA CTD PMID:28374803 TOP2A Human rotenone increases expression EXP 6480464 Rotenone results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human sarin decreases expression EXP 6480464 Sarin results in decreased expression of TOP2A mRNA CTD PMID:19522546 TOP2A Human SB 431542 multiple interactions EXP 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 and PMID:37664457 TOP2A Human senecionine increases expression ISO Top2a (Rattus norvegicus) 6480464 senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 TOP2A Human Senkirkine increases expression ISO Top2a (Rattus norvegicus) 6480464 senkirkine results in increased expression of TOP2A mRNA CTD PMID:32419051 TOP2A Human silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of TOP2A mRNA CTD PMID:25351596 TOP2A Human silicon dioxide increases expression ISO Top2a (Mus musculus) 6480464 Silicon Dioxide results in increased expression of TOP2A mRNA CTD PMID:29341224 TOP2A Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of TOP2A mRNA CTD PMID:12760830 more ... TOP2A Human sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of TOP2A mRNA CTD PMID:29301061 TOP2A Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of TOP2A mRNA CTD PMID:12016162 TOP2A Human sodium dichromate increases expression ISO Top2a (Rattus norvegicus) 6480464 sodium bichromate results in increased expression of TOP2A mRNA CTD PMID:22561333 TOP2A Human sodium dichromate decreases expression ISO Top2a (Mus musculus) 6480464 sodium bichromate results in decreased expression of TOP2A mRNA CTD PMID:31558096 TOP2A Human sodium dichromate affects expression ISO Top2a (Rattus norvegicus) 6480464 sodium bichromate affects the expression of TOP2A mRNA CTD PMID:11960910 TOP2A Human Stemphyltoxin III decreases activity EXP 6480464 stemphyltoxin III results in decreased activity of TOP2A protein CTD PMID:27682608 TOP2A Human succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TOP2A mRNA CTD PMID:26378955 TOP2A Human sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of TOP2A mRNA CTD PMID:31533062 TOP2A Human T-2 toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of TOP2A mRNA CTD PMID:34581912 TOP2A Human tamibarotene affects expression EXP 6480464 tamibarotene affects the expression of TOP2A mRNA CTD PMID:15498508 TOP2A Human tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of TOP2A protein CTD PMID:10785588 TOP2A Human tamoxifen decreases expression ISO Top2a (Rattus norvegicus) 6480464 Tamoxifen results in decreased expression of TOP2A mRNA CTD PMID:19224547 TOP2A Human teniposide multiple interactions EXP 6480464 TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] CTD PMID:11325482 TOP2A Human testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA CTD PMID:21592394 TOP2A Human testosterone multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA CTD PMID:32741896 TOP2A Human testosterone increases expression ISO Top2a (Mus musculus) 6480464 Testosterone results in increased expression of TOP2A mRNA CTD PMID:19693291 TOP2A Human testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of TOP2A mRNA CTD PMID:21592394 TOP2A Human tetrachloromethane increases expression ISO Top2a (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of TOP2A mRNA CTD PMID:27339419 more ... TOP2A Human tetrachloromethane decreases expression ISO Top2a (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of TOP2A mRNA CTD PMID:31150632 TOP2A Human tetracycline decreases expression ISO Top2a (Rattus norvegicus) 6480464 Tetracycline results in decreased expression of TOP2A mRNA CTD PMID:19224547 TOP2A Human tetracycline decreases expression EXP 6480464 Tetracycline results in decreased expression of TOP2A protein CTD PMID:23293027 TOP2A Human thalidomide multiple interactions EXP 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA CTD PMID:18720364 TOP2A Human thapsigargin increases expression ISO Top2a (Mus musculus) 6480464 Thapsigargin results in increased expression of TOP2A protein CTD PMID:24648495 TOP2A Human thapsigargin decreases expression ISO Top2a (Rattus norvegicus) 6480464 Thapsigargin results in decreased expression of TOP2A protein CTD PMID:35544339 TOP2A Human thifluzamide increases expression EXP 6480464 thifluzamide results in increased expression of TOP2A mRNA CTD PMID:33512557 TOP2A Human thimerosal decreases activity EXP 6480464 Thimerosal results in decreased activity of TOP2A protein CTD PMID:18197631 TOP2A Human thioacetamide increases expression ISO Top2a (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of TOP2A mRNA and Thioacetamide results in increased expression of TOP2A protein CTD PMID:22659510 more ... TOP2A Human thiram decreases expression EXP 6480464 Thiram results in decreased expression of TOP2A mRNA CTD PMID:38568856 TOP2A Human thymoquinone affects activity EXP 6480464 thymoquinone affects the activity of TOP2A protein CTD PMID:24650156 TOP2A Human titanium dioxide increases expression ISO Top2a (Mus musculus) 6480464 titanium dioxide results in increased expression of TOP2A mRNA CTD PMID:23557971 TOP2A Human titanium dioxide increases expression ISO Top2a (Rattus norvegicus) 6480464 titanium dioxide results in increased expression of TOP2A mRNA CTD PMID:30012374 TOP2A Human titanium dioxide multiple interactions EXP 6480464 [Vitallium analog binds to titanium dioxide] which results in decreased expression of TOP2A mRNA CTD PMID:23825117 TOP2A Human titanium dioxide affects expression ISO Top2a (Mus musculus) 6480464 titanium dioxide affects the expression of TOP2A mRNA CTD PMID:17656681 TOP2A Human topotecan decreases expression ISO Top2a (Rattus norvegicus) 6480464 Topotecan results in decreased expression of TOP2A mRNA CTD PMID:25729387 TOP2A Human topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of TOP2A mRNA CTD PMID:16026610 TOP2A Human topotecan multiple interactions ISO Top2a (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA CTD PMID:25729387 TOP2A Human tremolite asbestos increases expression ISO Top2a (Mus musculus) 6480464 tremolite results in increased expression of TOP2A mRNA CTD PMID:29279043 TOP2A Human triacsin C decreases expression EXP 6480464 triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 TOP2A Human triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of TOP2A mRNA CTD PMID:30510588 TOP2A Human trimellitic anhydride increases expression ISO Top2a (Mus musculus) 6480464 trimellitic anhydride results in increased expression of TOP2A mRNA CTD PMID:19042947 TOP2A Human triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of TOP2A mRNA CTD PMID:37042841 TOP2A Human triptonide decreases expression ISO Top2a (Mus musculus) 6480464 triptonide results in decreased expression of TOP2A mRNA CTD PMID:33045310 TOP2A Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of TOP2A mRNA CTD PMID:19140230 TOP2A Human trovafloxacin decreases activity EXP 6480464 trovafloxacin results in decreased activity of TOP2A protein CTD PMID:24817034 TOP2A Human trovafloxacin decreases expression ISO Top2a (Mus musculus) 6480464 trovafloxacin results in decreased expression of TOP2A mRNA CTD PMID:35537566 TOP2A Human tungsten decreases expression ISO Top2a (Mus musculus) 6480464 Tungsten results in decreased expression of TOP2A mRNA CTD PMID:30912803 TOP2A Human ursolic acid decreases activity EXP 6480464 Ursolic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 TOP2A Human valproic acid increases expression ISO Top2a (Rattus norvegicus) 6480464 Valproic Acid results in increased expression of TOP2A mRNA CTD PMID:19224547 TOP2A Human valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of TOP2A mRNA CTD PMID:20585447 and PMID:28001369 TOP2A Human vincaleukoblastine affects response to substance EXP 6480464 TOP2A protein affects the susceptibility to Vinblastine CTD PMID:16217747 TOP2A Human vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of TOP2A mRNA CTD PMID:23649840 TOP2A Human Xanthatin decreases activity EXP 6480464 xanthatin results in decreased activity of TOP2A protein CTD PMID:23313378 TOP2A Human Xanthatin multiple interactions EXP 6480464 [xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA CTD PMID:23824011 TOP2A Human Xanthatin decreases expression EXP 6480464 xanthatin results in decreased expression of TOP2A CTD PMID:23824011 TOP2A Human zaragozic acid A decreases expression ISO Top2a (Rattus norvegicus) 6480464 squalestatin 1 results in decreased expression of TOP2A mRNA CTD PMID:27225895 TOP2A Human zaragozic acid A decreases expression ISO Top2a (Mus musculus) 6480464 squalestatin 1 results in decreased expression of TOP2A mRNA CTD PMID:27225895 TOP2A Human zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of TOP2A mRNA CTD PMID:22171008 TOP2A Human zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of TOP2A mRNA CTD PMID:22171008 TOP2A Human zoledronic acid decreases expression EXP 6480464 zoledronic acid results in decreased expression of TOP2A mRNA CTD PMID:24714768
