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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62340
Species: Mus musculus
RGD Object: Gene
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2adecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of TOP2A mRNAPMID:25896364
Top2aincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of TOP2A mRNAPMID:22712078 PMID:36227756
Top2amultiple interactionsEXP 6480464CTDLovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA]PMID:22712078
Top2aaffects activityISOTOP2A (Homo sapiens)6480464CTDDoxorubicin affects the activity of TOP2A proteinPMID:19182879
Top2aaffects response to substanceISOTOP2A (Homo sapiens)6480464CTDTOP2A protein affects the susceptibility to DoxorubicinPMID:16217747
Top2adecreases expressionISOTOP2A (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of TOP2A mRNAPMID:15205334 PMID:16026610 PMID:29803840
Top2adecreases response to substanceISOTOP2A (Homo sapiens)6480464CTDTOP2A mRNA results in decreased susceptibility to Doxorubicin; TOP2A protein mutant form results in decreased susceptibility to Doxorubicin; TOP2A protein results in decreased susceptibility to DoxorubicinPMID:11470519 PMID:15765123
Top2aincreases expressionISOTOP2A (Homo sapiens)6480464CTDDoxorubicin results in increased expression of TOP2A proteinPMID:17351394 PMID:22751436
Top2aincreases response to substanceISOTOP2A (Homo sapiens)6480464CTDTOP2A mRNA results in increased susceptibility to Doxorubicin; TOP2A results in increased susceptibility to DoxorubicinPMID:15239142 PMID:9862568
Top2amultiple interactionsISOTOP2A (Homo sapiens)6480464CTD[Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter]; [DPP4 protein results in increased expression of TOP2A protein] which results in increased susceptibility to Doxorubicin; [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Doxorubicin; [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Doxorubicin; [TOP2A protein co-treated with ERBB2 protein] results in increased susceptibility to Doxorubicin; delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]PMID:15486187 PMID:15753397 PMID:16969495 PMID:19182879 PMID:22293659 PMID:22751436 PMID:28323900
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