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GENE - TERM ANNOTATION REPORT

RGD ID: 62340
Species: Mus musculus
RGD Object: Gene
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
Acc ID: GO:0005634
Term: nucleus
Definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Definition Source(s): GOC:go_curators
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2ais_active_inIBAPANTHER:PTN000018888 or SGD:S000005032 or UniProtKB:Q02880 or UniProtKB:Q5B224 or UniProtKB:O42131 or TAIR:locus:2076201 or MGI:98791 or MGI:98790 or FB:FBgn0284220 or PomBase:SPBC1A4.03c or UniProtKB:P11388 or UniProtKB:O421302290270GO_Central GO_REF:0000033
Top2ais_active_inIDA 2290270MGI PMID:25961503

PMID:25961503
Top2alocated_inIDA 2290270MGI PMID:9224616

PMID:9224616
Top2alocated_inISOUniProtKB:P113882290270MGI GO_REF:0000119 MGI:4834177
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