Hdac11 (histone deacetylase 11) - Rat Genome Database
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Gene: Hdac11 (histone deacetylase 11) Mus musculus
Analyze
Symbol: Hdac11
Name: histone deacetylase 11
RGD ID: 1323303
MGI Page MGI
Description: Predicted to have histone deacetylase activity. Predicted to be involved in histone deacetylation and oligodendrocyte development. Predicted to localize to histone deacetylase complex and plasma membrane. Orthologous to human HDAC11 (histone deacetylase 11); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HD11; MGC27683
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,133,652 - 91,151,674 (+)NCBIGRCm39mm39
GRCm38691,156,670 - 91,174,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,156,665 - 91,174,692 (+)EnsemblGRCm38mm10GRCm38
MGSCv37691,106,809 - 91,124,677 (+)NCBIGRCm37mm9NCBIm37
MGSCv36691,122,319 - 91,140,187 (+)NCBImm8
Celera693,049,682 - 93,067,648 (+)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12711221   PMID:14581517   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:17568773   PMID:17893925   PMID:18824292   PMID:19011628   PMID:20059953   PMID:21677750   PMID:21731673   PMID:21985497   PMID:23657855   PMID:24047695   PMID:24726361  
PMID:24747960   PMID:25011550   PMID:25155994   PMID:28028172   PMID:28550044   PMID:28550123   PMID:28584078   PMID:28819166   PMID:28927261   PMID:28928414   PMID:29655790   PMID:29958910  
PMID:30089714   PMID:30456376   PMID:30819897   PMID:31138677   PMID:31750881   PMID:31910069  


Genomics

Comparative Map Data
Hdac11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,133,652 - 91,151,674 (+)NCBIGRCm39mm39
GRCm38691,156,670 - 91,174,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,156,665 - 91,174,692 (+)EnsemblGRCm38mm10GRCm38
MGSCv37691,106,809 - 91,124,677 (+)NCBIGRCm37mm9NCBIm37
MGSCv36691,122,319 - 91,140,187 (+)NCBImm8
Celera693,049,682 - 93,067,648 (+)NCBICelera
Cytogenetic Map6D1NCBI
HDAC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl313,479,724 - 13,506,424 (+)EnsemblGRCh38hg38GRCh38
GRCh38313,478,903 - 13,506,416 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37313,521,806 - 13,547,916 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37313,521,671 - 13,547,924 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36313,496,824 - 13,521,834 (+)NCBINCBI36hg18NCBI36
Build 34313,496,823 - 13,521,834NCBI
Celera313,459,987 - 13,486,185 (+)NCBI
Cytogenetic Map3p25.1NCBI
HuRef313,454,981 - 13,481,181 (+)NCBIHuRef
CHM1_1313,471,748 - 13,497,959 (+)NCBICHM1_1
Hdac11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24123,645,873 - 123,667,407 (+)NCBI
Rnor_6.0 Ensembl4122,781,095 - 122,798,353 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04122,781,095 - 122,798,355 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04187,747,330 - 187,764,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,326,168 - 125,343,417 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14125,570,644 - 125,587,876 (+)NCBI
Celera4112,570,281 - 112,587,541 (+)NCBICelera
Cytogenetic Map4q34NCBI
Hdac11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542912,890,879 - 12,907,749 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542912,890,939 - 12,907,749 (-)NCBIChiLan1.0ChiLan1.0
HDAC11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1313,744,425 - 13,769,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl313,744,475 - 13,769,997 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0313,400,788 - 13,427,010 (+)NCBIMhudiblu_PPA_v0panPan3
HDAC11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl203,792,693 - 3,837,192 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1203,792,832 - 3,815,922 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hdac11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936898148,891 - 177,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,860,656 - 70,918,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,860,650 - 70,879,863 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21378,557,476 - 78,589,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12249,470,443 - 49,497,692 (+)NCBI
ChlSab1.1 Ensembl2249,471,368 - 49,498,178 (+)Ensembl
Hdac11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479612,666,544 - 12,683,223 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1658
Count of miRNA genes:662
Interacting mature miRNAs:837
Transcripts:ENSMUST00000041736, ENSMUST00000127768, ENSMUST00000134154, ENSMUST00000143621, ENSMUST00000154389, ENSMUST00000155007
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041736   ⟹   ENSMUSP00000043828
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,156,665 - 91,174,692 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,157,164 - 91,167,848 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134154
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,171,764 - 91,173,283 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143621   ⟹   ENSMUSP00000121624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,156,826 - 91,166,522 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,156,818 - 91,159,719 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155007   ⟹   ENSMUSP00000120923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,157,397 - 91,173,516 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204776   ⟹   ENSMUSP00000145014
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,165,651 - 91,169,459 (+)Ensembl
RefSeq Acc Id: NM_144919   ⟹   NP_659168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,133,797 - 91,151,665 (+)NCBI
GRCm38691,156,815 - 91,174,683 (+)NCBI
MGSCv37691,106,809 - 91,124,677 (+)RGD
Celera693,049,682 - 93,067,648 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036166054   ⟹   XP_036021947
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,142,603 - 91,151,674 (+)NCBI
RefSeq Acc Id: XR_003956189
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,133,652 - 91,151,674 (+)NCBI
GRCm38691,156,670 - 91,174,692 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003956190
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,133,652 - 91,151,674 (+)NCBI
GRCm38691,156,670 - 91,174,692 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_659168 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH16208 (Get FASTA)   NCBI Sequence Viewer  
  BAC32565 (Get FASTA)   NCBI Sequence Viewer  
  EDK99293 (Get FASTA)   NCBI Sequence Viewer  
  Q91WA3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_659168   ⟸   NM_144919
- UniProtKB: Q91WA3 (UniProtKB/Swiss-Prot),   Q543U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121624   ⟸   ENSMUST00000143621
RefSeq Acc Id: ENSMUSP00000145014   ⟸   ENSMUST00000204776
RefSeq Acc Id: ENSMUSP00000043828   ⟸   ENSMUST00000041736
RefSeq Acc Id: ENSMUSP00000120923   ⟸   ENSMUST00000155007
RefSeq Acc Id: XP_036021947   ⟸   XM_036166054
- Peptide Label: isoform X1
Protein Domains
Hist_deacetyl

Promoters
RGD ID:6839428
Promoter ID:MM_KWN:46910
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:OTTMUST00000041896,   OTTMUST00000041897,   OTTMUST00000041898,   OTTMUST00000041899,   OTTMUST00000041900
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36691,106,601 - 91,107,101 (+)MPROMDB
RGD ID:6839432
Promoter ID:MM_KWN:46912
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000041901
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36691,121,996 - 91,122,496 (+)MPROMDB
RGD ID:6890434
Promoter ID:EPDNEW_M8668
Type:initiation region
Name:Hdac11_1
Description:Mus musculus histone deacetylase 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38691,156,780 - 91,156,840EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385252 AgrOrtholog
Ensembl Genes ENSMUSG00000034245 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000043828 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000120923 UniProtKB/TrEMBL
  ENSMUSP00000121624 UniProtKB/TrEMBL
  ENSMUSP00000145014 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041736 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000143621 UniProtKB/TrEMBL
  ENSMUST00000155007 UniProtKB/TrEMBL
  ENSMUST00000204776 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HDAC_classIV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2385252 ENTREZGENE
NCBI Gene 232232 ENTREZGENE
Pfam Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdac11 PhenoGen
PRINTS HDASUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVA2_MOUSE UniProtKB/TrEMBL
  D3Z2G7_MOUSE UniProtKB/TrEMBL
  F6UL83_MOUSE UniProtKB/TrEMBL
  HDA11_MOUSE UniProtKB/Swiss-Prot
  Q543U1 ENTREZGENE, UniProtKB/TrEMBL
  Q91WA3 ENTREZGENE