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Gene: Melk (maternal embryonic leucine zipper kinase) Mus musculus

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Symbol:

Melk

Name:

maternal embryonic leucine zipper kinase

RGD ID:

1319060

MGI Page

MGI

Description:

Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AI327312; mKIAA0175; MPK3; MPK38; protein kinase PK38; tyrosine-protein kinase MELK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MELK (maternal embryonic leucine zipper kinase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Melk (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Melk (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MELK (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MELK (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Melk (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MELK (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MELK (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Melk (maternal embryonic leucine zipper kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Melk (maternal embryonic leucine zipper kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MELK (maternal embryonic leucine zipper kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	melk (maternal embryonic leucine zipper kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	pig-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPL150W	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	melk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	44,300,876 - 44,364,301 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	44,300,909 - 44,364,675 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	44,313,789 - 44,377,547 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	44,322,017 - 44,385,775 (+)	NCBI		MGSCv36	mm8
Celera	4	44,320,472 - 44,384,714 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	23.46	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

hepatocellular carcinoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3-methylcholanthrene (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (EXP)

azathioprine (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (EXP)

Biflorin (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (EXP)

choline (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

corticosterone (ISO)

coumestrol (ISO)

CU-O LINKAGE (ISO)

Cuprizon (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

emodin (ISO)

Enterolactone (ISO)

folic acid (EXP,ISO)

FR900359 (ISO)

furan (ISO)

genistein (ISO)

glycidol (ISO)

isoliquiritigenin (ISO)

ivermectin (ISO)

L-methionine (EXP)

lucanthone (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methoxychlor (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

ochratoxin A (ISO)

oxaliplatin (ISO)

ozone (EXP)

paclitaxel (ISO)

palbociclib (ISO)

paracetamol (ISO)

PCB138 (EXP,ISO)

perfluorohexanesulfonic acid (EXP)

perfluorononanoic acid (ISO)

phenobarbital (EXP)

PhIP (ISO)

potassium chromate (ISO)

propanal (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

silicon dioxide (EXP)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (ISO)

titanium dioxide (EXP,ISO)

topotecan (ISO)

trimellitic anhydride (EXP)

troglitazone (ISO)

trovafloxacin (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO,ISS)

cell population proliferation (ISO,ISS)

chromatin remodeling (IEA)

hemopoiesis (ISS)

intrinsic apoptotic signaling pathway in response to oxidative stress (IDA)

neural precursor cell proliferation (IDA)

positive regulation of apoptotic process (IDA)

protein autophosphorylation (ISO,ISS)

Cellular Component

cell cortex (ISO,ISS)

cytoplasm (IDA)

plasma membrane (ISO,ISS)

Molecular Function

3-phosphoinositide-dependent protein kinase activity (IEA)

AMP-activated protein kinase activity (IEA)

ATP binding (IEA)

calcium ion binding (ISO,ISS)

DNA-dependent protein kinase activity (IEA)

eukaryotic translation initiation factor 2alpha kinase activity (IEA)

histone H2AS1 kinase activity (IEA)

histone H2AS121 kinase activity (IEA)

histone H2AT120 kinase activity (IEA)

histone H2AXS139 kinase activity (IEA)

histone H2BS14 kinase activity (IEA)

histone H2BS36 kinase activity (IEA)

histone H3S10 kinase activity (IEA)

histone H3S28 kinase activity (IEA)

histone H3S57 kinase activity (IEA)

histone H3T11 kinase activity (IEA)

histone H3T3 kinase activity (IEA)

histone H3T45 kinase activity (IEA)

histone H3T6 kinase activity (IEA)

histone H4S1 kinase activity (IEA)

lipid binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IBA,ISO,ISS)

protein binding (IPI)

protein kinase activity (IDA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,ISA,ISO,ISS)

Rho-dependent protein serine/threonine kinase activity (IEA)

ribosomal protein S6 kinase activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal pancreas regeneration (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.	Easterday MC, etal., Dev Biol 2003 Dec 15;264(2):309-22.
2.	New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.	Heyer BS, etal., Mol Reprod Dev 1997 Jun;47(2):148-56.
3.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
6.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9305775	PMID:10349636	PMID:10417823	PMID:10922068	PMID:10934024	PMID:11042159	PMID:11076861	PMID:11747609	PMID:11802789	PMID:12477932	PMID:14610273	PMID:14660441
PMID:14681479	PMID:15782199	PMID:16061694	PMID:16141072	PMID:16141073	PMID:16144839	PMID:16602821	PMID:18948261	PMID:20659902	PMID:20861186	PMID:21267068	PMID:21677750
PMID:21873635	PMID:22532570	PMID:22544756	PMID:23747528	PMID:24319055	PMID:24531485	PMID:24844244	PMID:24885567	PMID:25194022	PMID:29700281	PMID:30973865	PMID:31097688
PMID:32325033	PMID:32554809	PMID:33268463	PMID:34321999	PMID:34365141	PMID:35730614	PMID:38355793

Genomics

Comparative Map Data

Melk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	44,300,876 - 44,364,301 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	44,300,909 - 44,364,675 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	44,313,789 - 44,377,547 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	44,322,017 - 44,385,775 (+)	NCBI		MGSCv36	mm8
Celera	4	44,320,472 - 44,384,714 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	23.46	NCBI

MELK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	36,572,895 - 36,677,682 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	36,572,862 - 36,677,683 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	36,572,892 - 36,677,679 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	36,562,905 - 36,667,679 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	36,562,904 - 36,667,678	NCBI
Celera	9	36,506,192 - 36,610,971 (+)	NCBI		Celera
Cytogenetic Map	9	p13.2	NCBI
HuRef	9	36,525,297 - 36,629,824 (+)	NCBI		HuRef
CHM1_1	9	36,573,419 - 36,678,272 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	36,595,568 - 36,700,421 (+)	NCBI		T2T-CHM13v2.0

Melk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	63,336,151 - 63,396,254 (+)	NCBI		GRCr8
mRatBN7.2	5	58,540,393 - 58,600,562 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	58,540,449 - 58,600,937 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	60,522,076 - 60,582,306 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	62,340,875 - 62,401,107 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	62,310,545 - 62,371,306 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	59,783,835 - 59,844,356 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	59,783,890 - 59,844,356 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	64,307,418 - 64,367,854 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	60,787,123 - 60,848,620 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	60,787,312 - 60,848,021 (+)	NCBI
Celera	5	57,118,072 - 57,178,790 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Melk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	29,717,978 - 29,815,170 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	29,718,291 - 29,815,163 (-)	NCBI	ChiLan1.0	ChiLan1.0

MELK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	87,915,014 - 88,018,519 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	87,920,955 - 88,024,441 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	36,419,974 - 36,522,584 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	37,219,170 - 37,321,318 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	37,219,170 - 37,321,318 (+)	Ensembl	panpan1.1		panPan2

MELK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	52,970,699 - 53,067,169 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	52,977,260 - 53,067,172 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	51,561,713 - 51,658,190 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	54,080,440 - 54,176,384 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	54,080,479 - 54,176,384 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	52,581,152 - 52,676,189 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	52,608,391 - 52,704,836 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	53,304,276 - 53,400,894 (+)	NCBI		UU_Cfam_GSD_1.0

Melk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,914,905 - 167,997,045 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	4,469,256 - 4,544,290 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	4,479,639 - 4,544,561 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MELK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	237,317,191 - 237,431,589 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	237,317,161 - 237,431,522 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	265,174,996 - 265,288,283 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MELK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	43,901,840 - 44,007,855 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	43,901,551 - 44,007,266 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	40,975,306 - 41,080,086 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Melk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624930	247,018 - 333,240 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Melk
3534 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	408
Count of miRNA genes:	311
Interacting mature miRNAs:	357
Transcripts:	ENSMUST00000045607, ENSMUST00000125708, ENSMUST00000137703, ENSMUST00000137759
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301203	Alcp8_m	alcohol preference locus 8 (mouse)			Not determined		4	17395160	51395290	Mouse
1301586	Stheal3_m	soft tissue heal 3 (mouse)			Not determined		4	28658442	62658566	Mouse
10401115	Pgia35_m	proteoglycan induced arthritis 35 (mouse)			Not determined		4	12562377	46562509	Mouse
39128211	Lwq22_m	liver weight QTL 22 (mouse)					4	17892616	88982216	Mouse
1301786	Bpq3_m	blood pressure QTL 3 (mouse)			Not determined		4	42402240	76402381	Mouse
4141555	Nbwa2_m	NZB and NZW autoimmunity 2 (mouse)			Not determined		4	17892515	51892635	Mouse
10412178	Habiir2_m	hyperoxic acute lung injury imprinted region 2 (mouse)			Not determined		4	39452126	63283678	Mouse
1300574	Im2_m	immunoregulatory 2 (mouse)			Not determined		4	28077682	62077816	Mouse
12880405	Jcdq1_m	joint cartilage degeneration QTL 1 (mouse)					4	12562377	46562509	Mouse
4142318	Lyr2_m	lymphoma resistance 2 (mouse)			Not determined			14010457	63283678	Mouse
1301697	Sluc18_m	susceptibility to lung cancer 18 (mouse)			Not determined		4	22373448	56373612	Mouse
1357453	Kidq4_m	kidney weight QTL 4 (mouse)			Not determined		4	17892616	88982216	Mouse
4142047	Mvwf3_m	modifier of von Willebrand factor 3 (mouse)			Not determined			14010457	117072206	Mouse
11567249	Elorr3_m	ethanol induced loss of righting response 3 (mouse)					4	3722677	156268235	Mouse
1357877	Synch1_m	synechia 1 (mouse)			Not determined		4	28709925	62710107	Mouse
1300977	Mopkd1_m	modifier of polycystic kidney disease progression 1 (mouse)			Not determined		4	36550839	70550967	Mouse
25440481	Moaq1_m	modifier of alien QTL 1 (mouse)					4	19500000	46000000	Mouse
1301237	Alcp7_m	alcohol preference locus 7 (mouse)			Not determined		4	17395160	51395290	Mouse
4141911	W6q15_m	weight 6 weeks QTL 15 (mouse)			Not determined			17892616	88982216	Mouse
1302075	Bdln6_m	body length 6 (mouse)			Not determined		4	22373448	56373612	Mouse
4142290	Ssrq9_m	stress response QTL 9 (mouse)			Not determined			34395160	46332776	Mouse
1301437	Scon1_m	sucrose consumption 1 (mouse)			Not determined		4	22373448	56373612	Mouse
1300769	Pcyts2_m	plasmacytoma susceptibility 2 (mouse)			Not determined		4	22111944	56112145	Mouse
1301792	Hdlq10_m	HDL QTL 10 (mouse)			Not determined		4	35859707	69859853	Mouse
1301990	Arvm1_m	autoimmune renal vasculitis 1 (mouse)			Not determined		4	29332646	63332776	Mouse
1302116	Bbaa1_m	B.burgdorferi-associated arthritis 1 (mouse)			Not determined		4	38250930	72251078	Mouse
1302058	Hrtfm3_m	heart failure modifier 3 (mouse)			Not determined		4	22111944	56112145	Mouse
1302184	Aaom1_m	autoimmune aoritis in MRL mice 1 (mouse)			Not determined		4	24322299	46332776	Mouse
26884449	Sklq2_m	skull length QTL 2, 5 week (mouse)					4	36700000	128993793	Mouse
27226724	Tibw2_m	tibia width 2, proximal, 10 week (mouse)					4	43000000	108357197	Mouse

Markers in Region

X95351

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	44,364,104 - 44,364,287	UniSTS	GRCm38
MGSCv37	4	44,376,976 - 44,377,159	UniSTS	GRCm37
Celera	4	44,384,143 - 44,384,326	UniSTS
Cytogenetic Map	4	B1	UniSTS
cM Map	4	26.7	UniSTS
Whitehead_YAC	4		UniSTS

Melk

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
MGSCv37	4	44,376,842 - 44,377,009	UniSTS	GRCm37
Celera	4	44,384,009 - 44,384,176	UniSTS
Cytogenetic Map	4	B1	UniSTS
cM Map	4	26.7	UniSTS
cM Map	4	26.7	UniSTS

AI327312

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	44,364,068 - 44,364,181	UniSTS	GRCm38
MGSCv37	4	44,376,940 - 44,377,053	UniSTS	GRCm37
Celera	4	44,384,107 - 44,384,220	UniSTS
Cytogenetic Map	4	B1	UniSTS
cM Map	4	26.7	UniSTS
Whitehead/MRC_RH	4	688.51	UniSTS
Whitehead/MRC_RH	4	690.65	UniSTS

Melk

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	44,363,970 - 44,364,137	UniSTS	GRCm38
MGSCv37	4	44,376,842 - 44,377,009	UniSTS	GRCm37
Celera	4	44,384,009 - 44,384,176	UniSTS
Cytogenetic Map	4	B1	UniSTS
cM Map	4	26.7	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001418999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001419000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_010790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_036163783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK010498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK129076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK137000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK161029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK164138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK206998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK208560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL805952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL807399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC055065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L76158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000045607 ⟹ ENSMUSP00000043806

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl
GRCm38.p6 Ensembl	4	44,300,876 - 44,364,675 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000125708 ⟹ ENSMUSP00000118359

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	44,303,568 - 44,318,070 (+)	Ensembl
GRCm38.p6 Ensembl	4	44,303,568 - 44,318,070 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000137703 ⟹ ENSMUSP00000120242

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	44,302,667 - 44,325,693 (+)	Ensembl
GRCm38.p6 Ensembl	4	44,302,667 - 44,325,693 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000137759

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	44,303,568 - 44,324,268 (+)	Ensembl
GRCm38.p6 Ensembl	4	44,303,568 - 44,324,268 (+)	Ensembl

RefSeq Acc Id:

NM_001418999 ⟹ NP_001405928

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	44,300,951 - 44,364,296 (+)	NCBI

RefSeq Acc Id:

NM_001419000 ⟹ NP_001405929

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	44,300,951 - 44,364,296 (+)	NCBI

RefSeq Acc Id:

NM_010790 ⟹ NP_034920

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	44,300,951 - 44,364,296 (+)	NCBI
GRCm38	4	44,300,917 - 44,364,675 (+)	NCBI
MGSCv37	4	44,313,789 - 44,377,547 (+)	RGD
Celera	4	44,320,472 - 44,384,714 (+)	RGD
cM Map	4		ENTREZGENE

Sequence:

show sequence

AGGTTTGATTCCTTTGGCGGGCGGAAGCTGCTGGAACTTGAATCCTGCAGAAATTCCCACCGAC
TTGTTCCGGCTTTGCTAGACTCTGCAGCCGGCTGCTTCACCTTCTGTCCTGTTCGGTCCTGTTC
GGTCCTTGCTGGGCCCGCTGCCCTTCAGGTTCTGGTTGTCATTTTGAATAACCTTCCAGGTGGA
CTATGAAAGATTATGACGAACTCCTCAAATACTATGAACTATATGAAACGATTGGGACAGGTGG
CTTTGCAAAGGTCAAACTGGCCTGCCATGTCCTCACTGGAGAGATGGTAGCTATAAAAATCATG
GATAAGAATGCGCTAGGGAGTGATTTGCCCCGAGTCAAAACTGAGATCGATGCGCTGAAGAGTC
TGAGACATCAGCACATATGTCAGCTCTACCATGTGCTGGAGACAAAGAACAAAATATTCATGGT
TCTGGAGTACTGTCCAGGAGGAGAGCTGTTTGACTACATAATCTCCCAGGATCGCCTGTCGGAA
GAGGAGACCCGGGTCGTCTTCCGTCAGATACTGTCTGCAGTTGCGTATGTCCACAGCCAGGGCT
ATGCCCACAGGGACCTCAAACCAGAAAATTTATTATTTGATGAAAATCATAAGCTAAAGCTGAT
TGACTTTGGTCTTTGTGCAAAACCCAAGGGCAACAAGGACTACCATCTGCAGACGTGCTGTGGG
AGCCTTGCTTATGCAGCTCCTGAACTAATACAAGGGAAGTCGTACCTTGGATCAGAGGCAGATG
TTTGGAGCATGGGCATCCTCCTGTATGTGCTCATGTGTGGATTTCTACCATTTGATGATGATAA
TGTCATGGCTTTGTACAAGAAGATAATGAGAGGGAAATACGAAGTTCCTAAGTGGCTCTCTCCC
AGTAGCATTCTGCTTCTCCAGCAGATGTTGCAGGTGGACCCAAAGAAACGGATTTCTATGAGAA
ATCTCCTGAACCATCCCTGGGTCATGCAAGATTACAGCTGTCCCGTGGAGTGGCAAAGCAAGAC
TCCTTTGACTCACCTCGATGAGGATTGCGTGACAGAGCTTTCTGTACATCACCGCAGCAGCAGG
CAGACAATGGAGGATTTAATTTCGTCGTGGCAGTACGATCACCTCACAGCCACCTACCTTCTGC
TTCTAGCCAAGAAGGCCCGGGGGAAGCCGGCTCGTCTACAGCTCCTGTCCTTCTCTTGTGGAAC
CGCCAGCACCACTCCAAAGTCAAAGAATCTGAGCCTGGAAGATATGAGCACAAGTGATGATAAC
TGTGTGGCTGGATTGATAGACTATGAATTGTGTGAAGATAAATTATTAGCTCCCAAGACGCCAC
AGGTTACCAAACACTTGGCAGAATCAAATCACGCAGCATCTAAATCACCAGCGCCAGGGGTACG
CAGAGCAGTGGCAAATAAATTAATGGACAAAGAAAATGTGTGCACTCCCAAGTCTTCTGTGAAG
AATGAAGAGCAGTTTGTATTTTCTGAGCCGAAGATTCCAGTTAGTAAGAACCAGTATAAGAGAG
AAATACCCGCCTCACCAACCCGTTTCCCAACACCTGCAAAAGCTAGAGCCCAGTGCCTGAGAGA
AGCCCCGGTTAGAACACCAGGGAATTCCGCAGGAGCAGACACACTAACGACAGGTGTCATTAGC
CCCGAGAGGAGGTGCCGTTCAATGGACGTGGATCTCAACCAGGCACACATGGAGGATACCCCGA
AAAAGAAAGGAACCAATGTGTTTGGGAGCCTTGAGAGAGGACTGGATAAGGTTCTCACTGCGCT
CACAAGGAACAAGAAGAAGGGCTCTGCCAGAGATGGACCAAGAAAGCGAAAGCTGCACTACAAT
GTGACTACAACTCGCCTGGTGAACCCCGACCAGCTCCTGAGCGAAATCATGGCTATTCTTCCAA
AGAAGAACGTGGACTTCGTACAGAAAGGTTACACTCTAAAGTGTCAAACGCAGTCTGATTTTGG
CAAAGTGACAATGCAGTTTGAACTGGAAGTGTGCCAGCTGCAGAGACCTGACGTGGTAGGCATC
CGGAGACAGCGGCTGAAGGGTGATGCCTGGGTTTACAAGAGATTAGTGGAAGATATCTTGTCTG
GCTGCAAGATGTGACCGATGACAGTGTCCGTCTGCCCGGATGAATGTGGGTGTGATGTTGCACA
CAGGAAGACTGTGAGATTGGTTCCATTTGGGGGCCATTGGATCTATGGAACTACAAGCTCATTT
AAATAGCCATCTTCAAGACCAATGTATTTTTGCTTTTTAAACAAAAATTTTTACTTTGTGGCTG
AATCCAAGGCAACTGTTCTGTCATTATCAATTACTCTCTGTTTTAATCATGGGCTTGGTATGTT
AGTAACTGTTTTTATATTCACTTCCATCAGGGGATGCCAGCTCTTCACTGTGACTCATTTTGAT
GTACAGTTTCTTTCTGAACTAAAACCATTTGTGAATATATCAAGCTCTTTTTTGTATCTGATTT
TGATCCAAATAAAACCTCGAATGGCTTCCTGACTGTTAAGTAGAGACTATTTGGAGTGTGTTTT
ATCTGTTATCAAATATGCCTTGGGCAGAAAAACAGATAAGAATTCATTTGCATAATTTTTTCCT
GTCTCTGATTTAAGTAGGATTTATTGAGATCGTTAACTAAGTCACAGCTGTGGTTACCAGAGTT
AAACAACACATTTAATATGTGGAATAAAAGCGTATTGACTTCAGTAAGTATGTCCAGTCAACAA
TGATAAGTATCCGAACTGCAGGCCCCATGAAATGTTACTTTATGGTAATCTCTAAGTCTCAACG
ATGGCCCCAGATTTGTATTTTTATTTCATTTTATTGGTCTCTAAAGGCCAGAACTCAAGTTACA
TTTGTATGGATTTTACCAATTAAACTAGTTGGAG

hide sequence

RefSeq Acc Id:

XM_036163783 ⟹ XP_036019676

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	44,300,876 - 44,364,301 (+)	NCBI

Sequence:

show sequence

TGGGACTGGGCTCCCTTGGGCCCCGCCTCTTCCGGCCCGCGAGGTTTGATTCCTTTGGCGGGCG
GAAGCTGCTGGAACTTGAATCCTGCAGAAATTCCCACCGACTTGTTCCGGCTTTGCTAGACTCT
GCAGCCGGCTGCTTCACCTTCTGTCCTGTTCGGTCCTGTTCGGTCCTTGCTGGGCCCGCTGCCC
TTCAGGTTCTGGTTGTCATTTTGAATAACCTTCCAGGTGGACTATGAAAGATTATGACGAACTC
CTCAAATACTATGAACTATATGAAACGATTGGGACAGGTGGCTTTGCAAAGGTCAAACTGGCCT
GCCATGTCCTCACTGGAGAGATGGTAGCTATAAAAATCATGGATAAGAATGCGCTAGGGAGTGA
TTTGCCCCGAGTCAAAACTGAGATCGATGCGCTGAAGAGTCTGAGACATCAGCACATATGTCAG
CTCTACCATGTGCTGGAGACAAAGAACAAAATATTCATGGTTCTGGAGTACTGTCCAGGAGGAG
AGCTGTTTGACTACATAATCTCCCAGGATCGCCTGTCGGAAGAGGAGACCCGGGTCGTCTTCCG
TCAGATACTGTCTGCAGTTGCGTATGTCCACAGCCAGGGCTATGCCCACAGGGACCTCAAACCA
GAAAATTTATTATTTGATGAAAATCATAAGCTAAAGCTGATTGACTTTGGTCTTTGTGCAAAAC
CCAAGGGCAACAAGGACTACCATCTGCAGACGTGCTGTGGGAGCCTTGCTTATGCAGCTCCTGA
ACTAATACAAGGGAAGTCGTACCTTGGATCAGAGGCAGATGTTTGGAGCATGGGCATCCTCCTG
TATGTGCTCATGTGTGGATTTCTACCATTTGATGATGATAATGTCATGGCTTTGTACAAGAAGA
TAATGAGAGGGAAATACGAAGTTCCTAAGTGGCTCTCTCCCAGTAGCATTCTGCTTCTCCAGCA
GATGTTGCAGGTGGACCCAAAGAAACGGATTTCTATGAGAAATCTCCTGAACCATCCCTGGGTC
ATGCAAGATTACAGCTGTCCCGTGGAGTGGCAAAGCAAGACTCCTTTGACTCACCTCGATGAGG
ATTGCGTGACAGAGCTTTCTGTACATCACCGCAGCAGCAGGCAGACAATGGAGGATTTAATTTC
GTCGTGGCAGTACGATCACCTCACAGCCACCTACCTTCTGCTTCTAGCCAAGAAGGCCCGGGGG
AAGCCGGCTCGTCTACAGCTCCTGTCCTTCTCTTGTGGAACCGCCAGCACCACTCCAAAGTCAA
AGAATCTGAGCCTGGAAGATATGAGCACAAGTGATGATAACTGTGTGGCTGGATTGATAGACTA
TGAATTGTGTGAAGATAAATTATTAGCTCCCAAGACGCCACAGGTTACCAAACACTTGGCAGAA
TCAAATCACGCAGCATCTAAATCACCAGCGCCAGGGGTACGCAGAGCAGTGGCAAATAAATTAA
TGGACAAAGAAAATGTGTGCACTCCCAAGTCTTCTGTGAAGAATGAAGAGCAGTTTGTATTTTC
TGAGCCGAAGATTCCAGTTAGTAAGAACCAGTATAAGAGAGAAATACCCGCCTCACCAACCCGT
TTCCCAACACCTGCAAAAGCTAGAGCCCAGTGCCTGAGAGAAGCCCCGGTTAGAACACCAGGGA
ATTCCGCAGGAGCAGACACACTAACGACAGGTGTCATTAGCCCCGAGAGGAGGTGCCGTTCAAT
GGACGTGGATCTCAACCAGGCACACATGGAGGATACCCCGAAAAAGAAAGGAACCAATGTGTTT
GGGAGCCTTGAGAGAGGACTGGATAAGGTTCTCACTGCGCTCACAAGGAACAAGAAGAAGGGCT
CTGCCAGAGATGGACCAAGAAAGCGAAAGTTACACTCTAAAGTGTCAAACGCAGTCTGATTTTG
GCAAAGTGACAATGCAGTTTGAACTGGAAGTGTGCCAGCTGCAGAGACCTGACGTGGTAGGCAT
CCGGAGACAGCGGCTGAAGGGTGATGCCTGGGTTTACAAGAGATTAGTGGAAGATATCTTGTCT
GGCTGCAAGATGTGACCGATGACAGTGTCCGTCTGCCCGGATGAATGTGGGTGTGATGTTGCAC
ACAGGAAGACTGTGAGATTGGTTCCATTTGGGGGCCATTGGATCTATGGAACTACAAGCTCATT
TAAATAGCCATCTTCAAGACCAATGTATTTTTGCTTTTTAAACAAAAATTTTTACTTTGTGGCT
GAATCCAAGGCAACTGTTCTGTCATTATCAATTACTCTCTGTTTTAATCATGGGCTTGGTATGT
TAGTAACTGTTTTTATATTCACTTCCATCAGGGGATGCCAGCTCTTCACTGTGACTCATTTTGA
TGTACAGTTTCTTTCTGAACTAAAACCATTTGTGAATATATCAAGCTCTTTTTTGTATCTGATT
TTGATCCAAATAAAACCTCGAATGGCTTCCTGACTGTTAAGTAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001405928	(Get FASTA)	NCBI Sequence Viewer
	NP_001405929	(Get FASTA)	NCBI Sequence Viewer
	NP_034920	(Get FASTA)	NCBI Sequence Viewer
	XP_036019676	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB72030	(Get FASTA)	NCBI Sequence Viewer
	BAB27923	(Get FASTA)	NCBI Sequence Viewer
	BAC97886	(Get FASTA)	NCBI Sequence Viewer
	BAE26188	(Get FASTA)	NCBI Sequence Viewer
	BAE26362	(Get FASTA)	NCBI Sequence Viewer
	BAE36156	(Get FASTA)	NCBI Sequence Viewer
	BAE37644	(Get FASTA)	NCBI Sequence Viewer
	BAE39542	(Get FASTA)	NCBI Sequence Viewer
	CAA64641	(Get FASTA)	NCBI Sequence Viewer
	EDL02425	(Get FASTA)	NCBI Sequence Viewer
	EDL02426	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000043806
	ENSMUSP00000043806.6
	ENSMUSP00000118359.2
	ENSMUSP00000120242.2
GenBank Protein	Q61846	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_034920 ⟸ NM_010790
- Peptide Label:	isoform 1
- UniProtKB:	Q61804 (UniProtKB/Swiss-Prot), Q3TPU1 (UniProtKB/Swiss-Prot), Q6ZQH6 (UniProtKB/Swiss-Prot), Q61846 (UniProtKB/Swiss-Prot), Q3TJF3 (UniProtKB/TrEMBL), Q3TU15 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSL RHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGY AHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADV WSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRN LLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYLLL LAKKARGKPARLQLLSFSCGTASTTPKSKNLSLEDMSTSDDNCVAGLIDYELCEDKLLAPKTPQ VTKHLAESNHAASKSPAPGVRRAVANKLMDKENVCTPKSSVKNEEQFVFSEPKIPVSKNQYKRE IPASPTRFPTPAKARAQCLREAPVRTPGNSAGADTLTTGVISPERRCRSMDVDLNQAHMEDTPK KKGTNVFGSLERGLDKVLTALTRNKKKGSARDGPRKRKLHYNVTTTRLVNPDQLLSEIMAILPK KNVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQRPDVVGIRRQRLKGDAWVYKRLVEDILSG CKM hide sequence

Ensembl Acc Id:

ENSMUSP00000118359 ⟸ ENSMUST00000125708

Ensembl Acc Id:

ENSMUSP00000043806 ⟸ ENSMUST00000045607

Ensembl Acc Id:

ENSMUSP00000120242 ⟸ ENSMUST00000137703

RefSeq Acc Id:	XP_036019676 ⟸ XM_036163783
- Peptide Label:	isoform X2
- UniProtKB:	Q3TU15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001405929 ⟸ NM_001419000
- Peptide Label:	isoform 3
- UniProtKB:	Q3TJF3 (UniProtKB/TrEMBL), Q3TU15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001405928 ⟸ NM_001418999
- Peptide Label:	isoform 2
- UniProtKB:	Q3TJF3 (UniProtKB/TrEMBL), Q3TU15 (UniProtKB/TrEMBL)

Protein Domains

KA1 Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q61846-F1-model_v2	AlphaFold	Q61846	1-643	view protein structure

Promoters

RGD ID:

6883278

Promoter ID:

EPDNEW_M5090

Type:

initiation region

Name:

Melk_1

Description:

Mus musculus maternal embryonic leucine zipper kinase , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	4	44,300,956 - 44,301,016	EPDNEW

RGD ID:

6835652

Promoter ID:

MM_KWN:37420

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, ES_Cell

Transcripts:

ENSMUST00000102933, ENSMUST00000107828, OTTMUST00000015242, UC008SRW.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	44,313,664 - 44,314,164 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:106924	AgrOrtholog
Ensembl Genes	ENSMUSG00000035683	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000045607	ENTREZGENE
	ENSMUST00000045607.12	UniProtKB/Swiss-Prot
	ENSMUST00000125708.2	UniProtKB/TrEMBL
	ENSMUST00000137703.8	UniProtKB/TrEMBL
Gene3D-CATH	Kinase associated domain 1, KA1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	KA1/Ssp2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KA1_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MELK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MELK_UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:17279	UniProtKB/Swiss-Prot
MGD	MGI:106924	ENTREZGENE
NCBI Gene	17279	ENTREZGENE
PANTHER	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	KA1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MELK_UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Melk	PhenoGen
PROSITE	KA1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103243	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A2ALQ9_MOUSE	UniProtKB/TrEMBL
	A2ALR0_MOUSE	UniProtKB/TrEMBL
	MELK_MOUSE	UniProtKB/Swiss-Prot
	Q3TJF3	ENTREZGENE, UniProtKB/TrEMBL
	Q3TPU1	ENTREZGENE
	Q3TU15	ENTREZGENE, UniProtKB/TrEMBL
	Q3UMB0_MOUSE	UniProtKB/TrEMBL
	Q61804	ENTREZGENE
	Q61846	ENTREZGENE
	Q6ZQH6	ENTREZGENE
UniProt Secondary	Q3TPU1	UniProtKB/Swiss-Prot
	Q61804	UniProtKB/Swiss-Prot
	Q6ZQH6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Mammalian Phenotype