Mx2 (MX dynamin-like GTPase 2) - Rat Genome Database

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Gene: Mx2 (MX dynamin-like GTPase 2) Mus musculus
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Symbol: Mx2
Name: MX dynamin-like GTPase 2
RGD ID: 1550081
MGI Page MGI
Description: Predicted to enable GTPase activity and microtubule binding activity. Predicted to be involved in defense response to virus. Predicted to be active in several cellular components, including cytoplasm; microtubule; and nucleus. Is expressed in several structures, including genitourinary system; liver; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI528743; interferon-induced GTP-binding protein Mx2; Mx-2; myxovirus (influenza virus) resistance 2; myxovirus resistance protein 2
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,337,281 - 97,362,101 (+)NCBIGRCm39mm39
GRCm39 Ensembl1697,336,508 - 97,362,100 (+)Ensembl
GRCm381697,536,081 - 97,560,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,535,308 - 97,560,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv371697,757,688 - 97,782,508 (+)NCBIGRCm37mm9NCBIm37
MGSCv361697,690,999 - 97,715,815 (+)NCBImm8
Celera1698,596,943 - 98,621,730 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1312277   PMID:2460745   PMID:2481229   PMID:10233954   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11266216   PMID:11374901   PMID:11932237   PMID:12477932  
PMID:14193387   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:23012479   PMID:23070814   PMID:25363729   PMID:27654285  


Genomics

Comparative Map Data
Mx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,337,281 - 97,362,101 (+)NCBIGRCm39mm39
GRCm39 Ensembl1697,336,508 - 97,362,100 (+)Ensembl
GRCm381697,536,081 - 97,560,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,535,308 - 97,560,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv371697,757,688 - 97,782,508 (+)NCBIGRCm37mm9NCBIm37
MGSCv361697,690,999 - 97,715,815 (+)NCBImm8
Celera1698,596,943 - 98,621,730 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.51NCBI
Mx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21136,905,698 - 36,936,308 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1136,906,111 - 36,930,342 (+)Ensembl
Rnor_6.01138,035,306 - 38,066,185 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,035,450 - 38,059,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,545,958 - 41,570,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,548,650 - 37,572,717 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11137,608,291 - 37,630,303 (+)NCBI
Celera1136,790,647 - 36,814,700 (+)NCBICelera
RH 3.4 Map11263.01RGD
Cytogenetic Map11q12NCBI

Position Markers
AB029920  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381697,560,582 - 97,560,667UniSTSGRCm38
MGSCv371697,782,189 - 97,782,274UniSTSGRCm37
Celera1698,621,411 - 98,621,496UniSTS
Cytogenetic Map16C4UniSTS
cM Map1671.2UniSTS
Whitehead/MRC_RH161006.04UniSTS
Whitehead/MRC_RH161006.57UniSTS
Mx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371697,668,755 - 97,668,978UniSTSGRCm37
MGSCv3768,838,657 - 8,838,815UniSTSGRCm37
MGSCv371697,668,564 - 97,668,897UniSTSGRCm37
Celera1698,507,489 - 98,507,712UniSTS
Celera1698,507,298 - 98,507,631UniSTS
Celera69,020,325 - 9,020,483UniSTS
Cytogenetic Map16C4UniSTS
cM Map1671.2UniSTS
Mx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C4UniSTS
cM Map1671.2UniSTS
Mx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166880383498207768Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166927924498207768Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166933072398207768Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166933072398207768Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166933072398207768Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166945759498207768Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167058336498207768Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:132
Interacting mature miRNAs:149
Transcripts:ENSMUST00000024112
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024112   ⟹   ENSMUSP00000024112
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1697,337,283 - 97,362,099 (+)Ensembl
GRCm38.p6 Ensembl1697,536,083 - 97,560,899 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188251   ⟹   ENSMUSP00000141038
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1697,337,281 - 97,362,100 (+)Ensembl
GRCm38.p6 Ensembl1697,536,081 - 97,560,900 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190097
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1697,351,587 - 97,353,170 (+)Ensembl
GRCm38.p6 Ensembl1697,550,387 - 97,551,970 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190447   ⟹   ENSMUSP00000140229
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1697,336,508 - 97,359,968 (+)Ensembl
GRCm38.p6 Ensembl1697,535,308 - 97,558,768 (+)Ensembl
RefSeq Acc Id: ENSMUST00000191103
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1697,359,612 - 97,361,718 (+)Ensembl
GRCm38.p6 Ensembl1697,558,412 - 97,560,518 (+)Ensembl
RefSeq Acc Id: NR_003508
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391697,337,281 - 97,362,101 (+)NCBI
GRCm381697,536,081 - 97,560,901 (+)ENTREZGENE
MGSCv371697,757,688 - 97,782,508 (+)RGD
Celera1698,596,943 - 98,621,730 (+)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: ENSMUSP00000140229   ⟸   ENSMUST00000190447
RefSeq Acc Id: ENSMUSP00000141038   ⟸   ENSMUST00000188251
RefSeq Acc Id: ENSMUSP00000024112   ⟸   ENSMUST00000024112
Protein Domains
Dynamin-type G   GED

Promoters
RGD ID:13674584
Promoter ID:EPDNEW_M21441
Type:multiple initiation site
Name:Mx2_1
Description:Mus musculus MX dynamin-like GTPase 2 , transcript variant 2,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381697,536,085 - 97,536,145EPDNEW
RGD ID:6827277
Promoter ID:MM_KWN:21884
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000024112,   ENSMUST00000088798,   NM_013606,   NR_003508,   NR_003508_MX2,   UC008ADK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361697,756,756 - 97,757,912 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97244 AgrOrtholog
Ensembl Genes ENSMUSG00000023341 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000024112 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024112 UniProtKB/Swiss-Prot
  ENSMUST00000188251 ENTREZGENE
InterPro Dynamin_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17858 UniProtKB/Swiss-Prot
MGD MGI:97244 ENTREZGENE
NCBI Gene 17858 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mx2 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D8DGT0_MOUSE UniProtKB/TrEMBL
  MX2_MOUSE UniProtKB/Swiss-Prot
  Q61924_MOUSE UniProtKB/TrEMBL
  Q61925_MOUSE UniProtKB/TrEMBL
  Q9WVP9 ENTREZGENE
UniProt Secondary Q922L4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-20 Mx2  MX dynamin-like GTPase 2  Mx2  myxovirus (influenza virus) resistance 2  Symbol and/or name change 5135510 APPROVED