Timp2 (tissue inhibitor of metalloproteinase 2) - Rat Genome Database
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Gene: Timp2 (tissue inhibitor of metalloproteinase 2) Mus musculus
Analyze
Symbol: Timp2
Name: tissue inhibitor of metalloproteinase 2
RGD ID: 62178
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Bwg1104e; metalloproteinase inhibitor 2; TIMP; Timp-2; tissue inhibitor of metalloproteinases 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39mm39
GRCm39 Ensembl11118,191,895 - 118,246,566 (-)Ensembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBImm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,4-dihydrocoumarin  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ambroxol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic acid  (EXP)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
benazepril  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
candesartan  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
casticin  (EXP)
celecoxib  (ISO)
chloroquine  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
Deguelin  (ISO)
demethoxycurcumin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (ISO)
gallic acid  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
glucose  (ISO)
Gly-His-Lys  (ISO)
graphene oxide  (EXP)
hexachlorobenzene  (ISO)
hinokiflavone  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indinavir  (EXP)
indometacin  (ISO)
juglone  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
losartan  (ISO)
LY294002  (ISO)
melatonin  (ISO)
menadione  (ISO)
mesalamine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
oroxylin A  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (EXP)
saquinavir  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
solasodine  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
3. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
4. Ding HL, etal., Rev Diabet Stud. 2005 Winter;2(4):216-20. Epub 2006 Feb 10.
5. Eissa S, etal., Eur Urol. 2007 Nov;52(5):1388-96. Epub 2007 Apr 10.
6. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
7. Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
8. Gipson TS, etal., J Immunol. 1999 Mar 15;162(6):3653-62.
9. Graesslin O, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1911-7.
10. Hu YB, etal., J Gene Med. 2007 Mar;9(3):217-29.
11. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
12. Jaworski DM Glia. 2000 Apr;30(2):199-208.
13. Jinga D, etal., Roum Arch Microbiol Immunol. 2004 Jul-Dec;63(3-4):141-58.
14. Kang HS, etal., Neurosurgery. 2006 Jun;58(6):1074-80; discussion 1074-80.
15. Kawata N, etal., Urology. 2007 Jun;69(6):1049-53.
16. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
17. Li Q, etal., Acta Cardiol. 2007 Oct;62(5):485-91.
18. Lorenzl S, etal., J Neurol Sci. 2003 Mar 15;207(1-2):71-6.
19. Mendes O, etal., Clin Exp Metastasis. 2007;24(5):341-51. Epub 2007 May 16.
20. MGD and Homologene mouse data transfer
21. MGD data from the GO Consortium
22. Noji Y, etal., Circ J. 2004 Apr;68(4):355-60.
23. Peihong S and Perry F, Ethiop Med J. 2007 Jan;45(1):79-83.
24. Pulukuri SM, etal., Oncogene. 2007 Aug 9;26(36):5229-37. Epub 2007 Feb 26.
25. RGD automated import pipeline
26. RGD automated import pipeline for gene-chemical interactions
27. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
28. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
29. Struckmann K, etal., Verh Dtsch Ges Pathol. 2005;89:178-83.
30. Trudel D, etal., Hum Pathol. 2008 Mar 7;.
31. Vasala K and Turpeenniemi-Hujanen T, Clin Biochem. 2007 Jun;40(9-10):640-4. Epub 2007 Feb 8.
32. von Moers A, etal., Acta Neuropathol (Berl). 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
33. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
34. Zhao YG, etal., Cancer Res. 2004 Jan 15;64(2):590-8.
Additional References at PubMed
PMID:1427908   PMID:1427919   PMID:1601312   PMID:1639268   PMID:1851244   PMID:7490456   PMID:7509775   PMID:7626795   PMID:7743917   PMID:7768998   PMID:7918391   PMID:8352925  
PMID:8674034   PMID:8674412   PMID:8743942   PMID:8862765   PMID:8872958   PMID:8889548   PMID:9013889   PMID:9108368   PMID:9285822   PMID:9291579   PMID:9325265   PMID:9417058  
PMID:9648071   PMID:10076570   PMID:10090151   PMID:10225966   PMID:10232461   PMID:10349636   PMID:10374394   PMID:10621841   PMID:10725249   PMID:10731089   PMID:10827175   PMID:10827176  
PMID:10922068   PMID:10952938   PMID:10985432   PMID:11042159   PMID:11052264   PMID:11076861   PMID:11165481   PMID:11217851   PMID:11359935   PMID:11675412   PMID:11739522   PMID:11865039  
PMID:11869290   PMID:11891989   PMID:11988080   PMID:12466851   PMID:12477932   PMID:12736828   PMID:12815621   PMID:12900406   PMID:12950084   PMID:14610273   PMID:15063736   PMID:15502710  
PMID:15536133   PMID:15782199   PMID:15901773   PMID:15947421   PMID:15979591   PMID:16113801   PMID:16135528   PMID:16141072   PMID:16141073   PMID:16216006   PMID:16326706   PMID:16418837  
PMID:16469749   PMID:16510589   PMID:16602821   PMID:16716258   PMID:16765565   PMID:16825197   PMID:16967503   PMID:16985004   PMID:17030988   PMID:17425593   PMID:17602244   PMID:17678891  
PMID:18060646   PMID:18287559   PMID:18559979   PMID:18560439   PMID:18596727   PMID:18639653   PMID:18989628   PMID:19092727   PMID:19339693   PMID:19411759   PMID:19542530   PMID:20056917  
PMID:20434371   PMID:20857180   PMID:21085640   PMID:21175899   PMID:21179735   PMID:21285317   PMID:21421844   PMID:21631912   PMID:21832167   PMID:21871178   PMID:21873635   PMID:21986284  
PMID:22014525   PMID:22664108   PMID:23089194   PMID:23098139   PMID:23113307   PMID:23349620   PMID:23398532   PMID:23524300   PMID:23760282   PMID:23825222   PMID:23991045   PMID:24006456  
PMID:24077247   PMID:24358288   PMID:24373743   PMID:24526442   PMID:24692173   PMID:24801603   PMID:25150980   PMID:25204377   PMID:25572963   PMID:25636537   PMID:25805621   PMID:25807548  
PMID:25920569   PMID:26133107   PMID:26358260   PMID:26645981   PMID:27621061   PMID:27855185   PMID:28077597   PMID:28424512   PMID:28671691   PMID:29438518   PMID:29567669   PMID:30240841  
PMID:30611221   PMID:30670377   PMID:30822518   PMID:31371388   PMID:31621840   PMID:33084572  


Genomics

Comparative Map Data
Timp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39mm39
GRCm39 Ensembl11118,191,895 - 118,246,566 (-)Ensembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBImm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
TIMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1778,852,977 - 78,925,387 (-)EnsemblGRCh38hg38GRCh38
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
Timp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210103,541,199 - 103,590,611 (-)NCBI
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Timp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
TIMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11778,476,807 - 78,495,885 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1778,476,807 - 78,495,649 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01772,928,692 - 73,001,892 (-)NCBIMhudiblu_PPA_v0panPan3
TIMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Timp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365943,232,433 - 3,244,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,254,493 - 3,300,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,254,794 - 3,300,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,294,254 - 3,340,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,819,591 - 70,850,471 (-)NCBI
ChlSab1.1 Ensembl1670,819,139 - 70,850,471 (-)Ensembl
Timp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248018,228,618 - 8,270,606 (-)NCBI

Position Markers
X62622  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,302,895 - 118,303,080UniSTSGRCm38
MGSCv3711118,164,209 - 118,164,394UniSTSGRCm37
Celera11130,047,847 - 130,048,032UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
Whitehead_YAC11 UniSTS
UniSTS:224264  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,327,075 - 118,327,237UniSTSGRCm38
MGSCv3711118,188,389 - 118,188,551UniSTSGRCm37
Celera11130,072,027 - 130,072,189UniSTS
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
cM Map1172.0UniSTS
Ddc8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,332,383 - 118,332,800UniSTSGRCm38
Celera11130,077,335 - 130,077,752UniSTS
Cytogenetic Map11E2UniSTS
cM Map1183.09UniSTS
cM Map1183.09UniSTS
D11Bwg1104e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,301,846 - 118,302,048UniSTSGRCm38
MGSCv3711118,163,160 - 118,163,362UniSTSGRCm37
Celera11130,046,798 - 130,047,000UniSTS
Cytogenetic Map11E2UniSTS
cM Map1175.0UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,354,961 - 118,355,090UniSTSGRCm38
Celera11130,099,932 - 130,100,061UniSTS
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,303,703 - 118,303,874UniSTSGRCm38
Celera11130,048,655 - 130,048,826UniSTS
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,317,421 - 118,317,527UniSTSGRCm38
Celera11130,062,373 - 130,062,479UniSTS
Cytogenetic Map11E2UniSTS
Timp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,310,578 - 118,310,697UniSTSGRCm38
Celera11130,055,530 - 130,055,649UniSTS
Cytogenetic Map11E2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir200bmmu-miR-200b-3pOncomiRDBexternal_infoNANA23205572

Predicted Target Of
Summary Value
Count of predictions:1355
Count of miRNA genes:597
Interacting mature miRNAs:769
Transcripts:ENSMUST00000017610, ENSMUST00000155707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK032818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY622854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ030835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M82858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000017610   ⟹   ENSMUSP00000017610
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11118,301,069 - 118,355,506 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155707   ⟹   ENSMUSP00000122642
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11118,303,701 - 118,355,740 (-)Ensembl
RefSeq Acc Id: NM_011594   ⟹   NP_035724
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911118,191,887 - 118,246,237 (-)NCBI
GRCm3811118,301,061 - 118,355,411 (-)ENTREZGENE
MGSCv3711118,162,375 - 118,216,725 (-)RGD
Celera11130,046,014 - 130,100,382 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035724   ⟸   NM_011594
- Peptide Label: precursor
- UniProtKB: Q6PI17 (UniProtKB/TrEMBL),   Q8BSJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000017610   ⟸   ENSMUST00000017610
RefSeq Acc Id: ENSMUSP00000122642   ⟸   ENSMUST00000155707
Protein Domains
NTR

Promoters
RGD ID:6822317
Promoter ID:MM_KWN:10780
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000008565,   OTTMUST00000008566
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611118,216,411 - 118,216,911 (-)MPROMDB
RGD ID:8677562
Promoter ID:EPDNEW_M16812
Type:initiation region
Name:Timp2_1
Description:Mus musculus tissue inhibitor of metalloproteinase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811118,355,326 - 118,355,386EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98753 AgrOrtholog
Ensembl Genes ENSMUSG00000017466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000017610 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000122642 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017610 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000155707 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21858 UniProtKB/TrEMBL
MGD MGI:98753 ENTREZGENE
NCBI Gene 21858 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timp2 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1AQJ3_MOUSE UniProtKB/TrEMBL
  P25785 ENTREZGENE
  Q6GXA8_MOUSE UniProtKB/TrEMBL
  Q6PI17 ENTREZGENE, UniProtKB/TrEMBL
  Q8BSJ3 ENTREZGENE, UniProtKB/TrEMBL
  TIMP2_MOUSE UniProtKB/Swiss-Prot