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Gene: Timp2 (tissue inhibitor of metalloproteinase 2) Mus musculus
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Symbol: Timp2
Name: tissue inhibitor of metalloproteinase 2
Description: Exhibits enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Involved in several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Localizes to the basement membrane and cell surface. Human ortholog(s) of this gene implicated in Moyamoya disease. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeletal system. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Bwg1104e; metalloproteinase inhibitor 2; Timp-2; tissue inhibitor of metalloproteinases 2
Orthologs:
Homo sapiens (human) : TIMP2 (TIMP metallopeptidase inhibitor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Timp2 (TIMP metallopeptidase inhibitor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp2 (TIMP metallopeptidase inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Canis lupus familiaris (dog) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp2 (TIMP metallopeptidase inhibitor 2)
Sus scrofa (pig) : TIMP2 (TIMP metallopeptidase inhibitor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBImm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11 E2NCBI
cM Map1183.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Timp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62178
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.