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Gene: Timp2 (tissue inhibitor of metalloproteinase 2) Mus musculus
Symbol: Timp2
Name: tissue inhibitor of metalloproteinase 2
Description: Exhibits enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Involved in several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Localizes to the basement membrane and cell surface. Human ortholog(s) of this gene implicated in Moyamoya disease. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeletal system. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Bwg1104e; metalloproteinase inhibitor 2; Timp-2; tissue inhibitor of metalloproteinases 2
Homo sapiens (human) : TIMP2 (TIMP metallopeptidase inhibitor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Timp2 (TIMP metallopeptidase inhibitor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp2 (TIMP metallopeptidase inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Canis lupus familiaris (dog) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp2 (TIMP metallopeptidase inhibitor 2)
Sus scrofa (pig) : TIMP2 (TIMP metallopeptidase inhibitor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBImm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11 E2NCBI
cM Map1183.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Timp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62178
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.