Ank (progressive ankylosis) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ank (progressive ankylosis) Mus musculus
Analyze
Symbol: Ank
Name: progressive ankylosis
RGD ID: 734406
MGI Page MGI
Description: Enables inorganic diphosphate transmembrane transporter activity. Involved in several processes, including cementum mineralization; diphosphate metabolic process; and inhibition of non-skeletal tissue mineralization. Located in plasma membrane. Is active in extracellular region. Is expressed in several structures, including bone; connective tissue; olfactory epithelium; telencephalon; and vibrissa follicle. Used to study craniometaphyseal dysplasia. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ankh; ATP carrier protein ANKH; D15Ertd221; D15Ertd221e; fn54 protein; mineralization regulator ANKH; mKIAA1581; progressive ankylosis protein; progressive ankylosis protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391527,466,763 - 27,594,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1527,466,763 - 27,594,995 (+)EnsemblGRCm39 Ensembl
GRCm381527,466,677 - 27,594,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1527,466,677 - 27,594,909 (+)EnsemblGRCm38mm10GRCm38
MGSCv371527,396,432 - 27,524,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361527,411,402 - 27,539,630 (+)NCBIMGSCv36mm8
Celera1528,188,363 - 28,342,822 (+)NCBICelera
Cytogenetic Map15B1NCBI
cM Map1510.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenthion  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
irinotecan  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
nefazodone  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (ISO)
pirinixic acid  (EXP)
progesterone  (EXP)
propanal  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IMP)
membrane  (IDA,ISO)
plasma membrane  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal articular cartilage morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal basioccipital bone morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cementum morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal cranial foramen morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal foramen magnum morphology  (IAGP)
abnormal gait  (IAGP)
abnormal intervertebral disk morphology  (IAGP)
abnormal ion homeostasis  (IAGP)
abnormal joint morphology  (IAGP)
abnormal ligament morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal posture  (IAGP)
abnormal sesamoid bone of gastrocnemius morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal synovial joint cavity morphology  (IAGP)
abnormal temporal bone petrous part morphology  (IAGP)
abnormal tendon morphology  (IAGP)
abnormal tooth hard tissue morphology  (IAGP)
abnormal transverse acetabular ligament morphology  (IAGP)
absent paranasal sinus  (IAGP)
autoimmune arthritis  (IAGP)
calcified aorta  (IAGP)
calcified intervertebral disk  (IAGP)
calcified joint  (IAGP)
calcified tendon  (IAGP)
club-shaped femur  (IAGP)
craniofacial hyperostosis  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased compact bone thickness  (IAGP)
decreased grip strength  (IAGP)
decreased joint mobility  (IAGP)
decreased trabecular bone connectivity density  (IAGP)
decreased trabecular bone volume  (IAGP)
foramen magnum stenosis  (IAGP)
fused joints  (IAGP)
fusion of middle ear ossicles  (IAGP)
hyperostosis  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased diameter of femur  (IAGP)
incudomalleolar fusion  (IAGP)
kyphosis  (IAGP)
mandibular hyperostosis  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
short femur  (IAGP)
thick neurocranium  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Role of the mouse ank gene in control of tissue calcification and arthritis. Ho AM, etal., Science 2000 Jul 14;289(5477):265-70.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nurnberg P, etal., Nat Genet 2001 May;28(1):37-41.
6. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mutations in ANKH cause chondrocalcinosis. Pendleton A, etal., Am J Hum Genet 2002 Oct;71(4):933-40. Epub 2002 Sep 20.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures. Yepes M, etal., Lab Invest 2003 Jul;83(7):1025-32.
Additional References at PubMed
PMID:1659102   PMID:2541245   PMID:2805429   PMID:3004514   PMID:3175755   PMID:3190783   PMID:3213824   PMID:6095872   PMID:7276519   PMID:8889548   PMID:9002021   PMID:9635372  
PMID:10349636   PMID:10813297   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11326338   PMID:11953986   PMID:12056852   PMID:12477932   PMID:12817751   PMID:15039209  
PMID:15489334   PMID:15611280   PMID:15625282   PMID:15833911   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16869722   PMID:17186460   PMID:17560335   PMID:17638573   PMID:17762177  
PMID:17950726   PMID:18187567   PMID:18331719   PMID:18728347   PMID:19257826   PMID:19338977   PMID:19419319   PMID:19910700   PMID:20200976   PMID:20200993   PMID:21149338   PMID:21389671  
PMID:21488756   PMID:21490328   PMID:21677750   PMID:21788370   PMID:21856950   PMID:21873635   PMID:22003394   PMID:22318228   PMID:22421045   PMID:22675556   PMID:23160629   PMID:23390527  
PMID:23895994   PMID:24663682   PMID:25428889   PMID:28135291   PMID:28286238   PMID:28866368   PMID:29174564   PMID:29313816   PMID:30356088   PMID:31059863   PMID:31064775   PMID:32188494  
PMID:32224162   PMID:32554809   PMID:32639996   PMID:33356859   PMID:35147247   PMID:37196079   PMID:37468461   PMID:38187761  


Genomics

Comparative Map Data
Ank
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391527,466,763 - 27,594,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1527,466,763 - 27,594,995 (+)EnsemblGRCm39 Ensembl
GRCm381527,466,677 - 27,594,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1527,466,677 - 27,594,909 (+)EnsemblGRCm38mm10GRCm38
MGSCv371527,396,432 - 27,524,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361527,411,402 - 27,539,630 (+)NCBIMGSCv36mm8
Celera1528,188,363 - 28,342,822 (+)NCBICelera
Cytogenetic Map15B1NCBI
cM Map1510.23NCBI
ANKH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38514,704,800 - 14,871,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl514,704,800 - 14,871,778 (-)EnsemblGRCh38hg38GRCh38
GRCh37514,704,909 - 14,871,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36514,762,019 - 14,924,876 (-)NCBINCBI36Build 36hg18NCBI36
Build 34514,762,018 - 14,924,876NCBI
Celera514,728,867 - 14,895,594 (-)NCBICelera
Cytogenetic Map5p15.2NCBI
HuRef514,677,712 - 14,844,731 (-)NCBIHuRef
CHM1_1514,704,654 - 14,871,772 (-)NCBICHM1_1
T2T-CHM13v2.0514,644,272 - 14,811,218 (-)NCBIT2T-CHM13v2.0
Ankh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8279,883,350 - 80,011,222 (+)NCBIGRCr8
mRatBN7.2278,153,027 - 78,280,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl278,153,026 - 78,280,187 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx285,240,253 - 85,367,690 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0283,361,989 - 83,489,422 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0278,394,033 - 78,521,764 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0280,131,563 - 80,256,948 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,131,563 - 80,256,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0299,796,579 - 99,921,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4279,289,427 - 79,418,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1279,234,387 - 79,363,480 (+)NCBI
Celera273,782,876 - 73,934,310 (+)NCBICelera
Cytogenetic Map2q22NCBI
Ankh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554263,992,671 - 4,130,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554263,992,671 - 4,130,754 (-)NCBIChiLan1.0ChiLan1.0
ANKH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2414,944,516 - 15,105,199 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1513,098,133 - 13,258,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0515,014,019 - 15,175,467 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1514,849,497 - 15,015,206 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl514,855,914 - 14,917,729 (-)Ensemblpanpan1.1panPan2
ANKH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1488,149,250 - 88,263,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl488,149,257 - 88,272,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha487,670,608 - 87,785,793 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0488,877,936 - 88,993,145 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl488,877,991 - 88,999,454 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1488,304,136 - 88,419,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0488,546,753 - 88,661,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0489,403,928 - 89,519,108 (+)NCBIUU_Cfam_GSD_1.0
Ankh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213232,927,281 - 233,060,862 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366651,520,800 - 1,653,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366651,520,800 - 1,654,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl164,105,165 - 4,271,170 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1164,095,582 - 4,271,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,444,997 - 4,610,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANKH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1414,401,681 - 14,559,342 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl414,408,116 - 14,559,454 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606413,973,098 - 14,126,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475111,716,369 - 11,847,758 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475111,716,369 - 11,847,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ank
4755 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:753
Count of miRNA genes:471
Interacting mature miRNAs:569
Transcripts:ENSMUST00000022875, ENSMUST00000134004
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562049439620614Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1302165Yv_myellow value (mouse)Not determined151384700647847148Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152631178060311880Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384700647847148Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346465237464652Mouse
13801027Toa1_mtesticular oocyte appearance 1 (mouse)152080735228494067Mouse
10412172Habiir5_mhyperoxic acute lung injury imprinted region 5 (mouse)Not determined15927302243311880Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
1301760Dob9_mdietary obesity 9 (mouse)Body fat amountadiposity index152603568037781301Mouse
14700788Mencq9_mmeniscus calcification QTL 9 (mouse)152731608627624086Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15762948155263396Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15722948155263396Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15762948159271849Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15612948138000244Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15612948171471849Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152446257258462805Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492758748927756Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660008666371849Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927302256186850Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152631178060311880Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15612948168271849Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15612948150763396Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15812948447663396Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492758748927756Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15682948144963396Mouse
14928313Manh78_mmandible shape 78 (mouse)152148464155484641Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15612948172471849Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603395450033954Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060008650763396Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152259376556593765Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2548497859484978Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162631178060311880Mouse
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218736Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492758748927756Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564534349645470Mouse
27095922Pglq11_mpelvic girdle length QTL 11, 10 week (mouse)15812948438763395Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2289301456893160Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152631178060311880Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152529580659295928Mouse
4140994Shali3_msurvival time to hyperoxic acute lung injury 3 (mouse)Not determined927302243311880Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse

Markers in Region
MT3505  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,582,331 - 27,582,471UniSTSGRCm38
MGSCv371527,512,086 - 27,512,226UniSTSGRCm37
Celera1528,330,244 - 28,330,384UniSTS
Cytogenetic Map15B1UniSTS
cM Map1515.6UniSTS
Whitehead Genetic1510.9UniSTS
D15Mit164.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,582,231 - 27,582,341UniSTSGRCm38
MGSCv371527,511,986 - 27,512,096UniSTSGRCm37
Celera1528,330,144 - 28,330,254UniSTS
Cytogenetic Map15B1UniSTS
cM Map1515.6UniSTS
cM Map15 UniSTS
Whitehead Genetic1510.9UniSTS
D15Mit20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,582,373 - 27,582,523UniSTSGRCm38
MGSCv371527,512,128 - 27,512,278UniSTSGRCm37
Celera1528,330,286 - 28,330,436UniSTS
Cytogenetic Map15B1UniSTS
cM Map1514.0UniSTS
Whitehead Genetic1510.9UniSTS
Whitehead/MRC_RH15258.89UniSTS
Whitehead_YAC15 UniSTS
D15Mit94  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,443,957 - 27,444,106UniSTSGRCm38
MGSCv371527,373,712 - 27,373,861UniSTSGRCm37
Celera1528,191,810 - 28,191,957UniSTS
Cytogenetic Map15B1UniSTS
cM Map1529.0UniSTS
Whitehead Genetic1532.8UniSTS
Whitehead_YAC15 UniSTS
C78987  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,593,881 - 27,593,967UniSTSGRCm38
MGSCv371527,523,636 - 27,523,722UniSTSGRCm37
Celera1528,341,794 - 28,341,880UniSTS
Cytogenetic Map15B1UniSTS
cM Map1514.4UniSTS
Whitehead/MRC_RH15254.64UniSTS
UniSTS:237276  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,499,656 - 27,499,983UniSTSGRCm38
MGSCv371527,429,411 - 27,429,738UniSTSGRCm37
Celera1528,247,543 - 28,247,870UniSTS
Cytogenetic Map15B1UniSTS
cM Map1514.4UniSTS
RH126011  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,509,354 - 27,509,589UniSTSGRCm38
MGSCv371527,439,109 - 27,439,344UniSTSGRCm37
Celera1528,257,331 - 28,257,566UniSTS
Cytogenetic Map15B1UniSTS
cM Map158.9UniSTS
Whitehead/MRC_RH15257.67UniSTS
RH126477  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381527,594,159 - 27,594,404UniSTSGRCm38
MGSCv371527,523,914 - 27,524,159UniSTSGRCm37
Celera1528,342,072 - 28,342,317UniSTS
Cytogenetic Map15B1UniSTS
cM Map1514.4UniSTS
cM Map158.9UniSTS
Whitehead/MRC_RH15257.67UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000022875   ⟹   ENSMUSP00000022875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1527,466,763 - 27,594,995 (+)Ensembl
GRCm38.p6 Ensembl1527,466,677 - 27,594,909 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1527,571,533 - 27,594,538 (+)Ensembl
GRCm38.p6 Ensembl1527,571,447 - 27,594,452 (+)Ensembl
RefSeq Acc Id: NM_020332   ⟹   NP_065065
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391527,466,763 - 27,594,995 (+)NCBI
GRCm381527,466,677 - 27,594,909 (+)ENTREZGENE
MGSCv371527,396,432 - 27,524,664 (+)RGD
Celera1528,214,608 - 28,342,822 (+)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_065065   ⟸   NM_020332
- UniProtKB: O35138 (UniProtKB/Swiss-Prot),   O35139 (UniProtKB/Swiss-Prot),   Q9JHZ2 (UniProtKB/Swiss-Prot),   Q3UG85 (UniProtKB/TrEMBL),   Q8C438 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000022875   ⟸   ENSMUST00000022875

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHZ2-F1-model_v2 AlphaFold Q9JHZ2 1-492 view protein structure

Promoters
RGD ID:6825764
Promoter ID:MM_KWN:18152
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour
Transcripts:OTTMUST00000065059
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361527,395,896 - 27,396,562 (+)MPROMDB
RGD ID:8683498
Promoter ID:EPDNEW_M19779
Type:initiation region
Name:Ank_1
Description:Mus musculus progressive ankylosis , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19780  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381527,466,686 - 27,466,746EPDNEW
RGD ID:8683500
Promoter ID:EPDNEW_M19780
Type:initiation region
Name:Ank_2
Description:Mus musculus progressive ankylosis , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19779  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381527,466,843 - 27,466,903EPDNEW
RGD ID:6825771
Promoter ID:MM_KWN:18155
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC007VJP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361527,500,491 - 27,501,392 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045421 AgrOrtholog
Ensembl Genes ENSMUSG00000022265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022875 ENTREZGENE
  ENSMUST00000022875.7 UniProtKB/Swiss-Prot
InterPro ANKH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3045421 ENTREZGENE
NCBI Gene 11732 ENTREZGENE
PANTHER PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28384 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANKH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ank PhenoGen
UniProt ANKH_MOUSE UniProtKB/Swiss-Prot
  O35138 ENTREZGENE
  O35139 ENTREZGENE
  Q3UG85 ENTREZGENE, UniProtKB/TrEMBL
  Q8C438 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHZ2 ENTREZGENE
UniProt Secondary O35138 UniProtKB/Swiss-Prot
  O35139 UniProtKB/Swiss-Prot