Il12rb1 (interleukin 12 receptor, beta 1) - Rat Genome Database
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Gene: Il12rb1 (interleukin 12 receptor, beta 1) Mus musculus
Analyze
Symbol: Il12rb1
Name: interleukin 12 receptor, beta 1
RGD ID: 1550152
MGI Page MGI
Description: Is expressed in mandible; maxilla; orbito-sphenoid; rib; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R; IL-12R subunit beta-1; IL-12R-beta-1; IL-12R[b]; Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component); interleukin-12 receptor subunit beta-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,261,005 - 71,276,186 (+)NCBIGRCm39mm39
GRCm39 Ensembl871,261,093 - 71,274,068 (+)Ensembl
GRCm38870,808,360 - 70,823,542 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,808,449 - 70,821,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,332,348 - 73,345,323 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,737,483 - 73,750,411 (+)NCBImm8
Celera873,369,767 - 73,382,761 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7594587   PMID:7911493   PMID:8943050   PMID:8982780   PMID:9038232   PMID:9257825   PMID:10349636   PMID:10385085   PMID:11042159   PMID:11076861   PMID:11114383   PMID:11217851  
PMID:11489994   PMID:11673566   PMID:11748115   PMID:11782017   PMID:12165484   PMID:12466851   PMID:12477932   PMID:12574388   PMID:12671732   PMID:12707353   PMID:12746919   PMID:12874225  
PMID:14568135   PMID:14568921   PMID:14662893   PMID:14978082   PMID:15170228   PMID:15220916   PMID:15245428   PMID:15345588   PMID:15457342   PMID:15579433   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:16688182   PMID:16880257   PMID:16949558   PMID:17506816   PMID:17579029   PMID:17937931   PMID:17954566   PMID:18059273   PMID:18490715   PMID:18504307   PMID:19084435  
PMID:19100623   PMID:19306359   PMID:19544494   PMID:19548244   PMID:19587012   PMID:19830723   PMID:20212068   PMID:21267068   PMID:21516112   PMID:21669537   PMID:21677750   PMID:21813451  
PMID:21873635   PMID:22306691   PMID:22706089   PMID:22711893   PMID:22907814   PMID:23178247   PMID:23260194   PMID:23467089   PMID:23673666   PMID:24194600   PMID:24224652   PMID:24238342  
PMID:24532579   PMID:24586521   PMID:25404030   PMID:27626380   PMID:29123149  


Genomics

Comparative Map Data
Il12rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,261,005 - 71,276,186 (+)NCBIGRCm39mm39
GRCm39 Ensembl871,261,093 - 71,274,068 (+)Ensembl
GRCm38870,808,360 - 70,823,542 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,808,449 - 70,821,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,332,348 - 73,345,323 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,737,483 - 73,750,411 (+)NCBImm8
Celera873,369,767 - 73,382,761 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.21NCBI
IL12RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,058,995 - 18,098,944 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,058,994 - 18,099,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,169,805 - 18,209,626 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,031,371 - 18,058,697 (-)NCBINCBI36hg18NCBI36
Build 341918,042,372 - 18,058,697NCBI
Celera1918,072,103 - 18,099,423 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,735,230 - 17,761,934 (-)NCBIHuRef
CHM1_11918,169,404 - 18,209,196 (-)NCBICHM1_1
Il12rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,620,228 - 18,633,207 (-)NCBI
Rnor_6.0 Ensembl1620,371,338 - 20,383,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01620,370,722 - 20,383,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01620,227,894 - 20,240,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,126,653 - 19,137,584 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,126,957 - 19,128,305 (-)NCBI
Celera1618,812,772 - 18,825,080 (-)NCBICelera
Cytogenetic Map16p14NCBI
Il12rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,276,932 - 3,299,617 (+)NCBIChiLan1.0ChiLan1.0
IL12RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,513,585 - 18,541,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,513,585 - 18,541,383 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,536,709 - 17,547,665 (-)NCBIMhudiblu_PPA_v0panPan3
IL12RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,885,337 - 44,904,538 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,885,410 - 44,908,139 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il12rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,062,620 - 3,076,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,707,961 - 59,736,282 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,707,958 - 59,736,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,276,610 - 59,305,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL12RB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,527,392 - 16,557,250 (-)NCBI
ChlSab1.1 Ensembl616,528,271 - 16,556,840 (-)Ensembl
Il12rb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,472,059 - 1,481,423 (-)NCBI

Position Markers
U23922  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,821,028 - 70,821,135UniSTSGRCm38
MGSCv37873,344,927 - 73,345,034UniSTSGRCm37
Celera873,382,365 - 73,382,472UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8744.28UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:186
Interacting mature miRNAs:208
Transcripts:ENSMUST00000000808
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000808   ⟹   ENSMUSP00000000808
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,808,449 - 70,821,424 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211936
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,808,449 - 70,813,923 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212146   ⟹   ENSMUSP00000148314
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,808,487 - 70,811,201 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,812,340 - 70,813,699 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212657   ⟹   ENSMUSP00000148279
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,808,484 - 70,821,424 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212826
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,813,216 - 70,813,923 (+)Ensembl
RefSeq Acc Id: NM_008353   ⟹   NP_032379
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,261,093 - 71,274,068 (+)NCBI
GRCm38870,808,449 - 70,821,424 (+)NCBI
MGSCv37873,332,348 - 73,345,323 (+)RGD
Celera873,369,767 - 73,382,761 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509557   ⟹   XP_006509620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,261,005 - 71,276,186 (+)NCBI
GRCm38870,808,360 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509558   ⟹   XP_006509621
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,261,876 - 71,276,186 (+)NCBI
GRCm38870,809,218 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509559   ⟹   XP_006509622
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,261,005 - 71,276,186 (+)NCBI
GRCm38870,808,360 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509560   ⟹   XP_006509623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,261,006 - 71,276,186 (+)NCBI
GRCm38870,808,361 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509561   ⟹   XP_006509624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,264,570 - 71,276,186 (+)NCBI
GRCm38870,811,925 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509562   ⟹   XP_006509625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,266,326 - 71,276,186 (+)NCBI
GRCm38870,813,702 - 70,823,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011242266   ⟹   XP_011240568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,264,659 - 71,276,186 (+)NCBI
GRCm38870,812,014 - 70,823,542 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032379   ⟸   NM_008353
- Peptide Label: precursor
- UniProtKB: Q60837 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509622   ⟸   XM_006509559
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006509620   ⟸   XM_006509557
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006509623   ⟸   XM_006509560
- Peptide Label: isoform X4
- UniProtKB: A0A1D5RL98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509621   ⟸   XM_006509558
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006509624   ⟸   XM_006509561
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006509625   ⟸   XM_006509562
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011240568   ⟸   XM_011242266
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSMUSP00000000808   ⟸   ENSMUST00000000808
RefSeq Acc Id: ENSMUSP00000148279   ⟸   ENSMUST00000212657
RefSeq Acc Id: ENSMUSP00000148314   ⟸   ENSMUST00000212146
Protein Domains
Fibronectin type-III

Promoters
RGD ID:8667355
Promoter ID:EPDNEW_M11709
Type:initiation region
Name:Il12rb1_1
Description:Mus musculus interleukin 12 receptor, beta 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,808,471 - 70,808,531EPDNEW
RGD ID:6843316
Promoter ID:MM_KWN:54748
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000093452,   NM_008353
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,332,199 - 73,332,699 (+)MPROMDB
RGD ID:6848304
Promoter ID:MM_ACW:47865
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:IL12RB1.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,334,961 - 73,335,461 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104579 AgrOrtholog
Ensembl Genes ENSMUSG00000000791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000111872 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000000808 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148279 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000148314 UniProtKB/TrEMBL
  ENSMUSP00000149385 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000808 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212146 UniProtKB/TrEMBL
  ENSMUST00000212657 UniProtKB/TrEMBL
  ENSMUST00000217569 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16161 UniProtKB/Swiss-Prot
MGD MGI:104579 ENTREZGENE
NCBI Gene 16161 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il12rb1 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RL98 ENTREZGENE, UniProtKB/TrEMBL
  A0A1D5RLC9_MOUSE UniProtKB/TrEMBL
  I12R1_MOUSE UniProtKB/Swiss-Prot
  Q3TAD0_MOUSE UniProtKB/TrEMBL
  Q60837 ENTREZGENE
UniProt Secondary Q3UV59 UniProtKB/Swiss-Prot