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Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Mus musculus
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Description: Exhibits long-chain fatty acid-CoA ligase activity. Involved in embryonic process involved in female pregnancy and neuron differentiation. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Is expressed in several structures, including alimentary system; integumental system; limb mesenchyme; nervous system; and sensory organ. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4); PARTICIPATES IN fatty acid beta degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9430020A05Rik; ACS4; arachidonate--CoA ligase; AU018108; Facl4; fatty acid-Coenzyme A ligase, long chain 4; LACS 4; Lacs4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4; mACS4
Homo sapiens (human) : ACSL4 (acyl-CoA synthetase long chain family member 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Canis lupus familiaris (dog) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Sus scrofa (pig) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Chlorocebus sabaeus (African green monkey) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Heterocephalus glaber (naked mole-rat) : Acsl4 (acyl-CoA synthetase long chain family member 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX142,317,993 - 142,390,535 (-)EnsemblGRCm38mm10GRCm38
GRCm38X142,317,993 - 142,390,802 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X138,752,536 - 138,825,078 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X137,564,361 - 137,636,903 (-)NCBImm8
CeleraX126,313,470 - 126,386,150 (-)NCBICelera
Cytogenetic MapXF2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Acsl4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69444
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.