Cyp2b9 (cytochrome P450, family 2, subfamily b, polypeptide 9) - Rat Genome Database

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Gene: Cyp2b9 (cytochrome P450, family 2, subfamily b, polypeptide 9) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
RGD ID: 1624098
MGI Page MGI
Description: Predicted to enable heme binding activity and monooxygenase activity. Involved in response to stilbenoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 16alphaoh-a; Cyp2; Cyp2b; CYPIIB9; cytochrome P450 2B9; cytochrome P450 clone PF26; cytochrome P450, 2b9, phenobarbitol inducible, type a; cytochrome P450-16-alpha; phenobarbitol inducible, type a; testosterone 16-alpha hydroxylase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,872,775 - 25,910,086 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,872,836 - 25,910,086 (+)EnsemblGRCm39 Ensembl
GRCm38726,173,350 - 26,210,661 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,173,411 - 26,210,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,958,428 - 26,995,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,882,169 - 25,919,420 (+)NCBIMGSCv36mm8
Celera720,779,234 - 20,803,450 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
Acetyl tributyl citrate  (EXP)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP)
berberine  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
cadmium sulfate  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
Chalepensin  (EXP)
chlorpyrifos  (EXP)
cholic acid  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyproconazole  (EXP)
cyproterone  (EXP)
dexamethasone  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP)
epoxiconazole  (EXP)
estrone  (EXP)
ethanol  (EXP)
fenofibrate  (EXP)
folic acid  (EXP)
griseofulvin  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lycopene  (EXP)
mercury dichloride  (EXP)
metformin  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (EXP)
paracetamol  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
rifampicin  (EXP)
selenium atom  (EXP)
sodium arsenite  (EXP)
streptozocin  (EXP)
tamoxifen  (EXP)
tert-butanol  (EXP)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetrahydrocurcumin  (EXP)
thiacloprid  (EXP)
thiophanate-methyl  (EXP)
titanium dioxide  (EXP)
toxaphene  (EXP)
valproic acid  (EXP)
ziram  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat. Sakuma T, etal., Xenobiotica. 2001 Apr;31(4):223-37.
4. High efavirenz serum concentrations in TB/HIV-coinfected Ugandan adults with a CYP2B6 516 TT genotype on anti-TB treatment. von Braun A, etal., J Antimicrob Chemother. 2019 Jan 1;74(1):135-138. doi: 10.1093/jac/dky379.
5. Association of CYP2B6 gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese population. Wang Y, etal., Infect Genet Evol. 2017 Jul;51:198-202. doi: 10.1016/j.meegid.2017.04.001. Epub 2017 Apr 5.
6. High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naive HIV patients from Ethiopia: a prospective cohort study. Yimer G, etal., Pharmacogenomics J. 2012 Dec;12(6):499-506. doi: 10.1038/tpj.2011.34. Epub 2011 Aug 23.
Additional References at PubMed
PMID:1497633   PMID:1638085   PMID:1973143   PMID:1997326   PMID:3219345   PMID:3219346   PMID:7565585   PMID:7771797   PMID:7840637   PMID:8713075   PMID:9480761   PMID:12093481  
PMID:12477932   PMID:14630516   PMID:15381067   PMID:17086191   PMID:17964055   PMID:18339816   PMID:21873635   PMID:22083726   PMID:22260863   PMID:23704697   PMID:27197076   PMID:29968852  
PMID:34215813   PMID:38355793  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:554
Count of miRNA genes:382
Interacting mature miRNAs:435
Transcripts:ENSMUST00000082214
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
AI256109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,210,298 - 26,210,430UniSTSGRCm38
MGSCv37726,995,317 - 26,995,449UniSTSGRCm37
Celera720,803,088 - 20,803,220UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Whitehead/MRC_RH7345.92UniSTS
Cyp2b10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000082214   ⟹   ENSMUSP00000080846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,872,836 - 25,910,086 (+)Ensembl
GRCm38.p6 Ensembl726,173,411 - 26,210,661 (+)Ensembl
RefSeq Acc Id: NM_010000   ⟹   NP_034130
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,872,834 - 25,910,085 (+)NCBI
GRCm38726,173,409 - 26,210,660 (+)NCBI
MGSCv37726,958,428 - 26,995,679 (+)RGD
Celera720,663,633 - 20,803,450 (+)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011250431   ⟹   XP_011248733
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,872,775 - 25,910,086 (+)NCBI
GRCm38726,173,350 - 26,210,661 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034130   ⟸   NM_010000
- Peptide Label: precursor
- UniProtKB: Q64463 (UniProtKB/Swiss-Prot),   P12790 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011248733   ⟸   XM_011250431
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000080846   ⟸   ENSMUST00000082214

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12790-F1-model_v2 AlphaFold P12790 1-491 view protein structure

Promoters
RGD ID:6892316
Promoter ID:EPDNEW_M9609
Type:multiple initiation site
Name:Cyp2b9_1
Description:Mus musculus cytochrome P450, family 2, subfamily b, polypeptide9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38726,173,410 - 26,173,470EPDNEW
RGD ID:6840904
Promoter ID:MM_KWN:49489
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_010000
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,958,171 - 26,958,671 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88600 AgrOrtholog
Ensembl Genes ENSMUSG00000040660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000082214 ENTREZGENE
  ENSMUST00000082214.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report mmu:13094 UniProtKB/Swiss-Prot
MGD MGI:88600 ENTREZGENE
NCBI Gene 13094 ENTREZGENE
PANTHER CYTOCHROME P450 2B9-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2b9 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2B UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A9CRD6_MOUSE UniProtKB/TrEMBL
  CP2B9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q64463 ENTREZGENE
UniProt Secondary Q64463 UniProtKB/Swiss-Prot