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Gene: Ephx1 (epoxide hydrolase 1, microsomal) Mus musculus
Symbol: Ephx1
Name: epoxide hydrolase 1, microsomal
RGD ID: 10529
Description: Predicted to have cis-stilbene-oxide hydrolase activity; enzyme binding activity; and epoxide hydrolase activity. Involved in cellular aromatic compound metabolic process and response to organic cyclic compound. Predicted to localize to intracellular membrane-bounded organelle and plasma membrane. Is expressed in several structures, including brain ventricle and choroid plexus; cranial ganglion; integumental system; nose; and salivary gland. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; bile acid transport pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (9R,10S)-9,10-epoxy-9,10-dihydrophenanthrene; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI195553; EH; Eph; Eph-; Eph-1; Eph1; epoxide hydratase; epoxide hydrolase 1; Epxh1; mEH; microsomal epoxide hydrolase
Homo sapiens (human) : EPHX1 (epoxide hydrolase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ephx1 (epoxide hydrolase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx1 (epoxide hydrolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX1 (epoxide hydrolase 1)
Canis lupus familiaris (dog) : EPHX1 (epoxide hydrolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx1 (epoxide hydrolase 1)
Sus scrofa (pig) : EPHX1 (epoxide hydrolase 1)
Chlorocebus sabaeus (African green monkey) : EPHX1 (epoxide hydrolase 1)
Heterocephalus glaber (naked mole-rat) : Ephx1 (epoxide hydrolase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391180,817,121 - 180,845,134 (-)NCBI
GRCm381180,989,556 - 181,017,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,976,210 - 181,020,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,919,687 - 182,947,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,826,231 - 182,854,170 (-)NCBImm8
Celera1188,055,356 - 188,083,565 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ephx1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10529
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.