Cda (cytidine deaminase) - Rat Genome Database
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Gene: Cda (cytidine deaminase) Mus musculus
Analyze
Symbol: Cda
Name: cytidine deaminase
RGD ID: 1322378
MGI Page MGI
Description: Exhibits identical protein binding activity. Predicted to be involved in cytidine deamination; negative regulation of cell growth; and negative regulation of nucleotide metabolic process. Predicted to localize to cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2210401N16Rik; cytidine aminohydrolase; MGC67370
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,065,839 - 138,095,623 (-)NCBIGRCm39mm39
GRCm384138,338,528 - 138,368,311 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,338,424 - 138,367,992 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,894,443 - 137,923,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv364137,610,604 - 137,640,031 (-)NCBImm8
Celera4140,122,623 - 140,152,350 (-)NCBICelera
Cytogenetic Map4D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (EXP)
5'-Deoxy-5-fluorocytidine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorocytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
celastrol  (ISO)
chlorambucil  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
fipronil  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
melphalan  (ISO)
methimazole  (ISO)
mitomycin C  (ISO)
oxaliplatin  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
tamoxifen  (EXP)
Tegafur  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11591653   PMID:12477932   PMID:12810823   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16784234   PMID:16835384   PMID:18554416   PMID:18716662   PMID:21267068   PMID:21677750   PMID:21841819   PMID:21873635   PMID:23095233   PMID:27461566   PMID:32325033  


Genomics

Comparative Map Data
Cda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,065,839 - 138,095,623 (-)NCBIGRCm39mm39
GRCm384138,338,528 - 138,368,311 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,338,424 - 138,367,992 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,894,443 - 137,923,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv364137,610,604 - 137,640,031 (-)NCBImm8
Celera4140,122,623 - 140,152,350 (-)NCBICelera
Cytogenetic Map4D3NCBI
CDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl120,589,086 - 20,618,903 (+)EnsemblGRCh38hg38GRCh38
GRCh38120,589,097 - 20,618,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37120,915,590 - 20,945,396 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37120,915,444 - 20,945,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,788,031 - 20,817,988 (+)NCBINCBI36hg18NCBI36
Build 34120,660,836 - 20,690,702NCBI
Celera119,239,772 - 19,269,752 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef119,161,467 - 19,190,528 (+)NCBIHuRef
CHM1_1121,025,824 - 21,055,781 (+)NCBICHM1_1
Cda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25150,556,615 - 150,583,231 (-)NCBI
Rnor_6.0 Ensembl5156,703,579 - 156,734,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05156,703,579 - 156,734,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05160,452,101 - 160,482,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,117,303 - 157,143,989 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15157,127,441 - 157,153,991 (-)NCBI
Celera5148,950,060 - 148,976,672 (-)NCBICelera
Cytogenetic Map5q36NCBI
Cda
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,132,049 - 1,156,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,131,968 - 1,156,777 (+)NCBIChiLan1.0ChiLan1.0
CDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1120,583,441 - 20,612,711 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,583,441 - 20,612,711 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0119,538,696 - 19,568,008 (+)NCBIMhudiblu_PPA_v0panPan3
CDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl278,304,726 - 78,327,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1278,305,328 - 78,327,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364746,543,295 - 6,564,575 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,824,284 - 78,879,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,824,248 - 78,849,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,017,555 - 73,042,459 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,931,365 - 111,960,172 (-)NCBI
ChlSab1.1 Ensembl20111,931,364 - 111,960,036 (-)Ensembl
Cda
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247645,621,888 - 5,645,055 (+)NCBI

Position Markers
Cda  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
cM Map4 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107161300141161387Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107371164141371360Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107371164141371360Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107371164141371360Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107897771141897963Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108583899142583899Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108583899142583899Mouse
10755521Hct1_mhematocrit 1 (mouse)4108583899142583899Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111115258145115487Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111115258145115487Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112288593146288593Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112629696146629696Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112930596146930596Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4124100000144600000Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124161300141845481Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124161300142711450Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124371164142504390Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131923413141151964Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
12050091Shm2_msperm head morphology 2 (mouse)4137148689138615442Mouse
1357534Cinda3_mcytokine induced activation 3 (mouse)Not determined4137890537142562902Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:361
Count of miRNA genes:266
Interacting mature miRNAs:302
Transcripts:ENSMUST00000030535, ENSMUST00000144986
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030535   ⟹   ENSMUSP00000030535
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4138,338,528 - 138,367,992 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4138,338,424 - 138,343,649 (-)Ensembl
RefSeq Acc Id: NM_028176   ⟹   NP_082452
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394138,065,839 - 138,095,266 (-)NCBI
GRCm384138,338,528 - 138,367,955 (-)NCBI
MGSCv374137,894,443 - 137,923,870 (-)RGD
Celera4140,122,623 - 140,152,350 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539196   ⟹   XP_006539259
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394138,079,173 - 138,095,623 (-)NCBI
GRCm384138,351,862 - 138,368,311 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082452   ⟸   NM_028176
- UniProtKB: P56389 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006539259   ⟸   XM_006539196
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000030535   ⟸   ENSMUST00000030535
Protein Domains
CMP/dCMP-type deaminase

Promoters
RGD ID:6835039
Promoter ID:MM_KWN:40312
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000023202
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364137,923,701 - 137,924,201 (-)MPROMDB
RGD ID:6885186
Promoter ID:EPDNEW_M6044
Type:initiation region
Name:Cda_1
Description:Mus musculus cytidine deaminase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384138,367,992 - 138,368,052EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919519 AgrOrtholog
Ensembl Genes ENSMUSG00000028755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000030535 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030535 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/Swiss-Prot
  CMP_dCMP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_deam_tetra UniProtKB/Swiss-Prot
  Cytidine_deaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72269 UniProtKB/Swiss-Prot
MGD MGI:1919519 ENTREZGENE
NCBI Gene 72269 ENTREZGENE
Pfam dCMP_cyt_deam_1 UniProtKB/Swiss-Prot
PharmGKB CDA RGD
PhenoGen Cda PhenoGen
PROSITE CYT_DCMP_DEAMINASES_1 UniProtKB/Swiss-Prot
  CYT_DCMP_DEAMINASES_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs cyt_deam_tetra UniProtKB/Swiss-Prot
UniProt CDD_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R219_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9D7V3 UniProtKB/Swiss-Prot