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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551496
Species: Mus musculus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2affects response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 5' UTR affects the susceptibility to MethylcholanthrenePMID:20804740
Abcg2increases expressionISOABCG2 (Homo sapiens)6480464CTDMethylcholanthrene results in increased expression of ABCG2; Methylcholanthrene results in increased expression of ABCG2 mRNA; Methylcholanthrene results in increased expression of ABCG2 mRNA alternative form; Methylcholanthrene results in increased expression of ABCG2 proteinPMID:20804740 PMID:23081912
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTDAHR protein affects the reaction [Methylcholanthrene results in increased expression of ABCG2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ABCG2 5' UTR]PMID:20804740
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