Gins3 (GINS complex subunit 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Gins3 (GINS complex subunit 3) Mus musculus
Analyze
Symbol: Gins3
Name: GINS complex subunit 3 (Ensembl:GINS complex subunit 3 (Psf3 homolog))
RGD ID: 1332506
MGI Page MGI
Description: Predicted to be involved in DNA unwinding involved in DNA replication and mitotic DNA replication initiation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human GINS3 (GINS complex subunit 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2700085M18Rik; AI616142; DNA replication complex GINS protein PSF3; GINS complex subunit 3 (Psf3 homolog); Psf3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39896,360,187 - 96,371,687 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl896,360,081 - 96,371,688 (+)EnsemblGRCm39 Ensembl
GRCm38895,633,559 - 95,645,059 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,633,453 - 95,645,060 (+)EnsemblGRCm38mm10GRCm38
MGSCv37898,157,459 - 98,168,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36898,522,688 - 98,534,188 (+)NCBIMGSCv36mm8
Celera899,944,776 - 99,956,285 (+)NCBICelera
Cytogenetic Map8D1NCBI
cM Map847.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
CMG complex  (ISO)
GINS complex  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (ISO,NAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17127213   PMID:17467990   PMID:19521500   PMID:21873635   PMID:22474384  
PMID:27694478   PMID:32554809   PMID:33590678   PMID:34321999   PMID:35603789   PMID:35920641  


Genomics

Comparative Map Data
Gins3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39896,360,187 - 96,371,687 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl896,360,081 - 96,371,688 (+)EnsemblGRCm39 Ensembl
GRCm38895,633,559 - 95,645,059 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,633,453 - 95,645,060 (+)EnsemblGRCm38mm10GRCm38
MGSCv37898,157,459 - 98,168,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36898,522,688 - 98,534,188 (+)NCBIMGSCv36mm8
Celera899,944,776 - 99,956,285 (+)NCBICelera
Cytogenetic Map8D1NCBI
cM Map847.12NCBI
GINS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381658,392,471 - 58,406,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1658,295,080 - 58,406,147 (+)EnsemblGRCh38hg38GRCh38
GRCh371658,426,375 - 58,440,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,983,924 - 56,997,549 (+)NCBINCBI36Build 36hg18NCBI36
Celera1642,926,079 - 42,939,099 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1644,295,208 - 44,308,210 (+)NCBIHuRef
CHM1_11659,833,197 - 59,847,353 (+)NCBICHM1_1
T2T-CHM13v2.01664,090,370 - 64,201,439 (+)NCBIT2T-CHM13v2.0
Gins3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,426,140 - 9,435,192 (-)NCBIGRCr8
mRatBN7.2199,420,085 - 9,428,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,420,086 - 9,428,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,388,571 - 9,397,105 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,155,401 - 10,163,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,441,718 - 9,450,252 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,835,113 - 9,843,649 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,835,057 - 9,843,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,820,191 - 9,828,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4199,876,690 - 9,885,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1199,883,128 - 9,890,016 (-)NCBI
Celera199,315,072 - 9,323,608 (-)NCBICelera
Cytogenetic Map19p13NCBI
Gins3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,842,991 - 15,863,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,843,025 - 15,864,942 (+)NCBIChiLan1.0ChiLan1.0
GINS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,851,754 - 67,866,510 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,772,572 - 73,790,151 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01638,653,876 - 38,672,154 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,790,392 - 57,801,904 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,790,392 - 57,801,904 (+)Ensemblpanpan1.1panPan2
GINS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,233,425 - 58,244,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,234,321 - 58,245,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,863,478 - 54,874,485 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,771,765 - 58,783,038 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,771,765 - 58,782,959 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1255,601,435 - 55,612,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0256,609,125 - 56,620,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,503,855 - 57,514,873 (-)NCBIUU_Cfam_GSD_1.0
Gins3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934949,372,998 - 49,379,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647510,209,071 - 10,218,051 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647510,209,127 - 10,216,701 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GINS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl620,162,636 - 20,170,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1620,162,264 - 20,170,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2618,222,183 - 18,230,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GINS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1544,331,392 - 44,342,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl544,331,802 - 44,342,812 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604731,828,877 - 31,839,914 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gins3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474627,836,267 - 27,853,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474627,824,318 - 27,853,034 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gins3
413 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:367
Interacting mature miRNAs:397
Transcripts:ENSMUST00000034094
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
14696809Rbcn3_mrod bipolar cell number 3 (mouse)895056628102856632Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse

Markers in Region
AI616142  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38895,643,766 - 95,643,849UniSTSGRCm38
MGSCv37898,167,666 - 98,167,749UniSTSGRCm37
Celera899,954,991 - 99,955,074UniSTS
Cytogenetic Map8D1UniSTS
Whitehead/MRC_RH81164.57UniSTS
UniSTS:235973  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38895,644,856 - 95,645,060UniSTSGRCm38
MGSCv37898,168,756 - 98,168,960UniSTSGRCm37
Celera899,956,082 - 99,956,286UniSTS
Cytogenetic Map8D1UniSTS
BE103022  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38895,644,817 - 95,645,016UniSTSGRCm38
MGSCv37898,168,717 - 98,168,916UniSTSGRCm37
Celera899,956,043 - 99,956,242UniSTS
Cytogenetic Map8D1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034094   ⟹   ENSMUSP00000034094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl896,360,081 - 96,371,688 (+)Ensembl
GRCm38.p6 Ensembl895,633,453 - 95,645,060 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212434   ⟹   ENSMUSP00000148516
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl896,360,182 - 96,364,861 (+)Ensembl
GRCm38.p6 Ensembl895,633,554 - 95,638,233 (+)Ensembl
RefSeq Acc Id: NM_030198   ⟹   NP_084474
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39896,360,187 - 96,371,687 (+)NCBI
GRCm38895,633,559 - 95,645,059 (+)ENTREZGENE
MGSCv37898,157,459 - 98,168,959 (+)RGD
Celera899,944,776 - 99,956,285 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_084474   ⟸   NM_030198
- UniProtKB: Q9CY94 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034094   ⟸   ENSMUST00000034094
RefSeq Acc Id: ENSMUSP00000148516   ⟸   ENSMUST00000212434
Protein Domains
GINS subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CY94-F1-model_v2 AlphaFold Q9CY94 1-216 view protein structure

Promoters
RGD ID:8667967
Promoter ID:EPDNEW_M12015
Type:initiation region
Name:Gins3_1
Description:Mus musculus GINS complex subunit 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38895,633,528 - 95,633,588EPDNEW
RGD ID:6843186
Promoter ID:MM_KWN:55401
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   MEF_B6
Transcripts:ENSMUST00000034094
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36898,157,099 - 98,157,599 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926083 AgrOrtholog
Ensembl Genes ENSMUSG00000031669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034094 ENTREZGENE
  ENSMUST00000034094.11 UniProtKB/Swiss-Prot
  ENSMUST00000212434.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GINS_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GINS_bundle-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GINS_Psf3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GINS_Psf3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78833 UniProtKB/Swiss-Prot
MGD MGI:1926083 ENTREZGENE
NCBI Gene 78833 ENTREZGENE
PANTHER DNA REPLICATION COMPLEX GINS PROTEIN PSF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sld5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gins3 PhenoGen
Superfamily-SCOP PriA/YqbF domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF158573 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RLV2_MOUSE UniProtKB/TrEMBL
  PSF3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Gins3  GINS complex subunit 3  Gins3  GINS complex subunit 3 (Psf3 homolog)  Symbol and/or name change 5135510 APPROVED