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Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) Mus musculus
Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Description: Predicted to have Rac guanyl-nucleotide exchange factor activity and phospholipid binding activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to localize to several cellular components, including the dendritic shaft; growth cone; and perinuclear region of cytoplasm. Used to study autism spectrum disorder. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 3-methylcholanthrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G630042G04; P-REX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; ptdIns(3,4,5)-dependent Rac exchanger 1; RP23-183N8.1; SET domain containing 6; Setd6
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBImm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prex1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315206
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.