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Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) Mus musculus
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Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Description: Predicted to have Rac guanyl-nucleotide exchange factor activity and phospholipid binding activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to localize to several cellular components, including the dendritic shaft; growth cone; and perinuclear region of cytoplasm. Used to study autism spectrum disorder. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 3-methylcholanthrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G630042G04; P-REX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; ptdIns(3,4,5)-dependent Rac exchanger 1; RP23-183N8.1; SET domain containing 6; Setd6
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBImm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prex1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315206
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.