Tmem119 (transmembrane protein 119) - Rat Genome Database

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Gene: Tmem119 (transmembrane protein 119) Mus musculus
Analyze
Symbol: Tmem119
Name: transmembrane protein 119
RGD ID: 1316846
MGI Page MGI
Description: Involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Acts upstream of or within osteoblast differentiation. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skeleton. Orthologous to human TMEM119 (transmembrane protein 119).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW208946; BC025600; MGC38046; ob; obif; osteoblast induction factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,931,790 - 113,938,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,931,790 - 113,938,577 (-)EnsemblGRCm39 Ensembl
GRCm385113,793,729 - 113,800,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,793,729 - 113,800,516 (-)EnsemblGRCm38mm10GRCm38
MGSCv375114,243,738 - 114,250,367 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,054,728 - 114,061,357 (-)NCBIMGSCv36mm8
Celera5110,894,838 - 110,901,705 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16829211   PMID:20025746   PMID:20562862  
PMID:21239498   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22416756   PMID:22579779   PMID:24194600   PMID:24362451   PMID:24952961   PMID:26207632   PMID:26884166   PMID:27546376  
PMID:27626380   PMID:29752062   PMID:29973370   PMID:30606613   PMID:30760929   PMID:31202927   PMID:31371457   PMID:32541010   PMID:33887203   PMID:34233165   PMID:35045285   PMID:35195906  
PMID:35567352   PMID:36090351   PMID:36162816   PMID:36505450   PMID:36701202   PMID:36763532   PMID:36768434   PMID:36798430   PMID:36928411   PMID:37118341   PMID:37248420   PMID:37365181  
PMID:37416774   PMID:37426748   PMID:37428916   PMID:37486903   PMID:37532932   PMID:37572655   PMID:37572666   PMID:37635351   PMID:37749326   PMID:37820974   PMID:37926132   PMID:38100356  
PMID:38131301   PMID:38190982   PMID:38190983   PMID:38217856   PMID:38238430   PMID:38308250   PMID:38309272   PMID:38316336   PMID:38355793   PMID:38363678   PMID:38474068   PMID:38489263  
PMID:38492223   PMID:38614103   PMID:38625796   PMID:38636518   PMID:38906887   PMID:38942344   PMID:38961498  


Genomics

Comparative Map Data
Tmem119
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,931,790 - 113,938,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,931,790 - 113,938,577 (-)EnsemblGRCm39 Ensembl
GRCm385113,793,729 - 113,800,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,793,729 - 113,800,516 (-)EnsemblGRCm38mm10GRCm38
MGSCv375114,243,738 - 114,250,367 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,054,728 - 114,061,357 (-)NCBIMGSCv36mm8
Celera5110,894,838 - 110,901,705 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
TMEM119
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,589,851 - 108,598,084 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,589,851 - 108,598,320 (-)EnsemblGRCh38hg38GRCh38
GRCh3712108,983,627 - 108,991,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,507,756 - 107,515,913 (-)NCBINCBI36Build 36hg18NCBI36
Celera12108,653,016 - 108,661,288 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12106,047,977 - 106,056,250 (-)NCBIHuRef
CHM1_112108,950,373 - 108,958,645 (-)NCBICHM1_1
T2T-CHM13v2.012108,564,436 - 108,572,683 (-)NCBIT2T-CHM13v2.0
Tmem119
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,489,157 - 48,496,214 (+)NCBIGRCr8
mRatBN7.21242,828,621 - 42,835,678 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,828,418 - 42,835,689 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,994,907 - 44,001,984 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,608,504 - 44,615,581 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,669,038 - 43,676,115 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,598,498 - 48,605,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,598,647 - 48,605,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,380,454 - 50,387,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,863,011 - 43,870,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,731,406 - 43,732,498 (+)NCBI
Celera1244,430,205 - 44,437,274 (+)NCBICelera
Cytogenetic Map12q16NCBI
Tmem119
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,856,443 - 9,863,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,856,443 - 9,863,100 (-)NCBIChiLan1.0ChiLan1.0
TMEM119
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,654,849 - 116,663,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,651,254 - 116,659,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,166,737 - 106,173,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,561,987 - 109,570,389 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,563,684 - 109,564,535 (-)Ensemblpanpan1.1panPan2
TMEM119
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,275,719 - 18,282,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,260,923 - 18,282,409 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,519,003 - 17,526,176 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,619,952 - 18,627,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,605,512 - 18,626,613 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,728,101 - 17,735,247 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,610,928 - 18,618,116 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,629,671 - 18,636,823 (+)NCBIUU_Cfam_GSD_1.0
Tmem119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,959,979 - 144,962,199 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936769513,695 - 515,769 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM119
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11442,190,958 - 42,197,384 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,736,255 - 44,742,678 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM119
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,787,911 - 103,796,217 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11103,788,407 - 103,789,249 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037141,300,326 - 141,308,958 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem119
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474711,828,292 - 11,834,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:739
Count of miRNA genes:463
Interacting mature miRNAs:532
Transcripts:ENSMUST00000067853, ENSMUST00000160374
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
AW208946  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,793,767 - 113,793,908UniSTSGRCm38
MGSCv375114,243,776 - 114,243,917UniSTSGRCm37
Celera5110,894,876 - 110,895,017UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51366.58UniSTS
UniSTS:235267  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,794,661 - 113,794,872UniSTSGRCm38
MGSCv375114,244,670 - 114,244,881UniSTSGRCm37
Celera5110,895,770 - 110,895,981UniSTS
Cytogenetic Map5FUniSTS
Tmem119  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,793,771 - 113,793,948UniSTSGRCm38
MGSCv375114,243,780 - 114,243,957UniSTSGRCm37
Celera5110,894,880 - 110,895,057UniSTS
Cytogenetic Map5FUniSTS
cM Map5 UniSTS
Tmem119  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,793,845 - 113,793,915UniSTSGRCm38
MGSCv375114,243,854 - 114,243,924UniSTSGRCm37
Celera5110,894,954 - 110,895,024UniSTS
Cytogenetic Map5FUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000067853   ⟹   ENSMUSP00000070551
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,931,790 - 113,938,577 (-)Ensembl
GRCm38.p6 Ensembl5113,793,729 - 113,800,516 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160374   ⟹   ENSMUSP00000124226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,933,699 - 113,938,507 (-)Ensembl
GRCm38.p6 Ensembl5113,795,638 - 113,800,446 (-)Ensembl
RefSeq Acc Id: NM_001425854   ⟹   NP_001412783
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,931,790 - 113,938,457 (-)NCBI
RefSeq Acc Id: NM_146162   ⟹   NP_666274
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,931,790 - 113,938,457 (-)NCBI
GRCm385113,793,729 - 113,800,396 (-)NCBI
MGSCv375114,243,738 - 114,250,367 (-)RGD
Celera5110,894,838 - 110,901,705 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_666274   ⟸   NM_146162
- Peptide Label: precursor
- UniProtKB: Q8BP14 (UniProtKB/Swiss-Prot),   Q8R138 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000070551   ⟸   ENSMUST00000067853
Ensembl Acc Id: ENSMUSP00000124226   ⟸   ENSMUST00000160374
RefSeq Acc Id: NP_001412783   ⟸   NM_001425854
- Peptide Label: precursor
- UniProtKB: Q8R138 (UniProtKB/Swiss-Prot),   Q8BP14 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R138-F1-model_v2 AlphaFold Q8R138 1-280 view protein structure

Promoters
RGD ID:6887646
Promoter ID:EPDNEW_M7274
Type:initiation region
Name:Tmem119_1
Description:Mus musculus transmembrane protein 119 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385113,800,381 - 113,800,441EPDNEW
RGD ID:6838504
Promoter ID:MM_KWN:43520
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000071297,   OTTMUST00000071298
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,250,069 - 114,250,569 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385228 AgrOrtholog
Ensembl Genes ENSMUSG00000054675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067853 ENTREZGENE
  ENSMUST00000067853.6 UniProtKB/Swiss-Prot
  ENSMUST00000160374.2 UniProtKB/TrEMBL
InterPro TMEM119 UniProtKB/Swiss-Prot
KEGG Report mmu:231633 UniProtKB/Swiss-Prot
MGD MGI:2385228 ENTREZGENE
NCBI Gene 231633 ENTREZGENE
PANTHER PTHR28645 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 119 UniProtKB/Swiss-Prot
Pfam TMEM119 UniProtKB/Swiss-Prot
PhenoGen Tmem119 PhenoGen
UniProt E0CYG1_MOUSE UniProtKB/TrEMBL
  Q8BP14 ENTREZGENE
  Q8R138 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BP14 UniProtKB/Swiss-Prot