Tmem119 (transmembrane protein 119)

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Gene: Tmem119 (transmembrane protein 119) Mus musculus

Analyze

Symbol:

Tmem119

Name:

transmembrane protein 119

RGD ID:

1316846

MGI Page

MGI

Description:

Involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Acts upstream of or within osteoblast differentiation. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skeleton. Orthologous to human TMEM119 (transmembrane protein 119).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AW208946; BC025600; MGC38046; ob; obif; osteoblast induction factor

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM119 (transmembrane protein 119)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Tmem119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem119 (transmembrane protein 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Tmem119 (transmembrane protein 119)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM119 (transmembrane protein 119)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem119b (transmembrane protein 119b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	tmem119a (transmembrane protein 119a)	Alliance	DIOPT (PANTHER\|ZFIN)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	113,931,790 - 113,938,530 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	113,931,790 - 113,938,577 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	113,793,729 - 113,800,396 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	113,793,729 - 113,800,516 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	114,243,738 - 114,250,367 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	114,054,728 - 114,061,357 (-)	NCBI		MGSCv36	mm8
Celera	5	110,894,838 - 110,901,705 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3-methylcholanthrene (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

butanal (ISO)

carbon nanotube (EXP)

chloroprene (EXP)

choline (EXP)

chromium(6+) (EXP)

Cuprizon (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dioxygen (EXP)

doxorubicin (ISO)

epoxiconazole (EXP)

ethanol (EXP)

folic acid (EXP)

furan (ISO)

gentamycin (ISO)

L-methionine (EXP)

lidocaine (ISO)

methapyrilene (ISO)

oxaliplatin (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

Soman (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

topotecan (ISO)

triclosan (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biomineral tissue development (IEA)

cell differentiation (IEA)

endochondral ossification (IMP)

negative regulation of bone resorption (IMP)

negative regulation of myotube differentiation (IDA)

ossification (IEA)

osteoblast differentiation (IDA,IMP)

positive regulation of bone development (IMP)

positive regulation of bone mineralization (IBA,IMP,ISO)

positive regulation of gene expression (IDA,IMP)

positive regulation of osteoblast differentiation (IBA,IDA,IMP,ISO)

positive regulation of osteoblast proliferation (IBA,IDA,ISO)

positive regulation of protein phosphorylation (IDA)

spermatid differentiation (IMP)

spermatogenesis (IMP)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IDA)

membrane (IEA)

plasma membrane (IBA,IDA,ISO)

Molecular Function

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal bone trabecula morphology (IAGP)

abnormal testis morphology (IEA)

decreased body length (IAGP)

decreased body weight (IAGP)

decreased bone trabecula number (IAGP)

decreased compact bone thickness (IAGP)

decreased trabecular bone connectivity density (IAGP)

decreased trabecular bone volume (IAGP)

delayed endochondral bone ossification (IAGP)

impaired osteoblast differentiation (IAGP)

postnatal growth retardation (IAGP)

preweaning lethality, incomplete penetrance (IEA)

small testis (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:15489334	PMID:16141072	PMID:16141073	PMID:16829211	PMID:20025746	PMID:20562862
PMID:21239498	PMID:21267068	PMID:21677750	PMID:21873635	PMID:22416756	PMID:22579779	PMID:24194600	PMID:24362451	PMID:24952961	PMID:26207632	PMID:26884166	PMID:27546376
PMID:27626380	PMID:29752062	PMID:29973370	PMID:30606613	PMID:30760929	PMID:31202927	PMID:31371457	PMID:32541010	PMID:33887203	PMID:34233165	PMID:35045285	PMID:35195906
PMID:35567352	PMID:36162816	PMID:36505450	PMID:36768434

Genomics

Comparative Map Data

Tmem119
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	113,931,790 - 113,938,530 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	113,931,790 - 113,938,577 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	113,793,729 - 113,800,396 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	113,793,729 - 113,800,516 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	114,243,738 - 114,250,367 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	114,054,728 - 114,061,357 (-)	NCBI		MGSCv36	mm8
Celera	5	110,894,838 - 110,901,705 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI

TMEM119
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	108,589,851 - 108,598,084 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	108,589,851 - 108,598,320 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	108,983,627 - 108,991,860 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	107,507,756 - 107,515,913 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	108,653,016 - 108,661,288 (-)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	106,047,977 - 106,056,250 (-)	NCBI		HuRef
CHM1_1	12	108,950,373 - 108,958,645 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	108,564,436 - 108,572,683 (-)	NCBI		T2T-CHM13v2.0

Tmem119
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	42,828,621 - 42,835,678 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	42,828,418 - 42,835,689 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	43,994,907 - 44,001,984 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	44,608,504 - 44,615,581 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	43,669,038 - 43,676,115 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	48,598,498 - 48,605,704 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	48,598,647 - 48,605,704 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	50,380,454 - 50,387,588 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	43,863,011 - 43,870,068 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	43,731,406 - 43,732,498 (+)	NCBI
Celera	12	44,430,205 - 44,437,274 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Tmem119
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	9,856,443 - 9,863,100 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	9,856,443 - 9,863,100 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM119
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	116,651,254 - 116,659,541 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	106,166,737 - 106,173,965 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	109,561,987 - 109,570,389 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	109,563,684 - 109,564,535 (-)	Ensembl	panpan1.1		panPan2

TMEM119
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	18,275,719 - 18,282,905 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	18,260,923 - 18,282,409 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	17,519,003 - 17,526,176 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	18,619,952 - 18,627,106 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	18,605,512 - 18,626,613 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	17,728,101 - 17,735,247 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	18,610,928 - 18,618,116 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	18,629,671 - 18,636,823 (+)	NCBI		UU_Cfam_GSD_1.0

Tmem119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	144,959,979 - 144,962,199 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936769	513,695 - 515,769 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM119
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	14	42,190,958 - 42,197,384 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	44,736,255 - 44,742,678 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM119
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	103,787,911 - 103,796,217 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	103,788,407 - 103,789,249 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	141,300,326 - 141,308,958 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem119
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	11,828,292 - 11,834,855 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem119
258 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	739
Count of miRNA genes:	463
Interacting mature miRNAs:	532
Transcripts:	ENSMUST00000067853, ENSMUST00000160374
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
4142064	Tmc1m4_m	Tmc1 modifier 4 (mouse)			Not determined		5	54500177	127001072	Mouse
26884395	Humsd2_m	humerus midshaft diameter 2, 10 week (mouse)					5	70057343	132528839	Mouse
27226719	Tibw6_m	tibia width 6, proximal, 16 week (mouse)					5	72857343	139985755	Mouse
25314315	Mlh1fc4_m	MLH1 foci count 4 (mouse)					5	74460661	132528839	Mouse
13506928	Recrq8_m	recombination rate in male meiosis QTL 8 (mouse)					5	74460661	132528839	Mouse
1357431	Cia27_m	collagen induced arthritis 27 (mouse)			Not determined		5	75315348	120018629	Mouse
10755524	Mono1_m	monocyte differential 1 (mouse)					5	80849259	114849259	Mouse
1301419	Cypr3_m	cytokine production 3 (mouse)			Not determined		5	81019649	115019803	Mouse
10401245	Bglu18_m	blood glucose level 18 (mouse)			Not determined		5	82838468	116838597	Mouse
13464242	Ahl17_m	age related hearing loss, early onset 17 (mouse)					5	82838468	116838597	Mouse
10043958	Chldq12_m	cholesterol and HDL QTL 12 (mouse)			Not determined		5	87386871	121387065	Mouse
1301126	Bwem1_m	body weight day 30 males 1 (mouse)			Not determined		5	87386871	121387065	Mouse
13464241	Ahl18_m	age related hearing loss, early onset 18 (mouse)					5	87386871	121387065	Mouse
1300801	Drb2_m	dopamine receptor binding 2 (mouse)			Not determined		5	87386871	121387065	Mouse
1301399	Cpfd3_m	cerebellum pattern fissures (mouse)			Not determined		5	87386871	121387065	Mouse
1357725	Eae39_m	experimental allergic encephalomyelitis 39 (mouse)			Not determined		5	89418876	118864028	Mouse
1300968	Skts4_m	skin tumor susceptibility 4 (mouse)			Not determined		5	89418876	124238239	Mouse
1301362	Prnr1_m	prion resistance 1 (mouse)			Not determined		5	89418876	146787935	Mouse
11049562	Lmr24f_m	leishmaniasis resistance 24f (mouse)					5	90320962	124321041	Mouse
1301457	Cfsw2_m	cystic fibrosis survival to weaning 2 (mouse)			Not determined		5	90561006	124561151	Mouse
1300993	Hycdc_m	hypercapnic duty cycle (mouse)			Not determined		5	90561006	124561151	Mouse
9587780	Afw16_m	abdominal fat weight QTL 16 (mouse)			Not determined		5	92830166	126830285	Mouse
1301974	Chab7_m	cholesterol absorption 7 (mouse)			Not determined		5	95233214	129233330	Mouse
1357644	Egrd1_m	early growth rate, direct effect 1 (mouse)			Not determined		5	95434580	129434786	Mouse
10402486	Dipa1_m	drug induced psychomotor activation 1 (mouse)			Not determined		5	95465549	129465722	Mouse
13464244	Ahl19_m	age related hearing loss, early onset 19 (mouse)					5	95465549	129465722	Mouse
1558774	Lith17_m	lithogenic gene 17 (mouse)			Not determined		5	95465549	129465722	Mouse
1300940	Actd3_m	activity-distance traveled 3 (mouse)			Not determined		5	96320385	130320533	Mouse
1300659	Pcd8ts1_m	p-glycoprotein positive CD8 T cell subset 1 (mouse)			Not determined		5	97021753	131021986	Mouse
1301858	Smdq1_m	segregation of mitochondrial DNA QTL 1 (mouse)			Not determined		5	97021753	131021986	Mouse
10045978	Tir10_m	trypanosome infection response 10 (mouse)			Not determined		5	98019649	114021986	Mouse
1301042	Elmaz1_m	elevated maze behavior 1 (mouse)			Not determined		5	98019649	116876624	Mouse
4141519	Hmtb5_m	hemostasis and thrombosis bleeding time 5 (mouse)			Not determined			99949422	126882944	Mouse
12904945	Tammq2_m	tibialis anterior muscle mass QTL 2 (mouse)					5	100665965	134665965	Mouse
12904959	Smmq1_m	soleus muscle mass QTL 1 (mouse)					5	100665965	134665965	Mouse
12859290	Criq2_m	Citrobacter rodentium infection QTL 2 (mouse)					5	101332579	135332579	Mouse
1301624	Aevm2_m	autoimmune extremity vasculitis in MRL mice 2 (mouse)			Not determined		5	101863832	135864028	Mouse
14746986	Manh58_m	mandible shape 58 (mouse)					5	102446283	136446283	Mouse
11532736	Sluc33b_m	susceptibility to lung cancer 33b (mouse)					5	102945037	136945196	Mouse
25314310	Syncl4_m	synaptonemal complex length 4 (mouse)					5	103047866	115538059	Mouse
25314317	Sccor3_m	synaptonemal complex length to mean MLH1 count ratio 3 (mouse)					5	104347866	114738061	Mouse
11528550	Sluc33_m	susceptibility to lung cancer 33 (mouse)					5	104386871	120711986	Mouse
1357886	Diht_m	dopamine-induced hypothermia (mouse)			Not determined		5	104498738	115101540	Mouse
10412202	Bbaa26_m	B.burgdorferi-associated arthritis 26 (mouse)			Not determined		5	104583688	138555455	Mouse
10412239	Alpq7_m	alcohol preference QTL 7 (mouse)			Not determined		5	104705939	138705939	Mouse
10043890	Trigq4_m	triglyceride QTL 4 (mouse)			Not determined		5	107906299	141906412	Mouse
4142473	Chlq11_m	circulating hormone level QTL 11 (mouse)			Not determined		5	107906299	141906412	Mouse
13464243	Ahl20_m	age related hearing loss, early onset 20 (mouse)					5	107906299	141906412	Mouse
4141139	Hmtb4_m	hemostasis and thrombosis rebleeding time 4 (mouse)			Not determined			108762509	126882944	Mouse
10412197	Bbaa25_m	B.burgdorferi-associated arthritis 25 (mouse)			Not determined		5	109167240	143167381	Mouse
13464251	Ahl21_m	age related hearing loss, early onset 21 (mouse)					5	109167240	143167381	Mouse
1301543	Hypch_m	hypercholesterolemia (mouse)			Not determined		5	109238624	139118905	Mouse
1300913	Bwefm_m	body weight females and males day 10 (mouse)			Not determined		5	109439348	143439459	Mouse
4141652	Mrdq2_m	modifier of retinal degeneration QTL 2 (mouse)			Not determined			110253106	118093673	Mouse
1301102	Cia14_m	collagen induced arthritis 14 (mouse)			Not determined		5	113320385	138555455	Mouse

Markers in Region

AW208946

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	113,793,767 - 113,793,908	UniSTS	GRCm38
MGSCv37	5	114,243,776 - 114,243,917	UniSTS	GRCm37
Celera	5	110,894,876 - 110,895,017	UniSTS
Cytogenetic Map	5	F	UniSTS
Whitehead/MRC_RH	5	1366.58	UniSTS

UniSTS:235267

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	113,794,661 - 113,794,872	UniSTS	GRCm38
MGSCv37	5	114,244,670 - 114,244,881	UniSTS	GRCm37
Celera	5	110,895,770 - 110,895,981	UniSTS
Cytogenetic Map	5	F	UniSTS

Tmem119

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	113,793,771 - 113,793,948	UniSTS	GRCm38
MGSCv37	5	114,243,780 - 114,243,957	UniSTS	GRCm37
Celera	5	110,894,880 - 110,895,057	UniSTS
Cytogenetic Map	5	F	UniSTS
cM Map	5		UniSTS

Tmem119

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	113,793,845 - 113,793,915	UniSTS	GRCm38
MGSCv37	5	114,243,854 - 114,243,924	UniSTS	GRCm37
Celera	5	110,894,954 - 110,895,024	UniSTS
Cytogenetic Map	5	F	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_146162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_036165089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC132939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK078473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK135223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK170712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000067853 ⟹ ENSMUSP00000070551

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	113,931,790 - 113,938,577 (-)	Ensembl
GRCm38.p6 Ensembl	5	113,793,729 - 113,800,516 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000160374 ⟹ ENSMUSP00000124226

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	113,933,699 - 113,938,507 (-)	Ensembl
GRCm38.p6 Ensembl	5	113,795,638 - 113,800,446 (-)	Ensembl

RefSeq Acc Id:

NM_146162 ⟹ NP_666274

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	113,931,790 - 113,938,457 (-)	NCBI
GRCm38	5	113,793,729 - 113,800,396 (-)	NCBI
MGSCv37	5	114,243,738 - 114,250,367 (-)	RGD
Celera	5	110,894,838 - 110,901,705 (-)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

AGAGCAGCTGGCGGCAGACGGCAGGCAGACAGTCAGACCGTCTAGCGGGCCTGGCTTGCCTACC
TGGCAGCTGCACCCGGTCCTTCACCCAGAGCTGGTTCCATAGCTCAACATGGTCCCCTGGTTCC
TCCTGTCTCTGCTGCTACTTGCGAGGCCTGTGCCTGGGGTGGCCTACTCTGTGTCACTCCCGGC
CTCCTTCCTGGAGGATGTAGCCGGCAGCGGGGAAGCTGAGGGTTCTTCAGCCTCTTCCCCGAGC
CTGCCGCCGCCTGGGACTCCAGCCTTCAGTCCCACACCGGAGAGACCCCAGCCCACAGCTCTGG
ACGGCCCCGTGCCACCCACCAACCTCCTGGAAGGGATCATGGATTTCTTCCGGCAGTACGTGAT
GCTCATCGCGGTGGTGGGCTCGCTGACCTTCCTCATCATGTTCATAGTCTGCGCCGCCCTCATC
ACGCGCCAGAAGCACAAGGCCACAGCCTACTACCCATCCTCGTTCCCTGAAAAGAAGTATGTGG
ACCAGAGAGACCGGGCTGGGGGACCCCGTACCTTCAGCGAGGTCCCTGACAGGGCACCTGACAG
CCGGCATGAAGAAGGCCTGGACACCTCCCATCAGCTCCAGGCTGACATTCTGGCTGCTACCCAG
AACCTCCGGTCTCCAGCTAGAGCCCTGCCAGGCAATGGGGAGGGAGCAAAGCCTGTGAAGGGTG
GGTCGGAGGAGGAGGAGGAAGAGGTGCTCAGCGGTCAGGAGGAGGCCCAGGAAGCCCCAGTATG
TGGGGTCACTGAAGAGAAGCTGGGGGTCCCAGAGGAGTCGGTCTCAGCAGAGGCTGAAGGGGTT
CCTGCCACCAGTGAGGGCCAAGGGGAAGCAGAAGGGTCTTTCTCCTTAGCCCAGGAATCCCAGG
GAGCAACTGGTCCTCCTGAAAGTCCCTGTGCCTGCAACAGAGTCTCCCCCAGTGTCTAACAGGC
CCCAGAACTGCTGGGACCCGAATGTTGGGTCCTTGAGGGTCACCTCTTTGGTCAAGAAAGGCAT
TCAGCTCTAACTGCTCCTTGATACCACGTGGCTTGGCCATTGCTGGTGCCAAGGCTGACCCCGA
ACTGGCAGAGCCGATGCCCTCTGGTGCACCCCAGGAAACATCTCCCCAAGTTCCAGCGCCCTTA
ATGACTCTTGCCACCCTGGGGGCTTCACCCTAACGCACCACTTCTCTGGAAGGGGAAGGCCAGA
CACATGCCAGTTGGGGCTGCATGAGGCAGTCCTCAGAGCAGAAGGGGACCAGGCCAGAGGCCAC
CTGTGACGGGGCAAACTGCATCTCGGCTGTGGAGACCAGAGGGGCTGTTAGATTTGGAAGACAT
CAATGACTGGGCCTGCGGCGCAGCCCGTGTCTGGTAATACCAGGGACGGCAGAGGCGTTTGCAT
CTTCCCATCACCTGCAATGTCGCTGTCACTCTGCCCCTGTTCAGTGGACTTGATTAGTTAGGAA
ACTTCTGGAAGGGGCCCCCTACTTTATATCACAGAGTTTGCCCTAGACACCCCGTGGAAACACA
AACTCAAAATCAAGTGGCTTTAGGAGCCGCTGTGCCCCTCCACAAGCTGACATGGCTACTCTAA
GGGTTCCTGCTGGGCTGGCTTTGCTACGCTTTCCTCAAGCTGCTTTCTTATTACCAGGATGCCT
CACAGCTACAAAGTCCAATCTCACAGCACCCGCACTGGAAAATACTGTTCTCCATTTTTTTCCA
AGGCACCCTGCTTTATGATTGGCTCAGAGTTGGAATATGGGATGCAGGGCGTCTGGCTCTCTCA
AGTGTCAAGCAACCCTGGCTTCCGCATGTGGGGCGAGGGGAGTGAGCAGAACTCTTCTCTGTCA
GTCCACGAAGTAGACTAGAAGCCAACGGGTGCCTGGGGGCAACTGACGGTCTGGATTCTGACGC
CCAGCCTGGAGCAGGGGCCTGGCCCATCCTATGCTCACACAGTGGTCTGGCAGCCTGAGCCCAC
ACAACTCCTCAGTCCTTGACAATGCTTAGGCTCTGTTCTGAGGGACTCCCCACACCTCCATTCA
GGGCTCCCCGAGTCCTCAGCTCTTCGGATGTGGATATATGACACACTAGCATAATAAATCTTGA
TCTGGCTTGA

hide sequence

RefSeq Acc Id:

XM_036165089 ⟹ XP_036020982

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	113,931,790 - 113,938,530 (-)	NCBI

Sequence:

show sequence

CAAGCTGGCCCTCCAGCCCAGCAGGGAGGAGGAAAGGGGAGGGCCTGGAGGCCGAGGCGGGCAG
GCACCAGCCAGAGCAGCTGGCGGCAGACGGCAGGCAGACAGTCAGACCGTCTAGCGGGCCTGGC
TTGCCTACCTGGCAGCTGCACCCGGTCCTTCACCCAGAGCTGTCACTCCATCCCAGTTTCACCA
GAGCCTCTGTCACTTAAGTTGGAAATGGGGACAATGACAGCTCTTCACCGGGTTCCATAGCTCA
ACATGGTCCCCTGGTTCCTCCTGTCTCTGCTGCTACTTGCGAGGCCTGTGCCTGGGGTGGCCTA
CTCTGTGTCACTCCCGGCCTCCTTCCTGGAGGATGTAGCCGGCAGCGGGGAAGCTGAGGGTTCT
TCAGCCTCTTCCCCGAGCCTGCCGCCGCCTGGGACTCCAGCCTTCAGTCCCACACCGGAGAGAC
CCCAGCCCACAGCTCTGGACGGCCCCGTGCCACCCACCAACCTCCTGGAAGGGATCATGGATTT
CTTCCGGCAGTACGTGATGCTCATCGCGGTGGTGGGCTCGCTGACCTTCCTCATCATGTTCATA
GTCTGCGCCGCCCTCATCACGCGCCAGAAGCACAAGGCCACAGCCTACTACCCATCCTCGTTCC
CTGAAAAGAAGTATGTGGACCAGAGAGACCGGGCTGGGGGACCCCGTACCTTCAGCGAGGTCCC
TGACAGGGCACCTGACAGCCGGCATGAAGAAGGCCTGGACACCTCCCATCAGCTCCAGGCTGAC
ATTCTGGCTGCTACCCAGAACCTCCGGTCTCCAGCTAGAGCCCTGCCAGGCAATGGGGAGGGAG
CAAAGCCTGTGAAGGGTGGGTCGGAGGAGGAGGAGGAAGAGGTGCTCAGCGGTCAGGAGGAGGC
CCAGGAAGCCCCAGTATGTGGGGTCACTGAAGAGAAGCTGGGGGTCCCAGAGGAGTCGGTCTCA
GCAGAGGCTGAAGGGGTTCCTGCCACCAGTGAGGGCCAAGGGGAAGCAGAAGGGTCTTTCTCCT
TAGCCCAGGAATCCCAGGGAGCAACTGGTCCTCCTGAAAGTCCCTGTGCCTGCAACAGAGTCTC
CCCCAGTGTCTAACAGGCCCCAGAACTGCTGGGACCCGAATGTTGGGTCCTTGAGGGTCACCTC
TTTGGTCAAGAAAGGCATTCAGCTCTAACTGCTCCTTGATACCACGTGGCTTGGCCATTGCTGG
TGCCAAGGCTGACCCCGAACTGGCAGAGCCGATGCCCTCTGGTGCACCCCAGGAAACATCTCCC
CAAGTTCCAGCGCCCTTAATGACTCTTGCCACCCTGGGGGCTTCACCCTAACGCACCACTTCTC
TGGAAGGGGAAGGCCAGACACATGCCAGTTGGGGCTGCATGAGGCAGTCCTCAGAGCAGAAGGG
GACCAGGCCAGAGGCCACCTGTGACGGGGCAAACTGCATCTCGGCTGTGGAGACCAGAGGGGCT
GTTAGATTTGGAAGACATCAATGACTGGGCCTGCGGCGCAGCCCGTGTCTGGTAATACCAGGGA
CGGCAGAGGCGTTTGCATCTTCCCATCACCTGCAATGTCGCTGTCACTCTGCCCCTGTTCAGTG
GACTTGATTAGTTAGGAAACTTCTGGAAGGGGCCCCCTACTTTATATCACAGAGTTTGCCCTAG
ACACCCCGTGGAAACACAAACTCAAAATCAAGTGGCTTTAGGAGCCGCTGTGCCCCTCCACAAG
CTGACATGGCTACTCTAAGGGTTCCTGCTGGGCTGGCTTTGCTACGCTTTCCTCAAGCTGCTTT
CTTATTACCAGGATGCCTCACAGCTACAAAGTCCAATCTCACAGCACCCGCACTGGAAAATACT
GTTCTCCATTTTTTTCCAAGGCACCCTGCTTTATGATTGGCTCAGAGTTGGAATATGGGATGCA
GGGCGTCTGGCTCTCTCAAGTGTCAAGCAACCCTGGCTTCCGCATGTGGGGCGAGGGGAGTGAG
CAGAACTCTTCTCTGTCAGTCCACGAAGTAGACTAGAAGCCAACGGGTGCCTGGGGGCAACTGA
CGGTCTGGATTCTGACGCCCAGCCTGGAGCAGGGGCCTGGCCCATCCTATGCTCACACAGTGGT
CTGGCAGCCTGAGCCCACACAACTCCTCAGTCCTTGACAATGCTTAGGCTCTGTTCTGAGGGAC
TCCCCACACCTCCATTCAGGGCTCCCCGAGTCCTCAGCTCTTCGGATGTGGATATATGACACAC
TAGCATAATAAATCTTGATCTGGCTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_666274	(Get FASTA)	NCBI Sequence Viewer
	XP_036020982	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH25600	(Get FASTA)	NCBI Sequence Viewer
	BAC37292	(Get FASTA)	NCBI Sequence Viewer
	BAE41970	(Get FASTA)	NCBI Sequence Viewer
	EDL19935	(Get FASTA)	NCBI Sequence Viewer
	Q8R138	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_666274 ⟸ NM_146162
- Peptide Label:	precursor
- UniProtKB:	Q8BP14 (UniProtKB/Swiss-Prot), Q8R138 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MVPWFLLSLLLLARPVPGVAYSVSLPASFLEDVAGSGEAEGSSASSPSLPPPGTPAFSPTPERP QPTALDGPVPPTNLLEGIMDFFRQYVMLIAVVGSLTFLIMFIVCAALITRQKHKATAYYPSSFP EKKYVDQRDRAGGPRTFSEVPDRAPDSRHEEGLDTSHQLQADILAATQNLRSPARALPGNGEGA KPVKGGSEEEEEEVLSGQEEAQEAPVCGVTEEKLGVPEESVSAEAEGVPATSEGQGEAEGSFSL AQESQGATGPPESPCACNRVSPSV hide sequence

RefSeq Acc Id:

ENSMUSP00000070551 ⟸ ENSMUST00000067853

RefSeq Acc Id:

ENSMUSP00000124226 ⟸ ENSMUST00000160374

RefSeq Acc Id:	XP_036020982 ⟸ XM_036165089
- Peptide Label:	isoform X1
- UniProtKB:	Q8BP14 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R138-F1-model_v2	AlphaFold	Q8R138	1-280	view protein structure

Promoters

RGD ID:

6887646

Promoter ID:

EPDNEW_M7274

Type:

initiation region

Name:

Tmem119_1

Description:

Mus musculus transmembrane protein 119 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	113,800,381 - 113,800,441	EPDNEW

RGD ID:

6838504

Promoter ID:

MM_KWN:43520

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, Kidney, Lung, MEF_B4, MEF_B6

Transcripts:

OTTMUST00000071297, OTTMUST00000071298

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	114,250,069 - 114,250,569 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2385228	AgrOrtholog
Ensembl Genes	ENSMUSG00000054675	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000070551	ENTREZGENE
	ENSMUSP00000070551.6	UniProtKB/Swiss-Prot
	ENSMUSP00000124226.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000067853	ENTREZGENE
	ENSMUST00000067853.6	UniProtKB/Swiss-Prot
	ENSMUST00000160374.2	UniProtKB/TrEMBL
InterPro	TMEM119	UniProtKB/Swiss-Prot
KEGG Report	mmu:231633	UniProtKB/Swiss-Prot
MGD	MGI:2385228	ENTREZGENE
NCBI Gene	231633	ENTREZGENE
PANTHER	PTHR28645	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 119	UniProtKB/Swiss-Prot
Pfam	TMEM119	UniProtKB/Swiss-Prot
PhenoGen	Tmem119	PhenoGen
UniProt	E0CYG1_MOUSE	UniProtKB/TrEMBL
	Q8BP14	ENTREZGENE
	Q8R138	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q8BP14	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype