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Gene: Sp1 (trans-acting transcription factor 1) Mus musculus
Symbol: Sp1
Name: trans-acting transcription factor 1
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryo development; and mRNA transcription by RNA polymerase II. Localizes to nuclear chromatin. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut epithelium; and sensory organ. Orthologous to human SP1 (Sp1 transcription factor); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; interleukin-4 signaling pathway; INTERACTS WITH (R)-lipoic acid; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110003E12Rik; AA450830; AI845540; Sp1-1; specificity protein 1; transcription factor Sp1
Homo sapiens (human) : SP1 (Sp1 transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sp1 (Sp1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp1 (Sp1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SP1 (Sp1 transcription factor)
Canis lupus familiaris (dog) : SP1 (Sp1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp1 (Sp1 transcription factor)
Sus scrofa (pig) : SP1 (Sp1 transcription factor)
Chlorocebus sabaeus (African green monkey) : SP1 (Sp1 transcription factor)
Heterocephalus glaber (naked mole-rat) : Sp1 (Sp1 transcription factor)
more info ...
Related Pseudogenes: Gm18697  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBImm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11334
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.