Sp1 (trans-acting transcription factor 1) - Rat Genome Database

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Gene: Sp1 (trans-acting transcription factor 1) Mus musculus
Analyze
Symbol: Sp1
Name: trans-acting transcription factor 1
RGD ID: 11334
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to hydroperoxide. Acts upstream of or within several processes, including embryo development; hemopoiesis; and mRNA transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; epithelium; eye; and genitourinary system. Orthologous to human SP1 (Sp1 transcription factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110003E12Rik; AA450830; AI845540; Sp1-1; specificity protein 1; transcription factor Sp1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18697  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,314,751 - 102,344,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,314,578 - 102,344,839 (+)EnsemblGRCm39 Ensembl
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBIMGSCv36mm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Sp1MouseCarotid Artery Injuries  ISORGD:37389854624protein:increased phosphorylation:smooth muscle cell:RGD 
Sp1MousePlaque, Atherosclerotic  ISORGD:7320359854624protein:increased phosphorylation:smooth muscle cell:RGD 
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Original Reference(s)
Sp1MouseNeurodevelopmental Disorders  ISORGD:7320358554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
Sp1MouseColorectal Neoplasms  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Sp1MouseDisease Progression  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Sp1Mousehyperglycemia  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:11696579
Sp1MouseNeoplasm Invasiveness  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:26317792|PMID:35072892
Sp1MouseNeoplasm Metastasis  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:12538496|PMID:35072892
Sp1MouseNeoplastic Cell Transformation  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:22009531
Sp1MouseSkin Neoplasms  ISORGD:73203511554173CTD Direct Evidence: marker/mechanismCTDPMID:22009531

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Original Reference(s)
Sp1Mouse(+)-catechin multiple interactionsISORGD:7320356480464Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein]CTDPMID:28768059
Sp1Mouse(+)-catechin increases expressionISORGD:7320356480464Catechin results in increased expression of SP1 proteinCTDPMID:28768059
Sp1Mouse(-)-demecolcine decreases expressionISORGD:7320356480464Demecolcine results in decreased expression of SP1 mRNACTDPMID:23649840
Sp1Mouse(-)-epigallocatechin 3-gallate multiple interactionsISORGD:7320356480464epigallocatechin gallate inhibits the reaction [EGF protein results in increased activity of SP1 protein]CTDPMID:12931129
Sp1Mouse(20S)-ginsenoside Rg3 multiple interactionsISORGD:7320356480464ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 more ...CTDPMID:26427350
Sp1Mouse(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 proteinCTDPMID:21351249
Sp1Mouse(S)-nicotine multiple interactionsISORGD:7320356480464Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; more ...CTDPMID:24089524
Sp1Mouse1,2-dimethylhydrazine decreases expressionISORGD:373864804641,2-Dimethylhydrazine results in decreased expression of SP1 mRNACTDPMID:32387197
Sp1Mouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISORGD:373864804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNACTDPMID:23538867
Sp1Mouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substanceEXP 6480464SP1 affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineCTDPMID:25851821
Sp1Mouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISORGD:373864804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein; [mithramycin A more ...CTDPMID:23538867
Sp1Mouse17alpha-ethynylestradiol multiple interactionsISORGD:7320356480464SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA]CTDPMID:15878629
Sp1Mouse17alpha-ethynylestradiol increases activityISORGD:7320356480464Ethinyl Estradiol results in increased activity of SP1 proteinCTDPMID:15878629
Sp1Mouse17beta-estradiol multiple interactionsISORGD:7320356480464[Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA; Estradiol promotes the more ...CTDPMID:16675542|PMID:17088408|PMID:23733894|PMID:29783106
Sp1Mouse17beta-estradiol decreases expressionISORGD:7320356480464Estradiol results in decreased expression of SP1 mRNACTDPMID:29783106
Sp1Mouse17beta-estradiol increases activityISORGD:7320356480464Estradiol results in increased activity of SP1 proteinCTDPMID:17088408
Sp1Mouse2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:373864804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of SP1 mRNACTDPMID:27291303
Sp1Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:373864804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SP1 mRNACTDPMID:27291303
Sp1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNACTDPMID:14708085|PMID:24058054
Sp1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:37386480464Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNACTDPMID:33387578

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Biological Process
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Original Reference(s)
Sp1Mousecellular response to estrogen stimulus  ISORGD:37389068941 RGDPMID:17272396|REF_RGD_ID:152177689
Sp1Mousecellular response to insulin stimulus involved_inISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousecellular response to wortmannin  ISORGD:37389068941 RGDPMID:17272396|REF_RGD_ID:152177689
Sp1Mousecellular response to zinc ion starvation  ISORGD:37389068941 RGDPMID:21893222|REF_RGD_ID:151667428
Sp1Mousedefinitive hemopoiesis acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseembryonic camera-type eye morphogenesis acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseembryonic placenta development acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseembryonic process involved in female pregnancy acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseembryonic skeletal system development acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseenucleate erythrocyte differentiation acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mousegene expression acts_upstream_of_or_withinISSUniProtKB:P080472290270 PMID:24736457MGIPMID:24736457
Sp1Mousein utero embryonic development acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseliver development acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouselung development acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mousemegakaryocyte differentiation acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1MousemRNA transcription by RNA polymerase II acts_upstream_of_or_withinIDA 2290270 PMID:22331133MGIPMID:22331133
Sp1Mousemyeloid progenitor cell differentiation acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mouseneuron differentiation acts_upstream_of_or_withinIMP 2290270 PMID:29781215MGIPMID:29781215
Sp1Mouseossification acts_upstream_of_or_withinIGIMGI:12771662290270 PMID:17584888MGIPMID:17584888
Sp1Mousepositive regulation by host of viral transcription involved_inISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
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Cellular Component
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Original Reference(s)
Sp1Mousechromatin located_inIDA 2290270 PMID:21029371BHF-UCLPMID:21029371
Sp1Mousechromatin located_inISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousechromatin located_inISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mousecytoplasm located_inIEAUniProtKB-SubCell:SL-00862290270 UniProtGO_REF:0000044
Sp1Mouseeuchromatin is_active_inISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mousenucleoplasm located_inISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mousenucleus located_inISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mousenucleus located_inISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousenucleus located_inIDA 2290270 PMID:11004506, PMID:12119294, PMID:15016652, PMID:15282343, PMID:15817708, PMID:16141233, PMID:27918959, PMID:9705320MGIPMID:11004506|PMID:12119294|PMID:15016652|PMID:15282343|PMID:15817708|PMID:16141233|PMID:27918959|PMID:9705320
Sp1Mouseprotein-containing complex part_ofISSUniProtKB:P080472290270 PMID:24736457MGIPMID:24736457
Sp1Mouseprotein-DNA complex  ISORGD:37389068941 RGDPMID:19765194|REF_RGD_ID:2316171
Sp1Mouseprotein-DNA complex part_ofISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousetranscription repressor complex part_ofISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
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Molecular Function
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Original Reference(s)
Sp1MousebHLH transcription factor binding enablesIPIUniProtKB:Q99PV52290270 PMID:12657651BHF-UCLPMID:12657651
Sp1Mousecis-regulatory region sequence-specific DNA binding enablesIDA 2290270 PMID:15511642, PMID:19943855, PMID:9705320MGIPMID:15511642|PMID:19943855|PMID:9705320
Sp1MouseDNA binding enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1MouseDNA binding enablesISS 2290270 PMID:15820306MGIPMID:15820306
Sp1MouseDNA binding enablesIDA 2290270 PMID:12119294, PMID:14630713, PMID:14667815, PMID:15589828, PMID:16886906, PMID:9738004MGIPMID:12119294|PMID:14630713|PMID:14667815|PMID:15589828|PMID:16886906|PMID:9738004
Sp1MouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 2290270 PMID:19943855MGIPMID:19943855
Sp1MouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1MouseDNA-binding transcription factor activity enablesIMP 2290270 PMID:12119294MGIPMID:12119294
Sp1MouseDNA-binding transcription factor activity enablesIDA 2290270 PMID:1524678, PMID:15282343, PMID:15589828, PMID:29781215MGIPMID:1524678|PMID:15282343|PMID:15589828|PMID:29781215
Sp1MouseDNA-binding transcription factor activity enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1MouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN004619861|FB:FBgn0000233|RGD:621445|MGI:1306780|UniProtKB:O95600|UniProtKB:Q9UIH9|UniProtKB:Q13887|MGI:1342287|UniProtKB:P11161|MGI:1354948|ZFIN:ZDB-GENE-021115-9|MGI:95295|UniProtKB:Q99612|MGI:1333796|MGI:1277166|UniProtKB:Q9Y4X4|UniProtKB:P18146|MGI:1927715|MGI:1338056|SGD:S000004972|MGI:98372|UniProtKB:Q05215|MGI:2153568|MGI:1342771|WB:WBGene00012735|UniProtKB:O75840|ZFIN:ZDB-GENE-980526-55|UniProtKB:P19544|ZFIN:ZDB-GENE-011116-1|UniProtKB:Q02086|UniProtKB:Q9Y5W3|MGI:98968|RGD:2544|UniProtKB:Q13118|RGD:1583765|MGI:2153049|MGI:2181068|MGI:1333856|MGI:95296|UniProtKB:O43474|UniProtKB:O14901|UniProtKB:P080472290270 GO_CentralGO_REF:0000033
Sp1MouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIDA 2290270 PMID:22331133MGIPMID:22331133
Sp1Mousedouble-stranded DNA binding  ISORGD:37389068941 RGDPMID:10837920|REF_RGD_ID:1626488
Sp1Mousedouble-stranded DNA binding enablesIDA 2290270 PMID:15282343MGIPMID:15282343
Sp1Mousedouble-stranded DNA binding enablesISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousedouble-stranded DNA binding enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mousehistone acetyltransferase binding  ISORGD:6200369068941 RGDPMID:19765194|REF_RGD_ID:2316171
Sp1Mousehistone acetyltransferase binding enablesISORGD:37382290270 GO_CentralGO_REF:0000096
Sp1Mousehistone deacetylase binding enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
Sp1Mouseidentical protein binding enablesISOUniProtKB:P080472290270 GO_CentralGO_REF:0000119
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RGD Manual Annotations


  
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Original Reference(s)
Sp1Mousephosphatidylinositol 3-kinase-Akt signaling pathway   ISORGD:3738152177689 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Sp1MouseHuntington's disease pathway   IEA 6907045 KEGGmmu:05016
Sp1Mousetransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGmmu:04350

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Sp1Mouseforkhead class A signaling pathway  ISORGD:7320356484113 PIDPID:200226
Sp1Mouseforkhead class A signaling pathway  ISORGD:7320356484113 PIDPID:200087
Sp1Mousehypoxia inducible factor pathway   ISORGD:7320356484113 PIDPID:200202
Sp1Mousehypoxia inducible factor pathway   ISORGD:7320356484113 PIDPID:200036
Sp1Mouseinterleukin-4 signaling pathway  ISORGD:7320356484113 PIDPID:200022
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Object Symbol
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Original Reference(s)
Sp1Mouseabnormal bone ossification  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal cranium morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal embryonic tissue morphology  IAGP 5509061 MGIPMID:9160753
Sp1Mouseabnormal erythropoiesis  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal liver sinusoid morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal lung morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal phalanx morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal placenta intervillous maternal lacunae morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseabnormal placenta morphology  IAGP 5509061 MGIPMID:17584888
Sp1Mouseanemia  IAGP 5509061 MGIPMID:17584888
Sp1Mouseanophthalmia  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased body size  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased embryo size  IAGP 5509061 MGIPMID:9160753
Sp1Mousedecreased erythroid progenitor cell number  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased fetal weight  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased liver weight  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased placenta weight  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased spongiotrophoblast cell number  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased spongiotrophoblast size  IAGP 5509061 MGIPMID:17584888
Sp1Mousedecreased trophoblast glycogen cell number  IAGP 5509061 MGIPMID:17584888
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#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
3. Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells. Li H, etal., Biochim Biophys Acta 2004 Aug 12;1679(2):141-55.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Tan NY, etal., Circ Res. 2008 Feb 29;102(4):e38-51. doi: 10.1161/CIRCRESAHA.107.167395. Epub 2008 Feb 7.
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PMID:1377062   PMID:1524678   PMID:1633330   PMID:1797234   PMID:1909605   PMID:1980424   PMID:1981055   PMID:1989904   PMID:7568082   PMID:8012111   PMID:8244404   PMID:8530040  
PMID:8593813   PMID:8617793   PMID:8657141   PMID:8871649   PMID:8889548   PMID:9041129   PMID:9060426   PMID:9160753   PMID:9177236   PMID:9250660   PMID:9582278   PMID:9628590  
PMID:9705320   PMID:9738004   PMID:10215616   PMID:10349636   PMID:10366853   PMID:10381567   PMID:10409740   PMID:10490658   PMID:10547281   PMID:10922068   PMID:10973950   PMID:11004506  
PMID:11042159   PMID:11071760   PMID:11076861   PMID:11230134   PMID:11532028   PMID:11745351   PMID:11777901   PMID:11855856   PMID:12004059   PMID:12054741   PMID:12089157   PMID:12119294  
PMID:12220517   PMID:12239153   PMID:12433697   PMID:12520002   PMID:12569082   PMID:12591615   PMID:12657651   PMID:12682245   PMID:12752447   PMID:12794070   PMID:12799440   PMID:12801994  
PMID:12847250   PMID:12904583   PMID:14570593   PMID:14576192   PMID:14580349   PMID:14610273   PMID:14630713   PMID:14667815   PMID:14681479   PMID:14701757   PMID:14988733   PMID:15016652  
PMID:15094381   PMID:15157741   PMID:15219855   PMID:15247247   PMID:15265983   PMID:15282343   PMID:15310743   PMID:15451065   PMID:15462672   PMID:15467729   PMID:15482850   PMID:15511642  
PMID:15528196   PMID:15550398   PMID:15589828   PMID:15601926   PMID:15618518   PMID:15650415   PMID:15663180   PMID:15688401   PMID:15741318   PMID:15817708   PMID:15820306   PMID:15936277  
PMID:16021625   PMID:16052479   PMID:16141072   PMID:16141073   PMID:16141233   PMID:16249485   PMID:16266294   PMID:16325481   PMID:16339759   PMID:16377629   PMID:16423470   PMID:16453304  
PMID:16484221   PMID:16582099   PMID:16595660   PMID:16709865   PMID:16765933   PMID:16876120   PMID:16886906   PMID:16949047   PMID:16951346   PMID:17090534   PMID:17093407   PMID:17097063  
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Sp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,314,751 - 102,344,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,314,578 - 102,344,839 (+)EnsemblGRCm39 Ensembl
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBIMGSCv36mm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.55NCBI
SP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,380,176 - 53,416,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,380,176 - 53,416,446 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,773,960 - 53,810,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,060,246 - 52,096,497 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,060,245 - 52,096,491NCBI
Celera1253,423,138 - 53,460,427 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,814,656 - 50,850,614 (+)NCBIHuRef
CHM1_11253,741,140 - 53,777,425 (+)NCBICHM1_1
T2T-CHM13v2.01253,346,223 - 53,382,489 (+)NCBIT2T-CHM13v2.0
Sp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
Sp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458644,378 - 677,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458644,435 - 677,360 (+)NCBIChiLan1.0ChiLan1.0
SP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,770,223 - 40,809,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,766,986 - 40,806,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,338,492 - 35,374,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,122,583 - 36,158,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,127,681 - 36,158,356 (-)Ensemblpanpan1.1panPan2
SP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,802,587 - 1,861,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBIUU_Cfam_GSD_1.0
Sp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,467,059 - 62,509,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,655,349 - 10,693,042 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,655,116 - 10,693,025 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,588,758 - 18,630,089 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,588,763 - 18,633,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,024,941 - 19,070,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,484,459 - 49,516,941 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,484,518 - 49,512,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,540,987 - 196,574,325 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,475,664 - 1,507,588 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sp1
859 total Variants

Predicted Target Of
Summary Value
Count of predictions:4063
Count of miRNA genes:895
Interacting mature miRNAs:1270
Transcripts:ENSMUST00000001326, ENSMUST00000163709, ENSMUST00000165837, ENSMUST00000165924, ENSMUST00000168802, ENSMUST00000169619, ENSMUST00000170042, ENSMUST00000170884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse

1 to 10 of 27 rows
RH133875  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,432,044 - 102,432,239UniSTSGRCm38
MGSCv3715102,262,475 - 102,262,670UniSTSGRCm37
Celera15104,589,847 - 104,590,042UniSTS
Cytogenetic Map15F3UniSTS
AI845540  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,436,165 - 102,436,281UniSTSGRCm38
MGSCv3715102,266,596 - 102,266,712UniSTSGRCm37
Celera15104,593,968 - 104,594,084UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15921.04UniSTS
X60136  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,431,091 - 102,431,166UniSTSGRCm38
MGSCv3715102,261,522 - 102,261,597UniSTSGRCm37
Celera15104,588,894 - 104,588,969UniSTS
Cytogenetic Map15F3UniSTS
Whitehead_YAC15 UniSTS
UniSTS:237408  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,434,766 - 102,435,064UniSTSGRCm38
MGSCv3715102,265,197 - 102,265,495UniSTSGRCm37
Celera15104,592,569 - 104,592,867UniSTS
Cytogenetic Map15F3UniSTS
PMC114562P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,408,638 - 102,409,168UniSTSGRCm38
MGSCv3715102,239,069 - 102,239,599UniSTSGRCm37
Celera15104,566,421 - 104,566,951UniSTS
Cytogenetic Map15F3UniSTS






1 to 19 of 19 rows
RefSeq Transcripts NM_013672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC137156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF062566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF729889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ181598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S79832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSMUST00000001326   ⟹   ENSMUSP00000001326
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,314,815 - 102,344,839 (+)Ensembl
GRCm38.p6 Ensembl15102,406,380 - 102,436,404 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163709   ⟹   ENSMUSP00000130747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,314,768 - 102,341,114 (+)Ensembl
GRCm38.p6 Ensembl15102,406,333 - 102,432,679 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165837   ⟹   ENSMUSP00000126143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,315,190 - 102,317,052 (+)Ensembl
GRCm38.p6 Ensembl15102,406,755 - 102,408,617 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168802   ⟹   ENSMUSP00000127445
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,316,023 - 102,316,820 (+)Ensembl
GRCm38.p6 Ensembl15102,407,588 - 102,408,385 (+)Ensembl
Ensembl Acc Id: ENSMUST00000169619   ⟹   ENSMUSP00000127714
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,315,704 - 102,316,670 (+)Ensembl
GRCm38.p6 Ensembl15102,407,269 - 102,408,235 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170884   ⟹   ENSMUSP00000129638
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,314,578 - 102,316,670 (+)Ensembl
GRCm38.p6 Ensembl15102,406,143 - 102,408,235 (+)Ensembl
RefSeq Acc Id: NM_013672   ⟹   NP_038700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,314,751 - 102,344,839 (+)NCBI
GRCm3815102,406,316 - 102,436,404 (+)NCBI
MGSCv3715102,236,747 - 102,266,835 (+)RGD
Celera15104,563,277 - 104,594,207 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017316523   ⟹   XP_017172012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,315,709 - 102,344,828 (+)NCBI
GRCm3815102,407,274 - 102,436,393 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_038700 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB35321 (Get FASTA)   NCBI Sequence Viewer  
  AAC08527 (Get FASTA)   NCBI Sequence Viewer  
  AAC16484 (Get FASTA)   NCBI Sequence Viewer  
  ABM98419 (Get FASTA)   NCBI Sequence Viewer  
  CAA42721 (Get FASTA)   NCBI Sequence Viewer  
  EDL03985 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000001326
  ENSMUSP00000130747.2
GenBank Protein O89090 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_038700   ⟸   NM_013672
- UniProtKB: Q64167 (UniProtKB/Swiss-Prot),   Q62251 (UniProtKB/Swiss-Prot),   O89087 (UniProtKB/Swiss-Prot),   O89090 (UniProtKB/Swiss-Prot),   G3X8Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172012   ⟸   XM_017316523
- Peptide Label: isoform X1
- UniProtKB: Q64167 (UniProtKB/Swiss-Prot),   Q62251 (UniProtKB/Swiss-Prot),   O89090 (UniProtKB/Swiss-Prot),   O89087 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000130747   ⟸   ENSMUST00000163709
Ensembl Acc Id: ENSMUSP00000001326   ⟸   ENSMUST00000001326
Ensembl Acc Id: ENSMUSP00000129638   ⟸   ENSMUST00000170884
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-O89090-F1-model_v2 AlphaFold O89090 1-784 view protein structure

RGD ID:6826506
Promoter ID:MM_KWN:19846
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_013672
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,235,786 - 102,236,667 (+)MPROMDB
RGD ID:6826505
Promoter ID:MM_KWN:19847
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Kidney,   Liver,   Lung
Transcripts:UC007XVP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,236,916 - 102,237,452 (+)MPROMDB
RGD ID:8685204
Promoter ID:EPDNEW_M20633
Type:initiation region
Name:Sp1_1
Description:Mus musculus trans-acting transcription factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815102,406,312 - 102,406,372EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000001280 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001326 ENTREZGENE
  ENSMUST00000163709.8 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:20683 UniProtKB/Swiss-Prot
MGD MGI:98372 ENTREZGENE
NCBI Gene 20683 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR SP1 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Sp1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A979HLR9_MOUSE UniProtKB/TrEMBL
  A2TH11_MOUSE UniProtKB/TrEMBL
  E9Q0S7_MOUSE UniProtKB/TrEMBL
  E9Q113_MOUSE UniProtKB/TrEMBL
  E9Q2V3_MOUSE UniProtKB/TrEMBL
  G3X8Q0 ENTREZGENE, UniProtKB/TrEMBL
  O89087 ENTREZGENE
  O89090 ENTREZGENE
  Q62251 ENTREZGENE
  Q64167 ENTREZGENE
  SP1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O89087 UniProtKB/Swiss-Prot
  Q62251 UniProtKB/Swiss-Prot
  Q64167 UniProtKB/Swiss-Prot
1 to 31 of 31 rows