Sp1 | Mouse | (+)-catechin | multiple interactions | ISO | RGD:732035 | 6480464 | Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein] | CTD | PMID:28768059 |
Sp1 | Mouse | (+)-catechin | increases expression | ISO | RGD:732035 | 6480464 | Catechin results in increased expression of SP1 protein | CTD | PMID:28768059 |
Sp1 | Mouse | (-)-demecolcine | decreases expression | ISO | RGD:732035 | 6480464 | Demecolcine results in decreased expression of SP1 mRNA | CTD | PMID:23649840 |
Sp1 | Mouse | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732035 | 6480464 | epigallocatechin gallate inhibits the reaction [EGF protein results in increased activity of SP1 protein] | CTD | PMID:12931129 |
Sp1 | Mouse | (20S)-ginsenoside Rg3 | multiple interactions | ISO | RGD:732035 | 6480464 | ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 more ... | CTD | PMID:26427350 |
Sp1 | Mouse | (R)-lipoic acid | multiple interactions | EXP | | 6480464 | Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein | CTD | PMID:21351249 |
Sp1 | Mouse | (S)-nicotine | multiple interactions | ISO | RGD:732035 | 6480464 | Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; more ... | CTD | PMID:24089524 |
Sp1 | Mouse | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:3738 | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of SP1 mRNA | CTD | PMID:32387197 |
Sp1 | Mouse | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | RGD:3738 | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA | CTD | PMID:23538867 |
Sp1 | Mouse | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | affects response to substance | EXP | | 6480464 | SP1 affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | CTD | PMID:25851821 |
Sp1 | Mouse | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | RGD:3738 | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein; [mithramycin A more ... | CTD | PMID:23538867 |
Sp1 | Mouse | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA] | CTD | PMID:15878629 |
Sp1 | Mouse | 17alpha-ethynylestradiol | increases activity | ISO | RGD:732035 | 6480464 | Ethinyl Estradiol results in increased activity of SP1 protein | CTD | PMID:15878629 |
Sp1 | Mouse | 17beta-estradiol | multiple interactions | ISO | RGD:732035 | 6480464 | [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA; Estradiol promotes the more ... | CTD | PMID:16675542|PMID:17088408|PMID:23733894|PMID:29783106 |
Sp1 | Mouse | 17beta-estradiol | decreases expression | ISO | RGD:732035 | 6480464 | Estradiol results in decreased expression of SP1 mRNA | CTD | PMID:29783106 |
Sp1 | Mouse | 17beta-estradiol | increases activity | ISO | RGD:732035 | 6480464 | Estradiol results in increased activity of SP1 protein | CTD | PMID:17088408 |
Sp1 | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | RGD:3738 | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SP1 mRNA | CTD | PMID:27291303 |
Sp1 | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:3738 | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SP1 mRNA | CTD | PMID:27291303 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA | CTD | PMID:14708085|PMID:24058054 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:3738 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA | CTD | PMID:33387578 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:3738 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SP1 mRNA | CTD | PMID:34747641 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases phosphorylation | ISO | RGD:732035 | 6480464 | Tetrachlorodibenzodioxin results in increased phosphorylation of SP1 protein | CTD | PMID:20971882 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SP1 mRNA | CTD | PMID:21570461 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects activity | ISO | RGD:3738 | 6480464 | Tetrachlorodibenzodioxin affects the activity of SP1 protein | CTD | PMID:11926288 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNA | CTD | PMID:15251184 |
Sp1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732035 | 6480464 | [SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of more ... | CTD | PMID:12801909|PMID:16675542 |
Sp1 | Mouse | 2-chloroethanol | multiple interactions | ISO | RGD:3738 | 6480464 | Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein; more ... | CTD | PMID:31585129 |
Sp1 | Mouse | 2-chloroethanol | increases expression | ISO | RGD:3738 | 6480464 | Ethylene Chlorohydrin results in increased expression of SP1 mRNA | CTD | PMID:31585129 |
Sp1 | Mouse | 2-tert-butylhydroquinone | increases expression | ISO | RGD:732035 | 6480464 | 2-tert-butylhydroquinone results in increased expression of SP1 protein | CTD | PMID:36206955 |
Sp1 | Mouse | 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | increases expression | ISO | RGD:732035 | 6480464 | bisindolylmaleimide I results in increased expression of SP1 mRNA; bisindolylmaleimide I results in increased expression more ... | CTD | PMID:14653808 |
Sp1 | Mouse | 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | multiple interactions | ISO | RGD:3738 | 6480464 | bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in more ... | CTD | PMID:12499119 |
Sp1 | Mouse | 3-methylcholanthrene | increases expression | ISO | RGD:3738 | 6480464 | Methylcholanthrene results in increased expression of SP1 mRNA | CTD | PMID:29094188 |
Sp1 | Mouse | 3-methylcholanthrene | increases acetylation | ISO | RGD:3738 | 6480464 | Methylcholanthrene results in increased acetylation of SP1 promoter | CTD | PMID:29094188 |
Sp1 | Mouse | 3-methylcholanthrene | multiple interactions | ISO | RGD:3738 | 6480464 | alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone more ... | CTD | PMID:29094188 |
Sp1 | Mouse | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of SP1 mRNA | CTD | PMID:18648102 |
Sp1 | Mouse | 4,4'-sulfonyldiphenol | decreases expression | EXP | | 6480464 | bisphenol S results in decreased expression of SP1 mRNA | CTD | PMID:39298647 |
Sp1 | Mouse | 4-hydroxyphenyl retinamide | multiple interactions | EXP | | 6480464 | Fenretinide results in increased cleavage of and results in decreased activity of SP1 protein | CTD | PMID:9343396 |
Sp1 | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of SP1 mRNA | CTD | PMID:28973697 |
Sp1 | Mouse | 4-nonylphenol | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | 4-tert-Octylphenol | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:732035 | 6480464 | [[Decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which more ... | CTD | PMID:17986852|PMID:18033804|PMID:18706393|PMID:21246532 |
Sp1 | Mouse | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:732035 | 6480464 | Decitabine results in increased expression of SP1 mRNA; Decitabine results in increased expression of SP1 more ... | CTD | PMID:19027835 |
Sp1 | Mouse | 5-aza-2'-deoxycytidine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of SP1 mRNA | CTD | PMID:15251184 |
Sp1 | Mouse | 5-aza-2'-deoxycytidine | increases expression | EXP | | 6480464 | Decitabine results in increased expression of SP1 mRNA | CTD | PMID:15251184|PMID:27915011 |
Sp1 | Mouse | 5-azacytidine | multiple interactions | ISO | RGD:732035 | 6480464 | Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter]; Azacitidine promotes the reaction [SP1 more ... | CTD | PMID:18945643 |
Sp1 | Mouse | 5-azacytidine | decreases expression | ISO | RGD:732035 | 6480464 | Azacitidine results in decreased expression of SP1 mRNA | CTD | PMID:20823114 |
Sp1 | Mouse | 5-azacytidine | multiple interactions | EXP | | 6480464 | Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter] | CTD | PMID:17198683 |
Sp1 | Mouse | 5-fluorouracil | multiple interactions | ISO | RGD:732035 | 6480464 | Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter]; more ... | CTD | PMID:15489892|PMID:18927307 |
Sp1 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | RGD:3738 | 6480464 | Propylthiouracil results in decreased expression of SP1 mRNA | CTD | PMID:30047161 |
Sp1 | Mouse | 7,12-dimethyltetraphene | multiple interactions | ISO | RGD:732035 | 6480464 | [[9,10-Dimethyl-1,2-benzanthracene co-treated with 12-O-tetradecanoylphorbol-1,3-acetate] results in increased activity of TRP53 protein] inhibits the reaction [SP1 more ... | CTD | PMID:22009531|PMID:29663660 |
Sp1 | Mouse | 7,12-dimethyltetraphene | increases expression | ISO | RGD:732035 | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of SP1 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of SP1 more ... | CTD | PMID:29663660 |
Sp1 | Mouse | 7,12-dimethyltetraphene | increases expression | ISO | RGD:3738 | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of SP1 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of SP1 more ... | CTD | PMID:36863560 |
Sp1 | Mouse | acetaldehyde | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] | CTD | PMID:16025520 |
Sp1 | Mouse | AH23848 | multiple interactions | ISO | RGD:732035 | 6480464 | [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein | CTD | PMID:19407222 |
Sp1 | Mouse | aldehydo-D-glucose | multiple interactions | ISO | RGD:732035 | 6480464 | SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; SOD2 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | aldehydo-D-glucose | multiple interactions | ISO | RGD:3738 | 6480464 | UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; UCP1 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | alendronic acid | increases expression | ISO | RGD:732035 | 6480464 | Alendronate results in increased expression of SP1 mRNA; Alendronate results in increased expression of SP1 more ... | CTD | PMID:33522294 |
Sp1 | Mouse | alendronic acid | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein affects the reaction [Alendronate results in increased expression of SOX9 mRNA]; SP1 protein more ... | CTD | PMID:33522294 |
Sp1 | Mouse | all-trans-retinoic acid | increases activity | ISO | RGD:732035 | 6480464 | Tretinoin results in increased activity of SP1 protein | CTD | PMID:16757381 |
Sp1 | Mouse | all-trans-retinoic acid | increases expression | ISO | RGD:732035 | 6480464 | Tretinoin results in increased expression of SP1 mRNA; Tretinoin results in increased expression of SP1 more ... | CTD | PMID:23724009|PMID:26892147|PMID:33167477 |
Sp1 | Mouse | all-trans-retinoic acid | increases activity | EXP | | 6480464 | Tretinoin results in increased activity of SP1 protein | CTD | PMID:17097063 |
Sp1 | Mouse | all-trans-retinoic acid | multiple interactions | ISO | RGD:732035 | 6480464 | arsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]; Tretinoin promotes more ... | CTD | PMID:16740727|PMID:16757381|PMID:17307735|PMID:26892147 |
Sp1 | Mouse | allethrin | increases activity | ISO | RGD:732035 | 6480464 | Allethrins results in increased activity of SP1 protein | CTD | PMID:20143881 |
Sp1 | Mouse | alpha-D-galactose | increases expression | ISO | RGD:3738 | 6480464 | Galactose results in increased expression of SP1 protein | CTD | PMID:30367734 |
Sp1 | Mouse | alpha-D-galactose | multiple interactions | ISO | RGD:3738 | 6480464 | Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] | CTD | PMID:30367734 |
Sp1 | Mouse | alpha-naphthoflavone | multiple interactions | ISO | RGD:3738 | 6480464 | alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone more ... | CTD | PMID:29094188 |
Sp1 | Mouse | amitrole | decreases expression | ISO | RGD:3738 | 6480464 | Amitrole results in decreased expression of SP1 mRNA | CTD | PMID:30047161|PMID:38685447 |
Sp1 | Mouse | ammonium chloride | decreases expression | ISO | RGD:3738 | 6480464 | Ammonium Chloride results in decreased expression of SP1 mRNA; Ammonium Chloride results in decreased expression more ... | CTD | PMID:17442060 |
Sp1 | Mouse | ammonium chloride | decreases phosphorylation | ISO | RGD:3738 | 6480464 | Ammonium Chloride results in decreased phosphorylation of SP1 protein | CTD | PMID:17442060 |
Sp1 | Mouse | ammonium chloride | affects expression | ISO | RGD:3738 | 6480464 | Ammonium Chloride affects the expression of SP1 mRNA | CTD | PMID:16483693 |
Sp1 | Mouse | anthra[1,9-cd]pyrazol-6(2H)-one | multiple interactions | ISO | RGD:732035 | 6480464 | pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] | CTD | PMID:26385185 |
Sp1 | Mouse | anthra[1,9-cd]pyrazol-6(2H)-one | multiple interactions | ISO | RGD:3738 | 6480464 | [cypermethrin co-treated with pyrazolanthrone] results in decreased phosphorylation of SP1 protein | CTD | PMID:34794910 |
Sp1 | Mouse | antirheumatic drug | decreases expression | ISO | RGD:732035 | 6480464 | Antirheumatic Agents results in decreased expression of SP1 mRNA | CTD | PMID:25339124 |
Sp1 | Mouse | aristolochic acid A | decreases expression | ISO | RGD:732035 | 6480464 | aristolochic acid I results in decreased expression of SP1 mRNA; aristolochic acid I results in more ... | CTD | PMID:33212167 |
Sp1 | Mouse | Aroclor 1254 | increases activity | ISO | RGD:3738 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased activity of SP1 protein | CTD | PMID:16159668 |
Sp1 | Mouse | arsane | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased more ... | CTD | PMID:32179164 |
Sp1 | Mouse | arsane | multiple interactions | ISO | RGD:732035 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 more ... | CTD | PMID:36669534 |
Sp1 | Mouse | arsenic atom | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased more ... | CTD | PMID:32179164 |
Sp1 | Mouse | arsenic atom | multiple interactions | ISO | RGD:732035 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 more ... | CTD | PMID:36669534 |
Sp1 | Mouse | arsenous acid | decreases expression | ISO | RGD:732035 | 6480464 | Arsenic Trioxide results in decreased expression of SP1 mRNA; Arsenic Trioxide results in decreased expression more ... | CTD | PMID:17617380|PMID:20435036|PMID:25395240|PMID:25436934|PMID:28768059 |
Sp1 | Mouse | arsenous acid | affects methylation | ISO | RGD:732035 | 6480464 | Arsenic Trioxide affects the methylation of SP1 promoter | CTD | PMID:26046465 |
Sp1 | Mouse | arsenous acid | decreases activity | ISO | RGD:732035 | 6480464 | Arsenic Trioxide results in decreased activity of SP1 protein | CTD | PMID:11714746 |
Sp1 | Mouse | arsenous acid | multiple interactions | ISO | RGD:732035 | 6480464 | Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]; Arsenic Trioxide inhibits the more ... | CTD | PMID:11714746|PMID:15761015|PMID:25395240|PMID:26892147|PMID:28768059 |
Sp1 | Mouse | artesunate | decreases expression | ISO | RGD:732035 | 6480464 | artesunate results in decreased expression of SP1 protein | CTD | PMID:19513562 |
Sp1 | Mouse | asbestos | increases expression | ISO | RGD:732035 | 6480464 | Asbestos results in increased expression of SP1 | CTD | PMID:15636197 |
Sp1 | Mouse | asiatic acid | multiple interactions | ISO | RGD:3738 | 6480464 | asiatic acid inhibits the reaction [cypermethrin results in decreased phosphorylation of SP1 protein] | CTD | PMID:34794910 |
Sp1 | Mouse | astaxanthin | multiple interactions | ISO | RGD:3738 | 6480464 | [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and more ... | CTD | PMID:23538867 |
Sp1 | Mouse | bathocuproine disulfonic acid | multiple interactions | ISO | RGD:732035 | 6480464 | bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] | CTD | PMID:18483225 |
Sp1 | Mouse | benzene | decreases expression | ISO | RGD:732035 | 6480464 | Benzene results in decreased expression of SP1 mRNA | CTD | PMID:21382456 |
Sp1 | Mouse | benzo[a]pyrene | affects activity | ISO | RGD:732035 | 6480464 | Benzo(a)pyrene affects the activity of SP1 protein | CTD | PMID:20624995 |
Sp1 | Mouse | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SP1 mRNA | CTD | PMID:22228805 |
Sp1 | Mouse | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | POR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein] | CTD | PMID:21987461 |
Sp1 | Mouse | benzo[a]pyrene | affects expression | EXP | | 6480464 | Benzo(a)pyrene affects the expression of SP1 protein | CTD | PMID:21987461 |
Sp1 | Mouse | Benzo[ghi]perylene | increases expression | ISO | RGD:732035 | 6480464 | 1,12-benzoperylene results in increased expression of SP1 mRNA | CTD | PMID:35182551 |
Sp1 | Mouse | biotin | increases expression | EXP | | 6480464 | Biotin results in increased expression of SP1 mRNA | CTD | PMID:34699867 |
Sp1 | Mouse | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | bisphenol A | increases expression | ISO | RGD:3738 | 6480464 | bisphenol A results in increased expression of SP1 mRNA | CTD | PMID:25181051|PMID:33296240 |
Sp1 | Mouse | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SP1 mRNA | CTD | PMID:33221593|PMID:37894381 |
Sp1 | Mouse | bisphenol A | increases expression | ISO | RGD:732035 | 6480464 | bisphenol A results in increased expression of SP1 mRNA; bisphenol A results in increased expression more ... | CTD | PMID:29783106|PMID:30206973 |
Sp1 | Mouse | bisphenol A | multiple interactions | ISO | RGD:732035 | 6480464 | [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA | CTD | PMID:29783106 |
Sp1 | Mouse | bisphenol A | decreases expression | ISO | RGD:3738 | 6480464 | bisphenol A results in decreased expression of SP1 mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 |
Sp1 | Mouse | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of SP1 promoter | CTD | PMID:27334623 |
Sp1 | Mouse | butan-1-ol | multiple interactions | ISO | RGD:732035 | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... | CTD | PMID:29432896 |
Sp1 | Mouse | Butylbenzyl phthalate | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | Butylbenzyl phthalate | decreases expression | EXP | | 6480464 | butylbenzyl phthalate results in decreased expression of SP1 mRNA | CTD | PMID:29029336 |
Sp1 | Mouse | cadmium acetate | decreases expression | ISO | RGD:732035 | 6480464 | cadmium acetate results in decreased expression of SP1 mRNA | CTD | PMID:24132751 |
Sp1 | Mouse | cadmium atom | multiple interactions | EXP | | 6480464 | Cadmium inhibits the reaction [SP1 protein binds to SLC5A1 promoter]; Cadmium promotes the reaction [MTF1 more ... | CTD | PMID:15664265|PMID:18458062 |
Sp1 | Mouse | cadmium atom | multiple interactions | ISO | RGD:3738 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 more ... | CTD | PMID:35384129 |
Sp1 | Mouse | cadmium atom | affects binding | ISO | RGD:732035 | 6480464 | SP1 protein binds to Cadmium | CTD | PMID:20073493 |
Sp1 | Mouse | cadmium atom | multiple interactions | ISO | RGD:732035 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 more ... | CTD | PMID:15760895|PMID:18556457|PMID:20073493|PMID:24015267|PMID:35384129 |
Sp1 | Mouse | cadmium dichloride | multiple interactions | ISO | RGD:732035 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 more ... | CTD | PMID:18556457|PMID:35384129 |
Sp1 | Mouse | cadmium dichloride | increases expression | ISO | RGD:3738 | 6480464 | Cadmium Chloride results in increased expression of SP1 mRNA | CTD | PMID:35525383 |
Sp1 | Mouse | cadmium dichloride | decreases expression | ISO | RGD:3738 | 6480464 | Cadmium Chloride results in decreased expression of SP1 mRNA; Cadmium Chloride results in decreased expression more ... | CTD | PMID:33865896 |
Sp1 | Mouse | cadmium dichloride | increases cleavage | ISO | RGD:3738 | 6480464 | Cadmium Chloride results in increased cleavage of SP1 protein | CTD | PMID:12499119 |
Sp1 | Mouse | cadmium dichloride | multiple interactions | ISO | RGD:3738 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 more ... | CTD | PMID:12499119|PMID:35384129 |
Sp1 | Mouse | cadmium dichloride | multiple interactions | EXP | | 6480464 | Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 more ... | CTD | PMID:20060848|PMID:25046863 |
Sp1 | Mouse | cadmium dichloride | affects response to substance | ISO | RGD:732035 | 6480464 | SP1 affects the susceptibility to Cadmium Chloride | CTD | PMID:18556457 |
Sp1 | Mouse | caffeine | affects phosphorylation | ISO | RGD:732035 | 6480464 | Caffeine affects the phosphorylation of SP1 protein | CTD | PMID:35688186 |
Sp1 | Mouse | Calcimycin | multiple interactions | ISO | RGD:732035 | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein | CTD | PMID:24244623 |
Sp1 | Mouse | camptothecin | multiple interactions | ISO | RGD:732035 | 6480464 | Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Camptothecin results in more ... | CTD | PMID:11261509|PMID:30851366|PMID:30885713 |
Sp1 | Mouse | camptothecin | increases expression | ISO | RGD:732035 | 6480464 | Camptothecin results in increased expression of SP1 mRNA | CTD | PMID:30851366 |
Sp1 | Mouse | camptothecin | increases activity | ISO | RGD:732035 | 6480464 | Camptothecin results in increased activity of SP1 protein | CTD | PMID:11261509 |
Sp1 | Mouse | capsaicin | increases localization | ISO | RGD:732035 | 6480464 | Capsaicin results in increased localization of SP1 protein | CTD | PMID:22200406 |
Sp1 | Mouse | capsaicin | multiple interactions | ISO | RGD:732035 | 6480464 | Capsaicin promotes the reaction [SP1 protein binds to TNFSF10 promoter] | CTD | PMID:22200406 |
Sp1 | Mouse | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes, Carbon analog results in decreased expression of SP1 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 |
Sp1 | Mouse | carnosine | decreases expression | EXP | | 6480464 | Carnosine results in decreased expression of SP1 mRNA | CTD | PMID:30485136 |
Sp1 | Mouse | carnosine | decreases expression | ISO | RGD:3738 | 6480464 | Carnosine results in decreased expression of SP1 mRNA | CTD | PMID:30485136 |
Sp1 | Mouse | chloroprene | increases expression | ISO | RGD:3738 | 6480464 | Chloroprene results in increased expression of SP1 mRNA | CTD | PMID:23125180 |
Sp1 | Mouse | chloroquine | multiple interactions | ISO | RGD:732035 | 6480464 | Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein] | CTD | PMID:35561756 |
Sp1 | Mouse | chlorpyrifos | affects expression | ISO | RGD:3738 | 6480464 | Chlorpyrifos affects the expression of SP1 mRNA | CTD | PMID:17452286 |
Sp1 | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SP1 mRNA | CTD | PMID:37019170 |
Sp1 | Mouse | chlorpyrifos | increases expression | ISO | RGD:732035 | 6480464 | Chlorpyrifos results in increased expression of SP1 mRNA | CTD | PMID:24979751 |
Sp1 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 |
Sp1 | Mouse | chromium(6+) | multiple interactions | ISO | RGD:3738 | 6480464 | chromium hexavalent ion inhibits the reaction [SP1 protein binds to AR promoter] | CTD | PMID:32679048 |
Sp1 | Mouse | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of SP1 mRNA | CTD | PMID:21151649 |
Sp1 | Mouse | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of SP1 mRNA | CTD | PMID:38056807 |
Sp1 | Mouse | cisplatin | increases expression | ISO | RGD:732035 | 6480464 | [Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 more ... | CTD | PMID:22914438|PMID:24132751 |
Sp1 | Mouse | cisplatin | multiple interactions | ISO | RGD:732035 | 6480464 | Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA] | CTD | PMID:24132751 |
Sp1 | Mouse | clofarabine | multiple interactions | ISO | RGD:732035 | 6480464 | [resveratrol co-treated with clofarabine] affects the localization of SP1 protein; [resveratrol co-treated with clofarabine] results more ... | CTD | PMID:23146690 |
Sp1 | Mouse | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of SP1 mRNA | CTD | PMID:17585979 |
Sp1 | Mouse | cobalt dichloride | multiple interactions | ISO | RGD:732035 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]; [Plicamycin results more ... | CTD | PMID:17307335 |
Sp1 | Mouse | cobalt dichloride | increases phosphorylation | ISO | RGD:3738 | 6480464 | cobaltous chloride results in increased phosphorylation of SP1 protein | CTD | PMID:23814049 |
Sp1 | Mouse | cobalt dichloride | increases expression | ISO | RGD:732035 | 6480464 | cobaltous chloride results in increased expression of SP1 protein | CTD | PMID:17307335 |
Sp1 | Mouse | cobalt dichloride | increases activity | ISO | RGD:732035 | 6480464 | cobaltous chloride results in increased activity of SP1 protein | CTD | PMID:17307335 |
Sp1 | Mouse | cocaine | affects expression | ISO | RGD:3738 | 6480464 | Cocaine affects the expression of SP1 mRNA; Cocaine affects the expression of SP1 protein | CTD | PMID:16179556|PMID:20187946 |
Sp1 | Mouse | copper atom | increases expression | ISO | RGD:732035 | 6480464 | Copper deficiency results in increased expression of SP1 mRNA; Copper deficiency results in increased expression more ... | CTD | PMID:22172574|PMID:24132751 |
Sp1 | Mouse | copper atom | multiple interactions | ISO | RGD:732035 | 6480464 | [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744|PMID:18483225|PMID:22172574 |
Sp1 | Mouse | copper(0) | increases expression | ISO | RGD:732035 | 6480464 | Copper deficiency results in increased expression of SP1 mRNA; Copper deficiency results in increased expression more ... | CTD | PMID:22172574|PMID:24132751 |
Sp1 | Mouse | copper(0) | multiple interactions | ISO | RGD:732035 | 6480464 | [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744|PMID:18483225|PMID:22172574 |
Sp1 | Mouse | copper(II) sulfate | multiple interactions | ISO | RGD:732035 | 6480464 | Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA]; Copper Sulfate more ... | CTD | PMID:22172574|PMID:24132751|PMID:26241054 |
Sp1 | Mouse | copper(II) sulfate | decreases expression | ISO | RGD:732035 | 6480464 | [Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of more ... | CTD | PMID:22172574|PMID:22914438 |
Sp1 | Mouse | copper(II) sulfate | increases expression | ISO | RGD:732035 | 6480464 | Copper Sulfate results in increased expression of SP1 mRNA | CTD | PMID:19549813 |
Sp1 | Mouse | copper(II) sulfate | decreases activity | ISO | RGD:732035 | 6480464 | Copper Sulfate results in decreased activity of SP1 protein | CTD | PMID:22172574|PMID:26241054 |
Sp1 | Mouse | cordycepin | multiple interactions | ISO | RGD:3738 | 6480464 | cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the more ... | CTD | PMID:23690541 |
Sp1 | Mouse | cordycepin | decreases expression | EXP | | 6480464 | cordycepin results in decreased expression of SP1 protein | CTD | PMID:33948356 |
Sp1 | Mouse | cordycepin | affects metabolic processing | ISO | RGD:732035 | 6480464 | cordycepin affects the metabolism of SP1 polyA tail | CTD | PMID:33948356 |
Sp1 | Mouse | cordycepin | decreases expression | ISO | RGD:732035 | 6480464 | cordycepin results in decreased expression of SP1 mRNA; cordycepin results in decreased expression of SP1 more ... | CTD | PMID:25282637|PMID:33948356 |
Sp1 | Mouse | cordycepin | multiple interactions | ISO | RGD:732035 | 6480464 | cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression more ... | CTD | PMID:33948356 |
Sp1 | Mouse | cordycepin | increases activity | ISO | RGD:732035 | 6480464 | cordycepin results in increased activity of SP1 protein | CTD | PMID:19051361 |
Sp1 | Mouse | coumarin | decreases phosphorylation | ISO | RGD:732035 | 6480464 | coumarin results in decreased phosphorylation of SP1 protein | CTD | PMID:35688186 |
Sp1 | Mouse | crocidolite asbestos | affects expression | ISO | RGD:732035 | 6480464 | Asbestos, Crocidolite affects the expression of SP1 mRNA | CTD | PMID:17331233 |
Sp1 | Mouse | CU-O LINKAGE | increases expression | ISO | RGD:732035 | 6480464 | cupric oxide results in increased expression of SP1 mRNA | CTD | PMID:22077320 |
Sp1 | Mouse | curcumin | decreases expression | ISO | RGD:732035 | 6480464 | Curcumin results in decreased expression of SP1 protein | CTD | PMID:18347134|PMID:18593936 |
Sp1 | Mouse | cyclosporin A | multiple interactions | ISO | RGD:732035 | 6480464 | [Cyclosporine co-treated with NGF protein] affects the localization of SP1 protein; [Cyclosporine co-treated with NGF more ... | CTD | PMID:24244623 |
Sp1 | Mouse | cypermethrin | decreases phosphorylation | EXP | | 6480464 | cypermethrin results in decreased phosphorylation of SP1 protein | CTD | PMID:34794910 |
Sp1 | Mouse | cypermethrin | decreases expression | ISO | RGD:3738 | 6480464 | cypermethrin results in decreased expression of SP1 mRNA | CTD | PMID:34794910 |
Sp1 | Mouse | cypermethrin | multiple interactions | ISO | RGD:3738 | 6480464 | [cypermethrin co-treated with pyrazolanthrone] results in decreased phosphorylation of SP1 protein; asiatic acid inhibits the more ... | CTD | PMID:34794910 |
Sp1 | Mouse | cypermethrin | decreases phosphorylation | ISO | RGD:3738 | 6480464 | cypermethrin results in decreased phosphorylation of SP1 protein | CTD | PMID:34794910 |
Sp1 | Mouse | D-glucose | multiple interactions | ISO | RGD:3738 | 6480464 | UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; UCP1 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | D-glucose | multiple interactions | ISO | RGD:732035 | 6480464 | SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; SOD2 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | D-penicillamine | increases expression | ISO | RGD:732035 | 6480464 | Penicillamine results in increased expression of SP1 mRNA | CTD | PMID:22914438 |
Sp1 | Mouse | daunorubicin | multiple interactions | ISO | RGD:732035 | 6480464 | AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde more ... | CTD | PMID:34963561 |
Sp1 | Mouse | daunorubicin | decreases expression | ISO | RGD:732035 | 6480464 | Daunorubicin results in decreased expression of SP1 protein | CTD | PMID:34963561 |
Sp1 | Mouse | decabromodiphenyl ether | increases expression | ISO | RGD:3738 | 6480464 | decabromobiphenyl ether results in increased expression of SP1 mRNA | CTD | PMID:23640034 |
Sp1 | Mouse | deoxynivalenol | multiple interactions | ISO | RGD:732035 | 6480464 | deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter]; SP1 protein promotes the reaction more ... | CTD | PMID:19438726 |
Sp1 | Mouse | deoxynivalenol | affects expression | ISO | RGD:732035 | 6480464 | deoxynivalenol affects the expression of SP1 protein | CTD | PMID:33890134 |
Sp1 | Mouse | deoxynivalenol | increases phosphorylation | ISO | RGD:732035 | 6480464 | deoxynivalenol results in increased phosphorylation of SP1 protein | CTD | PMID:19438726 |
Sp1 | Mouse | desferrioxamine B | multiple interactions | ISO | RGD:732035 | 6480464 | [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744 |
Sp1 | Mouse | Diallyltetrasulfane | multiple interactions | ISO | RGD:3738 | 6480464 | diallyl tetrasulfide inhibits the reaction [cypermethrin results in decreased phosphorylation of SP1 protein] | CTD | PMID:34794910 |
Sp1 | Mouse | diarsenic trioxide | decreases activity | ISO | RGD:732035 | 6480464 | Arsenic Trioxide results in decreased activity of SP1 protein | CTD | PMID:11714746 |
Sp1 | Mouse | diarsenic trioxide | decreases expression | ISO | RGD:732035 | 6480464 | Arsenic Trioxide results in decreased expression of SP1 mRNA; Arsenic Trioxide results in decreased expression more ... | CTD | PMID:17617380|PMID:20435036|PMID:25395240|PMID:25436934|PMID:28768059 |
Sp1 | Mouse | diarsenic trioxide | affects methylation | ISO | RGD:732035 | 6480464 | Arsenic Trioxide affects the methylation of SP1 promoter | CTD | PMID:26046465 |
Sp1 | Mouse | diarsenic trioxide | multiple interactions | ISO | RGD:732035 | 6480464 | Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]; Arsenic Trioxide inhibits the more ... | CTD | PMID:11714746|PMID:15761015|PMID:25395240|PMID:26892147|PMID:28768059 |
Sp1 | Mouse | diazinon | increases methylation | ISO | RGD:732035 | 6480464 | Diazinon results in increased methylation of SP1 gene | CTD | PMID:22964155 |
Sp1 | Mouse | Dibutyl phosphate | affects expression | ISO | RGD:732035 | 6480464 | di-n-butylphosphoric acid affects the expression of SP1 mRNA | CTD | PMID:37042841 |
Sp1 | Mouse | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SP1 mRNA | CTD | PMID:29029336 |
Sp1 | Mouse | dibutyl phthalate | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein affects the reaction [Dibutyl Phthalate results in increased expression of CCL2 mRNA] | CTD | PMID:35397443 |
Sp1 | Mouse | dibutyl phthalate | increases expression | ISO | RGD:732035 | 6480464 | Dibutyl Phthalate results in increased expression of SP1 mRNA; Dibutyl Phthalate results in increased expression more ... | CTD | PMID:35397443 |
Sp1 | Mouse | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | dieldrin | decreases response to substance | ISO | RGD:732035 | 6480464 | SP1 gene mutant form results in decreased susceptibility to Dieldrin | CTD | PMID:32421776 |
Sp1 | Mouse | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of SP1 mRNA | CTD | PMID:16714842 |
Sp1 | Mouse | dimethyl sulfoxide | multiple interactions | ISO | RGD:732035 | 6480464 | Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter] | CTD | PMID:16675542 |
Sp1 | Mouse | dioxygen | increases expression | ISO | RGD:732035 | 6480464 | Oxygen deficiency results in increased expression of SP1 protein | CTD | PMID:17307335 |
Sp1 | Mouse | dioxygen | increases phosphorylation | ISO | RGD:3738 | 6480464 | Oxygen deficiency results in increased phosphorylation of SP1 protein | CTD | PMID:23814049 |
Sp1 | Mouse | dioxygen | multiple interactions | ISO | RGD:732035 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein]; SP1 protein more ... | CTD | PMID:17307335 |
Sp1 | Mouse | disodium selenite | multiple interactions | ISO | RGD:732035 | 6480464 | [Sodium Selenite results in decreased activity of SP1 protein] which results in decreased expression of more ... | CTD | PMID:16928829|PMID:35384129 |
Sp1 | Mouse | disodium selenite | multiple interactions | ISO | RGD:3738 | 6480464 | [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in more ... | CTD | PMID:35384129 |
Sp1 | Mouse | disodium selenite | multiple interactions | EXP | | 6480464 | Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of more ... | CTD | PMID:15650415 |
Sp1 | Mouse | doxorubicin | affects activity | ISO | RGD:732035 | 6480464 | Doxorubicin affects the activity of SP1 protein | CTD | PMID:17108358 |
Sp1 | Mouse | doxorubicin | decreases phosphorylation | ISO | RGD:732035 | 6480464 | Doxorubicin results in decreased phosphorylation of SP1 protein | CTD | PMID:38367682 |
Sp1 | Mouse | doxorubicin | increases ribosylation | ISO | RGD:732035 | 6480464 | Doxorubicin results in increased ribosylation of SP1 protein | CTD | PMID:22293659 |
Sp1 | Mouse | doxorubicin | decreases expression | ISO | RGD:732035 | 6480464 | Doxorubicin results in decreased expression of SP1 mRNA | CTD | PMID:29803840 |
Sp1 | Mouse | doxorubicin | multiple interactions | ISO | RGD:732035 | 6480464 | [Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to more ... | CTD | PMID:17124180|PMID:19351845|PMID:22293659|PMID:38367682 |
Sp1 | Mouse | elemental selenium | multiple interactions | ISO | RGD:3738 | 6480464 | [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in more ... | CTD | PMID:35384129 |
Sp1 | Mouse | elemental selenium | multiple interactions | ISO | RGD:732035 | 6480464 | [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in more ... | CTD | PMID:35384129 |
Sp1 | Mouse | enzyme inhibitor | multiple interactions | ISO | RGD:732035 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 |
Sp1 | Mouse | epoxomicin | multiple interactions | ISO | RGD:732035 | 6480464 | epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]; epoxomicin inhibits the more ... | CTD | PMID:17409431 |
Sp1 | Mouse | epoxomicin | increases ubiquitination | ISO | RGD:732035 | 6480464 | epoxomicin results in increased ubiquitination of SP1 protein | CTD | PMID:17409431 |
Sp1 | Mouse | esculetin | decreases expression | ISO | RGD:732035 | 6480464 | esculetin results in decreased expression of SP1 protein | CTD | PMID:31313495 |
Sp1 | Mouse | estrogen | increases expression | ISO | RGD:3738 | 152177689 | estrogen increases expression of Sp1 mRNA in rat uterus | RGD | |
Sp1 | Mouse | ethanol | multiple interactions | ISO | RGD:732035 | 6480464 | Ethanol promotes the reaction [SP1 protein binds to FASLG promoter] | CTD | PMID:24899502 |
Sp1 | Mouse | ethanol | multiple interactions | EXP | | 6480464 | Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]; PPARD gene mutant form inhibits more ... | CTD | PMID:27765815 |
Sp1 | Mouse | etoposide | increases phosphorylation | ISO | RGD:732035 | 6480464 | Etoposide results in increased phosphorylation of SP1 protein | CTD | PMID:17441964 |
Sp1 | Mouse | etoposide | increases expression | ISO | RGD:3738 | 6480464 | Etoposide results in increased expression of SP1 mRNA | CTD | PMID:23690541 |
Sp1 | Mouse | etoposide | increases activity | ISO | RGD:3738 | 6480464 | Etoposide results in increased activity of SP1 protein | CTD | PMID:23690541 |
Sp1 | Mouse | etoposide | multiple interactions | ISO | RGD:3738 | 6480464 | cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the more ... | CTD | PMID:23690541 |
Sp1 | Mouse | etoposide | multiple interactions | ISO | RGD:732035 | 6480464 | PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]; wortmannin inhibits more ... | CTD | PMID:17441964 |
Sp1 | Mouse | flutamide | increases expression | ISO | RGD:3738 | 6480464 | Flutamide results in increased expression of SP1 mRNA | CTD | PMID:24793618 |
Sp1 | Mouse | folic acid | multiple interactions | ISO | RGD:732035 | 6480464 | Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein]; Folic more ... | CTD | PMID:16728583|PMID:33360347 |
Sp1 | Mouse | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of SP1 mRNA | CTD | PMID:25629700 |
Sp1 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 |
Sp1 | Mouse | FR900359 | increases phosphorylation | ISO | RGD:732035 | 6480464 | FR900359 results in increased phosphorylation of SP1 protein | CTD | PMID:37730182 |
Sp1 | Mouse | fulvestrant | multiple interactions | ISO | RGD:732035 | 6480464 | fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter] | CTD | PMID:20211987 |
Sp1 | Mouse | galactose | increases expression | ISO | RGD:3738 | 6480464 | Galactose results in increased expression of SP1 protein | CTD | PMID:30367734 |
Sp1 | Mouse | galactose | multiple interactions | ISO | RGD:3738 | 6480464 | Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] | CTD | PMID:30367734 |
Sp1 | Mouse | genistein | multiple interactions | ISO | RGD:732035 | 6480464 | Genistein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction more ... | CTD | PMID:17088408 |
Sp1 | Mouse | genistein | increases expression | ISO | RGD:732035 | 6480464 | Genistein results in increased expression of SP1 protein | CTD | PMID:24685904 |
Sp1 | Mouse | genistein | increases activity | ISO | RGD:732035 | 6480464 | Genistein results in increased activity of SP1 protein | CTD | PMID:17088408 |
Sp1 | Mouse | gentamycin | increases expression | ISO | RGD:3738 | 6480464 | Gentamicins results in increased expression of SP1 mRNA | CTD | PMID:22061828 |
Sp1 | Mouse | glucose | multiple interactions | ISO | RGD:3738 | 6480464 | UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; UCP1 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | glucose | multiple interactions | ISO | RGD:732035 | 6480464 | SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; SOD2 protein more ... | CTD | PMID:11050244 |
Sp1 | Mouse | glutathione | multiple interactions | ISO | RGD:732035 | 6480464 | Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein] | CTD | PMID:20435036 |
Sp1 | Mouse | glutathione | decreases expression | ISO | RGD:732035 | 6480464 | Glutathione results in decreased expression of SP1 | CTD | PMID:18556457 |
Sp1 | Mouse | glycitein | increases activity | ISO | RGD:732035 | 6480464 | glycitein results in increased activity of SP1 protein | CTD | PMID:17088408 |
Sp1 | Mouse | glycitein | multiple interactions | ISO | RGD:732035 | 6480464 | glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction more ... | CTD | PMID:17088408 |
Sp1 | Mouse | glyphosate | increases expression | ISO | RGD:732035 | 6480464 | Glyphosate results in increased expression of SP1 mRNA | CTD | PMID:31295307 |
Sp1 | Mouse | homocysteic acid | increases activity | ISO | RGD:732035 | 6480464 | homocysteic acid results in increased activity of SP1 protein | CTD | PMID:11261509 |
Sp1 | Mouse | homocysteic acid | multiple interactions | ISO | RGD:732035 | 6480464 | mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein] | CTD | PMID:11261509 |
Sp1 | Mouse | hydrogen peroxide | multiple interactions | ISO | RGD:732035 | 6480464 | [Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased activity of more ... | CTD | PMID:17108117|PMID:17961220|PMID:19105596|PMID:20435036|PMID:33360347 |
Sp1 | Mouse | hydrogen peroxide | increases phosphorylation | EXP | | 6480464 | Hydrogen Peroxide results in increased phosphorylation of SP1 protein | CTD | PMID:31494107 |
Sp1 | Mouse | hydrogen peroxide | affects expression | ISO | RGD:732035 | 6480464 | Hydrogen Peroxide affects the expression of SP1 protein | CTD | PMID:17961220 |
Sp1 | Mouse | hydrogen peroxide | multiple interactions | EXP | | 6480464 | [Hydrogen Peroxide results in increased activity of and results in increased ADP-ribosylation of PARP1 protein] more ... | CTD | PMID:17108117|PMID:17961220|PMID:20478378|PMID:21569840|PMID:31494107 |
Sp1 | Mouse | hydrogen peroxide | decreases expression | ISO | RGD:732035 | 6480464 | Hydrogen Peroxide results in decreased expression of SP1 protein | CTD | PMID:20435036|PMID:33360347 |
Sp1 | Mouse | hydroquinone | multiple interactions | ISO | RGD:732035 | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression more ... | CTD | PMID:35561756 |
Sp1 | Mouse | indole-3-methanol | multiple interactions | ISO | RGD:732035 | 6480464 | indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter] | CTD | PMID:20570586 |
Sp1 | Mouse | indole-3-methanol | decreases activity | ISO | RGD:732035 | 6480464 | indole-3-carbinol results in decreased activity of SP1 protein | CTD | PMID:16082211 |
Sp1 | Mouse | irinotecan | increases phosphorylation | ISO | RGD:732035 | 6480464 | Irinotecan results in increased phosphorylation of SP1 protein | CTD | PMID:17441964 |
Sp1 | Mouse | irinotecan | decreases expression | ISO | RGD:732035 | 6480464 | Irinotecan analog results in decreased expression of SP1 mRNA | CTD | PMID:18927307 |
Sp1 | Mouse | irinotecan | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] | CTD | PMID:18927307 |
Sp1 | Mouse | iron atom | multiple interactions | ISO | RGD:732035 | 6480464 | [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744 |
Sp1 | Mouse | iron(0) | multiple interactions | ISO | RGD:732035 | 6480464 | [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744 |
Sp1 | Mouse | isoprenaline | multiple interactions | EXP | | 6480464 | [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the more ... | CTD | PMID:10710348 |
Sp1 | Mouse | jaceosidin | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein more ... | CTD | PMID:27729209 |
Sp1 | Mouse | ketoconazole | decreases expression | ISO | RGD:3738 | 6480464 | Ketoconazole results in decreased expression of SP1 mRNA | CTD | PMID:37077353 |
Sp1 | Mouse | L-ascorbic acid | decreases expression | ISO | RGD:732035 | 6480464 | Ascorbic Acid results in decreased expression of SP1 protein | CTD | PMID:21919647 |
Sp1 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 |
Sp1 | Mouse | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of SP1 mRNA; lead acetate results in increased expression more ... | CTD | PMID:23867794|PMID:24260418 |
Sp1 | Mouse | lead diacetate | increases expression | ISO | RGD:732035 | 6480464 | lead acetate results in increased expression of SP1 protein | CTD | PMID:24462621 |
Sp1 | Mouse | lead diacetate | multiple interactions | ISO | RGD:732035 | 6480464 | tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] | CTD | PMID:24462621 |
Sp1 | Mouse | lead(0) | increases expression | ISO | RGD:732035 | 6480464 | Lead results in increased expression of SP1 protein | CTD | PMID:22272629 |
Sp1 | Mouse | lead(0) | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased more ... | CTD | PMID:32179164 |
Sp1 | Mouse | lead(II) chloride | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased more ... | CTD | PMID:32179164 |
Sp1 | Mouse | lipoic acid | multiple interactions | EXP | | 6480464 | Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein | CTD | PMID:21351249 |
Sp1 | Mouse | lipopolysaccharide | multiple interactions | ISO | RGD:732035 | 6480464 | Lipopolysaccharides promotes the reaction [SP1 protein binds to BAG3 promoter]; trichostatin A inhibits the reaction more ... | CTD | PMID:21911040|PMID:22020323 |
Sp1 | Mouse | lipopolysaccharide | multiple interactions | EXP | | 6480464 | Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of more ... | CTD | PMID:15650415 |
Sp1 | Mouse | lipopolysaccharide | increases expression | ISO | RGD:732035 | 6480464 | Lipopolysaccharides results in increased expression of SP1 mRNA | CTD | PMID:21911040 |
Sp1 | Mouse | LY294002 | multiple interactions | ISO | RGD:732035 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits more ... | CTD | PMID:17307335|PMID:26385185 |
Sp1 | Mouse | LY294002 | increases phosphorylation | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein | CTD | PMID:21351249 |
Sp1 | Mouse | manganese atom | multiple interactions | ISO | RGD:3738 | 6480464 | Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in more ... | CTD | PMID:22975163 |
Sp1 | Mouse | manganese(0) | multiple interactions | ISO | RGD:3738 | 6480464 | Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in more ... | CTD | PMID:22975163 |
Sp1 | Mouse | mercury dichloride | increases expression | ISO | RGD:3738 | 6480464 | Mercuric Chloride results in increased expression of SP1 mRNA | CTD | PMID:16507785 |
Sp1 | Mouse | metformin | multiple interactions | ISO | RGD:732035 | 6480464 | [nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter]; [nickel more ... | CTD | PMID:25110054|PMID:38050843 |
Sp1 | Mouse | metformin | decreases expression | ISO | RGD:732035 | 6480464 | Metformin results in decreased expression of SP1 protein | CTD | PMID:25110054|PMID:26317792 |
Sp1 | Mouse | methapyrilene | decreases expression | ISO | RGD:3738 | 6480464 | Methapyrilene results in decreased expression of SP1 mRNA | CTD | PMID:30467583 |
Sp1 | Mouse | methimazole | decreases expression | ISO | RGD:3738 | 6480464 | Methimazole results in decreased expression of SP1 mRNA | CTD | PMID:30047161|PMID:38685447 |
Sp1 | Mouse | methylmercury chloride | decreases expression | ISO | RGD:3738 | 6480464 | methylmercuric chloride results in decreased expression of SP1 protein | CTD | PMID:28736149 |
Sp1 | Mouse | methylmercury chloride | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in more ... | CTD | PMID:32179164 |
Sp1 | Mouse | methylmercury chloride | decreases expression | ISO | RGD:732035 | 6480464 | methylmercuric chloride results in decreased expression of SP1 mRNA | CTD | PMID:28001369 |
Sp1 | Mouse | methylparaben | decreases expression | ISO | RGD:732035 | 6480464 | methylparaben results in decreased expression of SP1 mRNA | CTD | PMID:31745603 |
Sp1 | Mouse | methylseleninic acid | multiple interactions | ISO | RGD:732035 | 6480464 | methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter] | CTD | PMID:17876054 |
Sp1 | Mouse | mibolerone | multiple interactions | ISO | RGD:732035 | 6480464 | [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to more ... | CTD | PMID:15661808|PMID:20148354 |
Sp1 | Mouse | microcystin-LR | decreases expression | EXP | | 6480464 | cyanoginosin LR results in decreased expression of SP1 mRNA; cyanoginosin LR results in decreased expression more ... | CTD | PMID:36206955 |
Sp1 | Mouse | microcystin-LR | decreases expression | ISO | RGD:732035 | 6480464 | cyanoginosin LR results in decreased expression of SP1 mRNA | CTD | PMID:36206955 |
Sp1 | Mouse | mithramycin | decreases activity | ISO | RGD:732035 | 6480464 | Plicamycin results in decreased activity of SP1 protein | CTD | PMID:15946989 |
Sp1 | Mouse | mithramycin | decreases expression | EXP | | 6480464 | Plicamycin results in decreased expression of SP1 protein | CTD | PMID:34087332 |
Sp1 | Mouse | mithramycin | decreases expression | ISO | RGD:3738 | 6480464 | Plicamycin results in decreased expression of SP1 mRNA | CTD | PMID:23814049 |
Sp1 | Mouse | mithramycin | multiple interactions | ISO | RGD:732035 | 6480464 | [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression more ... | CTD | PMID:17307335|PMID:21603612|PMID:24244623 |
Sp1 | Mouse | monosodium L-glutamate | increases expression | ISO | RGD:3738 | 6480464 | Sodium Glutamate results in increased expression of SP1 mRNA | CTD | PMID:20928830 |
Sp1 | Mouse | morin | multiple interactions | EXP | | 6480464 | 2-chloro-5-nitrobenzanilide inhibits the reaction [morin promotes the reaction [PPARG protein binds to SP1 protein]]; morin more ... | CTD | PMID:36121554 |
Sp1 | Mouse | N-acetyl-L-cysteine | decreases expression | ISO | RGD:732035 | 6480464 | Acetylcysteine results in decreased expression of SP1 protein | CTD | PMID:18556457 |
Sp1 | Mouse | N-acetyl-L-cysteine | multiple interactions | ISO | RGD:3738 | 6480464 | Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] | CTD | PMID:33360347 |
Sp1 | Mouse | N-acetyl-L-cysteine | multiple interactions | ISO | RGD:732035 | 6480464 | Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Acetylcysteine inhibits the more ... | CTD | PMID:16928829|PMID:30851366|PMID:33360347 |
Sp1 | Mouse | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in more ... | CTD | PMID:14529614 |
Sp1 | Mouse | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | ISO | RGD:732035 | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde more ... | CTD | PMID:17409431|PMID:34963561 |
Sp1 | Mouse | N-butyl-N-(4-hydroxybutyl)nitrosamine | increases expression | EXP | | 6480464 | Butylhydroxybutylnitrosamine results in increased expression of SP1 protein | CTD | PMID:24998975 |
Sp1 | Mouse | N-ethylmaleimide | multiple interactions | EXP | | 6480464 | Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] | CTD | PMID:9343396 |
Sp1 | Mouse | N-ethylmaleimide | multiple interactions | ISO | RGD:732035 | 6480464 | Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] | CTD | PMID:9343396 |
Sp1 | Mouse | N-methyl-4-phenylpyridinium | multiple interactions | ISO | RGD:3738 | 6480464 | SP1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TIGAR protein] | CTD | PMID:33359019 |
Sp1 | Mouse | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:732035 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SP1 mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of SP1 more ... | CTD | PMID:34508910 |
Sp1 | Mouse | N-methyl-4-phenylpyridinium | multiple interactions | ISO | RGD:732035 | 6480464 | NEAT1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SP1 mRNA]; NEAT1 affects the more ... | CTD | PMID:34508910 |
Sp1 | Mouse | neocuproine | multiple interactions | ISO | RGD:732035 | 6480464 | [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity more ... | CTD | PMID:12633744 |
Sp1 | Mouse | nickel atom | increases activity | ISO | RGD:732035 | 6480464 | Nickel results in increased activity of SP1 protein | CTD | PMID:19403854 |
Sp1 | Mouse | nickel dichloride | multiple interactions | ISO | RGD:732035 | 6480464 | [nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter]; [nickel more ... | CTD | PMID:30055191|PMID:38050843 |
Sp1 | Mouse | nicotine | multiple interactions | ISO | RGD:732035 | 6480464 | Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; more ... | CTD | PMID:24089524 |
Sp1 | Mouse | nimustine | multiple interactions | ISO | RGD:732035 | 6480464 | [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein | CTD | PMID:29164620 |
Sp1 | Mouse | nimustine | decreases response to substance | ISO | RGD:732035 | 6480464 | SP1 protein results in decreased susceptibility to Nimustine | CTD | PMID:29164620 |
Sp1 | Mouse | NORCANTHARIDIN | multiple interactions | EXP | | 6480464 | SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA] | CTD | PMID:19616522 |
Sp1 | Mouse | NORCANTHARIDIN | decreases activity | EXP | | 6480464 | norcantharidin results in decreased activity of SP1 protein | CTD | PMID:19616522 |
Sp1 | Mouse | olomoucine | increases expression | ISO | RGD:732035 | 6480464 | olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 more ... | CTD | PMID:14653808 |
Sp1 | Mouse | oxaliplatin | multiple interactions | ISO | RGD:732035 | 6480464 | oxaliplatin inhibits the reaction [SP1 protein binds to DUT promoter] | CTD | PMID:19015155 |
Sp1 | Mouse | ozone | multiple interactions | ISO | RGD:732035 | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of SP1 mRNA | CTD | PMID:35430440 |
Sp1 | Mouse | p-tert-Amylphenol | multiple interactions | EXP | | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:29029336 |
Sp1 | Mouse | palbociclib | multiple interactions | ISO | RGD:732035 | 6480464 | palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein more ... | CTD | PMID:21880723 |
Sp1 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SP1 mRNA | CTD | PMID:17562736 |
Sp1 | Mouse | PD 168393 | multiple interactions | ISO | RGD:3738 | 6480464 | PD168393 inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]; more ... | CTD | PMID:25398788 |
Sp1 | Mouse | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of SP1 mRNA | CTD | PMID:23892564 |
Sp1 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of SP1 mRNA | CTD | PMID:36331819 |
Sp1 | Mouse | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of SP1 mRNA | CTD | PMID:23091169 |
Sp1 | Mouse | phenobarbital | decreases expression | ISO | RGD:3738 | 6480464 | Phenobarbital results in decreased expression of SP1 mRNA | CTD | PMID:30047161 |
Sp1 | Mouse | phenylephrine | multiple interactions | EXP | | 6480464 | [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the more ... | CTD | PMID:10710348 |
Sp1 | Mouse | PhIP | increases expression | ISO | RGD:732035 | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SP1 protein | CTD | PMID:22307971 |
Sp1 | Mouse | phorbol 13-acetate 12-myristate | increases expression | EXP | | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of SP1 mRNA | CTD | PMID:27351882 |
Sp1 | Mouse | phorbol 13-acetate 12-myristate | increases activity | ISO | RGD:732035 | 6480464 | Tetradecanoylphorbol Acetate results in increased activity of SP1 protein | CTD | PMID:15978937 |
Sp1 | Mouse | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:732035 | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein; Tetradecanoylphorbol Acetate promotes the more ... | CTD | PMID:10669635|PMID:15978937|PMID:24244623 |
Sp1 | Mouse | platycodin D | multiple interactions | ISO | RGD:732035 | 6480464 | platycodin D results in decreased expression of and results in decreased activity of SP1 protein | CTD | PMID:18093727 |
Sp1 | Mouse | promegestone | increases expression | ISO | RGD:732035 | 6480464 | Promegestone results in increased expression of SP1 mRNA; Promegestone results in increased expression of SP1 more ... | CTD | PMID:16807381 |
Sp1 | Mouse | promegestone | multiple interactions | ISO | RGD:732035 | 6480464 | mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]; more ... | CTD | PMID:16807381 |
Sp1 | Mouse | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of SP1 mRNA | CTD | PMID:21278054 |
Sp1 | Mouse | protein kinase inhibitor | multiple interactions | ISO | RGD:732035 | 6480464 | Protein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 more ... | CTD | PMID:26385185 |
Sp1 | Mouse | pterostilbene | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 more ... | CTD | PMID:18852136 |
Sp1 | Mouse | quercetin | decreases expression | ISO | RGD:732035 | 6480464 | Quercetin results in decreased expression of SP1 protein | CTD | PMID:18377872 |
Sp1 | Mouse | quercetin | multiple interactions | ISO | RGD:732035 | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]; [Quercetin more ... | CTD | PMID:15661808|PMID:18377872|PMID:18419748|PMID:18852136|PMID:18980244|PMID:20148354|PMID:23530649|PMID:24173369 |
Sp1 | Mouse | quercetin | multiple interactions | EXP | | 6480464 | MAPK14 protein promotes the reaction [Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]]; more ... | CTD | PMID:22711909 |
Sp1 | Mouse | quercetin | increases activity | ISO | RGD:732035 | 6480464 | Quercetin results in increased activity of SP1 protein | CTD | PMID:18980244 |
Sp1 | Mouse | quercetin 3-O-beta-D-galactopyranoside | multiple interactions | ISO | RGD:732035 | 6480464 | [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 more ... | CTD | PMID:24173369 |
Sp1 | Mouse | quinacrine | multiple interactions | ISO | RGD:732035 | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; BTRC protein inhibits more ... | CTD | PMID:28867437 |
Sp1 | Mouse | resveratrol | multiple interactions | ISO | RGD:732035 | 6480464 | [resveratrol co-treated with clofarabine] affects the localization of SP1 protein; [resveratrol co-treated with clofarabine] results more ... | CTD | PMID:16614140|PMID:17049495|PMID:23146690|PMID:23437203|PMID:23530649|PMID:25875864 |
Sp1 | Mouse | resveratrol | decreases acetylation | ISO | RGD:732035 | 6480464 | resveratrol results in decreased acetylation of SP1 protein | CTD | PMID:25875864 |
Sp1 | Mouse | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SP1 protein | CTD | PMID:25505154 |
Sp1 | Mouse | resveratrol | decreases expression | ISO | RGD:3738 | 6480464 | resveratrol results in decreased expression of SP1 mRNA | CTD | PMID:25905778 |
Sp1 | Mouse | resveratrol | affects localization | ISO | RGD:732035 | 6480464 | resveratrol affects the localization of SP1 protein | CTD | PMID:23437203 |
Sp1 | Mouse | resveratrol | decreases activity | ISO | RGD:732035 | 6480464 | resveratrol results in decreased activity of SP1 protein | CTD | PMID:23437203 |
Sp1 | Mouse | resveratrol | decreases activity | ISO | RGD:3738 | 6480464 | resveratrol results in decreased activity of SP1 protein | CTD | PMID:18420994 |
Sp1 | Mouse | resveratrol | increases activity | ISO | RGD:732035 | 6480464 | resveratrol results in increased activity of SP1 protein | CTD | PMID:17049495 |
Sp1 | Mouse | S-adenosyl-L-homocysteine | multiple interactions | ISO | RGD:3738 | 6480464 | S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] | CTD | PMID:19770485 |
Sp1 | Mouse | S-adenosyl-L-methioninate | multiple interactions | EXP | | 6480464 | S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] | CTD | PMID:15983038 |
Sp1 | Mouse | S-adenosyl-L-methioninate | multiple interactions | ISO | RGD:732035 | 6480464 | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein more ... | CTD | PMID:15983038 |
Sp1 | Mouse | S-adenosyl-L-methionine | multiple interactions | ISO | RGD:732035 | 6480464 | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein more ... | CTD | PMID:15983038 |
Sp1 | Mouse | S-adenosyl-L-methionine | multiple interactions | EXP | | 6480464 | S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] | CTD | PMID:15983038 |
Sp1 | Mouse | S-butyl-DL-homocysteine (S,R)-sulfoximine | increases activity | ISO | RGD:732035 | 6480464 | Buthionine Sulfoximine results in increased activity of SP1 protein | CTD | PMID:11261509 |
Sp1 | Mouse | S-butyl-DL-homocysteine (S,R)-sulfoximine | multiple interactions | ISO | RGD:732035 | 6480464 | mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein] | CTD | PMID:11261509 |
Sp1 | Mouse | S-nitrosoglutathione | increases activity | ISO | RGD:732035 | 6480464 | S-Nitrosoglutathione results in increased activity of SP1 protein | CTD | PMID:14766015 |
Sp1 | Mouse | SB 203580 | multiple interactions | ISO | RGD:732035 | 6480464 | SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased more ... | CTD | PMID:17108117 |
Sp1 | Mouse | SCH772984 | multiple interactions | ISO | RGD:3738 | 6480464 | SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased more ... | CTD | PMID:31585129 |
Sp1 | Mouse | selenium atom | multiple interactions | ISO | RGD:3738 | 6480464 | [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in more ... | CTD | PMID:35384129 |
Sp1 | Mouse | selenium atom | multiple interactions | ISO | RGD:732035 | 6480464 | [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in more ... | CTD | PMID:35384129 |
Sp1 | Mouse | silicon dioxide | decreases expression | ISO | RGD:732035 | 6480464 | Silicon Dioxide results in decreased expression of SP1 mRNA | CTD | PMID:25351596 |
Sp1 | Mouse | silver atom | decreases expression | ISO | RGD:732035 | 6480464 | Silver results in decreased expression of SP1 mRNA | CTD | PMID:26551752 |
Sp1 | Mouse | silver(0) | decreases expression | ISO | RGD:732035 | 6480464 | Silver results in decreased expression of SP1 mRNA | CTD | PMID:26551752 |
Sp1 | Mouse | silver(1+) nitrate | increases expression | ISO | RGD:732035 | 6480464 | Silver Nitrate results in increased expression of SP1 mRNA | CTD | PMID:24132751 |
Sp1 | Mouse | simvastatin | multiple interactions | ISO | RGD:732035 | 6480464 | Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter] | CTD | PMID:16575855 |
Sp1 | Mouse | sodium arsenite | increases expression | ISO | RGD:732035 | 6480464 | sodium arsenite results in increased expression of SP1 mRNA; sodium arsenite results in increased expression more ... | CTD | PMID:23562784|PMID:31170415 |
Sp1 | Mouse | sodium arsenite | multiple interactions | EXP | | 6480464 | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased more ... | CTD | PMID:32179164 |
Sp1 | Mouse | sodium arsenite | multiple interactions | ISO | RGD:3738 | 6480464 | Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] | CTD | PMID:33360347 |
Sp1 | Mouse | sodium arsenite | decreases expression | ISO | RGD:3738 | 6480464 | sodium arsenite results in decreased expression of SP1 mRNA; sodium arsenite results in decreased expression more ... | CTD | PMID:33360347 |
Sp1 | Mouse | sodium arsenite | decreases expression | ISO | RGD:732035 | 6480464 | sodium arsenite results in decreased expression of SP1 mRNA; sodium arsenite results in decreased expression more ... | CTD | PMID:33360347 |
Sp1 | Mouse | sodium arsenite | multiple interactions | ISO | RGD:732035 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 more ... | CTD | PMID:33360347|PMID:36669534 |
Sp1 | Mouse | sodium chloride | multiple interactions | ISO | RGD:3738 | 6480464 | [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride more ... | CTD | PMID:23816505 |
Sp1 | Mouse | sodium dichromate | increases activity | ISO | RGD:732035 | 6480464 | sodium bichromate results in increased activity of SP1 protein | CTD | PMID:10411148 |
Sp1 | Mouse | T-2 toxin | multiple interactions | ISO | RGD:732035 | 6480464 | T-2 Toxin promotes the reaction [SP1 protein binds to CYP1A1 promoter] | CTD | PMID:31470059 |
Sp1 | Mouse | tamoxifen | multiple interactions | ISO | RGD:732035 | 6480464 | Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] more ... | CTD | PMID:20211987|PMID:20215421 |
Sp1 | Mouse | tamoxifen | multiple interactions | EXP | | 6480464 | Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression more ... | CTD | PMID:20150657 |
Sp1 | Mouse | temozolomide | multiple interactions | ISO | RGD:732035 | 6480464 | Temozolomide promotes the reaction [TP53 protein binds to SP1 protein] | CTD | PMID:29164620 |
Sp1 | Mouse | terameprocol | multiple interactions | ISO | RGD:732035 | 6480464 | terameprocol inhibits the reaction [SP1 protein results in increased expression of ABCB1 mRNA] | CTD | PMID:16544145 |
Sp1 | Mouse | terameprocol | decreases activity | ISO | RGD:732035 | 6480464 | terameprocol results in decreased activity of SP1 protein | CTD | PMID:16544145 |
Sp1 | Mouse | tetrachloroethene | increases expression | EXP | | 6480464 | Tetrachloroethylene results in increased expression of SP1 mRNA | CTD | PMID:28973375 |
Sp1 | Mouse | tetrathiomolybdate(2-) | multiple interactions | ISO | RGD:732035 | 6480464 | [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; more ... | CTD | PMID:22172574 |
Sp1 | Mouse | tetrathiomolybdate(2-) | increases expression | ISO | RGD:732035 | 6480464 | tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA | CTD | PMID:22172574|PMID:22914438 |
Sp1 | Mouse | tetrathiomolybdate(2-) | increases activity | ISO | RGD:732035 | 6480464 | tetrathiomolybdate results in increased activity of SP1 protein | CTD | PMID:22172574 |
Sp1 | Mouse | thalidomide | decreases activity | ISO | RGD:732035 | 6480464 | Thalidomide results in decreased activity of SP1 protein | CTD | PMID:10533722 |
Sp1 | Mouse | thapsigargin | decreases expression | ISO | RGD:3738 | 6480464 | Thapsigargin results in decreased expression of SP1 mRNA | CTD | PMID:25398788 |
Sp1 | Mouse | Theaflavin 3,3'-digallate | multiple interactions | ISO | RGD:732035 | 6480464 | theaflavin-3,3'-digallate inhibits the reaction [EGF protein results in increased activity of SP1 protein] | CTD | PMID:12931129 |
Sp1 | Mouse | Tiron | multiple interactions | EXP | | 6480464 | SP1 protein affects the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased expression of TGFB1 more ... | CTD | PMID:11163763 |
Sp1 | Mouse | titanium dioxide | affects methylation | EXP | | 6480464 | titanium dioxide affects the methylation of SP1 promoter | CTD | PMID:35295148 |
Sp1 | Mouse | tolfenamic acid | multiple interactions | ISO | RGD:732035 | 6480464 | tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] | CTD | PMID:24462621 |
Sp1 | Mouse | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SP1 mRNA | CTD | PMID:21135412 |
Sp1 | Mouse | trichostatin A | multiple interactions | ISO | RGD:732035 | 6480464 | [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which more ... | CTD | PMID:16740727|PMID:16757381|PMID:17986852|PMID:18706393|PMID:18801729|PMID:21911040 |
Sp1 | Mouse | trichostatin A | affects expression | ISO | RGD:732035 | 6480464 | trichostatin A affects the expression of SP1 mRNA; trichostatin A affects the expression of SP1 more ... | CTD | PMID:18801729 |
Sp1 | Mouse | trichostatin A | increases activity | ISO | RGD:732035 | 6480464 | trichostatin A results in increased activity of SP1 protein | CTD | PMID:16757381 |
Sp1 | Mouse | Triptolide | increases expression | EXP | | 6480464 | triptolide results in increased expression of SP1 mRNA | CTD | PMID:32835833 |
Sp1 | Mouse | Triptolide | decreases expression | EXP | | 6480464 | triptolide results in decreased expression of SP1 protein | CTD | PMID:34087332 |
Sp1 | Mouse | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of SP1 mRNA | CTD | PMID:33045310 |
Sp1 | Mouse | troglitazone | decreases expression | ISO | RGD:732035 | 6480464 | troglitazone results in decreased expression of SP1 protein | CTD | PMID:15908479|PMID:17409431 |
Sp1 | Mouse | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of SP1 mRNA | CTD | PMID:28973697 |
Sp1 | Mouse | troglitazone | multiple interactions | ISO | RGD:732035 | 6480464 | [troglitazone results in increased degradation of SP1 protein] which results in decreased expression of AR more ... | CTD | PMID:17409431 |
Sp1 | Mouse | troglitazone | increases degradation | ISO | RGD:732035 | 6480464 | troglitazone results in increased degradation of SP1 protein | CTD | PMID:17409431 |
Sp1 | Mouse | tunicamycin | decreases expression | ISO | RGD:3738 | 6480464 | Tunicamycin results in decreased expression of SP1 mRNA | CTD | PMID:25398788 |
Sp1 | Mouse | tyrphostin AG 1478 | multiple interactions | ISO | RGD:3738 | 6480464 | RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 more ... | CTD | PMID:25398788 |
Sp1 | Mouse | urethane | decreases expression | ISO | RGD:732035 | 6480464 | Urethane results in decreased expression of SP1 mRNA | CTD | PMID:28818685 |
Sp1 | Mouse | valproic acid | multiple interactions | ISO | RGD:732035 | 6480464 | Valproic Acid promotes the reaction [SP1 protein binds to XPC promoter] | CTD | PMID:21507255 |
Sp1 | Mouse | valproic acid | decreases expression | ISO | RGD:732035 | 6480464 | Valproic Acid results in decreased expression of SP1 mRNA | CTD | PMID:23179753|PMID:28001369 |
Sp1 | Mouse | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of SP1 mRNA | CTD | PMID:21427059 |
Sp1 | Mouse | venetoclax | multiple interactions | ISO | RGD:732035 | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression more ... | CTD | PMID:35561756 |
Sp1 | Mouse | vincristine | decreases expression | ISO | RGD:732035 | 6480464 | Vincristine results in decreased expression of SP1 mRNA | CTD | PMID:23649840 |
Sp1 | Mouse | vorinostat | multiple interactions | ISO | RGD:732035 | 6480464 | SP1 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA] | CTD | PMID:11126357 |
Sp1 | Mouse | wortmannin | multiple interactions | ISO | RGD:732035 | 6480464 | wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] | CTD | PMID:17441964 |
Sp1 | Mouse | wortmannin | decreases reaction | ISO | RGD:3738 | 152177689 | wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus | RGD | |
Sp1 | Mouse | zinc acetate | increases expression | ISO | RGD:732035 | 6480464 | Zinc Acetate results in increased expression of SP1 mRNA | CTD | PMID:24132751 |
Sp1 | Mouse | zinc atom | multiple interactions | ISO | RGD:732035 | 6480464 | Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]; Cadmium more ... | CTD | PMID:20073493 |
Sp1 | Mouse | zinc atom | decreases expression | ISO | RGD:3738 | 6480464 | Zinc deficiency results in decreased expression of SP1 protein | CTD | PMID:21893222 |
Sp1 | Mouse | zinc atom | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to SP1 protein]; Zinc promotes the reaction [MTF1 more ... | CTD | PMID:18458062 |
Sp1 | Mouse | zinc atom | increases activity | ISO | RGD:732035 | 6480464 | Zinc deficiency results in increased activity of SP1 protein | CTD | PMID:18356318 |
Sp1 | Mouse | zinc atom | affects binding | ISO | RGD:732035 | 6480464 | SP1 protein binds to Zinc | CTD | PMID:20073493 |
Sp1 | Mouse | zinc dichloride | multiple interactions | EXP | | 6480464 | zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and more ... | CTD | PMID:20060848 |
Sp1 | Mouse | zinc dichloride | increases activity | ISO | RGD:732035 | 6480464 | zinc chloride results in increased activity of SP1 protein | CTD | PMID:9330853 |
Sp1 | Mouse | zinc sulfate | multiple interactions | ISO | RGD:732035 | 6480464 | Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein] | CTD | PMID:26241054 |
Sp1 | Mouse | zinc(0) | multiple interactions | ISO | RGD:732035 | 6480464 | Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]; Cadmium more ... | CTD | PMID:20073493 |
Sp1 | Mouse | zinc(0) | affects binding | ISO | RGD:732035 | 6480464 | SP1 protein binds to Zinc | CTD | PMID:20073493 |
Sp1 | Mouse | zinc(0) | increases activity | ISO | RGD:732035 | 6480464 | Zinc deficiency results in increased activity of SP1 protein | CTD | PMID:18356318 |
Sp1 | Mouse | zinc(0) | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to SP1 protein]; Zinc promotes the reaction [MTF1 more ... | CTD | PMID:18458062 |
Sp1 | Mouse | zinc(0) | decreases expression | ISO | RGD:3738 | 6480464 | Zinc deficiency results in decreased expression of SP1 protein | CTD | PMID:21893222 |
Sp1 | Mouse | zoledronic acid | increases expression | ISO | RGD:732035 | 6480464 | zoledronic acid results in increased expression of SP1 mRNA | CTD | PMID:20977926 |