SP1 Human (+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein] CTD PMID:28768059 SP1 Human (+)-catechin increases expression EXP 6480464 Catechin results in increased expression of SP1 protein CTD PMID:28768059 SP1 Human (-)-demecolcine decreases expression EXP 6480464 Demecolcine results in decreased expression of SP1 mRNA CTD PMID:23649840 SP1 Human (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 epigallocatechin gallate inhibits the reaction [EGF protein results in increased activity of SP1 protein] CTD PMID:12931129 SP1 Human (20S)-ginsenoside Rg3 multiple interactions EXP 6480464 ginsenoside Rg3 inhibits the reaction [cagA protein and Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 SP1 Human (R)-lipoic acid multiple interactions ISO Sp1 (Mus musculus) 6480464 Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 SP1 Human (S)-nicotine multiple interactions EXP 6480464 Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein] more ... CTD PMID:24089524 SP1 Human 1,2-dimethylhydrazine decreases expression ISO Sp1 (Rattus norvegicus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of SP1 mRNA CTD PMID:32387197 SP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 SP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substance ISO Sp1 (Mus musculus) 6480464 SP1 affects the susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:25851821 SP1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Sp1 (Rattus norvegicus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 SP1 Human 17alpha-ethynylestradiol multiple interactions EXP 6480464 SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA] CTD PMID:15878629 SP1 Human 17alpha-ethynylestradiol increases activity EXP 6480464 Ethinyl Estradiol results in increased activity of SP1 protein CTD PMID:15878629 SP1 Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA more ... CTD PMID:16675542 more ... SP1 Human 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of SP1 mRNA CTD PMID:29783106 SP1 Human 17beta-estradiol increases activity EXP 6480464 Estradiol results in increased activity of SP1 protein CTD PMID:17088408 SP1 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Sp1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27291303 SP1 Human 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO Sp1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27291303 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Sp1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA CTD PMID:14708085 and PMID:24058054 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA CTD PMID:33387578 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SP1 mRNA CTD PMID:34747641 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of SP1 protein CTD PMID:20971882 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sp1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SP1 mRNA CTD PMID:21570461 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects activity ISO Sp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the activity of SP1 protein CTD PMID:11926288 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Sp1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNA CTD PMID:15251184 SP1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] more ... CTD PMID:12801909 and PMID:16675542 SP1 Human 2-chloroethanol multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein more ... CTD PMID:31585129 SP1 Human 2-chloroethanol increases expression ISO Sp1 (Rattus norvegicus) 6480464 Ethylene Chlorohydrin results in increased expression of SP1 mRNA CTD PMID:31585129 SP1 Human 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of SP1 protein CTD PMID:36206955 SP1 Human 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases expression EXP 6480464 bisindolylmaleimide I results in increased expression of SP1 mRNA and bisindolylmaleimide I results in increased expression of SP1 protein CTD PMID:14653808 SP1 Human 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein] CTD PMID:12499119 SP1 Human 3-methylcholanthrene multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]] more ... CTD PMID:29094188 SP1 Human 3-methylcholanthrene increases acetylation ISO Sp1 (Rattus norvegicus) 6480464 Methylcholanthrene results in increased acetylation of SP1 promoter CTD PMID:29094188 SP1 Human 3-methylcholanthrene increases expression ISO Sp1 (Rattus norvegicus) 6480464 Methylcholanthrene results in increased expression of SP1 mRNA CTD PMID:29094188 SP1 Human 4,4'-diaminodiphenylmethane decreases expression ISO Sp1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of SP1 mRNA CTD PMID:18648102 SP1 Human 4-hydroxyphenyl retinamide multiple interactions ISO Sp1 (Mus musculus) 6480464 Fenretinide results in increased cleavage of and results in decreased activity of SP1 protein CTD PMID:9343396 SP1 Human 4-hydroxyphenyl retinamide increases expression ISO Sp1 (Mus musculus) 6480464 Fenretinide results in increased expression of SP1 mRNA CTD PMID:28973697 SP1 Human 4-nonylphenol multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human 4-tert-Octylphenol multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of SP1 mRNA and Decitabine results in increased expression of SP1 protein CTD PMID:19027835 SP1 Human 5-aza-2'-deoxycytidine multiple interactions ISO Sp1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of SP1 mRNA CTD PMID:15251184 SP1 Human 5-aza-2'-deoxycytidine increases expression ISO Sp1 (Mus musculus) 6480464 Decitabine results in increased expression of SP1 mRNA CTD PMID:15251184 and PMID:27915011 SP1 Human 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [[Decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA more ... CTD PMID:17986852 more ... SP1 Human 5-azacytidine multiple interactions EXP 6480464 Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter] and Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter] CTD PMID:18945643 SP1 Human 5-azacytidine decreases expression EXP 6480464 Azacitidine results in decreased expression of SP1 mRNA CTD PMID:20823114 SP1 Human 5-azacytidine multiple interactions ISO Sp1 (Mus musculus) 6480464 Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter] CTD PMID:17198683 SP1 Human 5-fluorouracil multiple interactions EXP 6480464 Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter] and SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:15489892 and PMID:18927307 SP1 Human 6-propyl-2-thiouracil decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of SP1 mRNA CTD PMID:30047161 SP1 Human 7,12-dimethyltetraphene multiple interactions EXP 6480464 [[9 more ... CTD PMID:22009531 and PMID:29663660 SP1 Human 7,12-dimethyltetraphene increases expression ISO Sp1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:36863560 SP1 Human 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:29663660 SP1 Human acetaldehyde multiple interactions EXP 6480464 SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 SP1 Human AH23848 multiple interactions EXP 6480464 [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein CTD PMID:19407222 SP1 Human aldehydo-D-glucose multiple interactions EXP 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human aldehydo-D-glucose multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human alendronic acid multiple interactions EXP 6480464 SP1 protein affects the reaction [Alendronate results in increased expression of SOX9 mRNA] more ... CTD PMID:33522294 SP1 Human alendronic acid increases expression EXP 6480464 Alendronate results in increased expression of SP1 mRNA and Alendronate results in increased expression of SP1 protein CTD PMID:33522294 SP1 Human all-trans-retinoic acid increases activity EXP 6480464 Tretinoin results in increased activity of SP1 protein CTD PMID:16757381 SP1 Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of SP1 mRNA and Tretinoin results in increased expression of SP1 protein CTD PMID:23724009 more ... SP1 Human all-trans-retinoic acid increases activity ISO Sp1 (Mus musculus) 6480464 Tretinoin results in increased activity of SP1 protein CTD PMID:17097063 SP1 Human all-trans-retinoic acid multiple interactions EXP 6480464 Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein] more ... CTD PMID:16740727 more ... SP1 Human allethrin increases activity EXP 6480464 Allethrins results in increased activity of SP1 protein CTD PMID:20143881 SP1 Human alpha-D-galactose increases expression ISO Sp1 (Rattus norvegicus) 6480464 Galactose results in increased expression of SP1 protein CTD PMID:30367734 SP1 Human alpha-D-galactose multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] CTD PMID:30367734 SP1 Human alpha-naphthoflavone multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]] more ... CTD PMID:29094188 SP1 Human amitrole decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Amitrole results in decreased expression of SP1 mRNA CTD PMID:30047161 and PMID:38685447 SP1 Human ammonium chloride decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Ammonium Chloride results in decreased expression of SP1 mRNA and Ammonium Chloride results in decreased expression of SP1 protein CTD PMID:17442060 SP1 Human ammonium chloride decreases phosphorylation ISO Sp1 (Rattus norvegicus) 6480464 Ammonium Chloride results in decreased phosphorylation of SP1 protein CTD PMID:17442060 SP1 Human ammonium chloride affects expression ISO Sp1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of SP1 mRNA CTD PMID:16483693 SP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 SP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with pyrazolanthrone] results in decreased phosphorylation of SP1 protein CTD PMID:34794910 SP1 Human antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of SP1 mRNA CTD PMID:25339124 SP1 Human aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of SP1 mRNA and aristolochic acid I results in decreased expression of SP1 protein CTD PMID:33212167 SP1 Human Aroclor 1254 increases activity ISO Sp1 (Rattus norvegicus) 6480464 Chlorodiphenyl (54% Chlorine) results in increased activity of SP1 protein CTD PMID:16159668 SP1 Human arsane multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein and [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human arsane multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 protein CTD PMID:36669534 SP1 Human arsenic atom multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein and [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human arsenic atom multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 protein CTD PMID:36669534 SP1 Human arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter] more ... CTD PMID:11714746 more ... SP1 Human arsenous acid affects methylation EXP 6480464 Arsenic Trioxide affects the methylation of SP1 promoter CTD PMID:26046465 SP1 Human arsenous acid decreases activity EXP 6480464 Arsenic Trioxide results in decreased activity of SP1 protein CTD PMID:11714746 SP1 Human arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SP1 mRNA and Arsenic Trioxide results in decreased expression of SP1 protein CTD PMID:17617380 more ... SP1 Human artesunate decreases expression EXP 6480464 artesunate results in decreased expression of SP1 protein CTD PMID:19513562 SP1 Human asbestos increases expression EXP 6480464 Asbestos results in increased expression of SP1 CTD PMID:15636197 SP1 Human asiatic acid multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 asiatic acid inhibits the reaction [cypermethrin results in decreased phosphorylation of SP1 protein] CTD PMID:34794910 SP1 Human astaxanthin multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 SP1 Human bathocuproine disulfonic acid multiple interactions EXP 6480464 bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 SP1 Human benzene decreases expression EXP 6480464 Benzene results in decreased expression of SP1 mRNA CTD PMID:21382456 SP1 Human benzo[a]pyrene affects activity EXP 6480464 Benzo(a)pyrene affects the activity of SP1 protein CTD PMID:20624995 SP1 Human benzo[a]pyrene affects expression ISO Sp1 (Mus musculus) 6480464 Benzo(a)pyrene affects the expression of SP1 protein CTD PMID:21987461 SP1 Human benzo[a]pyrene increases expression ISO Sp1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SP1 mRNA CTD PMID:22228805 SP1 Human benzo[a]pyrene multiple interactions ISO Sp1 (Mus musculus) 6480464 POR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein] CTD PMID:21987461 SP1 Human Benzo[ghi]perylene increases expression EXP 6480464 1 and 12-benzoperylene results in increased expression of SP1 mRNA CTD PMID:35182551 SP1 Human biotin increases expression ISO Sp1 (Mus musculus) 6480464 Biotin results in increased expression of SP1 mRNA CTD PMID:34699867 SP1 Human bis(2-ethylhexyl) phthalate multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human bisphenol A increases expression ISO Sp1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of SP1 mRNA CTD PMID:25181051 and PMID:33296240 SP1 Human bisphenol A decreases expression ISO Sp1 (Mus musculus) 6480464 bisphenol A results in decreased expression of SP1 mRNA CTD PMID:33221593 and PMID:37894381 SP1 Human bisphenol A multiple interactions EXP 6480464 [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA CTD PMID:29783106 SP1 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SP1 mRNA and bisphenol A results in increased expression of SP1 protein CTD PMID:29783106 and PMID:30206973 SP1 Human bisphenol A decreases expression ISO Sp1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SP1 mRNA CTD PMID:30816183 more ... SP1 Human bisphenol A affects methylation ISO Sp1 (Mus musculus) 6480464 bisphenol A affects the methylation of SP1 promoter CTD PMID:27334623 SP1 Human butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of SP1 mRNA CTD PMID:29432896 SP1 Human Butylbenzyl phthalate decreases expression ISO Sp1 (Mus musculus) 6480464 butylbenzyl phthalate results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human Butylbenzyl phthalate multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human cadmium atom multiple interactions ISO Sp1 (Mus musculus) 6480464 Cadmium inhibits the reaction [SP1 protein binds to SLC5A1 promoter] and Cadmium promotes the reaction [MTF1 protein binds to SP1 protein] CTD PMID:15664265 and PMID:18458062 SP1 Human cadmium atom multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:35384129 SP1 Human cadmium atom affects binding EXP 6480464 SP1 protein binds to Cadmium CTD PMID:20073493 SP1 Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:15760895 more ... SP1 Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:18556457 and PMID:35384129 SP1 Human cadmium dichloride increases expression ISO Sp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of SP1 mRNA CTD PMID:35525383 SP1 Human cadmium dichloride decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of SP1 mRNA and Cadmium Chloride results in decreased expression of SP1 protein CTD PMID:33865896 SP1 Human cadmium dichloride increases cleavage ISO Sp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased cleavage of SP1 protein CTD PMID:12499119 SP1 Human cadmium dichloride multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:12499119 and PMID:35384129 SP1 Human cadmium dichloride multiple interactions ISO Sp1 (Mus musculus) 6480464 Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter] more ... CTD PMID:20060848 and PMID:25046863 SP1 Human cadmium dichloride affects response to substance EXP 6480464 SP1 affects the susceptibility to Cadmium Chloride CTD PMID:18556457 SP1 Human caffeine affects phosphorylation EXP 6480464 Caffeine affects the phosphorylation of SP1 protein CTD PMID:35688186 SP1 Human Calcimycin multiple interactions EXP 6480464 [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein CTD PMID:24244623 SP1 Human camptothecin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA] more ... CTD PMID:11261509 more ... SP1 Human camptothecin increases expression EXP 6480464 Camptothecin results in increased expression of SP1 mRNA CTD PMID:30851366 SP1 Human camptothecin increases activity EXP 6480464 Camptothecin results in increased activity of SP1 protein CTD PMID:11261509 SP1 Human capsaicin increases localization EXP 6480464 Capsaicin results in increased localization of SP1 protein CTD PMID:22200406 SP1 Human capsaicin multiple interactions EXP 6480464 Capsaicin promotes the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:22200406 SP1 Human carbon nanotube decreases expression ISO Sp1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 SP1 Human carnosine decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Carnosine results in decreased expression of SP1 mRNA CTD PMID:30485136 SP1 Human carnosine decreases expression ISO Sp1 (Mus musculus) 6480464 Carnosine results in decreased expression of SP1 mRNA CTD PMID:30485136 SP1 Human chloroprene increases expression ISO Sp1 (Rattus norvegicus) 6480464 Chloroprene results in increased expression of SP1 mRNA CTD PMID:23125180 SP1 Human chloroquine multiple interactions EXP 6480464 Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein] CTD PMID:35561756 SP1 Human chlorpyrifos affects expression ISO Sp1 (Rattus norvegicus) 6480464 Chlorpyrifos affects the expression of SP1 mRNA CTD PMID:17452286 SP1 Human chlorpyrifos decreases expression ISO Sp1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SP1 mRNA CTD PMID:37019170 SP1 Human chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of SP1 mRNA CTD PMID:24979751 SP1 Human choline multiple interactions ISO Sp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 SP1 Human chromium(6+) multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 chromium hexavalent ion inhibits the reaction [SP1 protein binds to AR promoter] CTD PMID:32679048 SP1 Human cisplatin decreases expression ISO Sp1 (Mus musculus) 6480464 Cisplatin results in decreased expression of SP1 mRNA CTD PMID:21151649 SP1 Human cisplatin increases expression EXP 6480464 [Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 mRNA more ... CTD PMID:22914438 and PMID:24132751 SP1 Human cisplatin multiple interactions EXP 6480464 Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA] CTD PMID:24132751 SP1 Human clofarabine multiple interactions EXP 6480464 [Resveratrol co-treated with Clofarabine] affects the localization of SP1 protein and [Resveratrol co-treated with Clofarabine] results in decreased expression of SP1 protein CTD PMID:23146690 SP1 Human clofibrate increases expression ISO Sp1 (Mus musculus) 6480464 Clofibrate results in increased expression of SP1 mRNA CTD PMID:17585979 SP1 Human cobalt dichloride increases activity EXP 6480464 cobaltous chloride results in increased activity of SP1 protein CTD PMID:17307335 SP1 Human cobalt dichloride increases phosphorylation ISO Sp1 (Rattus norvegicus) 6480464 cobaltous chloride results in increased phosphorylation of SP1 protein CTD PMID:23814049 SP1 Human cobalt dichloride multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein] more ... CTD PMID:17307335 SP1 Human cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SP1 protein CTD PMID:17307335 SP1 Human cocaine affects expression ISO Sp1 (Rattus norvegicus) 6480464 Cocaine affects the expression of SP1 mRNA and Cocaine affects the expression of SP1 protein CTD PMID:16179556 and PMID:20187946 SP1 Human copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of SP1 mRNA and Copper deficiency results in increased expression of SP1 protein CTD PMID:22172574 and PMID:24132751 SP1 Human copper atom multiple interactions EXP 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] more ... CTD PMID:12633744 more ... SP1 Human copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of SP1 mRNA and Copper deficiency results in increased expression of SP1 protein CTD PMID:22172574 and PMID:24132751 SP1 Human copper(0) multiple interactions EXP 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] more ... CTD PMID:12633744 more ... SP1 Human copper(II) sulfate multiple interactions EXP 6480464 Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA] more ... CTD PMID:22172574 more ... SP1 Human copper(II) sulfate decreases expression EXP 6480464 [Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA and Copper Sulfate results in decreased expression of SP1 mRNA CTD PMID:22172574 and PMID:22914438 SP1 Human copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of SP1 mRNA CTD PMID:19549813 SP1 Human copper(II) sulfate decreases activity EXP 6480464 Copper Sulfate results in decreased activity of SP1 protein CTD PMID:22172574 and PMID:26241054 SP1 Human cordycepin multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein] and cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 SP1 Human cordycepin multiple interactions EXP 6480464 cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression of SP1 protein] more ... CTD PMID:33948356 SP1 Human cordycepin decreases expression EXP 6480464 cordycepin results in decreased expression of SP1 mRNA and cordycepin results in decreased expression of SP1 protein CTD PMID:25282637 and PMID:33948356 SP1 Human cordycepin decreases expression ISO Sp1 (Mus musculus) 6480464 cordycepin results in decreased expression of SP1 protein CTD PMID:33948356 SP1 Human cordycepin affects metabolic processing EXP 6480464 cordycepin affects the metabolism of SP1 polyA tail CTD PMID:33948356 SP1 Human cordycepin increases activity EXP 6480464 cordycepin results in increased activity of SP1 protein CTD PMID:19051361 SP1 Human coumarin decreases phosphorylation EXP 6480464 coumarin results in decreased phosphorylation of SP1 protein CTD PMID:35688186 SP1 Human crocidolite asbestos affects expression EXP 6480464 Asbestos and Crocidolite affects the expression of SP1 mRNA CTD PMID:17331233 SP1 Human CU-O LINKAGE increases expression EXP 6480464 cupric oxide results in increased expression of SP1 mRNA CTD PMID:22077320 SP1 Human curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of SP1 protein CTD PMID:18347134 and PMID:18593936 SP1 Human cyclosporin A multiple interactions EXP 6480464 [Cyclosporine co-treated with NGF protein] affects the localization of SP1 protein and [Cyclosporine co-treated with NGF protein] promotes the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 SP1 Human cypermethrin multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with pyrazolanthrone] results in decreased phosphorylation of SP1 protein more ... CTD PMID:34794910 SP1 Human cypermethrin decreases phosphorylation ISO Sp1 (Mus musculus) 6480464 cypermethrin results in decreased phosphorylation of SP1 protein CTD PMID:34794910 SP1 Human cypermethrin decreases expression ISO Sp1 (Rattus norvegicus) 6480464 cypermethrin results in decreased expression of SP1 mRNA CTD PMID:34794910 SP1 Human cypermethrin decreases phosphorylation ISO Sp1 (Rattus norvegicus) 6480464 cypermethrin results in decreased phosphorylation of SP1 protein CTD PMID:34794910 SP1 Human D-glucose multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human D-glucose multiple interactions EXP 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human D-penicillamine increases expression EXP 6480464 Penicillamine results in increased expression of SP1 mRNA CTD PMID:22914438 SP1 Human daunorubicin multiple interactions EXP 6480464 AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] more ... CTD PMID:34963561 SP1 Human daunorubicin decreases expression EXP 6480464 Daunorubicin results in decreased expression of SP1 protein CTD PMID:34963561 SP1 Human decabromodiphenyl ether increases expression ISO Sp1 (Rattus norvegicus) 6480464 decabromobiphenyl ether results in increased expression of SP1 mRNA CTD PMID:23640034 SP1 Human deoxynivalenol multiple interactions EXP 6480464 deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter] and SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA] CTD PMID:19438726 SP1 Human deoxynivalenol affects expression EXP 6480464 deoxynivalenol affects the expression of SP1 protein CTD PMID:33890134 SP1 Human deoxynivalenol increases phosphorylation EXP 6480464 deoxynivalenol results in increased phosphorylation of SP1 protein CTD PMID:19438726 SP1 Human desferrioxamine B multiple interactions EXP 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 SP1 Human Diallyltetrasulfane multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 diallyl tetrasulfide inhibits the reaction [cypermethrin results in decreased phosphorylation of SP1 protein] CTD PMID:34794910 SP1 Human diarsenic trioxide decreases activity EXP 6480464 Arsenic Trioxide results in decreased activity of SP1 protein CTD PMID:11714746 SP1 Human diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SP1 mRNA and Arsenic Trioxide results in decreased expression of SP1 protein CTD PMID:17617380 more ... SP1 Human diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter] more ... CTD PMID:11714746 more ... SP1 Human diarsenic trioxide affects methylation EXP 6480464 Arsenic Trioxide affects the methylation of SP1 promoter CTD PMID:26046465 SP1 Human diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of SP1 gene CTD PMID:22964155 SP1 Human Dibutyl phosphate affects expression EXP 6480464 di-n-butylphosphoric acid affects the expression of SP1 mRNA CTD PMID:37042841 SP1 Human dibutyl phthalate multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SP1 mRNA and Dibutyl Phthalate results in increased expression of SP1 protein CTD PMID:35397443 SP1 Human dibutyl phthalate multiple interactions EXP 6480464 SP1 protein affects the reaction [Dibutyl Phthalate results in increased expression of CCL2 mRNA] CTD PMID:35397443 SP1 Human dibutyl phthalate decreases expression ISO Sp1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human dieldrin decreases response to substance EXP 6480464 SP1 gene mutant form results in decreased susceptibility to Dieldrin CTD PMID:32421776 SP1 Human diethylstilbestrol increases expression ISO Sp1 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of SP1 mRNA CTD PMID:16714842 SP1 Human dimethyl sulfoxide multiple interactions EXP 6480464 Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter] CTD PMID:16675542 SP1 Human dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of SP1 protein CTD PMID:17307335 SP1 Human dioxygen increases phosphorylation ISO Sp1 (Rattus norvegicus) 6480464 Oxygen deficiency results in increased phosphorylation of SP1 protein CTD PMID:23814049 SP1 Human dioxygen multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein] and SP1 protein affects the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA] CTD PMID:17307335 SP1 Human disodium selenite multiple interactions EXP 6480464 [Sodium Selenite results in decreased activity of SP1 protein] which results in decreased expression of AR protein more ... CTD PMID:16928829 and PMID:35384129 SP1 Human disodium selenite multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 SP1 Human disodium selenite multiple interactions ISO Sp1 (Mus musculus) 6480464 Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein] CTD PMID:15650415 SP1 Human doxorubicin affects activity EXP 6480464 Doxorubicin affects the activity of SP1 protein CTD PMID:17108358 SP1 Human doxorubicin increases ribosylation EXP 6480464 Doxorubicin results in increased ribosylation of SP1 protein CTD PMID:22293659 SP1 Human doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SP1 mRNA CTD PMID:29803840 SP1 Human doxorubicin multiple interactions EXP 6480464 [Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter] more ... CTD PMID:17124180 more ... SP1 Human elemental selenium multiple interactions EXP 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] and [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein] CTD PMID:35384129 SP1 Human elemental selenium multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 SP1 Human enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SP1 protein CTD PMID:23301498 SP1 Human epoxomicin multiple interactions EXP 6480464 epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2 more ... CTD PMID:17409431 SP1 Human epoxomicin increases ubiquitination EXP 6480464 epoxomicin results in increased ubiquitination of SP1 protein CTD PMID:17409431 SP1 Human esculetin decreases expression EXP 6480464 esculetin results in decreased expression of SP1 protein CTD PMID:31313495 SP1 Human estrogen increases expression ISO Sp1 (Rattus norvegicus) 152177689 estrogen increases expression of Sp1 mRNA in rat uterus RGD SP1 Human ethanol multiple interactions EXP 6480464 Ethanol promotes the reaction [SP1 protein binds to FASLG promoter] CTD PMID:24899502 SP1 Human ethanol multiple interactions ISO Sp1 (Mus musculus) 6480464 Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter] and PPARD gene mutant form inhibits the reaction [Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]] CTD PMID:27765815 SP1 Human etoposide increases phosphorylation EXP 6480464 Etoposide results in increased phosphorylation of SP1 protein CTD PMID:17441964 SP1 Human etoposide increases expression ISO Sp1 (Rattus norvegicus) 6480464 Etoposide results in increased expression of SP1 mRNA CTD PMID:23690541 SP1 Human etoposide increases activity ISO Sp1 (Rattus norvegicus) 6480464 Etoposide results in increased activity of SP1 protein CTD PMID:23690541 SP1 Human etoposide multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein] and cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 SP1 Human etoposide multiple interactions EXP 6480464 PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein] and wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] CTD PMID:17441964 SP1 Human flutamide increases expression ISO Sp1 (Rattus norvegicus) 6480464 Flutamide results in increased expression of SP1 mRNA CTD PMID:24793618 SP1 Human folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] and Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter] CTD PMID:16728583 and PMID:33360347 SP1 Human folic acid decreases expression ISO Sp1 (Mus musculus) 6480464 Folic Acid results in decreased expression of SP1 mRNA CTD PMID:25629700 SP1 Human folic acid multiple interactions ISO Sp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 SP1 Human FR900359 increases phosphorylation EXP 6480464 FR900359 results in increased phosphorylation of SP1 protein CTD PMID:37730182 SP1 Human fulvestrant multiple interactions EXP 6480464 fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter] CTD PMID:20211987 SP1 Human galactose multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] CTD PMID:30367734 SP1 Human galactose increases expression ISO Sp1 (Rattus norvegicus) 6480464 Galactose results in increased expression of SP1 protein CTD PMID:30367734 SP1 Human genistein multiple interactions EXP 6480464 Genistein promotes the reaction [SP1 protein binds to VDR promoter] and U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein] CTD PMID:17088408 SP1 Human genistein increases expression EXP 6480464 Genistein results in increased expression of SP1 protein CTD PMID:24685904 SP1 Human genistein increases activity EXP 6480464 Genistein results in increased activity of SP1 protein CTD PMID:17088408 SP1 Human gentamycin increases expression ISO Sp1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of SP1 mRNA CTD PMID:22061828 SP1 Human glucose multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human glucose multiple interactions EXP 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] and SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 SP1 Human glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein] CTD PMID:20435036 SP1 Human glutathione decreases expression EXP 6480464 Glutathione results in decreased expression of SP1 CTD PMID:18556457 SP1 Human glycitein increases activity EXP 6480464 glycitein results in increased activity of SP1 protein CTD PMID:17088408 SP1 Human glycitein multiple interactions EXP 6480464 glycitein promotes the reaction [SP1 protein binds to VDR promoter] and U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein] CTD PMID:17088408 SP1 Human glyphosate increases expression EXP 6480464 Glyphosate results in increased expression of SP1 mRNA CTD PMID:31295307 SP1 Human homocysteic acid increases activity EXP 6480464 homocysteic acid results in increased activity of SP1 protein CTD PMID:11261509 SP1 Human homocysteic acid multiple interactions EXP 6480464 mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein] CTD PMID:11261509 SP1 Human hydrogen peroxide multiple interactions EXP 6480464 [Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased activity of SP1 protein more ... CTD PMID:17108117 more ... SP1 Human hydrogen peroxide increases phosphorylation ISO Sp1 (Mus musculus) 6480464 Hydrogen Peroxide results in increased phosphorylation of SP1 protein CTD PMID:31494107 SP1 Human hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of SP1 protein CTD PMID:17961220 SP1 Human hydrogen peroxide multiple interactions ISO Sp1 (Mus musculus) 6480464 [Hydrogen Peroxide results in increased activity of and results in increased ADP-ribosylation of PARP1 protein] which results in increased ADP-ribosylation of and results in decreased activity of SP1 protein more ... CTD PMID:17108117 more ... SP1 Human hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SP1 protein CTD PMID:20435036 and PMID:33360347 SP1 Human hydroquinone multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression of SP1 protein] more ... CTD PMID:35561756 SP1 Human indole-3-methanol multiple interactions EXP 6480464 indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter] CTD PMID:20570586 SP1 Human indole-3-methanol decreases activity EXP 6480464 indole-3-carbinol results in decreased activity of SP1 protein CTD PMID:16082211 SP1 Human irinotecan increases phosphorylation EXP 6480464 Irinotecan results in increased phosphorylation of SP1 protein CTD PMID:17441964 SP1 Human irinotecan multiple interactions EXP 6480464 SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 SP1 Human irinotecan decreases expression EXP 6480464 Irinotecan analog results in decreased expression of SP1 mRNA CTD PMID:18927307 SP1 Human iron atom multiple interactions EXP 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 SP1 Human iron(0) multiple interactions EXP 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 SP1 Human isoprenaline multiple interactions ISO Sp1 (Mus musculus) 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA and EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 SP1 Human jaceosidin multiple interactions EXP 6480464 SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein] and SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 SP1 Human ketoconazole decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Ketoconazole results in decreased expression of SP1 mRNA CTD PMID:37077353 SP1 Human L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of SP1 protein CTD PMID:21919647 SP1 Human L-methionine multiple interactions ISO Sp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 SP1 Human lead diacetate increases expression ISO Sp1 (Mus musculus) 6480464 lead acetate results in increased expression of SP1 mRNA and lead acetate results in increased expression of SP1 protein CTD PMID:23867794 and PMID:24260418 SP1 Human lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of SP1 protein CTD PMID:24462621 SP1 Human lead diacetate multiple interactions EXP 6480464 tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 SP1 Human lead(0) increases expression EXP 6480464 Lead results in increased expression of SP1 protein CTD PMID:22272629 SP1 Human lead(0) multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein and [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human lead(II) chloride multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein and [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human lipoic acid multiple interactions ISO Sp1 (Mus musculus) 6480464 Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 SP1 Human lipopolysaccharide multiple interactions EXP 6480464 Lipopolysaccharides promotes the reaction [SP1 protein binds to BAG3 promoter] and trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of SP1 mRNA] CTD PMID:21911040 and PMID:22020323 SP1 Human lipopolysaccharide multiple interactions ISO Sp1 (Mus musculus) 6480464 Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein] CTD PMID:15650415 SP1 Human lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of SP1 mRNA CTD PMID:21911040 SP1 Human LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein] more ... CTD PMID:17307335 and PMID:26385185 SP1 Human LY294002 increases phosphorylation ISO Sp1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein CTD PMID:21351249 SP1 Human manganese atom multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter] and Manganese results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:22975163 SP1 Human manganese(0) multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter] and Manganese results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:22975163 SP1 Human mercury dichloride increases expression ISO Sp1 (Rattus norvegicus) 6480464 Mercuric Chloride results in increased expression of SP1 mRNA CTD PMID:16507785 SP1 Human metformin multiple interactions EXP 6480464 [nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter] more ... CTD PMID:25110054 and PMID:38050843 SP1 Human metformin decreases expression EXP 6480464 Metformin results in decreased expression of SP1 protein CTD PMID:25110054 and PMID:26317792 SP1 Human methapyrilene decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Methapyrilene results in decreased expression of SP1 mRNA CTD PMID:30467583 SP1 Human methimazole decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Methimazole results in decreased expression of SP1 mRNA CTD PMID:30047161 and PMID:38685447 SP1 Human methylmercury chloride decreases expression ISO Sp1 (Rattus norvegicus) 6480464 methylmercuric chloride results in decreased expression of SP1 protein CTD PMID:28736149 SP1 Human methylmercury chloride multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein and [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of SP1 mRNA CTD PMID:28001369 SP1 Human methylparaben decreases expression EXP 6480464 methylparaben results in decreased expression of SP1 mRNA CTD PMID:31745603 SP1 Human methylseleninic acid multiple interactions EXP 6480464 methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter] CTD PMID:17876054 SP1 Human mibolerone multiple interactions EXP 6480464 [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein] more ... CTD PMID:15661808 and PMID:20148354 SP1 Human microcystin-LR decreases expression ISO Sp1 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of SP1 mRNA and cyanoginosin LR results in decreased expression of SP1 protein CTD PMID:36206955 SP1 Human microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of SP1 mRNA CTD PMID:36206955 SP1 Human mithramycin decreases activity EXP 6480464 Plicamycin results in decreased activity of SP1 protein CTD PMID:15946989 SP1 Human mithramycin decreases expression ISO Sp1 (Mus musculus) 6480464 Plicamycin results in decreased expression of SP1 protein CTD PMID:34087332 SP1 Human mithramycin decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Plicamycin results in decreased expression of SP1 mRNA CTD PMID:23814049 SP1 Human mithramycin multiple interactions EXP 6480464 [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein more ... CTD PMID:17307335 more ... SP1 Human monosodium L-glutamate increases expression ISO Sp1 (Rattus norvegicus) 6480464 Sodium Glutamate results in increased expression of SP1 mRNA CTD PMID:20928830 SP1 Human morin multiple interactions ISO Sp1 (Mus musculus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [morin promotes the reaction [PPARG protein binds to SP1 protein]] and morin promotes the reaction [PPARG protein binds to SP1 protein] CTD PMID:36121554 SP1 Human N-acetyl-L-cysteine decreases expression EXP 6480464 Acetylcysteine results in decreased expression of SP1 protein CTD PMID:18556457 SP1 Human N-acetyl-L-cysteine multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] CTD PMID:33360347 SP1 Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA] more ... CTD PMID:16928829 more ... SP1 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Sp1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:14529614 SP1 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2 more ... CTD PMID:17409431 and PMID:34963561 SP1 Human N-butyl-N-(4-hydroxybutyl)nitrosamine increases expression ISO Sp1 (Mus musculus) 6480464 Butylhydroxybutylnitrosamine results in increased expression of SP1 protein CTD PMID:24998975 SP1 Human N-ethylmaleimide multiple interactions ISO Sp1 (Mus musculus) 6480464 Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 SP1 Human N-ethylmaleimide multiple interactions EXP 6480464 Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 SP1 Human N-methyl-4-phenylpyridinium multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 SP1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TIGAR protein] CTD PMID:33359019 SP1 Human N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SP1 mRNA and 1-Methyl-4-phenylpyridinium results in increased expression of SP1 protein CTD PMID:34508910 SP1 Human N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 NEAT1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SP1 mRNA] and NEAT1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SP1 protein] CTD PMID:34508910 SP1 Human neocuproine multiple interactions EXP 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 SP1 Human nickel atom increases activity EXP 6480464 Nickel results in increased activity of SP1 protein CTD PMID:19403854 SP1 Human nickel dichloride multiple interactions EXP 6480464 [nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter] more ... CTD PMID:30055191 and PMID:38050843 SP1 Human nicotine multiple interactions EXP 6480464 Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein] more ... CTD PMID:24089524 SP1 Human nimustine multiple interactions EXP 6480464 [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein CTD PMID:29164620 SP1 Human nimustine decreases response to substance EXP 6480464 SP1 protein results in decreased susceptibility to Nimustine CTD PMID:29164620 SP1 Human NORCANTHARIDIN decreases activity ISO Sp1 (Mus musculus) 6480464 norcantharidin results in decreased activity of SP1 protein CTD PMID:19616522 SP1 Human NORCANTHARIDIN multiple interactions ISO Sp1 (Mus musculus) 6480464 SP1 protein affects the reaction [norcantharidin results in decreased expression of MMP9 mRNA] CTD PMID:19616522 SP1 Human olomoucine increases expression EXP 6480464 olomoucine results in increased expression of SP1 mRNA and olomoucine results in increased expression of SP1 protein CTD PMID:14653808 SP1 Human oxaliplatin multiple interactions EXP 6480464 oxaliplatin inhibits the reaction [SP1 protein binds to DUT promoter] CTD PMID:19015155 SP1 Human ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of SP1 mRNA CTD PMID:35430440 SP1 Human p-tert-Amylphenol multiple interactions ISO Sp1 (Mus musculus) 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 SP1 Human palbociclib multiple interactions EXP 6480464 palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]] and palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 SP1 Human paracetamol affects expression ISO Sp1 (Mus musculus) 6480464 Acetaminophen affects the expression of SP1 mRNA CTD PMID:17562736 SP1 Human PD 168393 multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 PD168393 inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]] and PD168393 inhibits the reaction [AGT protein results in increased expression of SP1 mRNA] CTD PMID:25398788 SP1 Human pentachlorophenol increases expression ISO Sp1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of SP1 mRNA CTD PMID:23892564 SP1 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Sp1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of SP1 mRNA CTD PMID:36331819 SP1 Human phenobarbital affects expression ISO Sp1 (Mus musculus) 6480464 Phenobarbital affects the expression of SP1 mRNA CTD PMID:23091169 SP1 Human phenobarbital decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Phenobarbital results in decreased expression of SP1 mRNA CTD PMID:30047161 SP1 Human phenylephrine multiple interactions ISO Sp1 (Mus musculus) 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA and EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 SP1 Human PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of SP1 protein CTD PMID:22307971 SP1 Human phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein more ... CTD PMID:10669635 more ... SP1 Human phorbol 13-acetate 12-myristate increases expression ISO Sp1 (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of SP1 mRNA CTD PMID:27351882 SP1 Human phorbol 13-acetate 12-myristate increases activity EXP 6480464 Tetradecanoylphorbol Acetate results in increased activity of SP1 protein CTD PMID:15978937 SP1 Human platycodin D multiple interactions EXP 6480464 platycodin D results in decreased expression of and results in decreased activity of SP1 protein CTD PMID:18093727 SP1 Human promegestone increases expression EXP 6480464 Promegestone results in increased expression of SP1 mRNA and Promegestone results in increased expression of SP1 protein CTD PMID:16807381 SP1 Human promegestone multiple interactions EXP 6480464 mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]] and Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter] CTD PMID:16807381 SP1 Human propiconazole decreases expression ISO Sp1 (Mus musculus) 6480464 propiconazole results in decreased expression of SP1 mRNA CTD PMID:21278054 SP1 Human protein kinase inhibitor multiple interactions EXP 6480464 Protein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 SP1 Human pterostilbene multiple interactions EXP 6480464 SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein] CTD PMID:18852136 SP1 Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of SP1 protein CTD PMID:18377872 SP1 Human quercetin multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]] more ... CTD PMID:15661808 more ... SP1 Human quercetin multiple interactions ISO Sp1 (Mus musculus) 6480464 MAPK14 protein promotes the reaction [Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]] more ... CTD PMID:22711909 SP1 Human quercetin increases activity EXP 6480464 Quercetin results in increased activity of SP1 protein CTD PMID:18980244 SP1 Human quercetin 3-O-beta-D-galactopyranoside multiple interactions EXP 6480464 [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA] more ... CTD PMID:24173369 SP1 Human quinacrine multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein] more ... CTD PMID:28867437 SP1 Human resveratrol multiple interactions EXP 6480464 [Resveratrol co-treated with Clofarabine] affects the localization of SP1 protein more ... CTD PMID:16614140 more ... SP1 Human resveratrol decreases acetylation EXP 6480464 resveratrol results in decreased acetylation of SP1 protein CTD PMID:25875864 SP1 Human resveratrol decreases expression ISO Sp1 (Mus musculus) 6480464 resveratrol results in decreased expression of SP1 protein CTD PMID:25505154 SP1 Human resveratrol decreases expression ISO Sp1 (Rattus norvegicus) 6480464 resveratrol results in decreased expression of SP1 mRNA CTD PMID:25905778 SP1 Human resveratrol affects localization EXP 6480464 resveratrol affects the localization of SP1 protein CTD PMID:23437203 SP1 Human resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of SP1 protein CTD PMID:23437203 SP1 Human resveratrol decreases activity ISO Sp1 (Rattus norvegicus) 6480464 resveratrol results in decreased activity of SP1 protein CTD PMID:18420994 SP1 Human resveratrol increases activity EXP 6480464 resveratrol results in increased activity of SP1 protein CTD PMID:17049495 SP1 Human S-adenosyl-L-homocysteine multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 SP1 Human S-adenosyl-L-methioninate multiple interactions ISO Sp1 (Mus musculus) 6480464 S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] CTD PMID:15983038 SP1 Human S-adenosyl-L-methioninate multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] and S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] CTD PMID:15983038 SP1 Human S-adenosyl-L-methionine multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] and S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] CTD PMID:15983038 SP1 Human S-adenosyl-L-methionine multiple interactions ISO Sp1 (Mus musculus) 6480464 S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] CTD PMID:15983038 SP1 Human S-butyl-DL-homocysteine (S,R)-sulfoximine increases activity EXP 6480464 Buthionine Sulfoximine results in increased activity of SP1 protein CTD PMID:11261509 SP1 Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein] CTD PMID:11261509 SP1 Human S-nitrosoglutathione increases activity EXP 6480464 S-Nitrosoglutathione results in increased activity of SP1 protein CTD PMID:14766015 SP1 Human SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]] CTD PMID:17108117 SP1 Human SCH772984 multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein] and SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA] CTD PMID:31585129 SP1 Human selenium atom multiple interactions EXP 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] and [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein] CTD PMID:35384129 SP1 Human selenium atom multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 SP1 Human silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SP1 mRNA CTD PMID:25351596 SP1 Human silver atom decreases expression EXP 6480464 Silver results in decreased expression of SP1 mRNA CTD PMID:26551752 SP1 Human silver(0) decreases expression EXP 6480464 Silver results in decreased expression of SP1 mRNA CTD PMID:26551752 SP1 Human silver(1+) nitrate increases expression EXP 6480464 Silver Nitrate results in increased expression of SP1 mRNA CTD PMID:24132751 SP1 Human simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter] CTD PMID:16575855 SP1 Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SP1 mRNA and sodium arsenite results in increased expression of SP1 protein CTD PMID:23562784 and PMID:31170415 SP1 Human sodium arsenite multiple interactions ISO Sp1 (Mus musculus) 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein and [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 SP1 Human sodium arsenite multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SP1 mRNA more ... CTD PMID:33360347 and PMID:36669534 SP1 Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SP1 mRNA and sodium arsenite results in decreased expression of SP1 protein CTD PMID:33360347 SP1 Human sodium arsenite multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] CTD PMID:33360347 SP1 Human sodium arsenite decreases expression ISO Sp1 (Rattus norvegicus) 6480464 sodium arsenite results in decreased expression of SP1 mRNA and sodium arsenite results in decreased expression of SP1 protein CTD PMID:33360347 SP1 Human sodium chloride multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 SP1 Human sodium dichromate increases activity EXP 6480464 sodium bichromate results in increased activity of SP1 protein CTD PMID:10411148 SP1 Human T-2 toxin multiple interactions EXP 6480464 T-2 Toxin promotes the reaction [SP1 protein binds to CYP1A1 promoter] CTD PMID:31470059 SP1 Human tamoxifen multiple interactions EXP 6480464 Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA] more ... CTD PMID:20211987 and PMID:20215421 SP1 Human tamoxifen multiple interactions ISO Sp1 (Mus musculus) 6480464 Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA] CTD PMID:20150657 SP1 Human temozolomide multiple interactions EXP 6480464 Temozolomide promotes the reaction [TP53 protein binds to SP1 protein] CTD PMID:29164620 SP1 Human terameprocol multiple interactions EXP 6480464 terameprocol inhibits the reaction [SP1 protein results in increased expression of ABCB1 mRNA] CTD PMID:16544145 SP1 Human terameprocol decreases activity EXP 6480464 terameprocol results in decreased activity of SP1 protein CTD PMID:16544145 SP1 Human tetrachloroethene increases expression ISO Sp1 (Mus musculus) 6480464 Tetrachloroethylene results in increased expression of SP1 mRNA CTD PMID:28973375 SP1 Human tetrathiomolybdate(2-) multiple interactions EXP 6480464 [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein more ... CTD PMID:22172574 SP1 Human tetrathiomolybdate(2-) increases expression EXP 6480464 tetrathiomolybdate results in increased expression of SP1 and tetrathiomolybdate results in increased expression of SP1 mRNA CTD PMID:22172574 and PMID:22914438 SP1 Human tetrathiomolybdate(2-) increases activity EXP 6480464 tetrathiomolybdate results in increased activity of SP1 protein CTD PMID:22172574 SP1 Human thalidomide decreases activity EXP 6480464 Thalidomide results in decreased activity of SP1 protein CTD PMID:10533722 SP1 Human thapsigargin decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Thapsigargin results in decreased expression of SP1 mRNA CTD PMID:25398788 SP1 Human Theaflavin 3,3'-digallate multiple interactions EXP 6480464 theaflavin-3 and 3'-digallate inhibits the reaction [EGF protein results in increased activity of SP1 protein] CTD PMID:12931129 SP1 Human Tiron multiple interactions ISO Sp1 (Mus musculus) 6480464 SP1 protein affects the reaction [1 more ... CTD PMID:11163763 SP1 Human titanium dioxide affects methylation ISO Sp1 (Mus musculus) 6480464 titanium dioxide affects the methylation of SP1 promoter CTD PMID:35295148 SP1 Human tolfenamic acid multiple interactions EXP 6480464 tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 SP1 Human trichloroethene increases expression ISO Sp1 (Mus musculus) 6480464 Trichloroethylene results in increased expression of SP1 mRNA CTD PMID:21135412 SP1 Human trichostatin A multiple interactions EXP 6480464 [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA more ... CTD PMID:16740727 more ... SP1 Human trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of SP1 mRNA and trichostatin A affects the expression of SP1 protein CTD PMID:18801729 SP1 Human trichostatin A increases activity EXP 6480464 trichostatin A results in increased activity of SP1 protein CTD PMID:16757381 SP1 Human Triptolide increases expression ISO Sp1 (Mus musculus) 6480464 triptolide results in increased expression of SP1 mRNA CTD PMID:32835833 SP1 Human Triptolide decreases expression ISO Sp1 (Mus musculus) 6480464 triptolide results in decreased expression of SP1 protein CTD PMID:34087332 SP1 Human triptonide decreases expression ISO Sp1 (Mus musculus) 6480464 triptonide results in decreased expression of SP1 mRNA CTD PMID:33045310 SP1 Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of SP1 protein CTD PMID:15908479 and PMID:17409431 SP1 Human troglitazone decreases expression ISO Sp1 (Mus musculus) 6480464 troglitazone results in decreased expression of SP1 mRNA CTD PMID:28973697 SP1 Human troglitazone multiple interactions EXP 6480464 [troglitazone results in increased degradation of SP1 protein] which results in decreased expression of AR mRNA CTD PMID:17409431 SP1 Human troglitazone increases degradation EXP 6480464 troglitazone results in increased degradation of SP1 protein CTD PMID:17409431 SP1 Human tunicamycin decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Tunicamycin results in decreased expression of SP1 mRNA CTD PMID:25398788 SP1 Human tyrphostin AG 1478 multiple interactions ISO Sp1 (Rattus norvegicus) 6480464 RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]] and RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA] CTD PMID:25398788 SP1 Human urethane decreases expression EXP 6480464 Urethane results in decreased expression of SP1 mRNA CTD PMID:28818685 SP1 Human valproic acid multiple interactions EXP 6480464 Valproic Acid promotes the reaction [SP1 protein binds to XPC promoter] CTD PMID:21507255 SP1 Human valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SP1 mRNA CTD PMID:23179753 and PMID:28001369 SP1 Human valproic acid decreases expression ISO Sp1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of SP1 mRNA CTD PMID:21427059 SP1 Human venetoclax multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression of SP1 protein] more ... CTD PMID:35561756 SP1 Human vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of SP1 mRNA CTD PMID:23649840 SP1 Human vorinostat multiple interactions EXP 6480464 SP1 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA] CTD PMID:11126357 SP1 Human wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] CTD PMID:17441964 SP1 Human wortmannin decreases reaction ISO Sp1 (Rattus norvegicus) 152177689 wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus RGD SP1 Human zinc acetate increases expression EXP 6480464 Zinc Acetate results in increased expression of SP1 mRNA CTD PMID:24132751 SP1 Human zinc atom multiple interactions EXP 6480464 Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter] more ... CTD PMID:20073493 SP1 Human zinc atom decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of SP1 protein CTD PMID:21893222 SP1 Human zinc atom multiple interactions ISO Sp1 (Mus musculus) 6480464 Zinc promotes the reaction [MTF1 protein binds to SP1 protein] and Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]] CTD PMID:18458062 SP1 Human zinc atom increases activity EXP 6480464 Zinc deficiency results in increased activity of SP1 protein CTD PMID:18356318 SP1 Human zinc atom affects binding EXP 6480464 SP1 protein binds to Zinc CTD PMID:20073493 SP1 Human zinc dichloride multiple interactions ISO Sp1 (Mus musculus) 6480464 zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]] CTD PMID:20060848 SP1 Human zinc dichloride increases activity EXP 6480464 zinc chloride results in increased activity of SP1 protein CTD PMID:9330853 SP1 Human zinc sulfate multiple interactions EXP 6480464 Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein] CTD PMID:26241054 SP1 Human zinc(0) multiple interactions EXP 6480464 Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter] more ... CTD PMID:20073493 SP1 Human zinc(0) affects binding EXP 6480464 SP1 protein binds to Zinc CTD PMID:20073493 SP1 Human zinc(0) increases activity EXP 6480464 Zinc deficiency results in increased activity of SP1 protein CTD PMID:18356318 SP1 Human zinc(0) multiple interactions ISO Sp1 (Mus musculus) 6480464 Zinc promotes the reaction [MTF1 protein binds to SP1 protein] and Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]] CTD PMID:18458062 SP1 Human zinc(0) decreases expression ISO Sp1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of SP1 protein CTD PMID:21893222 SP1 Human zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of SP1 mRNA CTD PMID:20977926
