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Gene: SP1 (Sp1 transcription factor) Canis lupus familiaris

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Symbol:

SP1

Name:

Sp1 transcription factor

RGD ID:

12296991

Description:

ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); cellular response to insulin stimulus (ortholog); cellular response to wortmannin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Carotid Artery Injuries (ortholog); Colorectal Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN protein-DNA complex (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; bisphenol A; sodium chloride

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transcription factor Sp1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SP1 (Sp1 transcription factor)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Sp1 (trans-acting transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sp1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sp1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SP1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sp1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SP1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SP1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sp1 (Sp1 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,802,587 - 1,861,187 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,805,184 - 1,847,226 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,404,740 - 44,448,820 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,804,038 - 1,848,490 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,804,038 - 1,848,385 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,823,470 - 1,867,184 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,807,708 - 1,852,315 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,805,663 - 44,849,851 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Carotid Artery Injuries (ISO)

Colorectal Neoplasms (ISO)

Disease Progression (ISO)

hyperglycemia (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Neoplastic Cell Transformation (ISO)

Neurodevelopmental Disorders (ISO)

Plaque, Atherosclerotic (ISO)

Skin Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

anthra[1,9-cd]pyrazol-6(2H)-one (EXP)

bisphenol A (EXP)

sodium chloride (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to estrogen stimulus (ISO)

cellular response to insulin stimulus (ISO)

cellular response to wortmannin (ISO)

cellular response to zinc ion starvation (ISO)

definitive hemopoiesis (ISO)

embryonic camera-type eye morphogenesis (ISO)

embryonic placenta development (ISO)

embryonic process involved in female pregnancy (ISO)

embryonic skeletal system development (ISO)

enucleate erythrocyte differentiation (ISO)

in utero embryonic development (ISO)

liver development (ISO)

lung development (ISO)

megakaryocyte differentiation (ISO)

mRNA transcription by RNA polymerase II (ISO)

myeloid progenitor cell differentiation (ISO)

ossification (ISO)

positive regulation by host of viral transcription (IEA)

positive regulation of amyloid-beta formation (IEA)

positive regulation of angiogenesis (IEA)

positive regulation of apoptotic signaling pathway (IEA)

positive regulation of blood vessel endothelial cell migration (IEA)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of gene expression (IEA)

positive regulation of hydrogen sulfide biosynthetic process (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of vascular endothelial cell proliferation (IEA)

regulation of DNA-templated transcription (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to hydroperoxide (ISO)

trophectodermal cell differentiation (ISO)

Cellular Component

chromatin (IEA)

euchromatin (IEA)

nucleoplasm (IEA)

nucleus (IEA)

protein-DNA complex (ISO)

transcription repressor complex (IEA)

Molecular Function

bHLH transcription factor binding (ISO)

cis-regulatory region sequence-specific DNA binding (ISO)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

double-stranded DNA binding (IEA,ISO)

histone acetyltransferase binding (ISO)

histone deacetylase binding (IEA)

identical protein binding (IEA)

molecular adaptor activity (ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (IEA)

transcription coregulator binding (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

hypoxia inducible factor pathway (ISO)

interleukin-4 signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

References

Additional References at PubMed

PMID:15485816	PMID:19064501	PMID:23816505	PMID:30032202

Genomics

Comparative Map Data

SP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,802,587 - 1,861,187 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,805,184 - 1,847,226 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,404,740 - 44,448,820 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,804,038 - 1,848,490 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,804,038 - 1,848,385 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,823,470 - 1,867,184 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,807,708 - 1,852,315 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,805,663 - 44,849,851 (+)	NCBI		UU_Cfam_GSD_1.0

SP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	53,380,176 - 53,416,446 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	53,380,176 - 53,416,446 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	53,773,960 - 53,810,230 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	52,060,246 - 52,096,497 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	52,060,245 - 52,096,491	NCBI
Celera	12	53,423,138 - 53,460,427 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	50,814,656 - 50,850,614 (+)	NCBI		HuRef
CHM1_1	12	53,741,140 - 53,777,425 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,346,223 - 53,382,489 (+)	NCBI		T2T-CHM13v2.0

Sp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	102,314,751 - 102,344,839 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	102,314,578 - 102,344,839 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	102,406,316 - 102,436,404 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	102,406,143 - 102,436,404 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	102,236,747 - 102,266,835 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,234,362 - 102,260,713 (+)	NCBI		MGSCv36	mm8
Celera	15	104,563,277 - 104,594,207 (+)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	57.55	NCBI

Sp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,419,864 - 135,450,513 (+)	NCBI		GRCr8
mRatBN7.2	7	133,541,302 - 133,571,961 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	133,541,491 - 133,571,961 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	135,298,300 - 135,327,653 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	137,527,694 - 137,557,048 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	137,513,816 - 137,543,172 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,014,173 - 144,044,635 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,014,173 - 144,044,629 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	141,805,281 - 141,836,504 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	141,164,180 - 141,194,509 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	141,240,616 - 141,265,690 (+)	NCBI
Celera	7	129,968,890 - 129,999,257 (+)	NCBI		Celera
RH 3.4 Map	7	1062.1	RGD
Cytogenetic Map	7	q36	NCBI

Sp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	644,378 - 677,441 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	644,435 - 677,360 (+)	NCBI	ChiLan1.0	ChiLan1.0

SP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	40,770,223 - 40,809,774 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	40,766,986 - 40,806,525 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	35,338,492 - 35,374,462 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	36,122,583 - 36,158,356 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	36,127,681 - 36,158,356 (-)	Ensembl	panpan1.1		panPan2

Sp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	62,467,059 - 62,509,967 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	10,655,349 - 10,693,042 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	10,655,116 - 10,693,025 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	18,588,758 - 18,630,089 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	18,588,763 - 18,633,177 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	19,024,941 - 19,070,820 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	49,484,459 - 49,516,941 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	49,484,518 - 49,512,541 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	196,540,987 - 196,574,325 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624904	1,475,664 - 1,507,588 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SP1
575 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005636771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014108420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022411220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038438059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038438060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038460159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038512761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038577785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038577786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000011152 ⟹ ENSCAFP00000010330

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	27	1,805,184 - 1,847,226 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845034689 ⟹ ENSCAFP00845027169

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	27	1,804,038 - 1,848,385 (-)	Ensembl

RefSeq Acc Id:

XM_014108420 ⟹ XP_013963895

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	27	1,802,587 - 1,846,928 (-)	NCBI
Dog10K_Boxer_Tasha	27	44,405,331 - 44,448,820 (+)	NCBI

Sequence:

show sequence

CTTTCCTTCCAGGGCCCGCCCTCTGTCCGCCCCGAAACCTCCAGATTCGTAACCCCTGGACCCC
GTAGCCCCTTAGCCGTATCCACAAATGTTTCCCCACTCACACTTTTTTGTTTTTTCTTTCCCCT
TTGCCCCTCTTCTCCTCGTGCTGCTTTTTACCCTTGAGTTTTTCTCTTTCTCTATATTCTTTGA
CCCTAATTTTAGCAAGCTTTCCATCCACCCACATGTTGTTCTTTGCCTTACCTATCCCTCTCCT
TTTTATCCCCAGGATACTTTTTTTTATTTTGAAACTCTTTGAACATGTCCATCGCCCCTCACAT
TTCCTATACGAAAAGTACATTTTTAATGTTTCCTGGGTGTAATTTTGTGCCAGGGAAGAATTGA
GGCCCAGTTTCAGCACTGCTAAGCCAAACCAAGATCACTCCATGGATGAAATGACAGCCGTGGT
GAAGATTGAAAAAGGAGTTGGTGGCAATAATGGGGGCAACGGTAATGGTGGTGGTGCCTTTTCT
CAGGCTCGAAGCAGCAGCACAGGCAGTAGCAGCAGTGGAGGAGGAGGGCAGGAATCCCAGCCAT
CCCCTCTGGCTCTGCTGGCAGCAACTTGCAGCAGAATTGAGTCACCCAATGAAAACAGCAACAA
CTCCCAAGGCCCAAGCCAGTCAGGGGGTACAGGTGAGCTTGACCTCACAGCCACACAGCTCTCA
CAGGGTGCCAATGGCTGGCAGATCATCTCTTCCTCCTCTGGGGCTACCCCTACCTCAAAGGAAC
AGAGTGGCAGCAGTACCAATGGCAGCAATGGCAGTGAGTCTTCCAAGAATCGTGCGGTCTCTGG
TGGGCAGTATGTTGTGGCCGCCACCTCCAATTTACAGAACCAGCAAGTCCTGACAGGATTACCT
GGAGTGATGCCTAATATTCAGTATCAAGTAATCCCACAGTTCCAGACCGTTGATGGGCAACAGC
TGCAGTTCGCTGCCACTGGGGCCCAAGTGCAGCAGGATGGTTCTGGTCAAATACAGATCATACC
AGGTGCAAACCAACAGATCATCACAAATCGAGGAAGTGGAGGCAACATCATTGCTGCTATGCCA
AACCTACTCCAGCAGGCTGTCCCCCTCCAAGGCCTGACTAATAACGTACTCTCAGGACAGACTC
AGTATGTGACCAATGTACCAGTGGCCCTGAACGGGAATATCACCTTGCTACCTGTCAACAGCGT
TTCTGCAGCTACCTTGACTCCTAGCTCTCAGGCAGTCACTATCAGCAGCTCTGGGTCCCAGGAG
AGTGGCTCACAGCCCTCCACCTCAGGGACTGCCATCAGTTCTGCCAGTTTGGTATCATCACAAG
CCAGTTCCAGCTCCTTTTTCACCAATGCCAATAGCTACTCAACAACTACTACCACCAGCAACAT
GGGAATTATGAACTTCACCACCAGCGGATCAGCAGGGACCAACTCTCAAGGGCAGACACCCCAG
AGGGTCAGTGGGCTACAGGGGTCTGATGCTCTAAACATTCAGCAGAACCAGACATCTGGAGGCT
CTCTGCAAGCAAGTCAGCAAAAAGAGGGAGAGCAAAACCAGCAGACACAGCAACAGCAACAAAT
TCTTATCCAGCCTCAGCTAGTTCAAGGGGGACAGGCTCTCCAGGCCCTCCAAGCAGCACCATTG
TCAGGGCAGACCTTTACAACCCAAGCTATCTCCCAGGAAACCCTCCAGAATCTCCAGCTTCAGG
CTGTTCCAAACTCCGGCCCCATCATCATCCGGACACCAACAGTGGGGCCCAATGGACAGGTCAG
TTGGCAGACTCTTCAGCTGCAGAATCTCCAAGTTCAGAACCCGCAGGCCCAGACAATCACCTTG
GCCCCAATGCAGGGTGTCTCCTTGGGGCAGACCAGCAGCAGCAATACCACCCTTACACCCATTG
CCTCAGCTGCCTCCATCCCTACCGGCACAGTCACTGTGAATGCTGCTCAGCTCTCCTCCATGCC
TGGCCTCCAGACCATTAACCTCAGTGCATTGGGTGCTTCAGGAATCCAGGTGCACCAGCTTCCA
AGCCTGCCACTGGCTATAGCAAATGCCCCAGGTGATCATGGAGCTCAGCTTGGCCTTCATGGAG
CTGGTGGTGATGGAATACATGATGACACAGCAGGTGGAGAAGAAGGGGAAAACAGCCCAGATCC
CCAGCCCCAAGCTGGTCGGAGGACTAGGCGGGAAGCATGCACCTGCCCCTACTGTAAAGACAGT
GAAGGAAGAGGCTCTGGGGATCCCGGCAAAAAGAAACAGCACATTTGCCACATCCAAGGGTGTG
GCAAAGTATATGGCAAGACCTCACACCTACGGGCACACTTGCGTTGGCATACAGGCGAGAGGCC
ATTCATGTGTACCTGGTCATACTGTGGGAAACGCTTTACACGTTCGGATGAACTACAAAGACAC
AAACGCACACATACAGGTGAGAAGAAATTTGCCTGCCCTGAGTGTCCCAAGCGCTTCATGAGGA
GTGACCACCTGTCAAAGCATATCAAGACCCACCAGAATAAGAAGGGAGGTCCAGGTGTATCCCT
GAGTGTGGGCACTTTGCCCCTGGACAGTGGGGCAGGTTCAGAAGGCAGCGGCACTGCTACCCCT
TCAGCCCTTATTACCACCAATATGGTAGCCATGGAGGCCATCTGTCCAGAGGGTATTGCCCGTC
TTGCCAACAGTGGCATCAACGTCATGCAGGTGGCAGATCTGCAGTCCATTAATATCAGTGGCAA
TGGCTTCTGAGATCAGGCACCCGGGGCCAGAGACATATGGGCCATACCCATCAACCCTGGGATA
CAAGGTAGCATGGGTCCAAGAGACATGTGGGAGAGAGAGCCATGAGGCATTAAAATGCATGGTG
GTGGGAAGAATTGGGGGAGGGATACAAGAGATGGGGTCCTGGCATCCATCTATTATCATCAGTA
CCTCCTGAAGTGAGAAACGTTATTGAAAATTCTGTTGGTGCCACCCTTTATGAGCATTTGTTTG
ACCCCACACAGTTTCTTACACTTCTTTCCCCAGCTTTCCCTTCTTGCATTTCCCTTCTCAGCTC
CCCCATGATGGATCCCCCCTTTCCTAAAGCCATCATGCCTTGATAAATATATATGATCATTGAA
ATACTTTTTAACAAAAAAAAAACCAGATTCTATATTATATATATATATATATATATATATATAT
AAAAGATATATAGAGATGCATTTGCAGGGGTTGGCTGGGAGGAGGAAGGAGACCATTCTGTGAC
CAAAAATACCTTGGTCATTTTTTTATATTGCCTTATTTCCCTATGGCTGAGCCTTGTTGTGACA
CATCAAGCTTTTCTATAGATGTTGTCTTGGCTTCCCACCAGATTAAGCGTTCATATGCTCTGCT
TTTAGTTTATATATACATACATAATGTTTTTTCTTAATTTTGTCTTTTTATTTGGGATCAGCTT
CTTGTACTCTTTTCTTGACTCAACCTTTCTGTCTCCCTTTCTCTCACCTGATCACTTCATGTTT
TGGTTTTGATAATGATCCCTGGATGAGGCACTTCTGTCAATCTTTTAAGGTCCTTGGTCCTAGC
AGCAGAGTGGAGAGAGCCTTGAAGCCCAGGCTGATGCTTGAGTTAGCTGTGGAGAGAGTGTTCA
AAATACTACTGACGCAGGCACCCTCTTGGCGCTGGAGAGTCCAAGGCACCTCTCCTCATTAGCT
GCTCTAAGCATCAAGAGTCAGACGTCTTTCTATGGAATTGTACAAAAGACCCTTTAAAGGTTAT
ATAATCTGGGATCAGTTTGTATAAATTGTCAAAAATGGTCAAGTAAAAGCTAGGGGCTTTCAAT
AGGAAAATGATGTGCTCAGAAGTGGAAGTGACTCAGAGTAGTCCAGTTCAGGAGTTAGTAGAGT
ATTTGGACATTTGTACAGCTGTCTTCCAAAGTAGCTCTGAGCTTTGGTGTATGGGTTTCTGAGG
TCATATTCTGAAAGGAAATGCACTTCCTCTTTTGAACATCCCCAGTAGTTTCTTTCTCATGTTA
TTAAGGAACATCAGCCAATGAATCTGTTCGGGTTTCCATTCCGCAGAACTCCAGAGCATGTACT
AGTGGCAAGGCAGAGGTTCTTTGACCTTTTCCCTTAACTCTTCCTTGGGTGGTTCCTGAGGGAA
AAGGAAGCACACGATCATGGGAGTGATAGCCCAGAACAAAAAGAAATCTTGTCTTACCACTGTG
GTTTATAAGAGAGATCGGGAGACACCATCCTGCTTTCTCCATGGCCTGATTCCTGAAGAGACTG
ATCCAAAAATTATAGCGGCAGGGAACTCTTAGTGCATTTGGCACTGAGATTTAAATGCAACCAG
AGTTGTCCTCAAGGCCCAGCCATTAAAACGTTGTCTCTCTTGACCTTCTGGTATCCTGTCAGAG
AGCTTTTCACTGTGAGGAAGTGTGGAAATGGCTGTGTGTATGTGTGTAACCTGTTAGGTTGGGG
ATAGGTTTTCTGTTAGCCTATACTAAAAAGAGACCTGCAATAAAAAATTGCCCTGATCTGATAG
AAAATGAAGTGTTTGTGTATGACTGTGTGTGAGTGTGTGTTTGTGCCTGTATATATCTACACAC
AGATGAGAAATTATATTTGAAATTGTTGGAAAATAAATCAAATTCAGCTCAAAATGCCTTTCAG
GCCCATTACCTAGAAATCTGTCTTTAAACCTGGGTATGTTCCTGAGGTCATTTCTTTGCTTATG
CTAAATTAGTTACAATTAATGATGGGGGATATTCTACTGCACTTTTGAAGAAGAAACTATTTTT
GTGTTTGAAAGTGAAACCAACATCCAGAACTATACCAGAGTCCTAGTTTCTTTCATAAGTCTTT
TTACCTTGACTACAAATAGATGATGCTATGATTCTACTATATATTTTATACCAAATCTATTCAA
ATTAGGGTCTGGGTAAGTTTGTGTTGTTGTTTAACCTGAAATACAATAACTGTTAATATTCTAA
ACAGTAGTTCGCTCCATTTGGTCCTTTCTCTGCAGACTTTAACACGCTCAGGAATTATTTTGAG
GAACTTTCCCCAGATCAAATTAATATTGAAATAAAAATCATCCATGCCCAGCCACCTATCACAC
ACCCTTTATTCCCACTGAAAGGCAGAACTCAGAACCTGTTATTTTATGTCTGTAATCATGTACA
TGTAGGCATCTTTTGGAAGAAAGGGGCAGGATAACTCACCATAGCGTGTAGTATTTTGCTAGAG
AATTTCGAGGAATGGAATCTTCCCCAGTATGAAATTATTTGATATAAACCAGCTTAATGATGCT
GAGGACTACAGGTGTTTAGAAGGTTATCTCATGATGATTTTGTCTAGGTTGGAATGCTGGTTTA
CCCTCGACCCTCCATTAACATTGCTATAAGTGAATTCATAATCCGTTCTTTCCACTTACCCTCT
TTCCTTATCACCAAGGAAGCTCCAGATCCAGTATCTTGTTTGGCCCCCAAACTGAAGCAGCTTC
TGCTCTTGTCTCCCAGCAGCAGTGAGCCGCTCAGTCTTTTCCACAGGGAGTTAGGAGCCTACAT
TCCTTGAGTCATGAGCTTATTGCTGAAAATCCCTTTCCCTGAACATTTTGGCCAGCAGAAATTA
ATGTAACTGACAGGCATATTGATTCTAACATTTTTTTCATGAGTTGCTTTTTTATTTAAATTTT
TTAAATGACCAAACCTGTGGGGCAGGGGATGCCCAGAGGAGTGGTAATATTAAAGCACTCATTC
CCTTGCCCTTTCAGGTTGCCTATTCACATTCATCTGCGTGCCATTTGACTGTCTCACTTTTAAC
CCAGAGCAGTAACAACCCACACCATTTTCCTTCAGGGACCTCCCAGCTGGCACCCTGTTTGTGG
GTGCTATGCAGAATGCAATTTAATGGATATTTCTCAGCCTGATTCAGAATAAATAGAACCCTTG
ATCCCAGAAAGTATAGACTGAAGTGTGGGGTAAAGATTATGATTGGGGGAGGGTTAGAGACAAA
AGCTGTAAATTACTATGGCTGATTGATTTATTTCTACTATATACATATATATATATATTTTTTG
CTTTTGTATATCCTATATAGGAAACTAAGCATTGTATTTTTTTAACAAATCTGAGAAAGCACTA
TGAACTGCAGATGTTTGACTTTCAGAATATATTTTGTATTGTTAATATCTTCACAATGTGTGAA
TACTGGAAGCTGCAGATCTTTGCTAGGACGCAATAAATTTATATACTTTGTGAGGGGTTCTTCT
GGGGGTATTAATCAGGCCCCTGTTATGCTTTGGGGGAGCCCTGGTGCTACTCGCTTAGAGTTTT
CATTCAATTTTAAGTACCCTGATGCCTTTTGGACCTTGGGATCAAAGCAAACAATTTTTGGAGA
TCCCGGTACCAAGGAAATGTGGATAGTCTAGCTGCCTCAAGTGAGGGACCCTTAGCATAGCTCT
CCTTCCCCCTATTCAAAGCTGGGTAGCCTCTTGGGGTGGGGAAGAGAAATGTGAAATCTCAGAG
TTTCATCTCCCTTAGAAGAGAGCCAGTAACTTATATGCAAGGATGAAAGGTGGCAGCAGTAGTT
TTGGGGAAAGGGAGGAGGATATGGCACTCCTCCAATCCCGGAAAGCATTGCTTTTGAAACTGCT
GATAAAACATGGGCAGGTTATTACTTTTGTTTTGGAGCCTGTGTTCTCTCTGGTGCCTCTCTTG
GCTCTCCTCCTGGGGTACAGACCTCTTCTAGGAGGATGAGCAGACCAGCTTTGAGGTTGACCTG
TTTCTTTTCTTTGTCTGCCTTCCCTAAACACCAGCCCCCAGGAGGATATTAAGCAGCCTTAAGC
TTAAATTCCTACTCCCTCTTCCCAGTTTGGCTCACTTGCCTTAGAGTGAAGGCTAGGAAAGGAA
AAAAAAAGGGGGGGTGGGGATTCCCTAGCTTCATTCCTCCCCTAGATCTTTCCAGTTTGACTTC
CCCAAACCCAGAAAGATTTCCTCTACCACATTCGAGAGAAATGAGTACCTTGTCCCCTTTTCCT
CTTTCCTTATTGTCAAACAGTCCCAGCCTTCCTTGTCCCTTTTAAGTGAGAAGAGGTGTGGTGA
TCTGTCCCTCAACTCCCTTCAGTATCAAAAAAAAAAAAAAAAAAAAG

hide sequence

RefSeq Acc Id:

XM_038438059 ⟹ XP_038293987

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	27	1,804,038 - 1,848,490 (-)	NCBI

RefSeq Acc Id:

XM_038438060 ⟹ XP_038293988

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	27	1,804,038 - 1,847,899 (-)	NCBI

RefSeq Acc Id:

XM_038460159 ⟹ XP_038316087

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	27	44,404,740 - 44,448,820 (+)	NCBI

RefSeq Acc Id:

XM_038512760 ⟹ XP_038368688

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	27	1,823,470 - 1,867,184 (-)	NCBI

RefSeq Acc Id:

XM_038512761 ⟹ XP_038368689

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	27	1,823,470 - 1,866,593 (-)	NCBI

RefSeq Acc Id:

XM_038577785 ⟹ XP_038433713

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	27	44,805,663 - 44,849,851 (+)	NCBI

RefSeq Acc Id:

XM_038577786 ⟹ XP_038433714

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	27	44,806,254 - 44,849,851 (+)	NCBI

RefSeq Acc Id:

XM_038640518 ⟹ XP_038496446

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	27	1,807,708 - 1,852,315 (-)	NCBI

RefSeq Acc Id:

XM_038640519 ⟹ XP_038496447

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	27	1,807,708 - 1,851,724 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013963895	(Get FASTA)	NCBI Sequence Viewer
	XP_038293987	(Get FASTA)	NCBI Sequence Viewer
	XP_038293988	(Get FASTA)	NCBI Sequence Viewer
	XP_038316087	(Get FASTA)	NCBI Sequence Viewer
	XP_038368688	(Get FASTA)	NCBI Sequence Viewer
	XP_038368689	(Get FASTA)	NCBI Sequence Viewer
	XP_038433713	(Get FASTA)	NCBI Sequence Viewer
	XP_038433714	(Get FASTA)	NCBI Sequence Viewer
	XP_038496446	(Get FASTA)	NCBI Sequence Viewer
	XP_038496447	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000010330.5
	ENSCAFP00030040110.1
	ENSCAFP00040034514.1
	ENSCAFP00040034557.1
	ENSCAFP00040034608.1
	ENSCAFP00040034640.1
	ENSCAFP00845027169
	ENSCAFP00845027169.1

RefSeq Acc Id:	XP_013963895 ⟸ XM_014108420
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0L4D2 (UniProtKB/TrEMBL), A0A8I3S186 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSGGGGQESQPSPLALLAATCSRIE SPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSES SKNRAVSGGQYVVAATSNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDG SGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLTNNVLSGQTQYVTNVPVALNGNI TLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPSTSGTAISSASLVSSQASSSSFFTNANSYS TTTTTSNMGIMNFTTSGSAGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQASQQKEGEQNQ QTQQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPT VGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPTGTVTVN AAQLSSMPGLQTINLSALGASGIQVHQLPSLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGE EGENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHL RWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNK KGGPGVSLSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADL QSINISGNGF hide sequence

Ensembl Acc Id:

ENSCAFP00000010330 ⟸ ENSCAFT00000011152

RefSeq Acc Id:	XP_038368688 ⟸ XM_038512760
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038368689 ⟸ XM_038512761
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038496446 ⟸ XM_038640518
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038496447 ⟸ XM_038640519
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038293987 ⟸ XM_038438059
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0PDR8 (UniProtKB/TrEMBL), A0A8P0SC80 (UniProtKB/TrEMBL), A0A8I3S186 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038293988 ⟸ XM_038438060
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0L4D2 (UniProtKB/TrEMBL), A0A8I3S186 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038316087 ⟸ XM_038460159
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0PDR8 (UniProtKB/TrEMBL), A0A8P0SC80 (UniProtKB/TrEMBL), A0A8I3S186 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038433713 ⟸ XM_038577785
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3S186 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038433714 ⟸ XM_038577786
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3S186 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845027169 ⟸ ENSCAFT00845034689

Protein Domains

C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000006950	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030024899	UniProtKB/TrEMBL
	ENSCAFG00040021228	UniProtKB/TrEMBL
	ENSCAFG00845019670	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011152.5	UniProtKB/TrEMBL
	ENSCAFT00030045914.1	UniProtKB/TrEMBL
	ENSCAFT00040039555.1	UniProtKB/TrEMBL
	ENSCAFT00040039605.1	UniProtKB/TrEMBL
	ENSCAFT00040039660.1	UniProtKB/TrEMBL
	ENSCAFT00040039698.1	UniProtKB/TrEMBL
	ENSCAFT00845034689	ENTREZGENE
	ENSCAFT00845034689.1	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
KEGG Report	cfa:486507	UniProtKB/TrEMBL
NCBI Gene	SP1	ENTREZGENE
PANTHER	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR SP1	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A8C0L4D2	ENTREZGENE
	A0A8C0PDR8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TB92_CANLF	UniProtKB/TrEMBL
	A0A8C0TDL9_CANLF	UniProtKB/TrEMBL
	A0A8C0TGU9_CANLF	UniProtKB/TrEMBL
	A0A8I3S186	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SC80	ENTREZGENE
UniProt Secondary	A0A8P0SC80	UniProtKB/TrEMBL
VGNC ID	VGNC:49654	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)