SP1 (Sp1 transcription factor) - Rat Genome Database

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Gene: SP1 (Sp1 transcription factor) Canis lupus familiaris
Analyze
Symbol: SP1
Name: Sp1 transcription factor
RGD ID: 12296991
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); cellular response to insulin stimulus (ortholog); cellular response to wortmannin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Carotid Artery Injuries (ortholog); Colorectal Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN euchromatin (ortholog); protein-DNA complex (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; sodium chloride
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor Sp1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,802,587 - 1,861,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:15485816   PMID:19064501   PMID:23816505   PMID:30032202  


Genomics

Comparative Map Data
SP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,802,587 - 1,861,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBIUU_Cfam_GSD_1.0
SP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,380,176 - 53,416,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,380,176 - 53,416,446 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,773,960 - 53,810,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,060,246 - 52,096,497 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,060,245 - 52,096,491NCBI
Celera1253,423,138 - 53,460,427 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,814,656 - 50,850,614 (+)NCBIHuRef
CHM1_11253,741,140 - 53,777,425 (+)NCBICHM1_1
T2T-CHM13v2.01253,346,223 - 53,382,489 (+)NCBIT2T-CHM13v2.0
Sp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,314,751 - 102,344,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,314,578 - 102,344,839 (+)EnsemblGRCm39 Ensembl
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBIMGSCv36mm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.55NCBI
Sp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
Sp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458644,378 - 677,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458644,435 - 677,360 (+)NCBIChiLan1.0ChiLan1.0
SP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,770,223 - 40,809,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,766,986 - 40,806,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,338,492 - 35,374,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,122,583 - 36,158,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,127,681 - 36,158,356 (-)Ensemblpanpan1.1panPan2
Sp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,467,059 - 62,509,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,655,349 - 10,693,042 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,655,116 - 10,693,025 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,588,758 - 18,630,089 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,588,763 - 18,633,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,024,941 - 19,070,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,484,459 - 49,516,941 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,484,518 - 49,512,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,540,987 - 196,574,325 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,475,664 - 1,507,588 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SP1
575 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 22 6 5 6 6 6 8 10 6
Low 4 1 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005636771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014108420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022411220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038438059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038438060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038460159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038577785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038577786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000011152   ⟹   ENSCAFP00000010330
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034689   ⟹   ENSCAFP00845027169
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)Ensembl
RefSeq Acc Id: XM_014108420   ⟹   XP_013963895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1271,802,587 - 1,846,928 (-)NCBI
Dog10K_Boxer_Tasha2744,405,331 - 44,448,820 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038438059   ⟹   XP_038293987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBI
RefSeq Acc Id: XM_038438060   ⟹   XP_038293988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0271,804,038 - 1,847,899 (-)NCBI
RefSeq Acc Id: XM_038460159   ⟹   XP_038316087
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBI
RefSeq Acc Id: XM_038512760   ⟹   XP_038368688
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBI
RefSeq Acc Id: XM_038512761   ⟹   XP_038368689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1271,823,470 - 1,866,593 (-)NCBI
RefSeq Acc Id: XM_038577785   ⟹   XP_038433713
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBI
RefSeq Acc Id: XM_038577786   ⟹   XP_038433714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02744,806,254 - 44,849,851 (+)NCBI
RefSeq Acc Id: XM_038640518   ⟹   XP_038496446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBI
RefSeq Acc Id: XM_038640519   ⟹   XP_038496447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0271,807,708 - 1,851,724 (-)NCBI
RefSeq Acc Id: XP_013963895   ⟸   XM_014108420
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L4D2 (UniProtKB/TrEMBL),   A0A8I3S186 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010330   ⟸   ENSCAFT00000011152
RefSeq Acc Id: XP_038368688   ⟸   XM_038512760
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038368689   ⟸   XM_038512761
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496446   ⟸   XM_038640518
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038496447   ⟸   XM_038640519
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038293987   ⟸   XM_038438059
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PDR8 (UniProtKB/TrEMBL),   A0A8P0SC80 (UniProtKB/TrEMBL),   A0A8I3S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038293988   ⟸   XM_038438060
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L4D2 (UniProtKB/TrEMBL),   A0A8I3S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316087   ⟸   XM_038460159
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PDR8 (UniProtKB/TrEMBL),   A0A8P0SC80 (UniProtKB/TrEMBL),   A0A8I3S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433713   ⟸   XM_038577785
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433714   ⟸   XM_038577786
- Peptide Label: isoform X2
- UniProtKB: A0A8I3S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845027169   ⟸   ENSCAFT00845034689
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006950 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024899 UniProtKB/TrEMBL
  ENSCAFG00040021228 UniProtKB/TrEMBL
  ENSCAFG00845019670 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011152.5 UniProtKB/TrEMBL
  ENSCAFT00030045914.1 UniProtKB/TrEMBL
  ENSCAFT00040039555.1 UniProtKB/TrEMBL
  ENSCAFT00040039605.1 UniProtKB/TrEMBL
  ENSCAFT00040039660.1 UniProtKB/TrEMBL
  ENSCAFT00040039698.1 UniProtKB/TrEMBL
  ENSCAFT00845034689 ENTREZGENE
  ENSCAFT00845034689.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report cfa:486507 UniProtKB/TrEMBL
NCBI Gene SP1 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SP1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0L4D2 ENTREZGENE
  A0A8C0PDR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TB92_CANLF UniProtKB/TrEMBL
  A0A8C0TDL9_CANLF UniProtKB/TrEMBL
  A0A8C0TGU9_CANLF UniProtKB/TrEMBL
  A0A8I3S186 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SC80 ENTREZGENE
UniProt Secondary A0A8P0SC80 UniProtKB/TrEMBL
VGNC ID VGNC:49654 ENTREZGENE