Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chrnb1 (cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)) Mus musculus
Analyze
Symbol: Chrnb1
Name: cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
RGD ID: 10358
Description: Exhibits acetylcholine binding activity. Contributes to acetylcholine-gated cation-selective channel activity. Involved in regulation of membrane potential. Localizes to acetylcholine-gated channel complex; integral component of postsynaptic specialization membrane; and neuromuscular junction. Is expressed in diaphragm; limb; lung; paraxial mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ac; acetylcholine receptor beta; acetylcholine receptor subunit beta; Achr; AChR beta; Achr-2; Acrb
Orthologs:
Homo sapiens (human) : CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrnb1 (cholinergic receptor nicotinic beta 1 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrnb1 (cholinergic receptor nicotinic beta 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)
Canis lupus familiaris (dog) : CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrnb1 (cholinergic receptor nicotinic beta 1 subunit)
Sus scrofa (pig) : CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)
Heterocephalus glaber (naked mole-rat) : Chrnb1 (cholinergic receptor nicotinic beta 1 subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1169,784,036 - 69,795,943 (-)EnsemblGRCm38mm10GRCm38
GRCm381169,784,036 - 69,795,966 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,597,538 - 69,609,439 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,600,232 - 69,612,138 (-)NCBImm8
MGSCv361170,368,144 - 70,380,050 (-)NCBImm8
Cytogenetic Map11B3NCBI
cM Map1142.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Chrnb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10358
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.