Pdcd4 (programmed cell death 4) - Rat Genome Database

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Gene: Pdcd4 (programmed cell death 4) Mus musculus
Analyze
Symbol: Pdcd4
Name: programmed cell death 4
RGD ID: 732160
MGI Page MGI
Description: Predicted to enable RNA binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; and positive regulation of inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; epithelium; oocyte; and thymus primordium. Orthologous to human PDCD4 (programmed cell death 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D19Ucl; D19Ucla1; MA-; Ma3; programmed cell death protein 4; protein MA-3; T; Tis; topoisomerase-inhibitor suppressed protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,880,662 - 53,926,024 (+)NCBIGRCm39mm39
GRCm39 Ensembl1953,880,662 - 53,918,291 (+)Ensembl
GRCm381953,892,231 - 53,937,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,892,231 - 53,929,860 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,966,721 - 54,004,351 (+)NCBIGRCm37mm9NCBIm37
MGSCv361953,956,779 - 53,983,162 (+)NCBImm8
Celera1956,087,143 - 56,124,829 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(-)-citrinin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
corosolic acid  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenhexamid  (ISO)
fenthion  (EXP)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fludioxonil  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
LY294002  (ISO)
maslinic acid  (EXP)
mechlorethamine  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
succimer  (EXP)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tolbutamide  (ISO)
topotecan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
Tungsten carbide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
wortmannin  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. Jiao J, etal., J Int Med Res. 2015 Oct;43(5):672-8. doi: 10.1177/0300060515583707. Epub 2015 Jul 6.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
4. An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease. Liu X, etal., Am J Physiol Cell Physiol. 2010 Jun;298(6):C1481-8. doi: 10.1152/ajpcell.00413.2009. Epub 2010 Mar 31.
5. Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability. Lü Y, etal., Oncol Lett. 2018 Apr;15(4):5971-5976. doi: 10.3892/ol.2018.7997. Epub 2018 Feb 8.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
Additional References at PubMed
PMID:8543179   PMID:8661734   PMID:8827514   PMID:8912629   PMID:9434961   PMID:9714845   PMID:9771644   PMID:10349636   PMID:10570194   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:12242666   PMID:12477932   PMID:12482958   PMID:12802278   PMID:12894233   PMID:14610273   PMID:15334056   PMID:15489334   PMID:16024603   PMID:16141072   PMID:16141073   PMID:16357133  
PMID:16602821   PMID:16682971   PMID:17060447   PMID:17114484   PMID:18296647   PMID:18372920   PMID:19153607   PMID:19414503   PMID:19946272   PMID:20455770   PMID:21267068   PMID:21454508  
PMID:21677750   PMID:21730150   PMID:21731673   PMID:21873635   PMID:22087031   PMID:22586265   PMID:22922362   PMID:23105104   PMID:23295647   PMID:23450345   PMID:23544605   PMID:23578931  
PMID:23597671   PMID:23891589   PMID:23990362   PMID:24098127   PMID:24196965   PMID:24626527   PMID:24732886   PMID:24895206   PMID:25322693   PMID:25737280   PMID:25738901   PMID:25862855  
PMID:25979949   PMID:26166769   PMID:26703592   PMID:26891257   PMID:26936421   PMID:27031966   PMID:27454120   PMID:27843203   PMID:28240263   PMID:28378742   PMID:28644433   PMID:28692058  
PMID:28750063   PMID:29238035   PMID:29361523   PMID:29923218   PMID:30257106   PMID:30552326   PMID:30760284   PMID:30841417   PMID:31040226   PMID:31288148   PMID:32203159   PMID:32747606  
PMID:32808325   PMID:32855524   PMID:33665757   PMID:33831322   PMID:34036390   PMID:34613548   PMID:34679210  


Genomics

Comparative Map Data
Pdcd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,880,662 - 53,926,024 (+)NCBIGRCm39mm39
GRCm39 Ensembl1953,880,662 - 53,918,291 (+)Ensembl
GRCm381953,892,231 - 53,937,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,892,231 - 53,929,860 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,966,721 - 54,004,351 (+)NCBIGRCm37mm9NCBIm37
MGSCv361953,956,779 - 53,983,162 (+)NCBImm8
Celera1956,087,143 - 56,124,829 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.73NCBI
PDCD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810110,871,928 - 110,900,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10110,871,795 - 110,900,006 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,631,686 - 112,659,764 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,621,586 - 112,649,754 (+)NCBINCBI36hg18NCBI36
Build 3410112,621,585 - 112,649,753NCBI
Celera10106,363,204 - 106,391,372 (+)NCBI
Cytogenetic Map10q25.2NCBI
HuRef10106,260,410 - 106,288,621 (+)NCBIHuRef
CHM1_110112,913,378 - 112,941,587 (+)NCBICHM1_1
T2T-CHM13v2.010111,755,712 - 111,783,789 (+)NCBI
Pdcd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21252,921,342 - 252,944,278 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1252,921,392 - 252,944,275 (+)Ensembl
Rnor_6.01274,616,625 - 274,648,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,625,224 - 274,648,204 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,029,865 - 282,061,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41260,183,648 - 260,202,032 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11260,394,692 - 260,413,077 (+)NCBI
Celera1248,639,428 - 248,657,812 (+)NCBICelera
Cytogenetic Map1q55NCBI
Pdcd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485529,860 - 553,601 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485530,642 - 553,508 (-)NCBIChiLan1.0ChiLan1.0
PDCD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110110,914,222 - 110,942,394 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10110,914,222 - 110,942,394 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010107,465,084 - 107,493,285 (+)NCBIMhudiblu_PPA_v0panPan3
PDCD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,198,274 - 22,227,184 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,198,322 - 22,226,717 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,350,385 - 22,379,252 (+)NCBI
ROS_Cfam_1.02822,722,838 - 22,751,713 (+)NCBI
ROS_Cfam_1.0 Ensembl2822,722,897 - 22,752,395 (+)Ensembl
UMICH_Zoey_3.12822,282,298 - 22,310,940 (+)NCBI
UNSW_CanFamBas_1.02822,289,098 - 22,317,724 (+)NCBI
UU_Cfam_GSD_1.02822,423,221 - 22,451,894 (+)NCBI
Pdcd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,855,886 - 23,877,135 (-)NCBI
SpeTri2.0NW_0049364861,684,167 - 1,705,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDCD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,305,629 - 121,338,740 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,271,824 - 121,334,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,232,416 - 132,261,645 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDCD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19103,809,005 - 103,836,402 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,813,211 - 103,836,002 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604865,014,586 - 65,042,439 (+)NCBIVero_WHO_p1.0
Pdcd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473735,414,078 - 35,451,023 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AU017267  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381953,922,807 - 53,922,892UniSTSGRCm38
MGSCv371953,997,297 - 53,997,382UniSTSGRCm37
Celera1956,117,764 - 56,117,849UniSTS
Cytogenetic Map19D2UniSTS
cM Map1920.0UniSTS
Whitehead/MRC_RH19567.29UniSTS
D19Mit36  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381953,922,910 - 53,923,073UniSTSGRCm38
MGSCv371953,997,400 - 53,997,563UniSTSGRCm37
Celera1956,117,867 - 56,118,037UniSTS
Cytogenetic Map19D2UniSTS
cM Map1952.0UniSTS
Whitehead Genetic1940.4UniSTS
Whitehead/MRC_RH19563.07UniSTS
Whitehead_YAC19 UniSTS
RH133731  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381953,929,103 - 53,929,825UniSTSGRCm38
MGSCv371954,003,593 - 54,004,315UniSTSGRCm37
Celera1956,124,073 - 56,124,793UniSTS
Cytogenetic Map19D2UniSTS
cM Map1920.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
4141412Acsns1_mAngiostrongylus costaricensis nematode susceptibility 1 (mouse)Not determined4789788055026545Mouse
11667075Led3_mlate embryonic death 3 (mouse)195108837859123872Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir182mmu-miR-182-5pOncomiRDBexternal_infoNANA23296900
Mir183mmu-miR-183-5pOncomiRDBexternal_infoNANA20602797
Mir21ammu-miR-21a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18372920
Mir21ammu-miR-21a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21273303
Mir21ammu-miR-21a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21295561
Mir21ammu-miR-21a-5pMirtarbaseexternal_infoWestern blotFunctional MTI20404348

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:173
Interacting mature miRNAs:201
Transcripts:ENSMUST00000025931, ENSMUST00000074371, ENSMUST00000165617
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001168491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001168492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ479921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025931   ⟹   ENSMUSP00000025931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,891,730 - 53,918,291 (+)Ensembl
GRCm38.p6 Ensembl1953,903,299 - 53,929,860 (+)Ensembl
RefSeq Acc Id: ENSMUST00000074371   ⟹   ENSMUSP00000073975
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,880,662 - 53,918,282 (+)Ensembl
GRCm38.p6 Ensembl1953,892,231 - 53,929,851 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165617   ⟹   ENSMUSP00000133135
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,891,847 - 53,918,284 (+)Ensembl
GRCm38.p6 Ensembl1953,903,416 - 53,929,853 (+)Ensembl
RefSeq Acc Id: ENSMUST00000235854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,880,667 - 53,884,748 (+)Ensembl
GRCm38.p6 Ensembl1953,892,236 - 53,896,317 (+)Ensembl
RefSeq Acc Id: ENSMUST00000237060   ⟹   ENSMUSP00000157883
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,891,806 - 53,917,866 (+)Ensembl
GRCm38.p6 Ensembl1953,903,375 - 53,929,435 (+)Ensembl
RefSeq Acc Id: ENSMUST00000237699
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,882,261 - 53,884,803 (+)Ensembl
GRCm38.p6 Ensembl1953,893,830 - 53,896,372 (+)Ensembl
RefSeq Acc Id: NM_001168491   ⟹   NP_001161963
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,891,782 - 53,918,292 (+)NCBI
GRCm381953,903,351 - 53,929,861 (+)NCBI
MGSCv371953,966,721 - 54,004,351 (+)RGD
Celera1956,087,143 - 56,124,829 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001168492   ⟹   NP_001161964
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,891,782 - 53,918,292 (+)NCBI
GRCm381953,903,351 - 53,929,861 (+)NCBI
MGSCv371953,966,721 - 54,004,351 (+)RGD
Celera1956,087,143 - 56,124,829 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011050   ⟹   NP_035180
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,880,662 - 53,918,292 (+)NCBI
GRCm381953,892,231 - 53,929,861 (+)ENTREZGENE
MGSCv371953,966,721 - 54,004,351 (+)RGD
Celera1956,087,143 - 56,124,829 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526762   ⟹   XP_006526825
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,891,940 - 53,918,284 (+)NCBI
GRCm381953,903,523 - 53,929,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250768   ⟹   XP_030106628
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,891,755 - 53,926,024 (+)NCBI
GRCm381953,903,324 - 53,937,592 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250769   ⟹   XP_030106629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,892,040 - 53,918,284 (+)NCBI
GRCm381953,903,609 - 53,929,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161459   ⟹   XP_036017352
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,891,940 - 53,918,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161460   ⟹   XP_036017353
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,892,236 - 53,918,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161461   ⟹   XP_036017354
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,892,017 - 53,918,284 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035180   ⟸   NM_011050
- UniProtKB: Q61823 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161963   ⟸   NM_001168491
- UniProtKB: Q61823 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161964   ⟸   NM_001168492
- UniProtKB: Q61823 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526825   ⟸   XM_006526762
- Peptide Label: isoform X1
- UniProtKB: Q61823 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030106628   ⟸   XM_030250768
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030106629   ⟸   XM_030250769
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000157883   ⟸   ENSMUST00000237060
RefSeq Acc Id: ENSMUSP00000025931   ⟸   ENSMUST00000025931
RefSeq Acc Id: ENSMUSP00000073975   ⟸   ENSMUST00000074371
RefSeq Acc Id: ENSMUSP00000133135   ⟸   ENSMUST00000165617
RefSeq Acc Id: XP_036017352   ⟸   XM_036161459
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036017354   ⟸   XM_036161461
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036017353   ⟸   XM_036161460
- Peptide Label: isoform X1
Protein Domains
MI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61823-F1-model_v2 AlphaFold Q61823 1-469 view protein structure

Promoters
RGD ID:13679792
Promoter ID:EPDNEW_M24045
Type:initiation region
Name:Pdcd4_1
Description:Mus musculus programmed cell death 4 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24046  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381953,903,396 - 53,903,456EPDNEW
RGD ID:13679794
Promoter ID:EPDNEW_M24046
Type:initiation region
Name:Pdcd4_2
Description:Mus musculus programmed cell death 4 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24045  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381953,906,534 - 53,906,594EPDNEW
RGD ID:6830289
Promoter ID:MM_KWN:27357
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B6
Transcripts:NM_001168491,   NM_001168492
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361953,977,236 - 53,977,937 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107490 AgrOrtholog
Ensembl Genes ENSMUSG00000024975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000073975 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133135 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157883.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000074371 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165617 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000237060.2 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Initiation_fac_eIF4g_MI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDCD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18569 UniProtKB/Swiss-Prot
MGD MGI:107490 ENTREZGENE
NCBI Gene 18569 ENTREZGENE
PANTHER PTHR12626 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdcd4 PhenoGen
PROSITE PS51366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BA05_MOUSE UniProtKB/TrEMBL
  PDCD4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P97296 UniProtKB/Swiss-Prot
  Q3T9A9 UniProtKB/Swiss-Prot