Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dhfr (dihydrofolate reductase) Mus musculus
Symbol: Dhfr
Name: dihydrofolate reductase
Description: Exhibits dihydrofolate reductase activity. Involved in positive regulation of nitric-oxide synthase activity; regulation of removal of superoxide radicals; and tetrahydrobiopterin biosynthetic process. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFRP1 (dihydrofolate reductase pseudogene 1); PARTICIPATES IN altered folate cycle metabolic pathway; dopa responsive dystonia pathway; folate cycle metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 8430436I03Rik; AA607882; AI662710; AW555094
Homo sapiens (human) : DHFR (dihydrofolate reductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhfr (dihydrofolate reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhfr (dihydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHFR (dihydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhfr (dihydrofolate reductase)
Sus scrofa (pig) : DHFR (dihydrofolate reductase)
Chlorocebus sabaeus (African green monkey) : DHFR (dihydrofolate reductase)
Heterocephalus glaber (naked mole-rat) : Dhfr (dihydrofolate reductase)
more info ...
Related Pseudogenes: Dhfr-rs1   Gm18226  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBImm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dhfr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10471
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.