Dhfr (dihydrofolate reductase) - Rat Genome Database

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Gene: Dhfr (dihydrofolate reductase) Mus musculus
Analyze
Symbol: Dhfr
Name: dihydrofolate reductase
RGD ID: 10471
MGI Page MGI
Description: Enables dihydrofolate reductase activity. Involved in regulation of removal of superoxide radicals; tetrahydrobiopterin biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion. Is active in nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR (dihydrofolate reductase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 8430436I03Rik; AA607882; AI662710; AW555094
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Dhfr-rs1   Gm18226  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,491,291 - 92,525,561 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,491,234 - 92,525,561 (+)EnsemblGRCm39 Ensembl
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBIMGSCv36mm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefazolin  (ISO)
cefepime  (ISO)
ceftazidime pentahydrate  (ISO)
ceftizoxime  (ISO)
ceftriaxone  (ISO)
chlorambucil  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (EXP)
cytarabine  (ISO)
diallyl trisulfide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
DISTAMYCIN A  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ferulic acid  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lamivudine  (ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
Mecamylamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naringin  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrogen mustard  (ISO)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrimethamine  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trabectedin  (EXP)
trimellitic anhydride  (EXP)
trimethoprim  (EXP)
trimetrexate  (ISO)
triptonide  (EXP)
tubocurarine  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia. Al-Shakfa F, etal., Clin Cancer Res. 2009 Nov 15;15(22):6931-8. doi: 10.1158/1078-0432.CCR-09-0641. Epub 2009 Oct 27.
2. Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Cario H, etal., Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007.
3. Survival and risk of relapse of acute lymphoblastic leukemia in a Mexican population is affected by dihydrofolate reductase gene polymorphisms. Gomez-Gomez Y, etal., Exp Ther Med. 2012 Apr;3(4):665-672. Epub 2012 Jan 9.
4. Assignment of two rat dihydrofolate (DHFR) genes to chromosomes 2 and 4. Hanson C, etal., Cytogenet Cell Genet 1990;53(1):23-5.
5. Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study. Levy AS, etal., J Pediatr Hematol Oncol. 2003 Sep;25(9):688-95.
6. Permissivity for methotrexate-induced DHFR gene amplification correlates with the metastatic potential of rat adenocarcinoma cells. Lucke-Huhle C Carcinogenesis. 1994 Apr;15(4):695-700.
7. Increased frequency of expression of elevated dihydrofolate reductase in T-cell versus B-precursor acute lymphoblastic leukemia in children. Matherly LH, etal., Blood. 1997 Jul 15;90(2):578-89.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Seujange Y, etal., Am J Nephrol. 2008;28(4):692-700. doi: 10.1159/000126927. Epub 2008 Apr 11.
16. Trafficking of intracellular folates. Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
17. Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase. Sweeney CL, etal., Cancer Res. 2003 Mar 15;63(6):1304-10.
18. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:360074   PMID:627542   PMID:715457   PMID:762074   PMID:1060915   PMID:1347472   PMID:1354640   PMID:1354647   PMID:1535334   PMID:1545788   PMID:1676978   PMID:1682216  
PMID:1970335   PMID:1989904   PMID:2233729   PMID:2263462   PMID:2307475   PMID:2674679   PMID:2676841   PMID:2722860   PMID:2947337   PMID:2982814   PMID:6121807   PMID:6244105  
PMID:6272123   PMID:6282858   PMID:6323448   PMID:6504041   PMID:6573667   PMID:6835212   PMID:7789972   PMID:7906967   PMID:7987046   PMID:8094303   PMID:8198617   PMID:8288218  
PMID:8611632   PMID:8828042   PMID:8889548   PMID:8903722   PMID:8975706   PMID:8975718   PMID:9076683   PMID:9111201   PMID:9119362   PMID:9121444   PMID:9160753   PMID:9357973  
PMID:9457670   PMID:9554740   PMID:9650531   PMID:9758703   PMID:9932288   PMID:10349636   PMID:10441734   PMID:10501972   PMID:10501973   PMID:10640815   PMID:10913163   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11598925   PMID:12466851   PMID:12477932   PMID:12588981   PMID:13710631   PMID:14610273   PMID:14667810   PMID:14681479   PMID:15489334  
PMID:16107879   PMID:16141072   PMID:16141073   PMID:16183885   PMID:17019704   PMID:19513116   PMID:19666465   PMID:20424322   PMID:21185283   PMID:21267068   PMID:21402147   PMID:21677750  
PMID:21873635   PMID:22162032   PMID:22993211   PMID:25980602   PMID:26166573   PMID:26381869   PMID:26542706   PMID:26830229   PMID:27626380   PMID:28496133   PMID:29874574   PMID:30134070  
PMID:30954686   PMID:31214845   PMID:32325033   PMID:34050187   PMID:34321999   PMID:36336227   PMID:36604605   PMID:37665322  


Genomics

Comparative Map Data
Dhfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,491,291 - 92,525,561 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,491,234 - 92,525,561 (+)EnsemblGRCm39 Ensembl
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBIMGSCv36mm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
DHFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,626,226 - 80,654,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,626,226 - 80,654,983 (-)EnsemblGRCh38hg38GRCh38
GRCh37579,922,045 - 79,950,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,957,801 - 79,986,556 (-)NCBINCBI36Build 36hg18NCBI36
Build 34579,957,803 - 79,986,572NCBI
Celera575,825,049 - 75,854,857 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,130,997 - 75,159,721 (-)NCBIHuRef
CHM1_1579,355,281 - 79,384,046 (-)NCBICHM1_1
T2T-CHM13v2.0581,111,116 - 81,139,892 (-)NCBIT2T-CHM13v2.0
Dhfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,320,895 - 25,346,004 (+)NCBIGRCr8
mRatBN7.2223,585,876 - 23,611,199 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,586,031 - 23,613,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,620,446 - 30,644,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,720,807 - 28,745,052 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,548,630 - 23,573,162 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,931,887 - 21,958,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl221,931,493 - 21,962,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,137,784 - 41,149,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0241,162,308 - 41,162,496 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,607,093 - 22,828,487 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,527,461 - 22,748,856 (+)NCBI
Celera219,675,965 - 19,700,103 (+)NCBICelera
Cytogenetic Map2q12NCBI
Dhfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541829,274,170 - 29,283,028 (+)NCBIChiLan1.0ChiLan1.0
DHFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,653,369 - 34,681,917 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,806,994 - 32,835,542 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,663,210 - 34,689,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,938,548 - 34,967,003 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,938,548 - 34,967,003 (+)Ensemblpanpan1.1panPan2
DHFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,521,214 - 26,556,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,762,458 - 27,797,614 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,441,764 - 26,476,948 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1326,381,985 - 26,417,256 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,356,657 - 26,413,875 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,636,300 - 26,671,702 (+)NCBIUU_Cfam_GSD_1.0
Dhfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,542,580 - 182,561,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493646967,962 - 83,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1289,230,660 - 89,255,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,077,865 - 91,102,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,787,292 - 74,811,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,787,629 - 74,810,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,650,277 - 23,674,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,446,643 - 1,461,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,446,643 - 1,462,319 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhfr
1082 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1393
Count of miRNA genes:678
Interacting mature miRNAs:849
Transcripts:ENSMUST00000022218
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse

Markers in Region
AW555094  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,385,356 - 92,385,438UniSTSGRCm38
MGSCv371393,155,311 - 93,155,393UniSTSGRCm37
Celera1395,991,218 - 95,991,300UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
Whitehead/MRC_RH13771.23UniSTS
L26316  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371393,154,820 - 93,154,958UniSTSGRCm37
Celera1395,990,727 - 95,990,865UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
Whitehead/MRC_RH13775.34UniSTS
Whitehead_YAC13 UniSTS
UniSTS:237076  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,387,460 - 92,387,679UniSTSGRCm38
MGSCv371393,157,415 - 93,157,634UniSTSGRCm37
Celera1395,993,314 - 95,993,533UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
UniSTS:237077  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,386,917 - 92,387,246UniSTSGRCm38
MGSCv371393,156,872 - 93,157,201UniSTSGRCm37
Celera1395,992,771 - 95,993,100UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
PMC138237P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,355,155 - 92,355,324UniSTSGRCm38
MGSCv371393,125,110 - 93,125,279UniSTSGRCm37
Celera1395,961,384 - 95,961,553UniSTS
Cytogenetic Map13C3UniSTS
cM Map1351.0UniSTS
cM Map1343.0UniSTS
RH74744  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,384,803 - 92,385,133UniSTSGRCm38
MGSCv371393,154,758 - 93,155,088UniSTSGRCm37
Celera1395,990,665 - 95,990,995UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
AI662710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,387,524 - 92,387,652UniSTSGRCm38
MGSCv371393,157,479 - 93,157,607UniSTSGRCm37
Celera1395,993,378 - 95,993,506UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
Whitehead/MRC_RH13771.03UniSTS
PMC86057P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,385,144 - 92,385,425UniSTSGRCm38
MGSCv371393,155,099 - 93,155,380UniSTSGRCm37
Celera1395,991,006 - 95,991,287UniSTS
Cytogenetic Map13C3UniSTS
cM Map1343.0UniSTS
L26316  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,384,865 - 92,385,003UniSTSGRCm38
MGSCv371393,154,820 - 93,154,958UniSTSGRCm37
Celera1395,990,727 - 95,990,865UniSTS
Cytogenetic Map13C3UniSTS
Whitehead/MRC_RH13775.34UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI854085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU058996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01146114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB247191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB293000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM974788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L26316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000022218   ⟹   ENSMUSP00000022218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,491,234 - 92,525,561 (+)Ensembl
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)Ensembl
RefSeq Acc Id: NM_010049   ⟹   NP_034179
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,491,291 - 92,525,561 (+)NCBI
GRCm381392,354,783 - 92,389,053 (+)ENTREZGENE
MGSCv371393,124,738 - 93,159,008 (+)RGD
Celera1395,961,012 - 95,994,907 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034179   ⟸   NM_010049
- UniProtKB: Q61487 (UniProtKB/Swiss-Prot),   Q61485 (UniProtKB/Swiss-Prot),   P70693 (UniProtKB/Swiss-Prot),   Q61579 (UniProtKB/Swiss-Prot),   P00375 (UniProtKB/Swiss-Prot),   Q544T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022218   ⟸   ENSMUST00000022218
Protein Domains
DHFR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00375-F1-model_v2 AlphaFold P00375 1-187 view protein structure

Promoters
RGD ID:8680976
Promoter ID:EPDNEW_M18519
Type:multiple initiation site
Name:Dhfr_2
Description:Mus musculus dihydrofolate reductase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18521  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381392,354,756 - 92,354,816EPDNEW
RGD ID:8680980
Promoter ID:EPDNEW_M18521
Type:initiation region
Name:Dhfr_1
Description:Mus musculus dihydrofolate reductase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18519  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381392,355,203 - 92,355,263EPDNEW
RGD ID:6823811
Promoter ID:MM_KWN:14890
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B4
Transcripts:NM_010049
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361393,124,191 - 93,125,217 (+)MPROMDB
RGD ID:6849720
Promoter ID:EP24032
Type:single initiation site
Name:MM_DYR_1
Description:Dihydrofolate reductase, DHFR gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP07057  
Tissues & Cell Lines:[G1/S]
Experiment Methods:Nuclease protection; Primer extension
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371393,125,099 - 93,125,159EPD
MGSCv361393,125,099 - 93,125,159EPD
RGD ID:6849722
Promoter ID:EP07057
Type:single initiation site
Name:MM_DYR_2
Description:Dihydrofolate reductase, DHFR gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 35; Mammalian dihydrofolate reductase (DHFR)
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2; major promoter.; see alsoEP24032  
Tissues & Cell Lines:[G1/S]
Experiment Methods:Nuclease protection; Primer extension
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371393,125,159 - 93,125,219EPD
MGSCv361393,125,159 - 93,125,219EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94890 AgrOrtholog
Ensembl Genes ENSMUSG00000021707 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022218 ENTREZGENE
  ENSMUST00000022218.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.430.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94890 ENTREZGENE
NCBI Gene 13361 ENTREZGENE
PANTHER DIHYDROFOLATE REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR48069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DHFR RGD
PhenoGen Dhfr PhenoGen
PRINTS DHFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DHFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53597 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DYR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P70693 ENTREZGENE
  Q544T5 ENTREZGENE, UniProtKB/TrEMBL
  Q61485 ENTREZGENE
  Q61487 ENTREZGENE
  Q61579 ENTREZGENE
UniProt Secondary P70693 UniProtKB/Swiss-Prot
  Q61485 UniProtKB/Swiss-Prot
  Q61487 UniProtKB/Swiss-Prot
  Q61579 UniProtKB/Swiss-Prot