Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | EXP | | 6480464 | vinylidene chloride results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of ATP6V1C2 mRNA | CTD | PMID:27840820 | 1,3-dinitrobenzene | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | 3-dinitrobenzene results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:21983209 | 17beta-estradiol | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of ATP6V1C2 mRNA | CTD | PMID:20404318 | 17beta-estradiol | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of ATP6V1C2 mRNA | CTD | PMID:31614463 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of ATP6V1C2 mRNA | CTD | PMID:19484750 | 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:23146750 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:23146750 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ATP6V1C2 mRNA | CTD | PMID:32109520 | 2-hydroxypropanoic acid | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:30851411 | 3-methylcholanthrene | multiple interactions | EXP | | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:23519560 | acetamide | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of ATP6V1C2 mRNA | CTD | PMID:31881176 | all-trans-retinoic acid | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:33167477 | all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:36189433 | arsane | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 mRNA and [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 protein | CTD | PMID:32525701 | arsane | affects methylation | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ATP6V1C2 gene | CTD | PMID:25304211 | arsenic atom | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 mRNA and [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 protein | CTD | PMID:32525701 | arsenic atom | affects methylation | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ATP6V1C2 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ATP6V1C2 promoter | CTD | PMID:27901495 | beta-naphthoflavone | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | beta-Naphthoflavone results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:32858204 | bisphenol A | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ATP6V1C2 mRNA | CTD | PMID:23146750 | bisphenol A | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of ATP6V1C2 mRNA | CTD | PMID:25181051 and PMID:34947998 | bromobenzene | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | bromobenzene results in increased expression of ATP6V1C2 mRNA | CTD | PMID:32479839 | Butylbenzyl phthalate | decreases expression | EXP | | 6480464 | butylbenzyl phthalate results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:36756972 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ATP6V1C2 gene] | CTD | PMID:28238834 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP6V1C2 gene | CTD | PMID:20938992 | cisplatin | affects response to substance | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | ATP6V1C2 mRNA affects the susceptibility to Cisplatin | CTD | PMID:18610736 | clofibric acid | multiple interactions | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATP6V1C2 mRNA | CTD | PMID:17602206 | copper(II) sulfate | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of ATP6V1C2 mRNA | CTD | PMID:26577399 | DDT | decreases methylation | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | DDT results in decreased methylation of ATP6V1C2 gene | CTD | PMID:31682807 | dibutyl phthalate | affects expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Dibutyl Phthalate affects the expression of ATP6V1C2 mRNA | CTD | PMID:36375677 | dioxygen | multiple interactions | EXP | | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ATP6V1C2 mRNA | CTD | PMID:30529165 | diuron | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Diuron results in increased expression of ATP6V1C2 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C2 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | entinostat results in increased expression of ATP6V1C2 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of ATP6V1C2 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP6V1C2 gene | CTD | PMID:20938992 | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of ATP6V1C2 mRNA | CTD | PMID:25629700 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:22061828 and PMID:33387578 | hydroquinone | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | hydroquinone results in increased expression of ATP6V1C2 mRNA | CTD | PMID:31256213 | indole-3-methanol | affects expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | indole-3-carbinol affects the expression of ATP6V1C2 mRNA | CTD | PMID:21396975 | indometacin | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Indomethacin results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:36868495 | ketamine | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Ketamine results in increased expression of ATP6V1C2 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP6V1C2 gene | CTD | PMID:20938992 | methamphetamine | decreases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Methamphetamine results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:19564919 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of ATP6V1C2 mRNA | CTD | PMID:22401849 | mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:36189433 | N-nitrosodiethylamine | multiple interactions | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATP6V1C2 mRNA | CTD | PMID:17602206 | nickel atom | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:24768652 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of ATP6V1C2 mRNA | CTD | PMID:32479839 and PMID:33387578 | phorbol 13-acetate 12-myristate | multiple interactions | EXP | | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:23519560 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ATP6V1C2 mRNA | CTD | PMID:20813756 | rac-lactic acid | decreases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:30851411 | rotenone | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Rotenone results in increased expression of ATP6V1C2 mRNA | CTD | PMID:31648047 | SB 431542 | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C2 mRNA | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 mRNA and [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ATP6V1C2 protein | CTD | PMID:32525701 | sodium arsenite | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of ATP6V1C2 mRNA | CTD | PMID:34032870 | testosterone | decreases expression | EXP | | 6480464 | Testosterone deficiency results in decreased expression of ATP6V1C2 mRNA | CTD | PMID:33848595 | testosterone | multiple interactions | EXP | | 6480464 | 1 more ... | CTD | PMID:33848595 | triphenyl phosphate | increases expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | triphenyl phosphate results in increased expression of ATP6V1C2 mRNA | CTD | PMID:30589522 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of ATP6V1C2 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ATP6V1C2 mRNA | CTD | PMID:23527032 more ... | valproic acid | multiple interactions | ISO | ATP6V1C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C2 mRNA | CTD | PMID:27188386 | vancomycin | increases expression | EXP | | 6480464 | Vancomycin results in increased expression of ATP6V1C2 mRNA | CTD | PMID:18930951 | vinclozolin | affects expression | ISO | Atp6v1c2 (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of ATP6V1C2 mRNA | CTD | PMID:19015723 | |