Thbd (thrombomodulin) - Rat Genome Database

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Gene: Thbd (thrombomodulin) Mus musculus
Analyze
Symbol: Thbd
Name: thrombomodulin
RGD ID: 1553030
MGI Page MGI
Description: Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin); PARTICIPATES IN protein C anticoagulant pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385582; CD141; fetomodulin; snoRNA MBII-339; TM
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,246,391 - 148,250,108 (-)NCBIGRCm39mm39
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)Ensembl
GRCm382148,404,471 - 148,408,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,230,207 - 148,233,924 (-)NCBIGRCm37mm9NCBIm37
MGSCv362148,095,912 - 148,099,544 (-)NCBImm8
Celera2149,679,568 - 149,683,285 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IDA,ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
asthma  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Injuries  (ISO)
carotid artery thrombosis  (ISO)
cerebral infarction  (ISO)
Cerebral Small Vessel Diseases  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dermatomyositis  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IEP,ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (IMP)
Experimental Liver Cirrhosis  (ISO)
familial combined hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
granulomatosis with polyangiitis  (ISO)
Habitual Abortions  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (IMP)
hemorrhagic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
idiopathic pulmonary fibrosis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver disease  (ISO)
lung non-small cell carcinoma  (ISO)
Metabolic Syndrome  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
Painful Neuropathy  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (IDA)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia  (IEA,ISO)
thrombophilia due to thrombomodulin defect  (ISO)
thrombosis  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carmustine  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gestodene  (ISO)
glucose  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
LY294002  (ISO)
methotrexate  (EXP,ISO)
methyl methacrylate  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentachlorophenol  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute phase protein level  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal placental thrombosis  (IAGP)
abnormal response to injury  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent vitelline blood vessels  (IAGP)
cardiac fibrosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased spleen weight  (IEA)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased trophoblast giant cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hematuria  (IAGP)
hemothorax  (IAGP)
increased circulating D-dimer level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased heart right ventricle weight  (IAGP)
increased heart weight  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased myocardial infarct size  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced thrombosis  (IAGP)
intracerebral hemorrhage  (IAGP)
lethality during fetal growth through weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hemorrhage  (IAGP)
lung hemorrhage  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
placenta hemorrhage  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
priapism  (IAGP)
pulmonary hypertension  (IAGP)
skin hemorrhage  (IAGP)
slow postnatal weight gain  (IAGP)
small ectoplacental cone  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:1372003   PMID:2162790   PMID:2536925   PMID:2844823   PMID:3036632   PMID:7846065   PMID:8207015   PMID:8388220   PMID:8389207   PMID:8395401   PMID:8575060   PMID:8578517  
PMID:8681807   PMID:8918245   PMID:9063732   PMID:9073507   PMID:9144489   PMID:9198243   PMID:9548583   PMID:9576763   PMID:9834223   PMID:10233896   PMID:10349636   PMID:10487767  
PMID:10550314   PMID:10565546   PMID:11015584   PMID:11042159   PMID:11066091   PMID:11076861   PMID:11217851   PMID:11222138   PMID:11387227   PMID:11518727   PMID:11557684   PMID:12053176  
PMID:12195698   PMID:12208873   PMID:12477932   PMID:12539040   PMID:12761846   PMID:14556079   PMID:14592828   PMID:14615369   PMID:15448005   PMID:15489334   PMID:15769825   PMID:16014564  
PMID:16141072   PMID:16141073   PMID:16537572   PMID:16602821   PMID:16844427   PMID:17068293   PMID:17299096   PMID:17438064   PMID:17848551   PMID:17973652   PMID:17982464   PMID:18287559  
PMID:18490515   PMID:18508817   PMID:18599803   PMID:19091791   PMID:19299737   PMID:19334288   PMID:19687358   PMID:20442369   PMID:21111988   PMID:21267068   PMID:21308776   PMID:21423464  
PMID:21685324   PMID:21788337   PMID:21833011   PMID:21840881   PMID:22323363   PMID:22573811   PMID:22729286   PMID:22903729   PMID:23014597   PMID:23267072   PMID:23321922   PMID:23325830  
PMID:23409043   PMID:23823180   PMID:24136651   PMID:24194600   PMID:24261709   PMID:24323314   PMID:24368584   PMID:25497974   PMID:25609841   PMID:25816372   PMID:25860286   PMID:26338301  
PMID:26457757   PMID:26573396   PMID:26634653   PMID:27427915   PMID:27590316   PMID:27808085   PMID:28306049   PMID:28687614   PMID:28737512   PMID:30341568   PMID:30442679   PMID:30550785  
PMID:31628891   PMID:31676784   PMID:32220631   PMID:32735640   PMID:32870264   PMID:33028093   PMID:33617784   PMID:33836597  


Genomics

Comparative Map Data
Thbd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,246,391 - 148,250,108 (-)NCBIGRCm39mm39
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)Ensembl
GRCm382148,404,471 - 148,408,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,230,207 - 148,233,924 (-)NCBIGRCm37mm9NCBIm37
MGSCv362148,095,912 - 148,099,544 (-)NCBImm8
Celera2149,679,568 - 149,683,285 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.45NCBI
THBD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2023,045,633 - 23,049,672 (-)EnsemblGRCh38hg38GRCh38
GRCh382023,045,633 - 23,049,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372023,026,270 - 23,030,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,974,270 - 22,978,301 (-)NCBINCBI36hg18NCBI36
Build 342022,974,270 - 22,978,301NCBI
Celera2023,099,650 - 23,103,681 (-)NCBI
Cytogenetic Map20p11.21NCBI
HuRef2022,987,792 - 22,991,823 (-)NCBIHuRef
CHM1_12023,026,970 - 23,031,001 (-)NCBICHM1_1
Thbd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23135,863,366 - 135,867,018 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3135,862,835 - 135,867,193 (-)Ensembl
Rnor_6.03142,748,673 - 142,752,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,748,674 - 142,752,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,159,895 - 149,163,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,158,955 - 137,162,607 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13137,064,528 - 137,068,180 (-)NCBI
Celera3134,707,185 - 134,710,838 (-)NCBICelera
Cytogenetic Map3q41NCBI
Thbd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541530,222,830 - 30,226,406 (-)NCBIChiLan1.0ChiLan1.0
THBD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12023,343,758 - 23,347,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,345,917 - 23,347,812 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02022,992,341 - 22,996,415 (-)NCBIMhudiblu_PPA_v0panPan3
THBD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.124599,773 - 601,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl24599,773 - 601,649 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24624,590 - 626,466 (+)NCBI
ROS_Cfam_1.024996,254 - 998,130 (+)NCBI
UMICH_Zoey_3.124595,131 - 597,007 (+)NCBI
UNSW_CanFamBas_1.024697,184 - 699,060 (+)NCBI
UU_Cfam_GSD_1.024978,557 - 980,433 (+)NCBI
Thbd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,143,805 - 149,147,659 (+)NCBI
SpeTri2.0NW_0049366202,563,900 - 2,568,117 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,221,819 - 30,230,177 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,219,870 - 30,223,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,274,132 - 34,277,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,041,950 - 52,045,946 (-)NCBI
ChlSab1.1 Ensembl252,043,746 - 52,045,626 (-)Ensembl
Vero_WHO_p1.0NW_0236660786,853,490 - 6,857,509 (-)NCBI
Thbd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474122,880,481 - 22,883,962 (-)NCBI

Position Markers
AI385582  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,404,686 - 148,404,811UniSTSGRCm38
MGSCv372148,230,422 - 148,230,547UniSTSGRCm37
Celera2149,679,783 - 149,679,908UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Whitehead/MRC_RH21746.87UniSTS
Thbd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372148,232,550 - 148,232,779UniSTSGRCm37
MGSCv372148,232,208 - 148,232,811UniSTSGRCm37
Celera2149,685,200 - 149,685,855UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
X14432  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,405,139 - 148,405,275UniSTSGRCm38
MGSCv372148,230,875 - 148,231,011UniSTSGRCm37
Celera2149,680,236 - 149,680,372UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Whitehead/MRC_RH21746.11UniSTS
PMC209404P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,407,696 - 148,408,070UniSTSGRCm38
MGSCv372148,233,432 - 148,233,806UniSTSGRCm37
Celera2149,682,793 - 149,683,167UniSTS
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
D19Mit15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,409,245 - 148,409,452UniSTSGRCm38
MGSCv372148,234,981 - 148,235,188UniSTSGRCm37
Celera2149,684,342 - 149,684,546UniSTS
Cytogenetic Map2G3UniSTS
cM Map1916.4UniSTS
cM Map2 UniSTS
Whitehead Genetic1916.4UniSTS
Iap2-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,410,125 - 148,410,815UniSTSGRCm38
MGSCv372148,235,861 - 148,236,551UniSTSGRCm37
Cytogenetic Map2G3UniSTS
cM Map284.0UniSTS
Thbd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,406,814 - 148,407,043UniSTSGRCm38
MGSCv372148,232,550 - 148,232,779UniSTSGRCm37
Celera2149,681,911 - 149,682,140UniSTS
Cytogenetic Map2G3UniSTS
Thbd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382148,406,472 - 148,407,075UniSTSGRCm38
MGSCv372148,232,208 - 148,232,811UniSTSGRCm37
Celera2149,681,569 - 149,682,172UniSTS
Cytogenetic Map2G3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132182239166182410Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143931525160461088Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143931525165823099Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142586427176586530Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133302991167303138Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133302991167303138Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129500000163500000Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
12801461Intim1_mintima modifier 1 (mouse)2142586427176586530Mouse
11353826Bdln10_mbody length 10 (mouse)2140599562174599562Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135590624173607823Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:529
Count of miRNA genes:382
Interacting mature miRNAs:423
Transcripts:ENSMUST00000099270
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000099270   ⟹   ENSMUSP00000096877
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2148,246,386 - 148,250,108 (-)Ensembl
GRCm38.p6 Ensembl2148,404,466 - 148,408,188 (-)Ensembl
RefSeq Acc Id: NM_009378   ⟹   NP_033404
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392148,246,391 - 148,250,108 (-)NCBI
GRCm382148,404,471 - 148,408,188 (-)ENTREZGENE
MGSCv372148,230,207 - 148,233,924 (-)RGD
Celera2149,679,568 - 149,683,285 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033404   ⟸   NM_009378
- Peptide Label: precursor
- UniProtKB: P15306 (UniProtKB/Swiss-Prot),   Q543W3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096877   ⟸   ENSMUST00000099270
Protein Domains
C-type lectin   EGF-like

Promoters
RGD ID:6832934
Promoter ID:MM_KWN:32138
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009378
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362148,230,946 - 148,234,797 (-)MPROMDB
RGD ID:6879050
Promoter ID:EPDNEW_M2976
Type:multiple initiation site
Name:Thbd_1
Description:Mus musculus thrombomodulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382148,408,119 - 148,408,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98736 AgrOrtholog
Ensembl Genes ENSMUSG00000074743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000096877 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099270 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tme5_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98736 ENTREZGENE
NCBI Gene 21824 ENTREZGENE
PANTHER PTHR24036:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tme5_EGF_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thbd PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P15306 ENTREZGENE
  Q543W3 ENTREZGENE, UniProtKB/TrEMBL
  TRBM_MOUSE UniProtKB/Swiss-Prot