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Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Mus musculus
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Description: Predicted to have prostaglandin-endoperoxide synthase activity. Involved in prostaglandin biosynthetic process; regulation of blood pressure; and regulation of cell population proliferation. Localizes to the cytoplasm and photoreceptor outer segment. Used to study pre-eclampsia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cox-1; Cox-3; COX1; cyclooxygenase 1; cyclooxygenase-1; PGH synthase 1; PGHS-1; Pghs1; PHS 1; prostaglandin G/H synthase 1; prostaglandin H2 synthase 1
Homo sapiens (human) : PTGS1 (prostaglandin-endoperoxide synthase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptgs1 (prostaglandin-endoperoxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Canis lupus familiaris (dog) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Sus scrofa (pig) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Chlorocebus sabaeus (green monkey) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl236,230,426 - 36,252,272 (+)Ensembl
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIGRCm37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBImm8
Celera235,934,252 - 35,956,095 (+)NCBICelera
Cytogenetic Map2 BNCBI
cM Map224.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptgs1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11184
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.