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Gene: Akr1c12 (aldo-keto reductase family 1, member C12) Mus musculus
Symbol: Akr1c12
Name: aldo-keto reductase family 1, member C12
Description: Predicted to have bile acid binding activity; ketosteroid monooxygenase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Is expressed in gut gland; male reproductive system; and stomach. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3); INTERACTS WITH 1,2-dichloroethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI266976; Akra; aldo-keto reductase a
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl134,268,176 - 4,279,433 (-)EnsemblGRCm38mm10GRCm38
GRCm38134,268,172 - 4,279,399 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37134,267,418 - 4,278,645 (-)NCBIGRCm37mm9NCBIm37
MGSCv36134,267,418 - 4,278,645 (-)NCBImm8
Celera134,246,724 - 4,257,933 (-)NCBICelera
Cytogenetic Map13A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Akr1c12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317889
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.