Dusp4 (dual specificity phosphatase 4) - Rat Genome Database

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Gene: Dusp4 (dual specificity phosphatase 4) Mus musculus
Analyze
Symbol: Dusp4
Name: dual specificity phosphatase 4
RGD ID: 1332569
MGI Page MGI
Description: Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of ERK1 and ERK2 cascade; and protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and tail unsegmented mesenchyme. Orthologous to human DUSP4 (dual specificity phosphatase 4).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2700078F24Rik; AI844617; BB104621; dual specificity protein phosphatase 4; E130306H24Rik; MKP; MKP2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39835,274,764 - 35,287,048 (+)NCBIGRCm39mm39
GRCm39 Ensembl835,274,451 - 35,287,048 (+)Ensembl
GRCm38834,807,610 - 34,819,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl834,807,297 - 34,819,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv37835,870,664 - 35,882,948 (+)NCBIGRCm37mm9NCBIm37
MGSCv36836,276,127 - 36,288,411 (+)NCBImm8
Celera837,423,596 - 37,435,832 (+)NCBICelera
Cytogenetic Map8A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
avobenzone  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
choline  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
equol  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
ferric oxide  (EXP)
fluoranthene  (EXP)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
indole-3-methanol  (ISO)
ionomycin  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PD 0325901  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
Rebamipide  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
toluene 2,4-diisocyanate  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10862698   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17452331   PMID:17681139  
PMID:17699753   PMID:18157121   PMID:18287559   PMID:18542059   PMID:18579680   PMID:18704116   PMID:19168680   PMID:20351138   PMID:20436479   PMID:21085614   PMID:21267068   PMID:21300886  
PMID:21317287   PMID:21533046   PMID:21632822   PMID:21677750   PMID:21873635   PMID:22101742   PMID:22434910   PMID:22683570   PMID:22993413   PMID:23431145   PMID:23471219   PMID:23665221  
PMID:23966857   PMID:25204653   PMID:25397900   PMID:26627244   PMID:26710253   PMID:26811378   PMID:26911683   PMID:27428650   PMID:27958388   PMID:28867346   PMID:29212025   PMID:29668927  
PMID:30475228   PMID:30710088   PMID:30713718   PMID:30758994   PMID:30862678   PMID:30938680   PMID:31320324   PMID:31336892   PMID:31989721   PMID:34553752  


Genomics

Comparative Map Data
Dusp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39835,274,764 - 35,287,048 (+)NCBIGRCm39mm39
GRCm39 Ensembl835,274,451 - 35,287,048 (+)Ensembl
GRCm38834,807,610 - 34,819,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl834,807,297 - 34,819,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv37835,870,664 - 35,882,948 (+)NCBIGRCm37mm9NCBIm37
MGSCv36836,276,127 - 36,288,411 (+)NCBImm8
Celera837,423,596 - 37,435,832 (+)NCBICelera
Cytogenetic Map8A4NCBI
DUSP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl829,333,064 - 29,350,684 (-)EnsemblGRCh38hg38GRCh38
GRCh38829,333,064 - 29,350,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37829,190,581 - 29,208,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36829,249,530 - 29,264,104 (-)NCBINCBI36hg18NCBI36
Build 34829,249,538 - 29,262,241NCBI
Celera828,153,208 - 28,167,802 (-)NCBI
Cytogenetic Map8p12NCBI
HuRef827,734,943 - 27,752,631 (-)NCBIHuRef
CHM1_1829,392,567 - 29,410,254 (-)NCBICHM1_1
Dusp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21657,376,659 - 57,398,161 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1657,377,229 - 57,398,138 (-)Ensembl
Rnor_6.01661,080,767 - 61,090,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1661,078,175 - 61,091,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,749,903 - 60,769,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41661,109,626 - 61,119,981 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11661,109,700 - 61,120,056 (-)NCBI
Celera1655,427,894 - 55,438,053 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
Dusp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554635,778,700 - 5,794,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554635,778,945 - 5,794,282 (-)NCBIChiLan1.0ChiLan1.0
DUSP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1825,816,714 - 25,834,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl825,819,989 - 25,834,332 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0828,623,777 - 28,641,432 (-)NCBIMhudiblu_PPA_v0panPan3
DUSP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.01636,828,592 - 36,844,313 (+)NCBI
Dusp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494344,363,746 - 44,376,514 (-)NCBI
SpeTri2.0NW_004936573765,954 - 778,524 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1555,490,468 - 55,509,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11555,491,084 - 55,508,460 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21562,906,062 - 62,923,413 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1827,459,455 - 27,473,811 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl827,456,430 - 27,473,352 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605214,654,175 - 14,671,595 (+)NCBIVero_WHO_p1.0
Dusp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248395,870,274 - 5,887,741 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AI844617  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38834,821,722 - 34,821,820UniSTSGRCm38
MGSCv37835,884,776 - 35,884,874UniSTSGRCm37
Celera837,437,652 - 37,437,750UniSTS
Cytogenetic Map8A4UniSTS
Whitehead/MRC_RH8392.31UniSTS
BB104621  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38834,819,696 - 34,819,784UniSTSGRCm38
MGSCv37835,882,750 - 35,882,838UniSTSGRCm37
Celera837,435,634 - 37,435,722UniSTS
Cytogenetic Map8A4UniSTS
Whitehead/MRC_RH8392.41UniSTS
UniSTS:235871  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38834,819,255 - 34,819,574UniSTSGRCm38
MGSCv37835,882,309 - 35,882,628UniSTSGRCm37
Celera837,435,193 - 37,435,512UniSTS
Cytogenetic Map8A4UniSTS
AA997460  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38834,821,618 - 34,821,830UniSTSGRCm38
MGSCv37835,884,672 - 35,884,884UniSTSGRCm37
Celera837,437,552 - 37,437,760UniSTS
Cytogenetic Map8A4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8749417341494326Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8761318541613356Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8761318541613356Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8761318541613356Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81339721034854071Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82613028560130285Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83278698850837502Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83464277644852835Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:256
Interacting mature miRNAs:272
Transcripts:ENSMUST00000033930
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033930   ⟹   ENSMUSP00000033930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl835,274,451 - 35,287,048 (+)Ensembl
GRCm38.p6 Ensembl834,807,297 - 34,819,894 (+)Ensembl
RefSeq Acc Id: NM_176933   ⟹   NP_795907
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39835,274,764 - 35,287,048 (+)NCBI
GRCm38834,807,610 - 34,819,894 (+)ENTREZGENE
MGSCv37835,870,664 - 35,882,948 (+)RGD
Celera837,423,596 - 37,435,832 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_795907   ⟸   NM_176933
- UniProtKB: Q8BFV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033930   ⟸   ENSMUST00000033930
Promoters
RGD ID:8666877
Promoter ID:EPDNEW_M11470
Type:multiple initiation site
Name:Dusp4_1
Description:Mus musculus dual specificity phosphatase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38834,807,614 - 34,807,674EPDNEW
RGD ID:6843052
Promoter ID:MM_KWN:54152
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000033930
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36835,869,846 - 35,871,212 (+)MPROMDB
RGD ID:6849250
Promoter ID:MM_XEF:7022
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:NM_057158
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36835,871,641 - 35,872,252 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442191 AgrOrtholog
Ensembl Genes ENSMUSG00000031530 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033930 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033930 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319520 UniProtKB/Swiss-Prot
MGD MGI:2442191 ENTREZGENE
NCBI Gene 319520 ENTREZGENE
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp4 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DUS4_MOUSE UniProtKB/Swiss-Prot
  Q0VF80_MOUSE UniProtKB/TrEMBL
  Q8BFV3 ENTREZGENE