Nherf2 (NHERF family PDZ scaffold protein 2) - Rat Genome Database

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Gene: Nherf2 (NHERF family PDZ scaffold protein 2) Mus musculus
Analyze
Symbol: Nherf2
Name: NHERF family PDZ scaffold protein 2
RGD ID: 733002
MGI Page MGI
Description: Enables phosphatase binding activity. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and sensory perception of sound. Located in several cellular components, including apical plasma membrane; nucleus; and stereocilium. Is expressed in atrioventricular valve; cochlea epithelium; organ of Corti; and semilunar valve. Orthologous to human NHERF2 (NHERF family PDZ scaffold protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610011L07Rik; 1200011K07Rik; 2010007A20Rik; E3k; E3karp; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein E3KARP; Nher; NHERF-2; Oct; Octs2; S; Si; Sip-1; Sip1; Slc9a3r2; sodium-hydrogen exchanger regulatory factor 2; sodium/hydrogen exchanger; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9 isoform 3 regulator 2, isoform A; solute carrier family 9 isoform A3 regulatory factor 2; Sr; Sry interacting protein 1; SRY-interacting protein 1; Sryip1; Tka-; Tka-1; tyrosine kinase activator protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,858,255 - 24,869,279 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,858,260 - 24,869,301 (-)EnsemblGRCm39 Ensembl
GRCm381724,639,281 - 24,650,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,639,286 - 24,650,327 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,776,227 - 24,787,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,366,888 - 24,377,878 (-)NCBIMGSCv36mm8
Celera1725,161,671 - 25,172,581 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
Deoxycorticosterone acetate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
fenthion  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
potassium chloride  (ISO)
propiconazole  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats. Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
3. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10410901   PMID:11042159   PMID:11076861   PMID:11099500   PMID:12169661   PMID:12477932   PMID:14531806   PMID:14610273   PMID:15665527   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16166090   PMID:16456542   PMID:16615918   PMID:16891310   PMID:17947234   PMID:17990980   PMID:18256311   PMID:18407958   PMID:18483404   PMID:18799693  
PMID:18931049   PMID:19221439   PMID:19293149   PMID:19800338   PMID:20706633   PMID:20962002   PMID:21267068   PMID:21427361   PMID:21430287   PMID:21865597   PMID:21873635   PMID:24297041  
PMID:24920589   PMID:26258413   PMID:26261085   PMID:26442671   PMID:26867566   PMID:28392297   PMID:28882822   PMID:28893864   PMID:29095442   PMID:30936179   PMID:30973865   PMID:32325033  
PMID:35364055   PMID:38355793   PMID:38533975  


Genomics

Comparative Map Data
Nherf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,858,255 - 24,869,279 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,858,260 - 24,869,301 (-)EnsemblGRCm39 Ensembl
GRCm381724,639,281 - 24,650,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,639,286 - 24,650,327 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,776,227 - 24,787,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,366,888 - 24,377,878 (-)NCBIMGSCv36mm8
Celera1725,161,671 - 25,172,581 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.43NCBI
NHERF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,026,902 - 2,039,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,025,356 - 2,039,026 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,076,903 - 2,089,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,016,930 - 2,028,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,016,911 - 2,028,481NCBI
Celera162,289,067 - 2,301,134 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,001,109 - 2,013,254 (+)NCBIHuRef
CHM1_1162,076,850 - 2,089,007 (+)NCBICHM1_1
T2T-CHM13v2.0162,046,859 - 2,058,835 (+)NCBIT2T-CHM13v2.0
Nherf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,167,005 - 14,177,519 (-)NCBIGRCr8
mRatBN7.21013,662,461 - 13,672,975 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,662,461 - 13,673,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,409,255 - 18,419,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,898,101 - 17,908,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,397,300 - 13,407,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,003,330 - 14,015,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,003,320 - 14,013,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,820,310 - 13,830,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,890,293 - 13,900,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,891,061 - 13,900,879 (-)NCBI
Celera1013,342,543 - 13,353,058 (-)NCBICelera
Cytogenetic Map10q12NCBI
Nherf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,224,214 - 15,235,379 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,224,214 - 15,235,372 (-)NCBIChiLan1.0ChiLan1.0
NHERF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,307,556 - 2,319,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,089,244 - 6,101,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016664,310 - 676,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,121,215 - 2,127,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,115,583 - 2,127,069 (+)Ensemblpanpan1.1panPan2
NHERF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,905,070 - 38,915,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,905,635 - 38,942,774 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,144,686 - 40,155,043 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,214,038 - 39,216,647 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,213,735 - 39,216,642 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,898,838 - 38,909,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,871,153 - 38,881,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,349,958 - 39,360,323 (-)NCBIUU_Cfam_GSD_1.0
Nherf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,703,346 - 104,707,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,000,854 - 2,006,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,000,977 - 2,006,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHERF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,942,367 - 39,952,825 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,942,366 - 39,952,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,205,136 - 42,239,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHERF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,923,773 - 1,935,641 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,924,131 - 1,939,062 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,129,026 - 29,140,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nherf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913210,315 - 221,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913210,315 - 220,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nherf2
392 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1054
Count of miRNA genes:350
Interacting mature miRNAs:416
Transcripts:ENSMUST00000002572, ENSMUST00000019684
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
12910769Rtmq1_mrenal tumor modifier QTL 1 (mouse)172290003625721472Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB026489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ194744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000002572   ⟹   ENSMUSP00000002572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,260 - 24,869,301 (-)Ensembl
GRCm38.p6 Ensembl1724,639,286 - 24,650,327 (-)Ensembl
Ensembl Acc Id: ENSMUST00000019684   ⟹   ENSMUSP00000019684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,260 - 24,863,964 (-)Ensembl
GRCm38.p6 Ensembl1724,639,286 - 24,644,990 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234121   ⟹   ENSMUSP00000157037
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,265 - 24,866,800 (-)Ensembl
GRCm38.p6 Ensembl1724,639,291 - 24,647,826 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234505   ⟹   ENSMUSP00000157065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,744 - 24,863,931 (-)Ensembl
GRCm38.p6 Ensembl1724,639,770 - 24,644,957 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234557   ⟹   ENSMUSP00000157103
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,260 - 24,869,263 (-)Ensembl
GRCm38.p6 Ensembl1724,639,286 - 24,650,289 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,858,265 - 24,868,987 (-)Ensembl
GRCm38.p6 Ensembl1724,639,291 - 24,650,013 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,860,662 - 24,868,967 (-)Ensembl
GRCm38.p6 Ensembl1724,641,688 - 24,649,993 (-)Ensembl
RefSeq Acc Id: NM_001357796   ⟹   NP_001344725
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,858,260 - 24,869,279 (-)NCBI
GRCm381724,639,286 - 24,650,305 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023055   ⟹   NP_075542
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,858,256 - 24,869,279 (-)NCBI
GRCm381724,639,282 - 24,650,305 (-)NCBI
MGSCv371724,776,227 - 24,787,250 (-)RGD
Celera1725,161,671 - 25,172,581 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_023449   ⟹   NP_075938
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,858,256 - 24,863,931 (-)NCBI
GRCm381724,639,282 - 24,644,957 (-)NCBI
MGSCv371724,776,227 - 24,787,250 (-)RGD
Celera1725,161,671 - 25,172,581 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030249980   ⟹   XP_030105840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,858,255 - 24,864,935 (-)NCBI
GRCm381724,639,281 - 24,645,970 (-)NCBI
Sequence:
RefSeq Acc Id: NP_075542   ⟸   NM_023055
- Peptide Label: isoform A
- UniProtKB: Q9DCR6 (UniProtKB/Swiss-Prot),   Q8BW05 (UniProtKB/Swiss-Prot),   Q8BGL9 (UniProtKB/Swiss-Prot),   Q6P074 (UniProtKB/Swiss-Prot),   Q3TDR3 (UniProtKB/Swiss-Prot),   Q9JHL1 (UniProtKB/Swiss-Prot),   A0A0R4IZX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_075938   ⟸   NM_023449
- Peptide Label: isoform B
- UniProtKB: A0A0R4J006 (UniProtKB/TrEMBL),   A0A3Q4EBU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030105840   ⟸   XM_030249980
- Peptide Label: isoform X1
- UniProtKB: A0A3Q4EHM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344725   ⟸   NM_001357796
- Peptide Label: isoform C
- UniProtKB: Q9JHL1 (UniProtKB/Swiss-Prot),   Q9DCR6 (UniProtKB/Swiss-Prot),   Q8BW05 (UniProtKB/Swiss-Prot),   Q8BGL9 (UniProtKB/Swiss-Prot),   Q6P074 (UniProtKB/Swiss-Prot),   Q3TDR3 (UniProtKB/Swiss-Prot),   Q6NS54 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000002572   ⟸   ENSMUST00000002572
Ensembl Acc Id: ENSMUSP00000019684   ⟸   ENSMUST00000019684
Ensembl Acc Id: ENSMUSP00000157065   ⟸   ENSMUST00000234505
Ensembl Acc Id: ENSMUSP00000157103   ⟸   ENSMUST00000234557
Ensembl Acc Id: ENSMUSP00000157037   ⟸   ENSMUST00000234121
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHL1-F1-model_v2 AlphaFold Q9JHL1 1-337 view protein structure

Promoters
RGD ID:13675046
Promoter ID:EPDNEW_M21672
Type:initiation region
Name:Slc9a3r2_2
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 3 regulator 2 , transcript variant A, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21673  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381724,644,941 - 24,645,001EPDNEW
RGD ID:13675048
Promoter ID:EPDNEW_M21673
Type:multiple initiation site
Name:Slc9a3r2_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 3 regulator 2 , transcript variant A, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21672  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381724,650,305 - 24,650,365EPDNEW
RGD ID:6828695
Promoter ID:MM_KWN:22532
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_023449
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,781,456 - 24,782,512 (-)MPROMDB
RGD ID:6847462
Promoter ID:MM_ACW:22055
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:SLC9A3R2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,784,451 - 24,784,951 (-)MPROMDB
RGD ID:6828696
Promoter ID:MM_KWN:22533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000088403,   NM_023055
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,786,829 - 24,787,329 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890662 AgrOrtholog
Ensembl Genes ENSMUSG00000002504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002572 ENTREZGENE
  ENSMUST00000002572.6 UniProtKB/TrEMBL
  ENSMUST00000019684 ENTREZGENE
  ENSMUST00000019684.13 UniProtKB/TrEMBL
  ENSMUST00000234121.2 UniProtKB/TrEMBL
  ENSMUST00000234505 ENTREZGENE
  ENSMUST00000234505.2 UniProtKB/TrEMBL
  ENSMUST00000234557 ENTREZGENE
  ENSMUST00000234557.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EBP50_C-term UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHERF-1/NHERF-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:65962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1890662 ENTREZGENE
NCBI Gene 65962 ENTREZGENE
PANTHER PDZ DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14191:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EBP50_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nherf2 PhenoGen
PIRSF EBP50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4IZX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0R4J006 ENTREZGENE, UniProtKB/TrEMBL
  A0A3Q4EBU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A3Q4EHM9 ENTREZGENE, UniProtKB/TrEMBL
  NHRF2_MOUSE UniProtKB/Swiss-Prot
  Q3TDR3 ENTREZGENE
  Q6NS54 ENTREZGENE, UniProtKB/TrEMBL
  Q6P074 ENTREZGENE
  Q8BGL9 ENTREZGENE
  Q8BW05 ENTREZGENE
  Q9DCR6 ENTREZGENE
  Q9JHL1 ENTREZGENE
UniProt Secondary Q3TDR3 UniProtKB/Swiss-Prot
  Q6P074 UniProtKB/Swiss-Prot
  Q8BGL9 UniProtKB/Swiss-Prot
  Q8BW05 UniProtKB/Swiss-Prot
  Q9DCR6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-12 Nherf2  NHERF family PDZ scaffold protein 2  Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2  Symbol and/or name updated 27372883 PROVISIONAL