Aspm (abnormal spindle microtubule assembly) - Rat Genome Database

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Gene: Aspm (abnormal spindle microtubule assembly) Mus musculus
Analyze
Symbol: Aspm
Name: abnormal spindle microtubule assembly
RGD ID: 1619289
MGI Page MGI
Description: Enables calmodulin binding activity. Involved in regulation of meiotic cell cycle. Acts upstream of or within several processes, including maintenance of centrosome location; nervous system development; and neuronal stem cell population maintenance. Located in cytoplasm; microtubule cytoskeleton; and midbody. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and perichondrium. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 5. Orthologous to human ASPM (assembly factor for spindle microtubules).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; abnormal spindle-like microcephaly-associated protein homolog; asp (abnormal spindle)-like, microcephaly associated; asp (abnormal spindle)-like, microcephaly associated (Drosophila); Calm; Calmbp1; calmodulin binding protein 1; calmodulin-binding protein 1; calmodulin-binding protein Sha1; D330028K02Rik; FLJ10518; MCPH; MCPH5; Sh; Sha1; spindle and hydroxyurea checkpoint abnormal protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,381,450 - 139,421,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,382,510 - 139,421,829 (+)EnsemblGRCm39 Ensembl
GRCm381139,454,188 - 139,494,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,454,772 - 139,494,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371141,351,350 - 141,390,665 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,271,184 - 141,310,501 (+)NCBIMGSCv36mm8
Celera1142,091,996 - 142,131,299 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol AF  (EXP)
boron nitride  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
chromium(3+) trichloride  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
gamma-tocopherol  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lucanthone  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nicotine  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
riboflavin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression. Alsiary R, etal., PLoS One. 2014 May 15;9(5):e97059. doi: 10.1371/journal.pone.0097059. eCollection 2014.
2. ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Bikeye SN, etal., Cancer Cell Int. 2010 Jan 11;10:1. doi: 10.1186/1475-2867-10-1.
3. Primary microcephaly with ASPM mutation shows simplified cortical gyration with antero-posterior gradient pre- and post-natally. Desir J, etal., Am J Med Genet A. 2008 Jun 1;146A(11):1439-43. doi: 10.1002/ajmg.a.32312.
4. Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas. Hagemann C, etal., Oncol Rep. 2008 Aug;20(2):301-8.
5. Mutation analysis of the ASPM gene in 18 Pakistani families with autosomal recessive primary microcephaly. Kousar R, etal., J Child Neurol. 2010 Jun;25(6):715-20. doi: 10.1177/0883073809346850. Epub 2009 Oct 6.
6. ASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinoma. Lin SY, etal., Clin Cancer Res. 2008 Aug 1;14(15):4814-20. doi: 10.1158/1078-0432.CCR-07-5262.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations. Passemard S, etal., Neurology. 2009 Sep 22;73(12):962-9. doi: 10.1212/WNL.0b013e3181b8799a.
9. Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Pulvers JN, etal., Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. ASPM mutations identified in patients with primary microcephaly and seizures. Shen J, etal., J Med Genet. 2005 Sep;42(9):725-9.
14. Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer. Vange P, etal., J Pathol. 2015 Dec;237(4):447-59. doi: 10.1002/path.4591. Epub 2015 Aug 26.
Additional References at PubMed
PMID:9819352   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11812828   PMID:12351193   PMID:12355089   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:14610273   PMID:14691545   PMID:14722158   PMID:15045028   PMID:15972725   PMID:16141072   PMID:16141073   PMID:16443634   PMID:16602821   PMID:16798874   PMID:17015433   PMID:18728014  
PMID:19521566   PMID:19896444   PMID:21267068   PMID:21559369   PMID:21677750   PMID:21737879   PMID:21937711   PMID:22031545   PMID:22154806   PMID:23152892   PMID:24220505   PMID:26410627  
PMID:26450969   PMID:26581405   PMID:26935419   PMID:27562601   PMID:27798109   PMID:27974163   PMID:28272472   PMID:29253521   PMID:30635555   PMID:30973865   PMID:31138677   PMID:32066665  
PMID:32325033   PMID:32469866   PMID:32554809   PMID:34059773   PMID:34237032   PMID:35901620   PMID:36883909   PMID:36980263   PMID:38019816   PMID:38199563   PMID:38355793   PMID:39271675  


Genomics

Comparative Map Data
Aspm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,381,450 - 139,421,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,382,510 - 139,421,829 (+)EnsemblGRCm39 Ensembl
GRCm381139,454,188 - 139,494,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,454,772 - 139,494,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371141,351,350 - 141,390,665 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,271,184 - 141,310,501 (+)NCBIMGSCv36mm8
Celera1142,091,996 - 142,131,299 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.45NCBI
ASPM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381197,084,127 - 197,146,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1197,084,121 - 197,146,694 (-)EnsemblGRCh38hg38GRCh38
GRCh371197,053,257 - 197,115,799 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,319,997 - 195,382,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 341193,785,110 - 193,847,224NCBI
Celera1170,178,726 - 170,241,291 (-)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,210,775 - 168,273,332 (-)NCBIHuRef
CHM1_11198,475,715 - 198,538,290 (-)NCBICHM1_1
T2T-CHM13v2.01196,345,951 - 196,408,493 (-)NCBIT2T-CHM13v2.0
Aspm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,625,584 - 53,674,489 (+)NCBIGRCr8
mRatBN7.21351,074,849 - 51,123,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,074,849 - 51,123,755 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,674,430 - 53,723,339 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,962,363 - 55,011,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,237,670 - 52,286,704 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,546,021 - 56,591,793 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,546,021 - 56,591,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,564,059 - 61,609,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,811,658 - 52,860,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,825,867 - 52,874,707 (+)NCBI
Celera1351,338,709 - 51,386,444 (+)NCBICelera
Cytogenetic Map13q13NCBI
Aspm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,661,322 - 33,720,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,665,675 - 33,720,468 (-)NCBIChiLan1.0ChiLan1.0
ASPM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2152,234,381 - 52,296,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,203,536 - 52,265,974 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,674,890 - 172,737,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,988,297 - 177,050,810 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,988,297 - 177,050,810 (-)Ensemblpanpan1.1panPan2
ASPM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,591,530 - 5,663,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,590,957 - 5,660,919 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,214,490 - 5,283,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,281,249 - 5,357,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,281,133 - 5,357,008 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,223,076 - 5,291,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,324,076 - 5,392,760 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,356,703 - 5,425,864 (+)NCBIUU_Cfam_GSD_1.0
Aspm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,418,215 - 77,467,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365676,653,728 - 6,701,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365676,653,382 - 6,701,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASPM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,975,192 - 20,039,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,971,516 - 20,039,680 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,612,797 - 24,657,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASPM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,269,518 - 32,334,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2532,281,424 - 32,334,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605533,177,890 - 33,242,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aspm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247983,165,393 - 3,225,181 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247983,164,145 - 3,223,810 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aspm
2236 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:221
Interacting mature miRNAs:235
Transcripts:ENSMUST00000053364, ENSMUST00000097554, ENSMUST00000128413, ENSMUST00000155402
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse

Markers in Region
RH136166  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381139,475,619 - 139,475,834UniSTSGRCm38
MGSCv371141,372,196 - 141,372,411UniSTSGRCm37
Celera1142,112,842 - 142,113,057UniSTS
Cytogenetic Map1FUniSTS
Aspm  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS
cM Map161.45UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC158946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF062378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF533752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY971958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI989704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01045133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN664812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV556405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV662096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000053364   ⟹   ENSMUSP00000059159
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1139,382,513 - 139,421,829 (+)Ensembl
GRCm38.p6 Ensembl1139,454,775 - 139,494,091 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1139,411,264 - 139,415,134 (+)Ensembl
GRCm38.p6 Ensembl1139,483,526 - 139,487,396 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197096
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1139,382,557 - 139,384,872 (+)Ensembl
GRCm38.p6 Ensembl1139,454,819 - 139,457,134 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1139,382,511 - 139,402,072 (+)Ensembl
GRCm38.p6 Ensembl1139,454,773 - 139,474,334 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200083   ⟹   ENSMUSP00000142880
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1139,382,510 - 139,421,826 (+)Ensembl
GRCm38.p6 Ensembl1139,454,772 - 139,494,088 (+)Ensembl
RefSeq Acc Id: NM_009791   ⟹   NP_033921
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391139,382,511 - 139,421,826 (+)NCBI
GRCm381139,454,773 - 139,494,088 (+)NCBI
MGSCv371141,351,350 - 141,390,665 (+)RGD
Celera1142,091,996 - 142,131,299 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006529108   ⟹   XP_006529171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391139,402,328 - 139,421,821 (+)NCBI
GRCm381139,474,594 - 139,494,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312957   ⟹   XP_017168446
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391139,381,450 - 139,402,566 (+)NCBI
GRCm381139,454,188 - 139,474,828 (+)NCBI
Sequence:
RefSeq Acc Id: NP_033921   ⟸   NM_009791
- UniProtKB: Q8BJI8 (UniProtKB/Swiss-Prot),   Q4G1G9 (UniProtKB/Swiss-Prot),   O88482 (UniProtKB/Swiss-Prot),   B1ARM7 (UniProtKB/Swiss-Prot),   A0A0G2JES1 (UniProtKB/Swiss-Prot),   Q8BKT4 (UniProtKB/Swiss-Prot),   Q8CJ27 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006529171   ⟸   XM_006529108
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017168446   ⟸   XM_017312957
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000059159   ⟸   ENSMUST00000053364
Ensembl Acc Id: ENSMUSP00000142880   ⟸   ENSMUST00000200083
Protein Domains
Calponin-homology (CH)   IQ

Promoters
RGD ID:6875146
Promoter ID:EPDNEW_M1024
Type:initiation region
Name:Aspm_1
Description:Mus musculus abnormal spindle microtubule assembly , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381139,454,873 - 139,454,933EPDNEW
RGD ID:6817398
Promoter ID:MM_KWN:2308
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000097554,   OTTMUST00000046913,   OTTMUST00000046915,   UC007CWJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361141,350,351 - 141,351,877 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1334448 AgrOrtholog
Ensembl Genes ENSMUSG00000033952 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053364 ENTREZGENE
  ENSMUST00000053364.12 UniProtKB/Swiss-Prot
  ENSMUST00000200083.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  1.20.5.190 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  ASH UniProtKB/Swiss-Prot
  ASPM UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:12316 UniProtKB/Swiss-Prot
MGD MGI:1334448 ENTREZGENE
NCBI Gene 12316 ENTREZGENE
PANTHER ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1 UniProtKB/Swiss-Prot
  UNCHARACTERIZED UniProtKB/Swiss-Prot
Pfam ASH UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Aspm PhenoGen
PROSITE PS50021 UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
SMART SM00015 UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JES1 ENTREZGENE
  ASPM_MOUSE UniProtKB/Swiss-Prot
  B1ARM7 ENTREZGENE
  O88482 ENTREZGENE
  Q4G1G9 ENTREZGENE
  Q8BJI8 ENTREZGENE
  Q8BKT4 ENTREZGENE
  Q8CJ27 ENTREZGENE
UniProt Secondary A0A0G2JES1 UniProtKB/Swiss-Prot
  B1ARM7 UniProtKB/Swiss-Prot
  O88482 UniProtKB/Swiss-Prot
  Q4G1G9 UniProtKB/Swiss-Prot
  Q8BJI8 UniProtKB/Swiss-Prot
  Q8BKT4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Aspm  abnormal spindle microtubule assembly    asp (abnormal spindle)-like, microcephaly associated (Drosophila)  Symbol and/or name change 5135510 APPROVED