P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7) - Rat Genome Database
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Gene: P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7) Mus musculus
Analyze
Symbol: P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
RGD ID: 730815
MGI Page MGI
Description: Exhibits several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of organic acid transport. Localizes to several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI467586; ATP receptor; P2X; P2X purinoceptor 7; P2X(7; P2X(7); P2X7 purinoceptor; P2X7 receptor; P2X7R; P2Z receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,781,990 - 122,830,399 (+)NCBIGRCm39mm39
GRCm385122,643,927 - 122,692,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,643,911 - 122,691,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,093,920 - 123,141,441 (+)NCBIGRCm37mm9NCBIm37
MGSCv365122,904,528 - 122,952,049 (+)NCBImm8
Celera5119,722,412 - 119,770,254 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(R)-adrenaline  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (EXP)
adenosine 5'-[gamma-thio]triphosphate  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (EXP,ISO)
avobenzone  (ISO)
azetidine  (EXP)
barium(0)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
berberine  (ISO)
bisphenol A  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP,ISO)
carrageenan  (ISO)
casticin  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
diethyl maleate  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
ethidium  (ISO)
etoposide  (EXP)
folic acid  (EXP)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (EXP)
ginsenoside C-K  (EXP)
ginsenoside Rd  (EXP)
glucose  (ISO)
graphene oxide  (EXP)
hexadecanoic acid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
melittin  (ISO)
metformin  (ISO)
N-nitrosodiethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
poly(I:C)  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
suramin  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IMP)
apoptotic signaling pathway  (ISO)
ATP export  (ISO)
bleb assembly  (IMP,ISO)
calcium ion transport  (IMP)
cation transmembrane transport  (IEA)
cation transport  (IMP)
cell death  (IDA,IMP)
cell morphogenesis  (IMP)
cell surface receptor signaling pathway  (ISO)
cell volume homeostasis  (IDA)
cellular response to dsRNA  (IMP)
cellular response to extracellular stimulus  (IMP)
cellular response to organic cyclic compound  (IDA)
ceramide biosynthetic process  (IDA)
collagen metabolic process  (IMP)
defense response to Gram-positive bacterium  (IMP)
extrinsic apoptotic signaling pathway  (IMP)
gene expression  (IMP)
homeostasis of number of cells within a tissue  (IMP)
inflammatory response  (IMP)
ion transport  (IEA)
membrane depolarization  (ISO)
membrane protein ectodomain proteolysis  (IMP)
mitochondrion organization  (IDA)
NAD transport  (IMP)
negative regulation of bone resorption  (IMP)
negative regulation of cell volume  (IMP,ISO)
negative regulation of MAPK cascade  (IDA)
neuronal action potential  (ISO)
phagolysosome assembly  (IMP)
phospholipid transfer to membrane  (IMP)
phospholipid translocation  (IDA)
plasma membrane organization  (IDA)
plasma membrane phospholipid scrambling  (ISO)
pore complex assembly  (IMP,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of bleb assembly  (ISO)
positive regulation of bone mineralization  (IMP)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of catalytic activity  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of cytoskeleton organization  (ISO)
positive regulation of gamma-aminobutyric acid secretion  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glutamate secretion  (IMP)
positive regulation of glycolytic process  (ISO)
positive regulation of interleukin-1 alpha production  (IMP)
positive regulation of interleukin-1 beta production  (IMP,ISO)
positive regulation of interleukin-6 production  (IMP)
positive regulation of ion transmembrane transport  (ISO)
positive regulation of lymphocyte apoptotic process  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of mitochondrial depolarization  (IMP)
positive regulation of ossification  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein secretion  (IDA)
positive regulation of T cell mediated cytotoxicity  (IMP)
programmed cell death  (IDA,IMP)
protein catabolic process  (IDA)
protein phosphorylation  (IMP)
protein processing  (IMP)
purinergic nucleotide receptor signaling pathway  (ISO)
reactive oxygen species metabolic process  (IMP)
regulation of presynaptic dense core granule exocytosis  (ISO)
regulation of sodium ion transport  (ISO)
release of sequestered calcium ion into cytosol  (IMP)
response to ATP  (IDA,IMP,ISO)
response to bacterium  (IMP)
response to calcium ion  (IDA,IMP)
response to drug  (IMP)
response to electrical stimulus  (IMP)
response to fluid shear stress  (IMP)
response to lipopolysaccharide  (IDA,IMP)
response to mechanical stimulus  (IMP)
response to organic cyclic compound  (IDA)
response to organic substance  (IMP)
response to zinc ion  (IMP)
sensory perception of pain  (IMP)
skeletal system morphogenesis  (IMP)
synaptic vesicle exocytosis  (IMP)
T cell homeostasis  (IMP)
T cell proliferation  (IMP)
vesicle budding from membrane  (IMP)

References

Additional References at PubMed
PMID:9849870   PMID:10349636   PMID:10395640   PMID:11016935   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11489964   PMID:11544199   PMID:11544318   PMID:11904160   PMID:12055263  
PMID:12370338   PMID:12466305   PMID:12466851   PMID:12477932   PMID:12598620   PMID:12621313   PMID:12677010   PMID:12759456   PMID:12796490   PMID:12814360   PMID:12968021   PMID:14511112  
PMID:14610273   PMID:14696971   PMID:14761980   PMID:14996828   PMID:15070812   PMID:15075209   PMID:15200422   PMID:15240711   PMID:15254086   PMID:15277380   PMID:15331634   PMID:15350640  
PMID:15640761   PMID:15670583   PMID:15713258   PMID:15777864   PMID:15845532   PMID:15899033   PMID:15905573   PMID:15914561   PMID:15937334   PMID:15964665   PMID:15978588   PMID:15984421  
PMID:16027239   PMID:16116196   PMID:16141072   PMID:16141073   PMID:16198349   PMID:16207496   PMID:16269410   PMID:16301672   PMID:16325464   PMID:16455971   PMID:16493071   PMID:16565512  
PMID:16571660   PMID:16602821   PMID:16817206   PMID:16836656   PMID:16920919   PMID:16969386   PMID:16985003   PMID:17135244   PMID:17175137   PMID:17286969   PMID:17304630   PMID:17306762  
PMID:17339442   PMID:17364502   PMID:17448897   PMID:17491021   PMID:17498208   PMID:17544414   PMID:17641058   PMID:17651941   PMID:17675190   PMID:17702819   PMID:17785580   PMID:17785807  
PMID:17803959   PMID:17825926   PMID:17849469   PMID:17905568   PMID:17962183   PMID:18082965   PMID:18097031   PMID:18211888   PMID:18293404   PMID:18305483   PMID:18384650   PMID:18407780  
PMID:18445587   PMID:18490713   PMID:18501702   PMID:18502993   PMID:18519738   PMID:18523246   PMID:18596211   PMID:18652259   PMID:18657557   PMID:18691411   PMID:18768840   PMID:18848528  
PMID:18942742   PMID:18987356   PMID:18996151   PMID:19047635   PMID:19051251   PMID:19066285   PMID:19076210   PMID:19097994   PMID:19151591   PMID:19171786   PMID:19174470   PMID:19174471  
PMID:19201858   PMID:19204004   PMID:19211924   PMID:19234185   PMID:19276178   PMID:19299738   PMID:19304656   PMID:19308630   PMID:19309360   PMID:19342685   PMID:19379509   PMID:19385050  
PMID:19389853   PMID:19396427   PMID:19403602   PMID:19426712   PMID:19439191   PMID:19536133   PMID:19542469   PMID:19546214   PMID:19547756   PMID:19570022   PMID:19652710   PMID:19682070  
PMID:19717510   PMID:19767732   PMID:19805629   PMID:19812205   PMID:19918053   PMID:20007545   PMID:20023662   PMID:20070863   PMID:20071520   PMID:20113349   PMID:20348425   PMID:20393140  
PMID:20477948   PMID:20488797   PMID:20508067   PMID:20508069   PMID:20522787   PMID:20529664   PMID:20563595   PMID:20639492   PMID:20643770   PMID:20645413   PMID:20709956   PMID:20722629  
PMID:20739479   PMID:20805478   PMID:20813842   PMID:20829501   PMID:20947763   PMID:20975043   PMID:21059855   PMID:21059925   PMID:21081501   PMID:21102458   PMID:21237152   PMID:21266468  
PMID:21267068   PMID:21278344   PMID:21289095   PMID:21292765   PMID:21311565   PMID:21357533   PMID:21357538   PMID:21474346   PMID:21478880   PMID:21505260   PMID:21508259   PMID:21518438  
PMID:21533069   PMID:21602824   PMID:21621419   PMID:21651910   PMID:21664437   PMID:21670495   PMID:21675966   PMID:21677750   PMID:21697458   PMID:21698237   PMID:21703403   PMID:21747211  
PMID:21794079   PMID:21812012   PMID:21819958   PMID:21821797   PMID:21830236   PMID:21838754   PMID:21856950   PMID:21865551   PMID:21873635   PMID:21915284   PMID:21941410   PMID:21982752  
PMID:21983632   PMID:22002608   PMID:22022466   PMID:22101787   PMID:22120528   PMID:22185840   PMID:22198387   PMID:22235111   PMID:22243662   PMID:22248690   PMID:22253851   PMID:22275804  
PMID:22343416   PMID:22349510   PMID:22383490   PMID:22387558   PMID:22405772   PMID:22415881   PMID:22426419   PMID:22447075   PMID:22451435   PMID:22490780   PMID:22496641   PMID:22529194  
PMID:22553206   PMID:22558229   PMID:22564028   PMID:22585038   PMID:22586114   PMID:22649196   PMID:22753929   PMID:22781627   PMID:22789015   PMID:22797941   PMID:22815977   PMID:22848454  
PMID:22859404   PMID:22875784   PMID:22891241   PMID:22915101   PMID:22934234   PMID:22948816   PMID:22981536   PMID:22984079   PMID:22987361   PMID:22988022   PMID:22988253   PMID:23017058  
PMID:23050672   PMID:23089744   PMID:23139414   PMID:23143333   PMID:23225887   PMID:23250993   PMID:23251531   PMID:23267025   PMID:23284663   PMID:23284917   PMID:23308196   PMID:23315496  
PMID:23428419   PMID:23454767   PMID:23479225   PMID:23489421   PMID:23540405   PMID:23562658   PMID:23575529   PMID:23583008   PMID:23589615   PMID:23613968   PMID:23657251   PMID:23689980  
PMID:23708969   PMID:23711511   PMID:23727220   PMID:23736299   PMID:23770338   PMID:23805233   PMID:23826152   PMID:23830920   PMID:23843215   PMID:23867818   PMID:23911869   PMID:23940597  
PMID:23958305   PMID:24091672   PMID:24114535   PMID:24157462   PMID:24157968   PMID:24194600   PMID:24218483   PMID:24222214   PMID:24247209   PMID:24453977   PMID:24458711   PMID:24470356  
PMID:24489101   PMID:24590064   PMID:24610121   PMID:24651438   PMID:24661878   PMID:24694658   PMID:24726878   PMID:24729618   PMID:24743022   PMID:24798220   PMID:24830427   PMID:24879505  
PMID:24895290   PMID:24922070   PMID:24925032   PMID:24941004   PMID:24952961   PMID:24991816   PMID:25048544   PMID:25127469   PMID:25155463   PMID:25170954   PMID:25225402   PMID:25239372  
PMID:25281740   PMID:25310682   PMID:25318104   PMID:25343479   PMID:25451844   PMID:25464855   PMID:25486274   PMID:25502294   PMID:25542352   PMID:25542768   PMID:25542861   PMID:25564520  
PMID:25588875   PMID:25605289   PMID:25651887   PMID:25675986   PMID:25681768   PMID:25690658   PMID:25692702   PMID:25700737   PMID:25719930   PMID:25740510   PMID:25772484   PMID:25796110  
PMID:25862090   PMID:25948251   PMID:25972159   PMID:25998681   PMID:26053862   PMID:26060214   PMID:26068648   PMID:26091541   PMID:26122280   PMID:26152185   PMID:26198936   PMID:26295445  
PMID:26358881   PMID:26384545   PMID:26461208   PMID:26474534   PMID:26483196   PMID:26522449   PMID:26529046   PMID:26553756   PMID:26556873   PMID:26572062   PMID:26592184   PMID:26631939  
PMID:26739809   PMID:26747786   PMID:26812038   PMID:26830892   PMID:26877061   PMID:26935289   PMID:27048203   PMID:27159053   PMID:27206526   PMID:27255725   PMID:27287410   PMID:27292635  
PMID:27322617   PMID:27466191   PMID:27544305   PMID:27559003   PMID:27559050   PMID:27626380   PMID:27663455   PMID:27663621   PMID:27666820   PMID:27707719   PMID:27730511   PMID:27775097  
PMID:27810364   PMID:27824163   PMID:27833023   PMID:27840225   PMID:27858314   PMID:27866341   PMID:27881823   PMID:27929040   PMID:27966552   PMID:28031477   PMID:28063215   PMID:28069296  
PMID:28089560   PMID:28225814   PMID:28244110   PMID:28286160   PMID:28297661   PMID:28322086   PMID:28351919   PMID:28377486   PMID:28428949   PMID:28430869   PMID:28495929   PMID:28554875  
PMID:28597172   PMID:28628761   PMID:28633291   PMID:28671696   PMID:28687662   PMID:28723547   PMID:28798231   PMID:28802645   PMID:28859168   PMID:28930866   PMID:28992079   PMID:29018292  
PMID:29044426   PMID:29075178   PMID:29079688   PMID:29176737   PMID:29222907   PMID:29270247   PMID:29279307   PMID:29467297   PMID:29472582   PMID:29508376   PMID:29616195   PMID:29725032  
PMID:29750294   PMID:29858571   PMID:29870687   PMID:29958799   PMID:29973721   PMID:30010623   PMID:30065030   PMID:30068016   PMID:30074479   PMID:30093975   PMID:30098501   PMID:30281537  
PMID:30383448   PMID:30458799   PMID:30552101   PMID:30626694   PMID:30653952   PMID:30655308   PMID:30683682   PMID:30777922   PMID:30892913   PMID:30919410   PMID:30926332   PMID:30949163  
PMID:30952064   PMID:30952430   PMID:31019207   PMID:31075901   PMID:31091450   PMID:31100367   PMID:31102752   PMID:31233552   PMID:31249344   PMID:31308092   PMID:31376190   PMID:31425346  
PMID:31445901   PMID:31533918   PMID:31676289   PMID:31693933   PMID:31699796   PMID:31736956   PMID:31934722   PMID:31982429   PMID:32049051   PMID:32103010   PMID:32286307   PMID:32325033  
PMID:32358018   PMID:32566102   PMID:32699136   PMID:32982684   PMID:33135636   PMID:33199725  


Genomics

Comparative Map Data
P2rx7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,781,990 - 122,830,399 (+)NCBIGRCm39mm39
GRCm385122,643,927 - 122,692,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,643,911 - 122,691,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,093,920 - 123,141,441 (+)NCBIGRCm37mm9NCBIm37
MGSCv365122,904,528 - 122,952,049 (+)NCBImm8
Celera5119,722,412 - 119,770,254 (+)NCBICelera
Cytogenetic Map5FNCBI
P2RX7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12121,132,819 - 121,188,032 (+)EnsemblGRCh38hg38GRCh38
GRCh3812121,132,819 - 121,188,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,570,679 - 121,625,835 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3712121,570,622 - 121,624,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,055,061 - 120,108,259 (+)NCBINCBI36hg18NCBI36
Build 3412120,033,397 - 120,086,591NCBI
Celera12121,208,365 - 121,262,089 (+)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,580,277 - 118,634,021 (+)NCBIHuRef
CHM1_112121,539,497 - 121,593,180 (+)NCBICHM1_1
P2rx7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21233,889,709 - 33,934,168 (-)NCBI
Rnor_6.0 Ensembl1239,353,613 - 39,396,042 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01239,353,613 - 39,396,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01241,804,060 - 41,808,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01241,242,368 - 41,284,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,074,025 - 35,117,152 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11234,937,412 - 34,980,540 (-)NCBI
Celera1235,564,374 - 35,607,476 (-)NCBICelera
Cytogenetic Map12q16NCBI
P2rx7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,048,776 - 7,086,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,048,674 - 7,087,525 (-)NCBIChiLan1.0ChiLan1.0
P2RX7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112122,102,888 - 122,154,068 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,102,888 - 122,154,068 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012118,731,761 - 118,786,039 (+)NCBIMhudiblu_PPA_v0panPan3
P2RX7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl267,940,985 - 7,983,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1267,928,863 - 7,983,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
P2rx7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365583,106,819 - 3,149,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,415,192 - 31,476,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,415,188 - 31,476,502 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,281,108 - 33,340,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,505,975 - 116,560,151 (+)NCBI
ChlSab1.1 Ensembl11116,529,346 - 116,563,059 (+)Ensembl
P2rx7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474721,725,813 - 21,768,123 (+)NCBI

Position Markers
AI467586  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51493.68UniSTS
P2rx7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map562.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99801563126805880Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100527900134527900Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100527900134527900Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101194514135194514Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101725767135725963Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104435822138557193Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104567876138567876Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108614643126805880Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109090758139133150Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113172519138557193Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5113883692129555542Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119806972141714711Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir150mmu-miR-150-5pOncomiRDBexternal_infoNANA18682393
Mir186mmu-miR-186-5pOncomiRDBexternal_infoNANA18682393

Predicted Target Of
Summary Value
Count of predictions:1625
Count of miRNA genes:656
Interacting mature miRNAs:815
Transcripts:ENSMUST00000031425, ENSMUST00000086247, ENSMUST00000100737, ENSMUST00000121489
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001038839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001038887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ009823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ489296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ489297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ554327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY752747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF912941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ436444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000031425   ⟹   ENSMUSP00000031425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,643,939 - 122,691,432 (+)Ensembl
RefSeq Acc Id: ENSMUST00000086247   ⟹   ENSMUSP00000083425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,644,009 - 122,655,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000100737   ⟹   ENSMUSP00000098303
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,643,911 - 122,684,289 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121489   ⟹   ENSMUSP00000112440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,643,911 - 122,684,297 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,682,182 - 122,684,284 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197102
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,681,942 - 122,683,524 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,644,165 - 122,647,794 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199371   ⟹   ENSMUSP00000158311
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5122,650,424 - 122,681,373 (+)Ensembl
RefSeq Acc Id: NM_001038839   ⟹   NP_001033928
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,822,352 (+)NCBI
GRCm385122,643,927 - 122,684,289 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001038845   ⟹   NP_001033934
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,830,399 (+)NCBI
GRCm385122,643,927 - 122,692,336 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001038887   ⟹   NP_001033976
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,793,329 (+)NCBI
GRCm385122,643,927 - 122,655,266 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001284402   ⟹   NP_001271331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,788,446 - 122,822,352 (+)NCBI
GRCm385122,650,383 - 122,684,289 (+)NCBI
Celera5119,722,412 - 119,770,254 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011027   ⟹   NP_035157
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395122,781,990 - 122,822,352 (+)NCBI
GRCm385122,643,927 - 122,684,289 (+)NCBI
MGSCv375123,093,920 - 123,141,441 (+)RGD
Celera5119,722,412 - 119,770,254 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001033976   ⟸   NM_001038887
- Peptide Label: isoform d
- UniProtKB: Q3UN00 (UniProtKB/TrEMBL),   Q6P5P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033934   ⟸   NM_001038845
- Peptide Label: isoform b
- UniProtKB: F8WI93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035157   ⟸   NM_011027
- Peptide Label: isoform a
- UniProtKB: Q9Z1M0 (UniProtKB/Swiss-Prot),   C8YIX4 (UniProtKB/TrEMBL),   Q8CHP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033928   ⟸   NM_001038839
- Peptide Label: isoform c
- UniProtKB: C8YIX4 (UniProtKB/TrEMBL),   Q3UN00 (UniProtKB/TrEMBL),   Q8CHP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271331   ⟸   NM_001284402
- Peptide Label: isoform e
- UniProtKB: C8YIX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000083425   ⟸   ENSMUST00000086247
RefSeq Acc Id: ENSMUSP00000031425   ⟸   ENSMUST00000031425
RefSeq Acc Id: ENSMUSP00000158311   ⟸   ENSMUST00000199371
RefSeq Acc Id: ENSMUSP00000112440   ⟸   ENSMUST00000121489
RefSeq Acc Id: ENSMUSP00000098303   ⟸   ENSMUST00000100737

Promoters
RGD ID:6887986
Promoter ID:EPDNEW_M7444
Type:initiation region
Name:P2rx7_1
Description:Mus musculus purinergic receptor P2X, ligand-gated ion channel,7 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7445  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385122,643,976 - 122,644,036EPDNEW
RGD ID:6887988
Promoter ID:EPDNEW_M7445
Type:multiple initiation site
Name:P2rx7_2
Description:Mus musculus purinergic receptor P2X, ligand-gated ion channel,7 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7444  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385122,650,383 - 122,650,443EPDNEW
RGD ID:6837991
Promoter ID:MM_KWN:43967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:ENSMUST00000121489,   NM_001038845,   OTTMUST00000066137,   OTTMUST00000066140
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365123,093,926 - 123,094,426 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339957 AgrOrtholog
Ensembl Genes ENSMUSG00000029468 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000031425 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000083425 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000098303 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112440 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000158311 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031425 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000086247 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000100737 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000121489 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000199371 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2X7_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18439 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1339957 ENTREZGENE
NCBI Gene 18439 ENTREZGENE
PANTHER PTHR10125:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx7 PhenoGen
PRINTS P2X7RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs P2X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2VCP3_MOUSE UniProtKB/TrEMBL
  C8YIX4 ENTREZGENE, UniProtKB/TrEMBL
  F8WI93 ENTREZGENE, UniProtKB/TrEMBL
  P2RX7_MOUSE UniProtKB/Swiss-Prot
  Q3TBP1_MOUSE UniProtKB/TrEMBL
  Q3ULZ7_MOUSE UniProtKB/TrEMBL
  Q3UM93_MOUSE UniProtKB/TrEMBL
  Q3UN00 ENTREZGENE, UniProtKB/TrEMBL
  Q6P5P0 ENTREZGENE, UniProtKB/TrEMBL
  Q8CHP3_MOUSE UniProtKB/TrEMBL
  Q8CHP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1M0 ENTREZGENE