Ugt1a6b (UDP glucuronosyltransferase 1 family, polypeptide A6B) - Rat Genome Database
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Gene: Ugt1a6b (UDP glucuronosyltransferase 1 family, polypeptide A6B) Mus musculus
Analyze
Symbol: Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
RGD ID: 1619652
MGI Page MGI
Description: Predicted to have enzyme binding activity; glucuronosyltransferase activity; and protein dimerization activity. Predicted to be involved in flavonoid glucuronidation and xenobiotic glucuronidation. Predicted to localize to endoplasmic reticulum and protein-containing complex. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6); PARTICIPATES IN paracetamol pharmacokinetics pathway; phenytoin pharmacodynamics pathway; ascorbate and aldarate metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A9; A9'; MGC36247; UDP glycosyltransferase 1 family polypeptide A9; Ugt1a9
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,030,979 - 88,146,720 (+)NCBIGRCm39mm39
GRCm38188,103,257 - 88,218,998 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,103,252 - 88,219,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv37189,999,832 - 90,115,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv36189,966,005 - 90,050,148 (+)NCBImm8
Celera191,064,552 - 91,180,057 (+)NCBICelera
Cytogenetic Map1DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (EXP)
1,7-phenanthroline  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4,6-Triphenyl-1-hexene  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Ethylphenol  (ISO)
3-methylcholanthrene  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxycoumarin  (ISO)
4-hydroxyphenytoin  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (ISO)
4-tert-butylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amentoflavone  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Bandrowski's base  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl viologen  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bosentan  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carboplatin  (ISO)
cefaloridine  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (ISO)
choline  (EXP)
chrysen-6-ol  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Diallyl sulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
erythrosin B  (ISO)
etofenprox  (ISO)
eugenol  (ISO)
farnesol  (ISO)
felbamate  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
flurbiprofen  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
gamma-hexachlorocyclohexane  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
ketoprofen  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
lorcaserin  (ISO)
melatonin  (ISO)
menadione  (ISO)
metazachlor  (ISO)
methotrexate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oltipraz  (EXP)
omeprazole  (ISO)
oxybenzone  (ISO)
p-cresol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenytoin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
rifampicin  (ISO)
rose bengal  (ISO)
rotenone  (EXP)
scopoletin  (ISO)
serotonin  (ISO)
sevoflurane  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spermidine  (EXP)
spironolactone  (EXP)
terbufos  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trans-isoeugenol  (ISO)
triadimefon  (ISO)
triclocarban  (ISO)
trifluralin  (ISO)
tungsten  (ISO)
umbelliferone  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
xanthenes  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:12477932   PMID:14672974   PMID:14681479   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Ugt1a6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,030,979 - 88,146,720 (+)NCBIGRCm39mm39
GRCm38188,103,257 - 88,218,998 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,103,252 - 88,219,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv37189,999,832 - 90,115,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv36189,966,005 - 90,050,148 (+)NCBImm8
Celera191,064,552 - 91,180,057 (+)NCBICelera
Cytogenetic Map1DNCBI
UGT1A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2233,691,607 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh382233,691,670 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372234,600,316 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372234,600,321 - 234,681,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,265,060 - 234,346,690 (+)NCBINCBI36hg18NCBI36
Build 342234,382,320 - 234,463,945NCBI
Celera2228,320,943 - 228,402,583 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2226,400,315 - 226,481,785 (+)NCBIHuRef
CHM1_12234,606,135 - 234,687,812 (+)NCBICHM1_1
Ugt1a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,747,229 - 88,808,465 (+)NCBI
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0995,241,609 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0994,928,825 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,037,154 - 87,098,362 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1987,226,279 - 87,284,238 (+)NCBI
Celera986,308,548 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2545,032,130 - 45,160,941 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12545,081,655 - 45,161,584 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1

Position Markers
PMC153064P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38188,201,037 - 88,201,490UniSTSGRCm38
MGSCv37190,097,612 - 90,098,065UniSTSGRCm37
Celera191,162,107 - 91,162,560UniSTS
Cytogenetic Map1DUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17557254793013355Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177146478110608345Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17750000095900000Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17900000091000000Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179930958113931066Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179930958113931066Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180267876126458780Mouse
14696692Tavq1_mtotal attack value QTL 1 (mouse)18200000088500000Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182904910116904910Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182904910116904910Mouse
25394564Skmw49_mskeletal muscle weight 49, TA (mouse)18344239888624908Mouse
11667074Led2_mlate embryonic death 2 (mouse)185768306117267351Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186556204120556204Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:371
Count of miRNA genes:168
Interacting mature miRNAs:174
Transcripts:ENSMUST00000113137, ENSMUST00000113138
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000113137   ⟹   ENSMUSP00000108762
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl188,106,862 - 88,218,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113138   ⟹   ENSMUSP00000108763
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl188,103,252 - 88,219,003 (+)Ensembl
RefSeq Acc Id: NM_201410   ⟹   NP_958812
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39188,030,979 - 88,146,720 (+)NCBI
GRCm38188,103,257 - 88,218,998 (+)ENTREZGENE
MGSCv37189,999,832 - 90,115,573 (+)RGD
Celera191,064,552 - 91,180,057 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_958812 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH26561 (Get FASTA)   NCBI Sequence Viewer  
  AAP48597 (Get FASTA)   NCBI Sequence Viewer  
  EDL40125 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_958812   ⟸   NM_201410
- Peptide Label: precursor
- UniProtKB: K9J7B2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108762   ⟸   ENSMUST00000113137
RefSeq Acc Id: ENSMUSP00000108763   ⟸   ENSMUST00000113138
Protein Domains
UDPGT

Promoters
RGD ID:6874402
Promoter ID:EPDNEW_M652
Type:multiple initiation site
Name:Ugt1a2_1
Description:Mus musculus UDP glucuronosyltransferase 1 family, polypeptideA2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M655  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38188,103,247 - 88,103,307EPDNEW
RGD ID:6874404
Promoter ID:EPDNEW_M653
Type:initiation region
Name:Ugt1a6a_1
Description:Mus musculus UDP glucuronosyltransferase 1 family, polypeptideA6A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38188,134,820 - 88,134,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3580629 AgrOrtholog
Ensembl Genes ENSMUSG00000090145 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000108762 UniProtKB/TrEMBL
  ENSMUSP00000108763 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000113137 UniProtKB/TrEMBL
  ENSMUST00000113138 ENTREZGENE, UniProtKB/TrEMBL
InterPro UDP_glucos_trans UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/TrEMBL
KEGG Report mmu:394435 UniProtKB/TrEMBL
MGD MGI:3580629 ENTREZGENE
NCBI Gene 394435 ENTREZGENE
Pfam UDPGT UniProtKB/TrEMBL
PhenoGen Ugt1a6b PhenoGen
PROSITE UDPGT UniProtKB/TrEMBL
UniProt K9J7B2 ENTREZGENE, UniProtKB/TrEMBL
  Q6XL46_MOUSE UniProtKB/TrEMBL
  Q8R0P3_MOUSE UniProtKB/TrEMBL