Dnmt1 (DNA methyltransferase 1) - Rat Genome Database

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Gene: Dnmt1 (DNA methyltransferase 1) Mus musculus
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Symbol: Dnmt1
Name: DNA methyltransferase 1
RGD ID: 1552151
MGI Page MGI
Description: Enables several functions, including lncRNA binding activity; methyl-CpG binding activity; and zinc ion binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within with a positive effect on epigenetic programming of gene expression. Acts upstream of or within several processes, including cellular response to bisphenol A; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of macromolecule biosynthetic process. Located in female germ cell nucleus; pericentric heterochromatin; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cxxc9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase MmuI; DNA MTase MmuI; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1; Met1; MommeD; MommeD2; MTa; MTase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)EnsemblGRCm39 Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBIMGSCv36mm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
alopecia areata  (ISO)
anxiety disorder  (ISO)
asthma  (IEP,ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autoimmune disease  (IMP)
autosomal dominant cerebellar ataxia, deafness and narcolepsy  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
Binge Drinking  (IEP)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (IEP)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
choline deficiency disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
dementia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Experimental Arthritis  (ISO)
familial hypercholesterolemia  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 1E  (ISO)
hypertrophic cardiomyopathy  (ISO)
immunodeficiency 35  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
medulloblastoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IMP)
middle cerebral artery infarction  (IMP)
mucoepidermoid carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Oral Lichen Planus  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
Peritoneal Fibrosis  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
prostate adenocarcinoma  (IEP)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (IEP,IMP,ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (IDA,ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
6-prenylnaringenin  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
amitriptyline  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brodifacoum  (ISO)
buta-1,3-diene  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
citalopram  (ISO)
cladribine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
Difenacoum  (ISO)
dihydro-beta-erythroidine  (ISO)
dimethyl sulfate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
escitalopram  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenthion  (EXP)
fenvalerate  (ISO)
fisetin  (ISO)
Flocoumafen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
Geniposide  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glucaric acid  (EXP)
glucose  (ISO)
glutathione  (EXP)
glycine betaine  (EXP)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexadecanoic acid  (ISO)
hexane  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (EXP)
ionomycin  (ISO)
isoniazide  (ISO)
isorhapontigenin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leptomycin B  (ISO)
linsidomine  (ISO)
magnesium atom  (ISO)
malathion  (ISO)
mancozeb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (EXP)
myricetin  (ISO)
N(4)-hydroxycytidine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (EXP)
pelargonidin  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (EXP)
procyanidin B2  (ISO)
pterostilbene  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sinefungin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tangeretin  (EXP)
tartrazine  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
withaferin A  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (IDA)
cellular response to bisphenol A  (IDA)
cellular response to lead ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (IEA)
chromosomal DNA methylation maintenance following DNA replication  (IDA,IGI,IMP)
DNA methylation-dependent constitutive heterochromatin formation  (IDA,IEA)
DNA-templated transcription  (IMP)
epigenetic programming of gene expression  (IGI,IMP)
methylation  (IEA)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of gene expression  (IEA,IMP,ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IBA,IEA,IMP,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IEA,ISO)
neuron differentiation  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
regulation of cell population proliferation  (IGI)
regulation of gene expression  (IMP)
response to activity  (ISO)
response to alcohol  (ISO)
response to bisphenol A  (IEA,ISO)
response to caffeine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal imprinting  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
absent somites  (IAGP)
anemia  (IAGP)
decreased cell proliferation  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal stem cell self-renewal  (IAGP)
decreased pro-B cell number  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
failure of initiation of embryo turning  (IAGP)
failure of somite differentiation  (IAGP)
female infertility  (IAGP)
genetic imprinting  (IAGP)
impaired somite development  (IAGP)
impaired spatial learning  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased tumor incidence  (IAGP)
intestine polyps  (IAGP)
lethargy  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pale yolk sac  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
small visceral yolk sac  (IAGP)
transmission ratio distortion  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease. Arakawa Y, etal., Clin Exp Immunol. 2012 Nov;170(2):194-201. doi: 10.1111/j.1365-2249.2012.04646.x.
2. Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus. Balada E, etal., Immunology. 2008 Jul;124(3):339-47. doi: 10.1111/j.1365-2567.2007.02771.x. Epub 2008 Jan 11.
3. Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Bian EB, etal., Toxicol Lett. 2014 Jan 13;224(2):175-85. doi: 10.1016/j.toxlet.2013.10.038. Epub 2013 Nov 6.
4. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
5. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
6. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
7. Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons. Endres M, etal., Neuroreport. 2001 Dec 4;12(17):3763-6.
8. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
9. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
10. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Fonseca-Silva T, etal., Pathobiology. 2012;79(1):18-23. doi: 10.1159/000330171. Epub 2012 Jan 12.
11. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
12. Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression. Gao P, etal., Cancer. 2009 Jul 15;115(14):3222-32.
13. Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers. Hu Y, etal., PLoS One. 2013 May 23;8(5):e64362. doi: 10.1371/journal.pone.0064362. Print 2013.
14. Heart failure and angiotensin II modulate atrial Pitx2c promotor methylation. Kao YH, etal., Clin Exp Pharmacol Physiol. 2013 Jun;40(6):379-84. doi: 10.1111/1440-1681.12089.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Ke X, etal., Physiol Genomics. 2006 Mar 13;25(1):16-28. Epub 2005 Dec 27.
17. Effect of DNA Demethylation in Experimental Encapsulating Peritoneal Sclerosis. Kim KH, etal., Ther Apher Dial. 2014 Sep 26. doi: 10.1111/1744-9987.12186.
18. Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Kinney SR, etal., Mol Cell Biol. 2010 Sep;30(17):4159-74. doi: 10.1128/MCB.00235-10. Epub 2010 Jun 28.
19. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Klein CJ, etal., Nat Genet. 2011 Jun;43(6):595-600. doi: 10.1038/ng.830. Epub 2011 May 1.
20. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. Kovacheva VP, etal., J Biol Chem. 2007 Oct 26;282(43):31777-88. Epub 2007 Aug 27.
21. Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. Kutay H, etal., PLoS One. 2012;7(8):e41949. doi: 10.1371/journal.pone.0041949. Epub 2012 Aug 8.
22. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Liu CC, etal., Immunol Lett. 2011 Mar 30;135(1-2):96-9. doi: 10.1016/j.imlet.2010.10.003. Epub 2010 Oct 16.
23. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Liu WB, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):70-8. doi: 10.1016/j.taap.2010.12.002. Epub 2010 Dec 14.
24. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
25. Traumatic brain injury induces relocalization of DNA-methyltransferase 1. Lundberg J, etal., Neurosci Lett. 2009 Jun 19;457(1):8-11. doi: 10.1016/j.neulet.2009.03.105. Epub 2009 Apr 5.
26. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
27. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Matrisciano F, etal., Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.
28. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Melas PA, etal., Int J Neuropsychopharmacol. 2012 Jun;15(5):669-79. doi: 10.1017/S1461145711000940. Epub 2011 Jun 20.
29. MGDs mouse GO annotations MGD data from the GO Consortium
30. MGD IEA MGD IEA
31. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
32. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
33. DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population. Mostowska A, etal., Mol Biol Rep. 2013 Aug;40(8):4893-9. doi: 10.1007/s11033-013-2589-0. Epub 2013 May 12.
34. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. Nakagawa T, etal., J Urol. 2003 Dec;170(6 Pt 1):2463-6.
35. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Pham TD, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R962-70. Epub 2003 Jul 17.
38. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Mouse MP Annotation Import Pipeline RGD automated import pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Ruzicka WB, etal., Mol Psychiatry. 2007 Apr;12(4):385-97. Epub 2007 Jan 30.
45. Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion. Sawada M, etal., Cancer Lett. 2007 Jun 28;251(2):211-9. Epub 2006 Dec 29.
46. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Shieh YS, etal., Cancer. 2005 Sep 1;104(5):1013-21.
47. 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. Tikoo K, etal., Toxicol Lett. 2009 Dec 15;191(2-3):158-66. doi: 10.1016/j.toxlet.2009.08.018. Epub 2009 Aug 31.
48. Differential gene expression in fetal mouse germ cells. Urven LE, etal., Biol Reprod 1993 Mar;48(3):564-74.
49. The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer. Valdez CD, etal., Prostate. 2013 Dec;73(16):1776-85. doi: 10.1002/pros.22715. Epub 2013 Sep 4.
50. Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis. van Kaam KJ, etal., Fertil Steril. 2011 Mar 15;95(4):1421-7. doi: 10.1016/j.fertnstert.2011.01.031. Epub 2011 Feb 12.
51. Epigenetic regulation of DNMT1 gene in mouse model of asthma disease. Verma M, etal., Mol Biol Rep. 2013 Mar;40(3):2357-68. doi: 10.1007/s11033-012-2317-1. Epub 2012 Nov 30.
52. Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Wang L, etal., Blood. 2013 May 2;121(18):3631-9. doi: 10.1182/blood-2012-08-451765. Epub 2013 Feb 26.
53. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Wang W, etal., Oncol Rep. 2009 Jun;21(6):1439-47.
54. Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Warnault V, etal., Transl Psychiatry. 2013 Feb 19;3:e231. doi: 10.1038/tp.2013.4.
55. Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Williams KT and Schalinske KL, Diabetes Metab Res Rev. 2012 Feb;28(2):123-31. doi: 10.1002/dmrr.1281.
56. Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin. Wu TT, etal., Lab Invest. 2020 Jul;100(7):974-985. doi: 10.1038/s41374-020-0402-y. Epub 2020 Feb 12.
57. DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer. Wu XY, etal., J Biochem. 2020 Aug 1;168(2):151-157. doi: 10.1093/jb/mvaa034.
58. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Xiong Y, etal., Gynecol Oncol. 2005 Mar;96(3):601-9.
59. Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers. Xu HT, etal., Hum Pathol. 2011 Oct;42(10):1491-8. doi: 10.1016/j.humpath.2011.01.004. Epub 2011 Apr 14.
60. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
61. Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus. Zhu X, etal., Int J Dermatol. 2011 Jun;50(6):697-704. doi: 10.1111/j.1365-4632.2010.04804.x.
62. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Zimmermann N, etal., Biochem J. 2012 Nov 15;448(1):93-102. doi: 10.1042/BJ20120674.
Additional References at PubMed
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PMID:39181896  


Genomics

Comparative Map Data
Dnmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)EnsemblGRCm39 Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBIMGSCv36mm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
DNMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,133,342 - 10,231,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,244,022 - 10,305,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,307 - 10,306,021 (-)NCBICHM1_1
T2T-CHM13v2.01910,259,569 - 10,321,116 (-)NCBIT2T-CHM13v2.0
Dnmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,716,797 - 27,763,405 (-)NCBIGRCr8
GRCr8 Ensembl827,716,797 - 27,763,119 (-)EnsemblGRCr8 Ensembl
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,459,969 - 23,505,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,757,816 - 21,803,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,670,294 - 19,716,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera820,835,612 - 20,881,380 (-)NCBICelera
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Cytogenetic Map8q13NCBI
Dnmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
DNMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
DNMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,872,213 - 50,928,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,879,527 - 50,928,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,741,748 - 50,797,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,393,895 - 51,450,128 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,401,720 - 51,450,127 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,599,735 - 50,657,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,028,945 - 51,085,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,269,676 - 51,325,956 (+)NCBIUU_Cfam_GSD_1.0
Dnmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,789,213 - 209,834,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659520,493 - 565,416 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659520,181 - 565,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,981,566 - 69,029,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,981,564 - 69,040,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,309,511 - 69,357,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,199,006 - 9,263,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,199,003 - 9,263,607 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,795,260 - 10,857,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnmt1
1990 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSMUST00000004202, ENSMUST00000177754, ENSMUST00000178110
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse

Markers in Region
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38920,926,456 - 20,926,554UniSTSGRCm38
MGSCv37920,730,900 - 20,730,998UniSTSGRCm37
Celera918,195,154 - 18,195,252UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
PMC133764P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38920,941,343 - 20,941,681UniSTSGRCm38
MGSCv37920,745,787 - 20,746,125UniSTSGRCm37
Celera918,210,039 - 18,210,377UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38920,926,651 - 20,926,828UniSTSGRCm38
MGSCv37920,731,095 - 20,731,272UniSTSGRCm37
Celera918,195,349 - 18,195,526UniSTS
Cytogenetic Map9A3UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Dnmt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38920,923,754 - 20,924,131UniSTSGRCm38
MGSCv37920,728,198 - 20,728,575UniSTSGRCm37
Celera918,192,452 - 18,192,829UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001199431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001314011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001404685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC170598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF036007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF036008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF036009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF162282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF175432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK636383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000004202   ⟹   ENSMUSP00000004202
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,818,505 - 20,864,275 (-)Ensembl
GRCm38.p6 Ensembl920,907,209 - 20,952,979 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177754   ⟹   ENSMUSP00000136982
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,818,505 - 20,871,184 (-)Ensembl
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)Ensembl
Ensembl Acc Id: ENSMUST00000178110   ⟹   ENSMUSP00000136669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,818,505 - 20,863,919 (-)Ensembl
GRCm38.p6 Ensembl920,907,209 - 20,952,623 (-)Ensembl
Ensembl Acc Id: ENSMUST00000214964
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,818,514 - 20,820,275 (-)Ensembl
GRCm38.p6 Ensembl920,907,218 - 20,908,979 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,840,387 - 20,864,141 (-)Ensembl
GRCm38.p6 Ensembl920,929,091 - 20,952,845 (-)Ensembl
Ensembl Acc Id: ENSMUST00000216135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,843,491 - 20,848,485 (-)Ensembl
GRCm38.p6 Ensembl920,932,195 - 20,937,189 (-)Ensembl
Ensembl Acc Id: ENSMUST00000216540   ⟹   ENSMUSP00000150433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,818,817 - 20,863,901 (-)Ensembl
GRCm38.p6 Ensembl920,907,521 - 20,952,605 (-)Ensembl
RefSeq Acc Id: NM_001199431   ⟹   NP_001186360
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,864,122 (-)NCBI
GRCm38920,907,206 - 20,952,979 (-)NCBI
Celera918,175,904 - 18,228,582 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001199432   ⟹   NP_001186361
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,871,084 (-)NCBI
GRCm38920,907,206 - 20,959,888 (-)NCBI
Celera918,175,904 - 18,228,582 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001199433   ⟹   NP_001186362
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,864,122 (-)NCBI
GRCm38920,907,206 - 20,952,623 (-)NCBI
Celera918,175,904 - 18,228,582 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001314011   ⟹   NP_001300940
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,864,122 (-)NCBI
GRCm38920,907,206 - 20,952,979 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001404685   ⟹   NP_001391614
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,864,122 (-)NCBI
RefSeq Acc Id: NM_010066   ⟹   NP_034196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,505 - 20,864,122 (-)NCBI
GRCm38920,907,206 - 20,952,979 (-)NCBI
MGSCv37920,711,653 - 20,757,317 (-)RGD
Celera918,175,904 - 18,228,582 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242393   ⟹   XP_011240695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,818,501 - 20,863,856 (-)NCBI
GRCm38920,907,209 - 20,951,909 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001186360 (Get FASTA)   NCBI Sequence Viewer  
  NP_001186361 (Get FASTA)   NCBI Sequence Viewer  
  NP_001186362 (Get FASTA)   NCBI Sequence Viewer  
  NP_001300940 (Get FASTA)   NCBI Sequence Viewer  
  NP_001391614 (Get FASTA)   NCBI Sequence Viewer  
  NP_034196 (Get FASTA)   NCBI Sequence Viewer  
  XP_011240695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40061 (Get FASTA)   NCBI Sequence Viewer  
  AAC52900 (Get FASTA)   NCBI Sequence Viewer  
  AAC53551 (Get FASTA)   NCBI Sequence Viewer  
  AAF19352 (Get FASTA)   NCBI Sequence Viewer  
  AAF60965 (Get FASTA)   NCBI Sequence Viewer  
  AAF97695 (Get FASTA)   NCBI Sequence Viewer  
  AAH48148 (Get FASTA)   NCBI Sequence Viewer  
  AAH53047 (Get FASTA)   NCBI Sequence Viewer  
  AAI19484 (Get FASTA)   NCBI Sequence Viewer  
  BAB28743 (Get FASTA)   NCBI Sequence Viewer  
  BAE22880 (Get FASTA)   NCBI Sequence Viewer  
  BAE25447 (Get FASTA)   NCBI Sequence Viewer  
  BAE27713 (Get FASTA)   NCBI Sequence Viewer  
  CAA32910 (Get FASTA)   NCBI Sequence Viewer  
  EDL25139 (Get FASTA)   NCBI Sequence Viewer  
  EDL25140 (Get FASTA)   NCBI Sequence Viewer  
  EDL25141 (Get FASTA)   NCBI Sequence Viewer  
  EDL25142 (Get FASTA)   NCBI Sequence Viewer  
  EDL25143 (Get FASTA)   NCBI Sequence Viewer  
  EDL25144 (Get FASTA)   NCBI Sequence Viewer  
  EDL25145 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000004202
  ENSMUSP00000004202.10
  ENSMUSP00000136982
  ENSMUSP00000150433
  ENSMUSP00000150433.2
GenBank Protein P13864 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034196   ⟸   NM_010066
- Peptide Label: isoform 2
- UniProtKB: Q3UHZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186361   ⟸   NM_001199432
- Peptide Label: isoform 3
- UniProtKB: J3QNW0 (UniProtKB/TrEMBL),   Q3UHZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186360   ⟸   NM_001199431
- Peptide Label: isoform 1
- UniProtKB: Q9CSC6 (UniProtKB/Swiss-Prot),   Q80ZU3 (UniProtKB/Swiss-Prot),   P97413 (UniProtKB/Swiss-Prot),   Q9QXX6 (UniProtKB/Swiss-Prot),   P13864 (UniProtKB/Swiss-Prot),   Q3UHZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186362   ⟸   NM_001199433
- Peptide Label: isoform 4
- UniProtKB: Q3UHZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240695   ⟸   XM_011242393
- Peptide Label: isoform X2
- UniProtKB: Q3UHZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300940   ⟸   NM_001314011
- Peptide Label: isoform 5
- UniProtKB: Q3UHZ3 (UniProtKB/TrEMBL),   Q7TSJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000136669   ⟸   ENSMUST00000178110
Ensembl Acc Id: ENSMUSP00000150433   ⟸   ENSMUST00000216540
Ensembl Acc Id: ENSMUSP00000136982   ⟸   ENSMUST00000177754
Ensembl Acc Id: ENSMUSP00000004202   ⟸   ENSMUST00000004202
RefSeq Acc Id: NP_001391614   ⟸   NM_001404685
- Peptide Label: isoform 6
- UniProtKB: Q3UHZ3 (UniProtKB/TrEMBL)
Protein Domains
BAH   CXXC-type   DMAP1-binding   SAM-dependent MTase C5-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13864-F1-model_v2 AlphaFold P13864 1-1620 view protein structure

Promoters
RGD ID:6848403
Promoter ID:MM_ACW:49728
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:DNMT1.NSEP07-UNSPLICED,   DNMT1.QSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,712,196 - 20,713,047 (-)MPROMDB
RGD ID:6844433
Promoter ID:MM_KWN:56534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:UC009OJN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,717,646 - 20,718,297 (-)MPROMDB
RGD ID:6848404
Promoter ID:MM_ACW:49731
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney,   Spleen
Transcripts:DNMT1.MSEP07,   DNMT1.RSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,728,966 - 20,729,466 (-)MPROMDB
RGD ID:6844437
Promoter ID:MM_KWN:56535
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000004202,   NM_010066,   UC009OJO.1,   UC009OJQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,757,071 - 20,757,571 (-)MPROMDB
RGD ID:8668902
Promoter ID:EPDNEW_M12482
Type:multiple initiation site
Name:Dnmt1_2
Description:Mus musculus DNA methyltransferase (cytosine-5) 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12483  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38920,952,577 - 20,952,637EPDNEW
RGD ID:8668904
Promoter ID:EPDNEW_M12483
Type:initiation region
Name:Dnmt1_1
Description:Mus musculus DNA methyltransferase (cytosine-5) 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12482  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38920,952,817 - 20,952,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94912 AgrOrtholog
Ensembl Genes ENSMUSG00000004099 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004202 ENTREZGENE
  ENSMUST00000004202.17 UniProtKB/Swiss-Prot
  ENSMUST00000177754 ENTREZGENE
  ENSMUST00000216540 ENTREZGENE
  ENSMUST00000216540.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.2230 UniProtKB/Swiss-Prot
  2.30.30.490 UniProtKB/Swiss-Prot
  3.40.50.150 UniProtKB/Swiss-Prot
  DNA Methylase, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro BAH_dom UniProtKB/Swiss-Prot
  BAH_sf UniProtKB/Swiss-Prot
  C5-Methyltransferase UniProtKB/Swiss-Prot
  C5_DNA_meth_AS UniProtKB/Swiss-Prot
  C5_MeTfrase UniProtKB/Swiss-Prot
  C5_meth_CS UniProtKB/Swiss-Prot
  Cytosine_MeTrfase1_RFD UniProtKB/Swiss-Prot
  DMAP1-bd UniProtKB/Swiss-Prot
  DNMT1-like UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
  Znf_CXXC UniProtKB/Swiss-Prot
KEGG Report mmu:13433 UniProtKB/Swiss-Prot
MGD MGI:94912 ENTREZGENE
NCBI Gene 13433 ENTREZGENE
PANTHER CYTOSINE-SPECIFIC METHYLTRANSFERASE UniProtKB/Swiss-Prot
  DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam BAH UniProtKB/Swiss-Prot
  DMAP_binding UniProtKB/Swiss-Prot
  DNA_methylase UniProtKB/Swiss-Prot
  DNMT1-RFD UniProtKB/Swiss-Prot
  zf-CXXC UniProtKB/Swiss-Prot
PhenoGen Dnmt1 PhenoGen
PIRSF DNMT1 UniProtKB/Swiss-Prot
PRINTS C5METTRFRASE UniProtKB/Swiss-Prot
PROSITE BAH UniProtKB/Swiss-Prot
  C5_MTASE_1 UniProtKB/Swiss-Prot
  C5_MTASE_2 UniProtKB/Swiss-Prot
  DMAP1_BIND UniProtKB/Swiss-Prot
  SAM_MT_C5 UniProtKB/Swiss-Prot
  ZF_CXXC UniProtKB/Swiss-Prot
SMART BAH UniProtKB/Swiss-Prot
  DMAP_binding UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt DNMT1_MOUSE UniProtKB/Swiss-Prot
  J3QNW0 ENTREZGENE, UniProtKB/TrEMBL
  P13864 ENTREZGENE
  P97413 ENTREZGENE
  Q0VDW2_MOUSE UniProtKB/TrEMBL
  Q3UHZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UPE8_MOUSE UniProtKB/TrEMBL
  Q3UWN4_MOUSE UniProtKB/TrEMBL
  Q7TSJ0 ENTREZGENE, UniProtKB/TrEMBL
  Q80ZU3 ENTREZGENE
  Q9CSC6 ENTREZGENE
  Q9QXX6 ENTREZGENE
UniProt Secondary P97413 UniProtKB/Swiss-Prot
  Q80ZU3 UniProtKB/Swiss-Prot
  Q9CSC6 UniProtKB/Swiss-Prot
  Q9QXX6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Dnmt1  DNA methyltransferase 1  Dnmt1  DNA methyltransferase (cytosine-5) 1  Symbol and/or name change 5135510 APPROVED