Hif1a (hypoxia inducible factor 1, alpha subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hif1a (hypoxia inducible factor 1, alpha subunit) Mus musculus
Analyze
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
RGD ID: 62221
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; negative regulation of ossification; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and negative regulation of apoptotic process. Located in euchromatin; motile cilium; and nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study glycogen storage disease V and glycogen storage disease VII. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA959795; ARNT-interacting protein; bHLHe7; bHLHe78; HIF-1; HIF-1-alpha; HIF1; HIF1-alpha; HIF1alpha; hypoxia-inducible factor 1-alpha; MO; MOP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,948,186 - 73,994,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)EnsemblGRCm39 Ensembl
GRCm381273,901,324 - 73,947,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv371275,008,854 - 75,048,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,826,868 - 74,865,729 (+)NCBIMGSCv36mm8
Celera1275,021,612 - 75,061,060 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1231.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 123 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseacute kidney failure  ISOHif1a (Rattus norvegicus)9068894mRNA:increased expression:renal cortex (rat)RGD 
Hif1aMouseacute kidney failure treatmentISOHif1a (Rattus norvegicus)10395386 RGD 
Hif1aMouseacute kidney failure  ISOHif1a (Rattus norvegicus)10395376 RGD 
Hif1aMouseAcute-Phase Reaction  ISOHif1a (Rattus norvegicus)10395370mRNA and protein:increased expression:liverRGD 
Hif1aMouseAlcoholic Liver Diseases  ISOHif1a (Rattus norvegicus)9068897mRNA:increased expression:liver (rat)RGD 
Hif1aMouseAlzheimer's disease  IEP 9068888protein:increased expression:brain and microvessel (mouse)RGD 
Hif1aMouseAlzheimer's disease  ISOHIF1A (Homo sapiens)9068875mRNA more ...RGD 
Hif1aMouseArterial Thrombosis  ISOHif1a (Rattus norvegicus)8695963protein:increased expression:plantar and foot muscle (rat)RGD 
Hif1aMouseAsphyxia  ISOHif1a (Rattus norvegicus)9068458mRNA more ...RGD 
Hif1aMouseasthma treatmentIEP 10402541 RGD 
Hif1aMouseatrial fibrillation  ISOHIF1A (Homo sapiens)8695924protein:increased expression:right atrium appendage and cytoplasm (human)RGD 
Hif1aMousebladder neck obstruction  ISOHif1a (Rattus norvegicus)9068887protein:increased expression:urinary bladder (rat)RGD 
Hif1aMouseBrain Hypoxia-Ischemia  ISOHif1a (Rattus norvegicus)9068873protein:increased expression:brain (rat)RGD 
Hif1aMouseBrain Hypoxia-Ischemia  ISOHif1a (Rattus norvegicus)155882534mRNA more ...RGD 
Hif1aMouseBrain Hypoxia-Ischemia treatmentISOHif1a (Rattus norvegicus)9068901 RGD 
Hif1aMousebrain infarction exacerbatesISOHif1a (Rattus norvegicus)155663378 RGD 
Hif1aMousebrain ischemia  IEP 1626331protein:increased expression:brainRGD 
Hif1aMousebrain ischemia treatmentISOHif1a (Rattus norvegicus)9068895 RGD 
Hif1aMousebrain ischemia  ISOHif1a (Rattus norvegicus)9068892mRNA and protein:increased expression:cerebral cortex (rat)RGD 
Hif1aMouseBreast Neoplasms disease_progressionISOHIF1A (Homo sapiens)2293195 RGD 
1 to 20 of 123 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMousecholangiocarcinoma  ISOHIF1A (Homo sapiens)8554872ClinVar Annotator: match by term: CholangiocarcinomaClinVarPMID:12919954 more ...
Hif1aMouseMaffucci syndrome  ISOHIF1A (Homo sapiens)8554872ClinVar Annotator: match by term: Maffucci syndromeClinVarPMID:25741868
Hif1aMouseOllier disease  ISOHIF1A (Homo sapiens)8554872ClinVar Annotator: match by term: EnchondromatosisClinVarPMID:25741868 and PMID:28492532
Hif1aMouseprostate cancer  ISOHIF1A (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
1 to 20 of 39 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseAnaplasia  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19808899
Hif1aMouseBrain Hypoxia-Ischemia  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23694759
Hif1aMousebrain ischemia  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19429140
Hif1aMouseBreast Neoplasms  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24349381
Hif1aMousecarcinoma  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19808899
Hif1aMouseCardiomegaly  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15942707
Hif1aMousechronic obstructive pulmonary disease  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26752192
Hif1aMousecongenital heart disease  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26073000
Hif1aMousecongestive heart failure  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15732037
Hif1aMouseDiabetes Complications  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26073000
Hif1aMouseDisease Progression  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30381462
Hif1aMouseDuctal Carcinoma  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20526721
Hif1aMouseductal carcinoma in situ  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20526721
Hif1aMouseesophagus squamous cell carcinoma  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17201171
Hif1aMouseExperimental Neoplasms  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28574600
Hif1aMouseExperimental Radiation Injuries  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23065176
Hif1aMouseglioblastoma  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12811834
Hif1aMousehemangioblastoma  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15341671
Hif1aMouseHyperplasia  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20526721
Hif1aMousehypertension  ISOHIF1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22349312
1 to 20 of 39 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseglycogen storage disease V  IAGP 13592920OMIM:232600MouseDO 
Hif1aMouseglycogen storage disease VII  IAGP 13592920OMIM:232800MouseDO 

1 to 20 of 1028 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouse(+)-catechin multiple interactionsISOHIF1A (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HIF1A mRNA and Catechin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]CTDPMID:24763279 and PMID:35883890
Hif1aMouse(+)-pilocarpine increases expressionISOHif1a (Rattus norvegicus)6480464Pilocarpine results in increased expression of HIF1A mRNACTDPMID:17166730
Hif1aMouse(-)-epigallocatechin 3-gallate multiple interactionsISOHIF1A (Homo sapiens)6480464epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]] more ...CTDPMID:16005427 and PMID:36162953
Hif1aMouse(-)-epigallocatechin 3-gallate decreases expressionISOHIF1A (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of HIF1A mRNA and epigallocatechin gallate results in decreased expression of HIF1A proteinCTDPMID:20346928
Hif1aMouse(-)-noscapine multiple interactionsISOHIF1A (Homo sapiens)6480464Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A proteinCTDPMID:16596621
Hif1aMouse(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOHIF1A (Homo sapiens)6480464HSPA9 protein promotes the reaction [27-hydroxycholesterol results in increased expression of HIF1A protein]CTDPMID:33880675
Hif1aMouse(25R)-cholest-5-ene-3beta,26-diol increases expressionISOHIF1A (Homo sapiens)648046427-hydroxycholesterol results in increased expression of HIF1A proteinCTDPMID:27856279 and PMID:33880675
Hif1aMouse(R)-adrenaline increases expressionEXP 6480464Epinephrine results in increased expression of HIF1A proteinCTDPMID:36423730
Hif1aMouse(R)-adrenaline increases expressionISOHIF1A (Homo sapiens)6480464Epinephrine results in increased expression of HIF1A proteinCTDPMID:36423730
Hif1aMouse(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of HIF1A mRNACTDPMID:22687363
Hif1aMouse(S)-nicotine multiple interactionsISOHIF1A (Homo sapiens)6480464CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]CTDPMID:24793809
Hif1aMouse(S)-nicotine increases expressionISOHIF1A (Homo sapiens)6480464Nicotine results in increased expression of HIF1A proteinCTDPMID:24793809
Hif1aMouse(S)-nicotine multiple interactionsEXP 6480464resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]CTDPMID:22687363
Hif1aMouse1,10-phenanthroline multiple interactionsISOHIF1A (Homo sapiens)64804644'-O-methylalpinumisoflavone inhibits the reaction [1 more ...CTDPMID:19091749
Hif1aMouse1,10-phenanthroline increases activityISOHIF1A (Homo sapiens)64804641 and 10-phenanthroline results in increased activity of HIF1A proteinCTDPMID:19502547
Hif1aMouse1,10-phenanthroline multiple interactionsEXP 6480464HIF1A protein promotes the reaction [1 and 10-phenanthroline results in increased expression of VEGFA protein]CTDPMID:19502547
Hif1aMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of HIF1A mRNACTDPMID:22206623
Hif1aMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HIF1A mRNACTDPMID:22206623
Hif1aMouse1,4-benzoquinone multiple interactionsISOHIF1A (Homo sapiens)6480464[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein more ...CTDPMID:30448556
Hif1aMouse1,4-benzoquinone increases expressionISOHIF1A (Homo sapiens)6480464quinone results in increased expression of HIF1A proteinCTDPMID:30448556

1 to 20 of 1028 rows

Biological Process
1 to 20 of 223 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseacute-phase response  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:19840250 and REF_RGD_ID:10395370
Hif1aMouseangiogenesis acts_upstream_of_or_withinIMPMGI:23866792290270 PMID:15073147MGIPMID:15073147
Hif1aMouseangiogenesis acts_upstream_of_or_withinIMPMGI:21794292290270 PMID:14659802MGIPMID:14659802
Hif1aMouseapoptotic process acts_upstream_ofIMPMGI:18577192290270 PMID:17181398MGIPMID:17181398
Hif1aMouseaxonal transport of mitochondrion involved_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseaxonal transport of mitochondrion involved_inISSUniProtKB:Q166652290270 UniProtGO_REF:0000024
Hif1aMouseB-1 B cell homeostasis acts_upstream_of_or_withinIMP 2290270 PMID:11854513MGIPMID:11854513
Hif1aMouseblood vessel development acts_upstream_of_or_withinIMPMGI:18577192290270 PMID:9436976MGIPMID:9436976
Hif1aMouseblood vessel morphogenesis acts_upstream_of_or_withinIMPMGI:23853582290270 PMID:9606183MGIPMID:9606183
Hif1aMousebone mineralization acts_upstream_ofIMPMGI:18577192290270 PMID:17181398MGIPMID:17181398
Hif1aMousecamera-type eye morphogenesis acts_upstream_of_or_withinIGIMGI:1032232290270 PMID:22627278MGIPMID:22627278
Hif1aMousecardiac ventricle morphogenesis acts_upstream_of_or_withinIMPMGI:18577192290270 PMID:9436976MGIPMID:9436976
Hif1aMousecartilage development acts_upstream_of_or_withinIMPMGI:2386649 and MGI:23866792290270 PMID:11691837MGIPMID:11691837
Hif1aMousecell differentiation acts_upstream_of_or_withinIGIMGI:1091692290270 PMID:16287860MGIPMID:16287860
Hif1aMousecellular response to anoxia  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:18614764 and REF_RGD_ID:2301848
Hif1aMousecellular response to carbon monoxide  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:17475674 and REF_RGD_ID:9068879
Hif1aMousecellular response to cobalt ion  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:10559391 and REF_RGD_ID:2313660
Hif1aMousecellular response to cyanide  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:21854848 and REF_RGD_ID:9068914
Hif1aMousecellular response to electrical stimulus  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:12193088 and REF_RGD_ID:9068876
Hif1aMousecellular response to estrogen stimulus  ISOHif1a (Rattus norvegicus)9068941 RGDPMID:17272396 and REF_RGD_ID:152177689
1 to 20 of 223 rows

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseaxon cytoplasm located_inIEAGO:00198962290270 GOCGO_REF:0000108
Hif1aMousechromatin located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousecytoplasm located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousecytosol located_inISSUniProtKB:Q166652290270 UniProtGO_REF:0000024
Hif1aMousecytosol located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseeuchromatin located_inIDA 2290270 PMID:25587068BHF-UCLPMID:25587068
Hif1aMousemotile cilium located_inIDA 2290270 PMID:11818497MGIPMID:11818497
Hif1aMousenuclear body located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousenuclear speck located_inIDA 2290270 PMID:21546903UniProtPMID:21546903
Hif1aMousenucleoplasm located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousenucleus located_inIDA 2290270 PMID:11691837 more ...MGIPMID:11691837 more ...
Hif1aMousenucleus  ISOHif1a (Rattus norvegicus)9068941MMO:0000679 cell fractionationRGDPMID:18614764 and REF_RGD_ID:2301848
Hif1aMousenucleus part_ofISOHIF1A (Homo sapiens)9068941 PMID:22848707CACAOPMID:22848707
Hif1aMousenucleus  ISOHif1a (Rattus norvegicus)9068941MMO:0000686RGDPMID:26071548 and REF_RGD_ID:401793712
Hif1aMousenucleus located_inISOHif1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hif1aMousenucleus located_inISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousenucleus located_inISSUniProtKB:Q166652290270 UniProtGO_REF:0000024
Hif1aMouseprotein-containing complex part_ofISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseRNA polymerase II transcription regulator complex part_ofISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseRNA polymerase II transcription regulator complex part_ofIEAUniProtKB:Q16665 and ensembl:ENSP000003380182290270 EnsemblGO_REF:0000107
1 to 20 of 21 rows

Molecular Function
1 to 20 of 63 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMousecis-regulatory region sequence-specific DNA binding enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA binding enablesIDA 2290270 PMID:15456877MGIPMID:15456877
Hif1aMouseDNA-binding transcription activator activity enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesIMP 2290270 PMID:25587068BHF-UCLPMID:25587068
Hif1aMouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 2290270 PMID:21856340MGIPMID:21856340
Hif1aMouseDNA-binding transcription factor activity enablesISOUniProtKB:Q166652290270 PMID:11782478MGIGO_REF:0000119 and PMID:11782478
Hif1aMouseDNA-binding transcription factor activity enablesIDA 2290270 PMID:15456877MGIPMID:15456877
Hif1aMouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIDA 2290270 PMID:24030251MGIPMID:24030251
Hif1aMouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN001889196 more ...2290270 GO_CentralGO_REF:0000033
Hif1aMouseDNA-binding transcription factor activity, RNA polymerase II-specific contributes_toISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA-binding transcription repressor activity enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseDNA-binding transcription repressor activity enablesIEAUniProtKB:Q16665 and ensembl:ENSP000003380182290270 EnsemblGO_REF:0000107
Hif1aMouseE-box binding enablesIMP 2290270 PMID:24011070BHF-UCLPMID:24011070
Hif1aMouseenzyme binding enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMousehistone deacetylase binding enablesIPIUniProtKB:P56524 and UniProtKB:Q9UQL62290270 PMID:19071119BHF-UCLPMID:19071119
Hif1aMouseHsp90 protein binding enablesISOUniProtKB:Q166652290270 GO_CentralGO_REF:0000119
Hif1aMouseHsp90 protein binding enablesIEAUniProtKB:Q16665 and ensembl:ENSP000003380182290270 EnsemblGO_REF:0000107
Hif1aMousenuclear receptor binding enablesIEAUniProtKB:Q16665 and ensembl:ENSP000003380182290270 EnsemblGO_REF:0000107
1 to 20 of 63 rows

RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMousemTOR signaling pathway   IEA 6907045 KEGGmmu:04150
Hif1aMouserenal cell carcinoma pathway   IEA 6907045 KEGGmmu:05211

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMousehypoxia inducible factor pathway   ISOHIF1A (Homo sapiens)6484113 PIDPID:200202
1 to 20 of 226 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1aMouseabnormal angiogenesis  IAGP 5509061 MGIPMID:14659802
Hif1aMouseabnormal angiogenesis  IAGP 5509061 MGIPMID:11691837
Hif1aMouseabnormal B cell differentiation  IAGP 5509061 MGIPMID:22995899
Hif1aMouseabnormal behavior  IAGP 5509061 MGIPMID:17554006
Hif1aMouseabnormal blood vessel morphology  IAGP 5509061 MGIPMID:9436976
Hif1aMouseabnormal body temperature  IAGP 5509061 MGIPMID:17548584
Hif1aMouseabnormal brain vasculature morphology  IAGP 5509061 MGIPMID:17554006
Hif1aMouseabnormal cardiac muscle relaxation  IAGP 5509061 MGIPMID:15132980
Hif1aMouseabnormal cardiac outflow tract development  IAGP 5509061 MGIPMID:9436976
Hif1aMouseabnormal cardiovascular system physiology  IAGP 5509061 MGIPMID:17334357
Hif1aMouseabnormal cartilage development  IAGP 5509061 MGIPMID:11691837
Hif1aMouseabnormal cell differentiation  IAGP 5509061 MGIPMID:18037992
Hif1aMouseabnormal cell migration  IAGP 5509061 MGIPMID:18037992
Hif1aMouseabnormal cell physiology  IAGP 5509061 MGIPMID:22539295
Hif1aMouseabnormal cerebral cortex morphology  IAGP 5509061 MGIPMID:12972594
Hif1aMouseabnormal cerebral hemisphere morphology  IAGP 5509061 MGIPMID:12972594
Hif1aMouseabnormal coronary vessel morphology  IAGP 5509061 MGIPMID:15132980
Hif1aMouseabnormal cortical plate morphology  IAGP 5509061 MGIPMID:12972594
Hif1aMouseabnormal cytokine level  IAGP 5509061 MGIPMID:17015677
Hif1aMouseabnormal dendritic cell number  IAGP 5509061 MGIPMID:22539295
1 to 20 of 226 rows

1 to 20 of 136 rows
#
Reference Title
Reference Citation
1. Expression of hypoxia-inducible factor-1alpha and the protein products of its target genes in diabetic fibrovascular epiretinal membranes. Abu El-Asrar AM, etal., Br J Ophthalmol. 2007 Jun;91(6):822-6. Epub 2007 Jan 17.
2. Expression of hypoxia inducible factor 1 alpha and Von Hippel Lindau protein in human middle ear cholesteatoma. Adunka O, etal., Laryngoscope. 2003 Jul;113(7):1210-5.
3. Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides--cutaneous T-cell lymphoma: clinical implications. Alcantara-Hernandez M, etal., Int J Cancer. 2014 May 1;134(9):2136-45. doi: 10.1002/ijc.28546. Epub 2013 Nov 4.
4. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. Assaraf MI, etal., J Neuropathol Exp Neurol. 2007 May;66(5):389-98.
5. Enhancement of the functional benefits of skeletal myoblast transplantation by means of coadministration of hypoxia-inducible factor 1alpha. Azarnoush K, etal., J Thorac Cardiovasc Surg. 2005 Jul;130(1):173-9.
6. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing. Baatar D, etal., Am J Pathol 2002 Oct;161(4):1449-57.
7. Regional expression of the hypoxia-inducible factor (HIF) system and association with cardiomyocyte cell cycle re-entry after myocardial infarction in rats. Bai CG, etal., Heart Vessels. 2008 May;23(3):193-200. Epub 2008 May 17.
8. Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. Baranova O, etal., J Neurosci. 2007 Jun 6;27(23):6320-32.
9. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Bernhardt WM, etal., Am J Pathol. 2007 Mar;170(3):830-42.
10. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. Bernhardt WM, etal., J Am Soc Nephrol. 2006 Jul;17(7):1970-8. Epub 2006 Jun 8.
11. Exposure to diesel exhaust particulates induces cardiac dysfunction and remodeling. Bradley JM, etal., J Appl Physiol (1985). 2013 Oct 1;115(7):1099-106. doi: 10.1152/japplphysiol.00343.2013. Epub 2013 Jul 25.
12. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Cancello R, etal., Diabetes. 2005 Aug;54(8):2277-86.
13. Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. Chang W, etal., J Vet Sci. 2013;14(1):69-76. doi: 10.4142/jvs.2013.14.1.69. Epub 2013 Feb 5.
14. Baicalein protects against retinal ischemia by antioxidation, antiapoptosis, downregulation of HIF-1alpha, VEGF, and MMP-9 and upregulation of HO-1. Chao HM, etal., J Ocul Pharmacol Ther. 2013 Jul-Aug;29(6):539-49. doi: 10.1089/jop.2012.0179. Epub 2013 Mar 28.
15. Transient expression of hypoxia-inducible factor-1 alpha and target genes in peripheral nerves from diabetic rats. Chavez JC, etal., Neurosci Lett. 2005 Feb 21;374(3):179-82. Epub 2004 Nov 23.
16. [Expression of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor in malignant melanoma]. Cheng Y, etal., Zhonghua Zheng Xing Wai Ke Za Zhi. 2009 Mar;25(2):134-6.
17. Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
18. Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice. Chung JW, etal., Environ Toxicol Pharmacol. 2011 Jan;31(1):153-9. doi: 10.1016/j.etap.2010.10.002. Epub 2010 Oct 16.
19. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
20. Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. Conde E, etal., PLoS One. 2012;7(3):e33258. doi: 10.1371/journal.pone.0033258. Epub 2012 Mar 14.
1 to 20 of 136 rows
1 to 10 of 142 rows
PMID:8470821   PMID:8660378   PMID:8662957   PMID:8702901   PMID:8786149   PMID:8816435   PMID:9113979   PMID:9178256   PMID:9210478   PMID:9368100   PMID:9393757   PMID:9436976  
PMID:9545558   PMID:9558407   PMID:9576906   PMID:9606183   PMID:9697772   PMID:9704006   PMID:9802338   PMID:10074486   PMID:10328919   PMID:10349636   PMID:10605934   PMID:10873592  
PMID:10922068   PMID:10945599   PMID:11042159   PMID:11043581   PMID:11076861   PMID:11169851   PMID:11278461   PMID:11289156   PMID:11292862   PMID:11304494   PMID:11404263   PMID:11439183  
PMID:11440986   PMID:11549290   PMID:11581158   PMID:11602577   PMID:11691837   PMID:11707426   PMID:11782478   PMID:11792862   PMID:11801735   PMID:11818497   PMID:11823643   PMID:11829741  
PMID:11854513   PMID:11859074   PMID:11860493   PMID:11909946   PMID:11914036   PMID:11919510   PMID:11959977   PMID:12053176   PMID:12054621   PMID:12068288   PMID:12133832   PMID:12149478  
PMID:12186875   PMID:12370313   PMID:12393646   PMID:12466851   PMID:12468553   PMID:12477932   PMID:12482858   PMID:12482987   PMID:12520002   PMID:12606552   PMID:12620994   PMID:12628185  
PMID:12660327   PMID:12832481   PMID:12848931   PMID:12855680   PMID:12858534   PMID:12876287   PMID:12897057   PMID:12917333   PMID:12972594   PMID:14610273   PMID:14633603   PMID:14659802  
PMID:14729612   PMID:14770308   PMID:15016652   PMID:15063179   PMID:15073147   PMID:15117738   PMID:15121835   PMID:15128677   PMID:15132980   PMID:15142852   PMID:15156201   PMID:15225651  
PMID:15226823   PMID:15315937   PMID:15328538   PMID:15369676   PMID:15383400   PMID:15385570   PMID:15456877   PMID:15489334   PMID:15489957   PMID:15542432   PMID:15557337   PMID:15618518  
PMID:15630139   PMID:15689487   PMID:15705785   PMID:15766748   PMID:15767462   PMID:15781641   PMID:15798202   PMID:15811624   PMID:15843612   PMID:15887267   PMID:15890996   PMID:15906272  
1 to 10 of 142 rows



Hif1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,948,186 - 73,994,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)EnsemblGRCm39 Ensembl
GRCm381273,901,324 - 73,947,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv371275,008,854 - 75,048,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,826,868 - 74,865,729 (+)NCBIMGSCv36mm8
Celera1275,021,612 - 75,061,060 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1231.99NCBI
HIF1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381461,695,513 - 61,748,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1461,695,513 - 61,748,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371462,162,231 - 62,214,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361461,231,992 - 61,284,729 (+)NCBINCBI36Build 36hg18NCBI36
Build 341461,231,991 - 61,284,729NCBI
Celera1442,212,391 - 42,265,247 (+)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1442,326,005 - 42,378,869 (+)NCBIHuRef
CHM1_11462,101,569 - 62,154,420 (+)NCBICHM1_1
T2T-CHM13v2.01455,902,080 - 55,954,826 (+)NCBIT2T-CHM13v2.0
Hif1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8698,357,788 - 98,405,068 (+)NCBIGRCr8
mRatBN7.2692,624,059 - 92,669,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,624,390 - 92,669,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx693,016,163 - 93,061,234 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0693,315,666 - 93,360,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,743,543 - 92,788,613 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,810,868 - 96,856,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,810,907 - 96,856,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06106,242,409 - 106,287,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4696,419,024 - 96,463,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1696,422,479 - 96,467,347 (+)NCBI
Celera691,083,300 - 91,128,125 (+)NCBICelera
Cytogenetic Map6q24NCBI
Hif1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,000,044 - 8,022,497 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,000,311 - 8,022,497 (-)NCBIChiLan1.0ChiLan1.0
HIF1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21562,825,050 - 62,878,472 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11462,041,761 - 62,094,986 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01442,295,691 - 42,348,478 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11460,552,374 - 60,604,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,552,374 - 60,604,885 (+)Ensemblpanpan1.1panPan2
HIF1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1836,614,045 - 36,656,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl836,614,045 - 36,656,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha836,366,891 - 36,409,562 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0836,847,226 - 36,889,848 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl836,847,066 - 36,889,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1836,456,745 - 36,499,380 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0836,534,215 - 36,576,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,896,640 - 36,939,279 (+)NCBIUU_Cfam_GSD_1.0
Hif1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864068,375,541 - 68,420,766 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364955,770,669 - 5,816,157 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364955,770,988 - 5,816,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1190,625,244 - 190,674,845 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11190,625,436 - 190,673,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,130,958 - 212,179,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,873,830 - 38,927,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2438,873,861 - 38,928,288 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605327,124,225 - 27,177,215 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hif1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473439,411,824 - 39,471,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473439,414,458 - 39,471,705 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Hif1a
1708 total Variants

Predicted Target Of
Summary Value
Count of predictions:1172
Count of miRNA genes:456
Interacting mature miRNAs:555
Transcripts:ENSMUST00000021530, ENSMUST00000110461, ENSMUST00000110464, ENSMUST00000149740, ENSMUST00000157041
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
13504832Bacszq2_mbaculum size QTL 2 (mouse)125694579875345787Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse

1 to 10 of 26 rows
X95580  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,945,786 - 73,945,985UniSTSGRCm38
MGSCv371275,046,773 - 75,046,972UniSTSGRCm37
Celera1275,059,316 - 75,059,515UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
Whitehead_YAC12 UniSTS
AA959795  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,946,806 - 73,947,053UniSTSGRCm38
MGSCv371275,047,793 - 75,048,040UniSTSGRCm37
Celera1275,060,336 - 75,060,583UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
Whitehead/MRC_RH12677.3UniSTS
PMC316445P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,926,492 - 73,926,826UniSTSGRCm38
MGSCv371275,027,479 - 75,027,813UniSTSGRCm37
Celera1275,040,199 - 75,040,533UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
Hif1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,926,557 - 73,926,738UniSTSGRCm38
MGSCv371275,027,544 - 75,027,725UniSTSGRCm37
Celera1275,040,264 - 75,040,445UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
MARC_6691-6694:992007331:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,945,639 - 73,946,206UniSTSGRCm38
MGSCv371275,046,626 - 75,047,193UniSTSGRCm37
Celera1275,059,169 - 75,059,736UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
MARC_6693-6692:992007336:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381273,945,620 - 73,946,705UniSTSGRCm38
MGSCv371275,046,607 - 75,047,692UniSTSGRCm37
Celera1275,059,150 - 75,060,235UniSTS
Cytogenetic Map12C3UniSTS
cM Map1231.0UniSTS
D6Mit13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386132,601,042 - 132,601,187UniSTSGRCm38
MGSCv376132,551,060 - 132,551,205UniSTSGRCm37
Cytogenetic Map6G1UniSTS
cM Map663.6UniSTS
Whitehead Genetic651.4UniSTS






1 to 28 of 28 rows
RefSeq Transcripts NM_001313919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF003695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY725437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO810618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX241289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U59496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 28 of 28 rows

Ensembl Acc Id: ENSMUST00000021530   ⟹   ENSMUSP00000021530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1273,954,678 - 73,994,304 (+)Ensembl
GRCm38.p6 Ensembl1273,907,904 - 73,947,530 (+)Ensembl
Ensembl Acc Id: ENSMUST00000110461   ⟹   ENSMUSP00000106088
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)Ensembl
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)Ensembl
Ensembl Acc Id: ENSMUST00000110464   ⟹   ENSMUSP00000106091
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1273,954,678 - 73,979,850 (+)Ensembl
GRCm38.p6 Ensembl1273,907,904 - 73,933,076 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1273,973,376 - 73,975,306 (+)Ensembl
GRCm38.p6 Ensembl1273,926,602 - 73,928,532 (+)Ensembl
Ensembl Acc Id: ENSMUST00000157041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1273,984,444 - 73,986,655 (+)Ensembl
GRCm38.p6 Ensembl1273,937,670 - 73,939,881 (+)Ensembl
RefSeq Acc Id: NM_001313919   ⟹   NP_001300848
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,954,775 - 73,994,304 (+)NCBI
GRCm381273,907,867 - 73,947,554 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001313920   ⟹   NP_001300849
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,948,186 - 73,994,304 (+)NCBI
GRCm381273,901,324 - 73,947,530 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001422141   ⟹   NP_001409070
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,948,186 - 73,994,304 (+)NCBI
RefSeq Acc Id: NM_001422142   ⟹   NP_001409071
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,954,775 - 73,994,304 (+)NCBI
RefSeq Acc Id: NM_001422143   ⟹   NP_001409072
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,954,775 - 73,994,304 (+)NCBI
RefSeq Acc Id: NM_010431   ⟹   NP_034561
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391273,954,775 - 73,994,304 (+)NCBI
GRCm381273,907,867 - 73,947,530 (+)NCBI
MGSCv371275,008,854 - 75,048,517 (+)RGD
Celera1275,021,612 - 75,061,060 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034561   ⟸   NM_010431
- Peptide Label: isoform 2
- UniProtKB: Q8R385 (UniProtKB/Swiss-Prot),   Q8CCB6 (UniProtKB/Swiss-Prot),   Q8CC19 (UniProtKB/Swiss-Prot),   Q8C681 (UniProtKB/Swiss-Prot),   Q61665 (UniProtKB/Swiss-Prot),   Q61664 (UniProtKB/Swiss-Prot),   O08993 (UniProtKB/Swiss-Prot),   O08741 (UniProtKB/Swiss-Prot),   Q9CYA8 (UniProtKB/Swiss-Prot),   Q61221 (UniProtKB/Swiss-Prot),   Q3UCW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300849   ⟸   NM_001313920
- Peptide Label: isoform 3
- UniProtKB: A0A0R4J1E9 (UniProtKB/TrEMBL),   Q3UCW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300848   ⟸   NM_001313919
- Peptide Label: isoform 1
- UniProtKB: Q3UCW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106088   ⟸   ENSMUST00000110461
Ensembl Acc Id: ENSMUSP00000106091   ⟸   ENSMUST00000110464
bHLH   PAC   PAS

Name Modeler Protein Id AA Range Protein Structure
AF-Q61221-F1-model_v2 AlphaFold Q61221 1-836 view protein structure

RGD ID:8678524
Promoter ID:EPDNEW_M17293
Type:initiation region
Name:Hif1a_2
Description:Mus musculus hypoxia inducible factor 1, alpha subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17294  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381273,901,412 - 73,901,472EPDNEW
RGD ID:8678526
Promoter ID:EPDNEW_M17294
Type:initiation region
Name:Hif1a_1
Description:Mus musculus hypoxia inducible factor 1, alpha subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17293  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381273,908,001 - 73,908,061EPDNEW
RGD ID:8678528
Promoter ID:EPDNEW_M17295
Type:single initiation site
Name:AK048798_2
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17296  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381273,949,657 - 73,949,717EPDNEW
RGD ID:8678530
Promoter ID:EPDNEW_M17296
Type:initiation region
Name:AK048798_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17295  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381273,949,788 - 73,949,848EPDNEW
RGD ID:6823056
Promoter ID:MM_KWN:11925
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:ENSMUST00000110461
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361275,002,161 - 75,002,661 (+)MPROMDB
RGD ID:6823057
Promoter ID:MM_KWN:11926
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000110464,   OTTMUST00000047239,   UC007NWR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361275,008,051 - 75,009,092 (+)MPROMDB
RGD ID:6823058
Promoter ID:MM_KWN:11927
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_4Hour
Transcripts:OTTMUST00000047244
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361275,026,906 - 75,027,882 (+)MPROMDB
RGD ID:6823059
Promoter ID:MM_KWN:11928
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Liver,   MEF_B6
Transcripts:OTTMUST00000047245
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361275,038,056 - 75,038,752 (+)MPROMDB
RGD ID:6822695
Promoter ID:MM_KWN:11930
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000047242,   UC007NWS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361275,050,401 - 75,051,572 (-)MPROMDB


1 to 40 of 59 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000021109 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021530 ENTREZGENE
  ENSMUST00000021530.8 UniProtKB/Swiss-Prot
  ENSMUST00000110461 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HIF-1_alpha UniProtKB/Swiss-Prot
  HIF-1_TAD_C UniProtKB/Swiss-Prot
  HIF_alpha_subunit UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
KEGG Report mmu:15251 UniProtKB/Swiss-Prot
MGD MGI:106918 ENTREZGENE
NCBI Gene 15251 ENTREZGENE
PANTHER HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/Swiss-Prot
  HYPOXIA-INDUCIBLE FACTOR 1-ALPHA UniProtKB/Swiss-Prot
Pfam HIF-1 UniProtKB/Swiss-Prot
  HIF-1a_CTAD UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
PharmGKB HIF1A RGD
PhenoGen Hif1a PhenoGen
PRINTS HYPOXIAIF1A UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
UniProt A0A0R4J1E9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0R4J1F0_MOUSE UniProtKB/TrEMBL
  HIF1A_MOUSE UniProtKB/Swiss-Prot
  O08741 ENTREZGENE
  O08993 ENTREZGENE
1 to 40 of 59 rows