Hif1a (hypoxia inducible factor 1, alpha subunit) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hif1a (hypoxia inducible factor 1, alpha subunit) Mus musculus
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
RGD ID: 62221
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; negative regulation of ossification; and positive regulation of autophagy of mitochondrion. Acts upstream of or within several processes, including animal organ development; negative regulation of apoptotic process; and tube morphogenesis. Located in motile cilium and nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; lung; and sensory organ. Used to study glycogen storage disease V and glycogen storage disease VII. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA959795; ARNT-interacting protein; bHLHe7; bHLHe78; HIF-1; HIF-1-alpha; HIF1; HIF1-alpha; HIF1alpha; hypoxia-inducible factor 1-alpha; MO; MOP1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391273,948,098 - 73,994,328 (+)NCBIGRCm39mm39
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)Ensembl
GRCm381273,901,324 - 73,947,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv371275,008,854 - 75,048,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv361274,826,868 - 74,865,729 (+)NCBImm8
Celera1275,021,612 - 75,061,060 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1231.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute-Phase Reaction  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (IEP,ISO)
Anaplasia  (ISO)
Arterial Thrombosis  (ISO)
Asphyxia  (ISO)
asthma  (IEP)
atrial fibrillation  (ISO)
bladder neck obstruction  (ISO)
brain ischemia  (IEP,ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Colonic Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
decubitus ulcer  (ISO)
Diabetes Complications  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (ISO)
Femur Head Necrosis  (ISO)
glioblastoma  (ISO)
glycogen storage disease V  (IEA)
glycogen storage disease VII  (IEA)
Hearing Loss, Noise-Induced  (IDA)
hemangioblastoma  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Infarction  (ISO)
Intervertebral Disc Disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Limb Ischemia  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Memory Disorders  (IEP)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
olfactory neuroblastoma  (ISO)
osteoarthritis  (IMP,ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (IDA,IEP)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
polycystic kidney disease  (ISO)
Postmenopausal Osteoporosis  (IMP,ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal ischemia  (ISO)
Retinal Neovascularization  (IDA)
rheumatoid arthritis  (ISO)
sclerosing cholangitis  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Subarachnoid Hemorrhage  (ISO)
Temporomandibular Joint Disorders  (ISO)
Testis Reperfusion Injury  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
Urologic Neoplasms  (ISO)
varicocele  (ISO)
Werner syndrome  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-noscapine  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
2,2'-bipyridine  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoate  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-bromopyruvic acid  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-17beta-estradiol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP,ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7H-xanthine  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-aminoacridine  (ISO)
9H-xanthine  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bromobenzene  (ISO)
bucladesine  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
calycosin  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosine  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP,ISO)
cobalt(II) acetate  (ISO)
cocaine  (ISO)
concanamycin A  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumarin 460  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (EXP,ISO)
cyclohexyl isocyanate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (EXP)
D-glucose  (EXP,ISO)
Deguelin  (ISO)
delphinidin  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
Dictamnine  (ISO)
digoxin  (ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
edaravone  (ISO)
ellagic acid  (ISO)
emodin  (EXP)
entinostat  (EXP)
epalrestat  (EXP,ISO)
epoxomicin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
fasudil hydrochloride  (EXP)
fenofibrate  (EXP,ISO)
finasteride  (ISO)
fisetin  (ISO)
flavanones  (ISO)
flavone  (ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formononetin  (ISO)
furan  (ISO)
Fusaric acid  (ISO)
galactose  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
gingerol  (EXP)
Ginsenoside Rg5  (ISO)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyphosate  (ISO)
GW 4064  (EXP)
hemin  (EXP,ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroxamic acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indoxyl sulfate  (ISO)
Iodine aqueous  (ISO)
ionomycin  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(3+) sulfate  (ISO)
iron(III) citrate  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (EXP)
kaempferol  (ISO)
ketorolac  (ISO)
KN-93  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
L-mimosine  (ISO)
lactacystin  (ISO)
lapatinib  (ISO)
leflunomide  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
malonic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (EXP,ISO)
mercury dichloride  (ISO)
metam  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
mevinphos  (ISO)
miconazole  (ISO)
minocycline  (ISO)
motexafin gadolinium  (ISO)
myricetin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
n-propyl gallate  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
nitroprusside  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oroxylin A  (EXP,ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Panaxynol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentachlorophenol  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisone  (ISO)
progesterone  (EXP)
promethazine  (ISO)
propofol  (EXP)
prostaglandin E2  (EXP,ISO)
protoporphyrin  (ISO)
quercetin  (ISO)
quinolone  (ISO)
Quinomycin A  (EXP)
rac-lactic acid  (ISO)
radicicol  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (ISO)
rimonabant  (EXP)
romidepsin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
scutellarin  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium cholate  (ISO)
sodium dichromate  (ISO)
sodium nitrite  (ISO)
sorafenib  (ISO)
spironolactone  (ISO)
squalene  (ISO)
stattic  (ISO)
streptozocin  (EXP)
succinic acid  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
Swertiamarin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Terpestacin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraconazole  (ISO)
tetraethylenepentamine  (ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thymidine  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
triamterene  (ISO)
trifluoperazine  (ISO)
trimellitic anhydride  (EXP)
trimethyltin  (EXP)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP)
udenafil  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
wogonin  (EXP)
wortmannin  (ISO)
Y-27632  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
angiogenesis  (IMP)
axonal transport of mitochondrion  (ISO)
B-1 B cell homeostasis  (IMP)
blood vessel development  (IMP)
blood vessel morphogenesis  (IMP)
camera-type eye morphogenesis  (IGI)
cardiac ventricle morphogenesis  (IMP)
cartilage development  (IMP)
cell differentiation  (IGI,IMP)
cellular glucose homeostasis  (ISO)
cellular iron ion homeostasis  (IMP)
cellular response to carbon monoxide  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to cyanide  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IBA,IGI,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to light stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nitrite  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to toxic substance  (ISO)
cellular response to virus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (IMP)
collagen metabolic process  (IMP)
connective tissue replacement involved in inflammatory response wound healing  (IMP)
digestive tract morphogenesis  (IMP)
dopaminergic neuron differentiation  (IGI,IMP)
elastin metabolic process  (IMP)
embryonic hemopoiesis  (IMP)
embryonic placenta development  (IGI,IMP)
epithelial cell differentiation involved in mammary gland alveolus development  (IMP)
epithelial to mesenchymal transition  (IMP)
glucose homeostasis  (IMP)
heart looping  (IMP)
hemoglobin biosynthetic process  (IMP)
hypoxia-inducible factor-1alpha signaling pathway  (IDA)
intestinal epithelial cell maturation  (IMP)
iris morphogenesis  (IGI)
lactate metabolic process  (IMP)
lactation  (IMP)
maternal process involved in female pregnancy  (ISO)
muscle cell cellular homeostasis  (IMP)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of bone mineralization  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of growth  (IMP)
negative regulation of mesenchymal cell apoptotic process  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of ossification  (IMP)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of thymocyte apoptotic process  (IMP)
negative regulation of TOR signaling  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
neural crest cell migration  (IMP)
neural fold elevation formation  (IMP)
outflow tract morphogenesis  (IMP)
oxygen homeostasis  (IMP,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IMP)
positive regulation of autophagy of mitochondrion  (IMP)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of epithelial cell migration  (IMP)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of hormone biosynthetic process  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of macroautophagy  (IMP)
positive regulation of neuroblast proliferation  (IGI)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IMP)
regulation of aerobic respiration  (IMP)
regulation of catalytic activity  (IMP)
regulation of cell population proliferation  (IMP)
regulation of cellular response to hypoxia  (ISO)
regulation of gene expression  (IMP,ISO)
regulation of glycolytic process  (IGI,ISO)
regulation of protein neddylation  (ISO)
regulation of thymocyte apoptotic process  (IGI)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (IMP,ISO)
regulation of transcription, DNA-templated  (IDA,ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to activity  (ISO)
response to alkaloid  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to fungicide  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (IDA,IGI,IMP,ISO)
response to iron ion  (ISO)
response to mechanical stimulus  (ISO)
response to muscle activity  (IMP)
response to purine-containing compound  (ISO)
response to reactive oxygen species  (ISO)
response to salt stress  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
retina vasculature development in camera-type eye  (IMP)
signal transduction  (ISO)
vascular endothelial growth factor production  (ISO)
vasculature development  (IGI)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal behavior  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal body temperature  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell migration  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal dendritic cell number  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal exercise endurance  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart left ventricle pressure  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart size  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal interleukin-1 beta secretion  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal milk composition  (IAGP)
abnormal milk sodium level  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal occipital lobe morphology  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal pericardium morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal spatial learning  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal temporal lobe morphology  (IAGP)
abnormal thoracic cage shape  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal tracheal ciliated epithelium morphology  (IAGP)
abnormal tumor necrosis factor secretion  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
abnormal vascular regression  (IAGP)
abnormal vasodilation  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent myocardial trabeculae  (IAGP)
absent pharyngeal arch arteries  (IAGP)
absent second pharyngeal arch  (IAGP)
absent third pharyngeal arch  (IAGP)
atelectasis  (IAGP)
cardia bifida  (IAGP)
cardiac hypertrophy  (IAGP)
cyanosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating erythropoietin level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 alpha secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased length of long bones  (IAGP)
decreased liver glycogen level  (IAGP)
decreased liver regeneration  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased vascular endothelial cell proliferation  (IAGP)
delayed wound healing  (IAGP)
dilated dorsal aorta  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
disorganized myocardium  (IAGP)
disorganized yolk sac vascular plexus  (IAGP)
domed cranium  (IAGP)
early cellular replicative senescence  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
extramedullary hematopoiesis  (IAGP)
hemorrhage  (IAGP)
hepatic steatosis  (IAGP)
hydrocephaly  (IAGP)
hypoxia  (IAGP)
impaired macrophage chemotaxis  (IAGP)
incomplete somite formation  (IAGP)
increased apoptosis  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cerebral infarction size  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased erythropoietin level  (IAGP)
increased hematocrit  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemoglobin content  (IAGP)
increased hepatic hemangioma incidence  (IAGP)
increased hindbrain size  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased left ventricle weight  (IAGP)
increased lens fiber apoptosis  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased lung weight  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to ischemic brain injury  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased vascular endothelial cell number  (IAGP)
kidney cysts  (IAGP)
kidney inflammation  (IAGP)
loss of cortex neurons  (IAGP)
loss of hippocampal neurons  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pericardial effusion  (IAGP)
pharyngeal arch artery hypoplasia  (IAGP)
polycythemia  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
renal fibrosis  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
short limbs  (IAGP)
small lens  (IAGP)
small second pharyngeal arch  (IAGP)
thick interventricular septum  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick ventricular wall  (IAGP)

References - curated
1. Abu El-Asrar AM, etal., Br J Ophthalmol. 2007 Jun;91(6):822-6. Epub 2007 Jan 17.
2. Adunka O, etal., Laryngoscope. 2003 Jul;113(7):1210-5.
3. Alcantara-Hernandez M, etal., Int J Cancer. 2014 May 1;134(9):2136-45. doi: 10.1002/ijc.28546. Epub 2013 Nov 4.
4. Assaraf MI, etal., J Neuropathol Exp Neurol. 2007 May;66(5):389-98.
5. Azarnoush K, etal., J Thorac Cardiovasc Surg. 2005 Jul;130(1):173-9.
6. Baatar D, etal., Am J Pathol 2002 Oct;161(4):1449-57.
7. Bai CG, etal., Heart Vessels. 2008 May;23(3):193-200. Epub 2008 May 17.
8. Baranova O, etal., J Neurosci. 2007 Jun 6;27(23):6320-32.
9. Bernhardt WM, etal., Am J Pathol. 2007 Mar;170(3):830-42.
10. Bernhardt WM, etal., J Am Soc Nephrol. 2006 Jul;17(7):1970-8. Epub 2006 Jun 8.
11. Cancello R, etal., Diabetes. 2005 Aug;54(8):2277-86.
12. Chao HM, etal., J Ocul Pharmacol Ther. 2013 Jul-Aug;29(6):539-49. doi: 10.1089/jop.2012.0179. Epub 2013 Mar 28.
13. Chavez JC, etal., Neurosci Lett. 2005 Feb 21;374(3):179-82. Epub 2004 Nov 23.
14. Cheng Y, etal., Zhonghua Zheng Xing Wai Ke Za Zhi. 2009 Mar;25(2):134-6.
15. Chou LW, etal., Arthritis Res Ther. 2011 Jun 16;13(3):R90. doi: 10.1186/ar3365.
16. Chung JW, etal., Environ Toxicol Pharmacol. 2011 Jan;31(1):153-9. doi: 10.1016/j.etap.2010.10.002. Epub 2010 Oct 16.
17. Conde E, etal., PLoS One. 2012;7(3):e33258. doi: 10.1371/journal.pone.0033258. Epub 2012 Mar 14.
18. Daponte A, etal., BMC Cancer. 2008 Nov 16;8:335.
19. Diensthuber M, etal., J Neurooncol. 2008 Sep;89(2):131-9. doi: 10.1007/s11060-008-9602-9. Epub 2008 Apr 23.
20. Dordevic G, etal., J Exp Clin Cancer Res. 2009 Mar 20;28(1):40.
21. Ece H, etal., Asian Pac J Cancer Prev. 2012;13(10):5143-8.
22. Fine JM, etal., Exp Brain Res. 2012 Jun;219(3):381-90. doi: 10.1007/s00221-012-3101-0. Epub 2012 May 1.
23. Foley R, etal., Cancer Biol Ther. 2009 Jan;8(2):118-24. Epub 2009 Feb 1.
24. Gelse K, etal., Arthritis Res Ther. 2008;10(5):R111. doi: 10.1186/ar2508. Epub 2008 Sep 12.
25. Generali D, etal., J Clin Oncol. 2009 Jan 10;27(2):227-34. Epub 2008 Dec 8.
26. Ghafar MA, etal., Lab Invest. 2002 Jul;82(7):903-9.
27. Giatromanolaki A, etal., Arthritis Res Ther. 2003;5(4):R193-201. Epub 2003 Apr 29.
28. Gramley F, etal., Cardiovasc Pathol. 2010 Mar-Apr;19(2):102-11. doi: 10.1016/j.carpath.2008.11.001. Epub 2009 Feb 11.
29. Grammas P, etal., Int J Clin Exp Pathol. 2011 Aug 15;4(6):616-27. Epub 2011 Jun 18.
30. Grammas P, etal., J Alzheimers Dis. 2006 Mar;9(1):51-8.
31. Grimm A, etal., Strahlenther Onkol. 2007 Mar;183(3):144-9.