RGD Reference Report - Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels?

General

Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels?
Authors:	Ece, H Cigdem, E Yuksel, K Ahmet, D Hakan, E Oktay, TM
Citation:	Ece H, etal., Asian Pac J Cancer Prev. 2012;13(10):5143-8.
RGD ID:	8695972
Pubmed:	PMID:23244125 (View Abstract at PubMed)
OBJECTIVE: The aim was to investigate indicators related to DNA damage and cancer pathogenesis in Type II diabetes cases with breast cancer. It was planned to evaluate the relationship between these markers with oral antidiabetic drugs. RESEARCH DESIGN AND METHODS: Fourty patients and 10 healthy individuals were included in the study. HIF-1alpha and 8-OHdG are examined in blood samples taken from these individuals with an ELISA Kit. Statistical analysis of data was performed with 95% confidence using Windows package program SPSS 15.0. RESULTS: HIF-1alpha parameters were found to be meaningfully higher in the patient group than the controls in both pretreatment and posttreatment periods (p<0.05). No significant differences in terms of 8-OHdG between patients and controls. However, posttreatment serum HIF-1alpha ve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone. Conversely, serum 8-OHdG levels decreased significantly in these patients. When patients were evaluated according to the treatment groups (pioglitazone vs. metformin) no significant differences in terms of serum HIF-1? and 8-OHdG levels between treatment groups. CONCLUSIONS: HIF-1alpha levels decreased significantly in the patient group receiving metformin. However, there was no significant difference in terms of HIF-1alpha levels in the patients receiving pioglitazone.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
type 2 diabetes mellitus		IEP		8695972	associated with Breast Neoplasms and protein:increased expression:serum (human)	RGD
type 2 diabetes mellitus		ISO	HIF1A (Homo sapiens)	8695972; 8695972	associated with Breast Neoplasms and protein:increased expression:serum (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Hif1a (hypoxia inducible factor 1 subunit alpha)

Genes (Mus musculus)

Hif1a (hypoxia inducible factor 1, alpha subunit)

Genes (Homo sapiens)

HIF1A (hypoxia inducible factor 1 subunit alpha)

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Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels?