HIF1A (hypoxia inducible factor 1 subunit alpha) - Rat Genome Database

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Gene: HIF1A (hypoxia inducible factor 1 subunit alpha) Homo sapiens
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
RGD ID: 730935
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Hsp90 protein binding activity; and enzyme binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including oxygen homeostasis; regulation of gene expression; and vascular endothelial growth factor production. Acts upstream of or within regulation of transcription, DNA-templated and response to hypoxia. Located in chromatin; cytosol; and nuclear body. Part of RNA polymerase II transcription regulator complex. Implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Biomarker of several diseases, including arthritis (multiple); invasive ductal carcinoma; kidney cancer (multiple); morbid obesity; and mycosis fungoides.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARNT interacting protein; ARNT-interacting protein; basic-helix-loop-helix-PAS protein MOP1; bHLHe78; class E basic helix-loop-helix protein 78; HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PAS domain-containing protein 8", "Class E basic helix-loop-helix protein 78", "Member of PAS protein 1; PASD8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HIF1AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1461,695,513 - 61,748,259 (+)EnsemblGRCh38hg38GRCh38
GRCh381461,695,513 - 61,748,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371462,162,231 - 62,214,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361461,231,992 - 61,284,729 (+)NCBINCBI36hg18NCBI36
Build 341461,231,991 - 61,284,729NCBI
Celera1442,212,391 - 42,265,247 (+)NCBI
Cytogenetic Map14q23.2NCBI
HuRef1442,326,005 - 42,378,869 (+)NCBIHuRef
CHM1_11462,101,569 - 62,154,420 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute-Phase Reaction  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (IEP,ISO)
Anaplasia  (EXP)
Arterial Thrombosis  (ISO)
Asphyxia  (ISO)
asthma  (ISO)
atrial fibrillation  (IEP)
bladder neck obstruction  (ISO)
brain ischemia  (EXP,ISO)
Breast Neoplasms  (EXP,IEP)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
carcinoma  (EXP)
Cardiomegaly  (EXP)
cholesteatoma of middle ear  (IEP)
Chronic Cerebral Hypoperfusion  (ISO)
Colonic Neoplasms  (IDA)
congenital heart disease  (EXP)
congestive heart failure  (EXP,ISO)
decubitus ulcer  (ISO)
Diabetes Complications  (EXP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
Disease Progression  (EXP)
Ductal Carcinoma  (EXP)
ductal carcinoma in situ  (EXP,IEP)
esophagus squamous cell carcinoma  (EXP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (EXP)
Femur Head Necrosis  (ISO)
glioblastoma  (EXP)
glycogen storage disease V  (ISS)
glycogen storage disease VII  (ISS)
Hearing Loss, Noise-Induced  (ISO)
hemangioblastoma  (EXP)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hot Flashes  (IAGP)
Hyperalgesia  (ISO)
Hyperplasia  (EXP)
hypertension  (EXP,IEP,ISO)
Hypoxia-Ischemia, Brain  (EXP,ISO)
idiopathic pulmonary fibrosis  (EXP)
Infarction  (ISO)
Intervertebral Disc Disease  (ISO)
invasive ductal carcinoma  (IEP)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Limb Ischemia  (ISO)
lung disease  (EXP)
lung non-small cell carcinoma  (EXP,IDA)
malignant astrocytoma  (EXP)
Mammary Neoplasms, Experimental  (ISO)
Memory Disorders  (ISO)
Micronuclei, Chromosome-Defective  (EXP)
middle cerebral artery infarction  (ISO)
morbid obesity  (IEP)
mycosis fungoides  (IEP)
myocardial infarction  (IMP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplastic Cell Transformation  (EXP)
nephroblastoma  (IEP)
olfactory neuroblastoma  (IEP)
osteoarthritis  (IEP,ISO)
ovarian cancer  (IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (EXP)
Phyllodes Tumor  (IEP)
polycystic kidney disease  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (EXP)
prostate cancer  (IAGP)
Prostatic Neoplasms  (EXP)
psoriasis  (IEP)
pulmonary hypertension  (EXP,ISO)
Radiation Injuries  (IDA)
Radiation Injuries, Experimental  (EXP,ISO)
renal cell carcinoma  (IEP)
Reperfusion Injury  (ISO)
retinal ischemia  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (IEP)
sclerosing cholangitis  (EXP)
skin melanoma  (IEP)
Skin Neoplasms  (EXP)
Spinal Cord Injuries  (EXP,ISO)
Subarachnoid Hemorrhage  (ISO)
Temporomandibular Joint Disorders  (ISO)
Testis Reperfusion Injury  (ISO)
Thyroid Neoplasms  (EXP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP,ISO)
Ulcer  (ISO)
Urologic Neoplasms  (IEP)
varicocele  (ISO)
Werner syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-noscapine  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (EXP)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
2,2'-bipyridine  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP,ISO)
26-hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoate  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-bromopyruvic acid  (ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP,ISO)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7H-xanthine  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-aminoacridine  (EXP)
9H-xanthine  (ISO)
acetamide  (ISO)
acrolein  (EXP)
actinomycin D  (EXP)
adenosine  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (EXP)
alpinumisoflavone  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amino acid  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
amphotericin B  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Azaspiracid  (EXP)
bafilomycin A1  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-D-glucosamine  (EXP)
betulin  (EXP)
betulinic acid  (EXP)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bromobenzene  (ISO)
bucladesine  (EXP)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calciol  (ISO)
calycosin  (EXP)
calycosin-7-O-beta-D-glucoside  (EXP)
cannabidiol  (ISO)
capecitabine  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosine  (ISO)
chenodeoxycholic acid  (EXP)
chetomin  (EXP)
chloroacetaldehyde  (EXP)
chloroquine  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
ciclopirox  (EXP,ISO)
cidofovir anhydrous  (EXP)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP,ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP,ISO)
cobalt(II) acetate  (EXP)
cocaine  (EXP)
concanamycin A  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
coumarin 460  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (EXP,ISO)
cyclohexyl isocyanate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
deguelin  (EXP)
delphinidin  (EXP)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
Dictamnine  (EXP)
digitonin  (EXP)
digitoxin  (EXP)
digoxin  (EXP)
Dihydrotanshinone I  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (EXP)
dimethylselenide  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
dopamine  (EXP,ISO)
dorsomorphin  (EXP)
doxifluridine  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
edaravone  (EXP)
ellagic acid  (EXP)
emodin  (ISO)
entinostat  (ISO)
epalrestat  (EXP,ISO)
epoxomicin  (EXP)
ethanol  (EXP,ISO)
eticlopride(1+)  (ISO)
etoposide  (EXP)
eugenol  (EXP)
fasudil  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanones  (EXP)
flavone  (EXP)
fluoranthene  (EXP)
folic acid  (EXP,ISO)
formononetin  (EXP)
fulvestrant  (ISO)
furan  (ISO)
Fusaric acid  (EXP)
galactose  (EXP)
galangin  (EXP)
gallic acid  (EXP)
gefitinib  (EXP)
geldanamycin  (EXP)
gemcitabine  (EXP)
Genipin  (EXP)
genistein  (EXP)
gentamycin  (EXP,ISO)
gingerol  (ISO)
Ginsenoside Rg5  (ISO)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glutathione disulfide  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
hemin  (EXP,ISO)
hexadecanoic acid  (EXP)
hyaluronic acid  (ISO)
hydrazines  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxamic acid  (EXP)
ibuprofen  (EXP)
ifosfamide  (EXP)
indoxyl sulfate  (EXP)
Iodine aqueous  (EXP)
ionomycin  (EXP)
iron atom  (EXP,ISO)
iron dichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(3+) sulfate  (EXP)
iron(III) citrate  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (ISO)
kaempferol  (EXP)
ketorolac  (EXP)
KN-93  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
L-mimosine  (EXP,ISO)
lactacystin  (EXP)
lapatinib  (EXP)
leflunomide  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
malonic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dichloride  (EXP)
metam  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
mevinphos  (ISO)
miconazole  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (EXP)
myricetin  (EXP)
N(6)-butyryl-cAMP  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
n-propyl gallate  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
nitrofurantoin  (ISO)
nitroprusside  (EXP)
NS-398  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleic acid  (EXP)
oroxylin A  (EXP,ISO)
ouabain  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (EXP)
paeoniflorin  (EXP)
Panaxynol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
prednisone  (EXP)
progesterone  (ISO)
promethazine  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP,ISO)
protoporphyrin  (EXP)
quercetin  (EXP,ISO)
quinolone  (EXP)
Quinomycin A  (ISO)
rac-lactic acid  (EXP)
radicicol  (ISO)
radon atom  (EXP)
radon(0)  (EXP)
razoxane  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rifampicin  (EXP)
rimonabant  (ISO)
romidepsin  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (EXP)
Salidroside  (ISO)
Salinomycin  (EXP)
SB 203580  (EXP)
scutellarin  (EXP)
Shikonin  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
sorafenib  (EXP)
spironolactone  (ISO)
squalene  (EXP)
stattic  (EXP)
streptozocin  (ISO)
succinic acid  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
sulfonyldimethane  (EXP)
sulforaphane  (EXP)
sulindac  (EXP)
sulprostone  (EXP)
sunitinib  (EXP)
Swertiamarin  (ISO)
tamoxifen  (EXP)
tanespimycin  (EXP)
Terpestacin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraconazole  (EXP)
tetraethylenepentamine  (EXP)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thymidine  (EXP)
Tiron  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
triamterene  (EXP)
trifluoperazine  (EXP)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
troglitazone  (EXP)
Tungsten carbide  (EXP)
tunicamycin  (ISO)
udenafil  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vemurafenib  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
wogonin  (ISO)
wortmannin  (EXP)
Y-27632  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
angiogenesis  (IEA,ISO)
axonal transport of mitochondrion  (IMP)
B-1 B cell homeostasis  (IEA,ISO)
blood vessel development  (IEA,ISO)
blood vessel morphogenesis  (IEA,ISO)
camera-type eye morphogenesis  (IEA,ISO)
cardiac ventricle morphogenesis  (IEA,ISO)
cartilage development  (IEA,ISO)
cell differentiation  (IEA,ISO)
cellular glucose homeostasis  (IDA)
cellular iron ion homeostasis  (IEA,ISO)
cellular response to carbon monoxide  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to cyanide  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IBA,IDA,IEA,IEP,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (IEP,ISO)
cellular response to light stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nitrite  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to toxic substance  (ISO)
cellular response to virus  (IDA)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (IEA,ISO)
collagen metabolic process  (IEA,ISS)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISS)
digestive tract morphogenesis  (IEA,ISO)
dopaminergic neuron differentiation  (IEA,ISO)
elastin metabolic process  (IEA,ISS)
embryonic hemopoiesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISS)
glucose homeostasis  (IEA,ISO)
heart looping  (IEA,ISO)
hemoglobin biosynthetic process  (IEA,ISO)
hypoxia-inducible factor-1alpha signaling pathway  (IEA,ISO)
intestinal epithelial cell maturation  (IEA,ISO)
iris morphogenesis  (IEA,ISO)
lactate metabolic process  (IEA,ISO)
lactation  (IEA,ISO)
maternal process involved in female pregnancy  (ISO)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of bone mineralization  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of growth  (IEA,ISO)
negative regulation of mesenchymal cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of ossification  (IEA)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IDA)
negative regulation of reactive oxygen species metabolic process  (IEA)
negative regulation of thymocyte apoptotic process  (IEA,ISO)
negative regulation of TOR signaling  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
neural crest cell migration  (IEA,ISO)
neural fold elevation formation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
oxygen homeostasis  (IDA,IEA,ISO)
positive regulation of angiogenesis  (IC,IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IEA)
positive regulation of autophagy of mitochondrion  (IEA)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine production  (TAS)
positive regulation of chemokine-mediated signaling pathway  (IDA)
positive regulation of cytokine production involved in inflammatory response  (IDA)
positive regulation of endothelial cell proliferation  (IC)
positive regulation of epithelial cell migration  (IEA,ISS)
positive regulation of erythrocyte differentiation  (IC,IEA,ISO)
positive regulation of gene expression  (IDA,IEA,IMP,ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of glycolytic process  (IC)
positive regulation of hormone biosynthetic process  (IDA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of miRNA transcription  (IDA,IMP)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of nitric-oxide synthase activity  (TAS)
positive regulation of signaling receptor activity  (IMP)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IGI,IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IDA,IMP)
positive regulation of transcription, DNA-templated  (IDA,IMP)
positive regulation of vascular endothelial growth factor production  (IDA,IMP)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IC,IEA,ISO)
regulation of aerobic respiration  (IEA)
regulation of catalytic activity  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular response to hypoxia  (ISO)
regulation of gene expression  (IDA,IEA)
regulation of glycolytic process  (IDA,IEA,ISO)
regulation of protein neddylation  (IMP)
regulation of thymocyte apoptotic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (IDA,IEA,ISO)
regulation of transcription, DNA-templated  (IDA,IEA)
regulation of transforming growth factor beta2 production  (IMP)
response to activity  (ISO)
response to alkaloid  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to fungicide  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (IDA,IEA,IMP,ISO)
response to iron ion  (IEP)
response to mechanical stimulus  (ISO)
response to muscle activity  (IEA,ISO)
response to purine-containing compound  (ISO)
response to reactive oxygen species  (IDA)
response to salt stress  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
retina vasculature development in camera-type eye  (IEA,ISO)
signal transduction  (IMP)
vascular endothelial growth factor production  (IDA)
vasculature development  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

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