HIF1A (hypoxia inducible factor 1 subunit alpha) - Rat Genome Database

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Gene: HIF1A (hypoxia inducible factor 1 subunit alpha) Pan paniscus
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Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
RGD ID: 12024672
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN acute-phase response (ortholog); angiogenesis (ortholog); axonal transport of mitochondrion (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute-Phase Reaction (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hypoxia inducible factor 1 alpha subunit; hypoxia-inducible factor 1-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11460,552,374 - 60,604,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,552,374 - 60,604,885 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01442,295,691 - 42,348,478 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute-Phase Reaction  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Anaplasia  (ISO)
Arterial Thrombosis  (ISO)
Asphyxia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bladder neck obstruction  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Colonic Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
decubitus ulcer  (ISO)
Diabetes Complications  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (ISO)
Femur Head Necrosis  (ISO)
glioblastoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemangioblastoma  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Infarction  (ISO)
Intervertebral Disc Disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Limb Ischemia  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Memory Disorders  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
olfactory neuroblastoma  (ISO)
osteoarthritis  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
polycystic kidney disease  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal ischemia  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
sclerosing cholangitis  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Subarachnoid Hemorrhage  (ISO)
Temporomandibular Joint Disorders  (ISO)
Testis Reperfusion Injury  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
Urologic Neoplasms  (ISO)
varicocele  (ISO)
Werner syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
angiogenesis  (ISO)
axonal transport of mitochondrion  (ISO)
B-1 B cell homeostasis  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cellular glucose homeostasis  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to carbon monoxide  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to cyanide  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to light stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nitrite  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to toxic substance  (ISO)
cellular response to virus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (ISO)
collagen metabolic process  (ISO)
connective tissue replacement involved in inflammatory response wound healing  (ISO)
digestive tract morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
elastin metabolic process  (ISO)
embryonic hemopoiesis  (ISO)
embryonic placenta development  (ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (ISO)
epithelial to mesenchymal transition  (ISO)
glucose homeostasis  (ISO)
heart looping  (ISO)
hemoglobin biosynthetic process  (ISO)
hypoxia-inducible factor-1alpha signaling pathway  (ISO)
intestinal epithelial cell maturation  (ISO)
iris morphogenesis  (ISO)
lactate metabolic process  (ISO)
lactation  (ISO)
maternal process involved in female pregnancy  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of growth  (ISO)
negative regulation of mesenchymal cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of thymocyte apoptotic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
neural crest cell migration  (ISO)
neural fold elevation formation  (ISO)
outflow tract morphogenesis  (ISO)
oxygen homeostasis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of autophagy of mitochondrion  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of hormone biosynthetic process  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
regulation of aerobic respiration  (ISO)
regulation of catalytic activity  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cellular response to hypoxia  (ISO)
regulation of gene expression  (ISO)
regulation of glycolytic process  (ISO)
regulation of protein neddylation  (ISO)
regulation of thymocyte apoptotic process  (ISO)
regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to activity  (ISO)
response to alkaloid  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to fungicide  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to iron ion  (ISO)
response to mechanical stimulus  (ISO)
response to muscle activity  (ISO)
response to purine-containing compound  (ISO)
response to reactive oxygen species  (ISO)
response to salt stress  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (ISO)
vascular endothelial growth factor production  (ISO)
vasculature development  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
HIF1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11460,552,374 - 60,604,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,552,374 - 60,604,885 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01442,295,691 - 42,348,478 (+)NCBIMhudiblu_PPA_v0panPan3
HIF1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1461,695,513 - 61,748,259 (+)EnsemblGRCh38hg38GRCh38
GRCh381461,695,513 - 61,748,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371462,162,231 - 62,214,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361461,231,992 - 61,284,729 (+)NCBINCBI36hg18NCBI36
Build 341461,231,991 - 61,284,729NCBI
Celera1442,212,391 - 42,265,247 (+)NCBI
Cytogenetic Map14q23.2NCBI
HuRef1442,326,005 - 42,378,869 (+)NCBIHuRef
CHM1_11462,101,569 - 62,154,420 (+)NCBICHM1_1
Hif1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,948,098 - 73,994,328 (+)NCBIGRCm39mm39
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)Ensembl
GRCm381273,901,324 - 73,947,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv371275,008,854 - 75,048,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv361274,826,868 - 74,865,729 (+)NCBImm8
Celera1275,021,612 - 75,061,060 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1231.99NCBI
Hif1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2692,624,059 - 92,669,262 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl696,810,907 - 96,856,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0696,810,868 - 96,856,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06106,242,409 - 106,287,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4696,419,024 - 96,463,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1696,422,479 - 96,467,347 (+)NCBI
Celera691,083,300 - 91,128,125 (+)NCBICelera
Cytogenetic Map6q24NCBI
Hif1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,000,044 - 8,022,497 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,000,311 - 8,022,497 (-)NCBIChiLan1.0ChiLan1.0
HIF1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1836,614,045 - 36,656,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl836,614,045 - 36,656,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha836,366,891 - 36,409,562 (+)NCBI
ROS_Cfam_1.0836,847,226 - 36,889,848 (+)NCBI
UMICH_Zoey_3.1836,456,745 - 36,499,380 (+)NCBI
UNSW_CanFamBas_1.0836,534,215 - 36,576,862 (+)NCBI
UU_Cfam_GSD_1.0836,896,640 - 36,939,279 (+)NCBI
Hif1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864068,375,541 - 68,420,766 (-)NCBI
SpeTri2.0NW_0049364955,770,988 - 5,816,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1190,625,181 - 190,674,850 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11190,625,436 - 190,673,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,130,958 - 212,179,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,873,830 - 38,927,657 (+)NCBI
ChlSab1.1 Ensembl2438,873,861 - 38,928,288 (+)Ensembl
Vero_WHO_p1.0NW_02366605327,124,225 - 27,177,215 (+)NCBI
Hif1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473439,414,458 - 39,471,705 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033541   ⟹   ENSPPAP00000010887
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1460,552,374 - 60,604,885 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033543   ⟹   ENSPPAP00000010889
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1460,552,821 - 60,603,566 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033558   ⟹   ENSPPAP00000010904
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1460,554,869 - 60,603,712 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033562   ⟹   ENSPPAP00000010908
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1460,574,653 - 60,603,712 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000033564   ⟹   ENSPPAP00000010910
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1460,577,096 - 60,603,712 (+)Ensembl
RefSeq Acc Id: XM_003831627   ⟹   XP_003831675
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11460,552,374 - 60,604,885 (+)NCBI
Mhudiblu_PPA_v01442,295,693 - 42,348,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008956978   ⟹   XP_008955226
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11460,552,452 - 60,604,885 (+)NCBI
Mhudiblu_PPA_v01442,295,692 - 42,348,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034937652   ⟹   XP_034793543
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01442,295,691 - 42,347,293 (+)NCBI
RefSeq Acc Id: XM_034937653   ⟹   XP_034793544
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01442,295,692 - 42,348,478 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003831675 (Get FASTA)   NCBI Sequence Viewer  
  XP_008955226 (Get FASTA)   NCBI Sequence Viewer  
  XP_034793543 (Get FASTA)   NCBI Sequence Viewer  
  XP_034793544 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM54325 (Get FASTA)   NCBI Sequence Viewer  
  ABM54326 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003831675   ⟸   XM_003831627
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008955226   ⟸   XM_008956978
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034793543   ⟸   XM_034937652
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034793544   ⟸   XM_034937653
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000010889   ⟸   ENSPPAT00000033543
RefSeq Acc Id: ENSPPAP00000010887   ⟸   ENSPPAT00000033541
RefSeq Acc Id: ENSPPAP00000010910   ⟸   ENSPPAT00000033564
RefSeq Acc Id: ENSPPAP00000010908   ⟸   ENSPPAT00000033562
RefSeq Acc Id: ENSPPAP00000010904   ⟸   ENSPPAT00000033558


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028617 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000010887 ENTREZGENE
  ENSPPAP00000010904 ENTREZGENE
NCBI Gene HIF1A ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 HIF1A  hypoxia inducible factor 1 subunit alpha    hypoxia inducible factor 1 alpha subunit  Symbol and/or name change 5135510 APPROVED