RGD Reference Report - Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. - Rat Genome Database

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Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1.

Authors: Chang, Woochul  Lee, Chang Youn  Park, Jun-Hee  Park, Moon-Seo  Maeng, Lee-So  Yoon, Chee Soon  Lee, Min Young  Hwang, Ki-Chul  Chung, Yong-An 
Citation: Chang W, etal., J Vet Sci. 2013;14(1):69-76. doi: 10.4142/jvs.2013.14.1.69. Epub 2013 Feb 5.
RGD ID: 155260336
Pubmed: PMID:23388440   (View Abstract at PubMed)
PMCID: PMC3615234   (View Article at PubMed Central)
DOI: DOI:10.4142/jvs.2013.14.1.69   (Journal Full-text)

The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. The expression of microRNA-210 (miR-210) is induced by hypoxia and is important for cell survival under hypoxic conditions. Hypoxia increases the levels of hypoxia inducible factor-1 (HIF-1) protein and miR-210 in human MSCs (hMSCs). miR-210 positively regulates HIF-1α activity. Furthermore, miR-210 expression is also induced by hypoxia through the regulation of HIF-1α. To investigate the effect of miR-210 on hMSC survival under hypoxic conditions, survival rates along with signaling related to cell survival were evaluated in hMSCs over-expressing miR-210 or ones that lacked HIF-1α expression. Elevated miR-210 expression increased survival rates along with Akt and ERK activity in hMSCs with hypoxia. These data demonstrated that a positive feedback loop involving miR-210 and HIF-1α was important for MSC survival under hypoxic conditions.

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cobalt dichloride increases expression EXP 155260336cobalt dichloride increases expression of HIF1A protein in mesenchymal stem cellsRGD 
cobalt dichloride increases expression ISOHIF1A (Homo sapiens)155260336; 155260336cobalt dichloride increases expression of HIF1A protein in mesenchymal stem cellsRGD 
cobalt dichloride increases expression EXP 155260336cobalt dichloride increases expression of MIR210 miRNA in mesenchymal stem cellsRGD 
cobalt dichloride increases expression ISOMIR210 (Homo sapiens)155260336; 155260336cobalt dichloride increases expression of MIR210 miRNA in mesenchymal stem cellsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hif1a  (hypoxia inducible factor 1 subunit alpha)
Mir210  (microRNA 210)

Genes (Mus musculus)
Hif1a  (hypoxia inducible factor 1, alpha subunit)
Mir210  (microRNA 210)

Genes (Homo sapiens)
HIF1A  (hypoxia inducible factor 1 subunit alpha)
MIR210  (microRNA 210)


Additional Information