RGD Reference Report - Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1alpha. - Rat Genome Database

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Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1alpha.

Authors: Correia, SC  Santos, RX  Cardoso, SM  Santos, MS  Oliveira, CR  Moreira, PI 
Citation: Correia SC, etal., Neurobiol Dis. 2012 Jan;45(1):206-18. doi: 10.1016/j.nbd.2011.08.005. Epub 2011 Aug 10.
RGD ID: 9068914
Pubmed: PMID:21854848   (View Abstract at PubMed)
DOI: DOI:10.1016/j.nbd.2011.08.005   (Journal Full-text)

The current study was undertaken to address the role of mitochondrial reactive oxygen species (ROS), and hypoxia inducible factor-1 alpha (HIF-1alpha) signaling pathway in the protection against high glucose levels in brain endothelial and NT2 neuron-like cells. Rat brain endothelial cells (RBE4) treated with non-toxic concentrations of cyanide (



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hif1aRatcellular response to cyanide  IEP  RGD 
Hif1aRatcellular response to toxic substance  IEP cyanideRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hif1a  (hypoxia inducible factor 1 subunit alpha)


Additional Information