Mir19a (microRNA 19a) - Rat Genome Database

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Gene: Mir19a (microRNA 19a) Mus musculus
Analyze
Symbol: Mir19a
Name: microRNA 19a
RGD ID: 1608165
MGI Page MGI
Description: Acts upstream of or within several processes, including long-term synaptic potentiation; pre-B cell differentiation; and ventricular septum morphogenesis. Is expressed in several structures, including alimentary system; liver; lung; submandibular gland primordium; and yolk sac. Orthologous to human MIR19A (microRNA 19a).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: Mir; mir-19a; Mirn19a; mmu-mir-; mmu-mir-19a
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,432 - 115,281,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,000 - 115,044,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,222 - 115,443,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,568 - 113,634,649 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir19aMousecolorectal cancer  ISOMIR19A (Homo sapiens)9068941miRNA:increased expression:colorectum (human)RGDPMID:23322774 and REF_RGD_ID:153002793
Mir19aMousemiddle cerebral artery infarction  IEP 156451661RNA:decreased expression:brain (mouse)RGD 
Mir19aMouseOral Lichen Planus  ISOMIR19A (Homo sapiens)21081545 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir19aMouseholoprosencephaly 5  ISOMIR19A (Homo sapiens)8554872ClinVar Annotator: match by term: Holoprosencephaly 5ClinVarPMID:17274816 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir19aMouseadult respiratory distress syndrome  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Mir19aMousebronchiolo-alveolar adenocarcinoma  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25926378
Mir19aMouseChemical and Drug Induced Liver Injury  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22363424
Mir19aMousecongestive heart failure  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
Mir19aMousemultiple myeloma  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29687521
Mir19aMouseNeoplasm Metastasis  ISOMIR19A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19487542

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir19aMouse1,4-dichlorobenzene increases expressionEXP 64804644-dichlorobenzene results in increased expression of MIR19A mRNACTDPMID:32105654
Mir19aMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMIR19A (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MIR19A mRNACTDPMID:30096437
Mir19aMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MIR19A mRNACTDPMID:37318321
Mir19aMouse2-methoxyethanol decreases expressionISOMir19a (Rattus norvegicus)6480464methyl cellosolve results in decreased expression of MIR19A mRNACTDPMID:22008535
Mir19aMouse3-methylcholanthrene multiple interactionsEXP 6480464[Methylcholanthrene co-treated with Nanotubes and Carbon] results in increased expression of MIR19A mRNACTDPMID:25926378
Mir19aMouseaflatoxin B1 decreases expressionISOMir19a (Rattus norvegicus)6480464Aflatoxin B1 results in decreased expression of MIR19A mRNACTDPMID:24472605
Mir19aMousearsenic trichloride increases expressionISOMIR19A (Homo sapiens)6480464arsenic trichloride results in increased expression of MIR19ACTDPMID:21750348
Mir19aMousearsenous acid affects response to substanceISOMIR19A (Homo sapiens)6480464MIR19A affects the susceptibility to Arsenic TrioxideCTDPMID:20857258
Mir19aMousearsenous acid increases expressionISOMIR19A (Homo sapiens)6480464Arsenic Trioxide results in increased expression of MIR19A mRNACTDPMID:22072212
Mir19aMousearsenous acid decreases expressionISOMIR19A (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of MIR19A mRNACTDPMID:20857258
Mir19aMousearsenous acid multiple interactionsISOMIR19A (Homo sapiens)6480464MIR19A inhibits the reaction [Arsenic Trioxide results in increased expression of PTEN protein]CTDPMID:20857258
Mir19aMouseatrazine increases expressionISOMir19a (Rattus norvegicus)6480464Atrazine results in increased expression of MIR19A mRNACTDPMID:31185338 and PMID:36841081
Mir19aMousebenzene decreases expressionEXP 6480464Benzene results in decreased expression of MIR19A mRNACTDPMID:32105654
Mir19aMouseberberine decreases expressionISOMIR19A (Homo sapiens)6480464Berberine results in decreased expression of MIR19A mRNACTDPMID:29687521
Mir19aMousebis(2-chloroethyl) sulfide increases expressionEXP 6480464Mustard Gas results in increased expression of MIR19A mRNACTDPMID:26456178
Mir19aMousebis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of MIR19ACTDPMID:31920986
Mir19aMousebisphenol A increases expressionISOMIR19A (Homo sapiens)6480464bisphenol A results in increased expression of MIR19A mRNACTDPMID:24831732
Mir19aMousebisphenol A decreases expressionISOMir19a (Rattus norvegicus)6480464bisphenol A results in decreased expression of MIR19A mRNACTDPMID:38583549
Mir19aMousebisphenol A multiple interactionsISOMIR19A (Homo sapiens)6480464Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA]CTDPMID:24831732
Mir19aMousebleomycin A2 affects expressionISOMir19a (Rattus norvegicus)6480464Bleomycin affects the expression of MIR19A mRNACTDPMID:25933445

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Biological Process
1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir19aMouseB cell activation involved_inISOMIR19A (Homo sapiens)9068941 PMID:26017478ARUK-UCLPMID:26017478
Mir19aMouseB cell apoptotic process acts_upstream_of_or_withinIGIMGI:2676844 more ...2290270 PMID:18329372MGIPMID:18329372
Mir19aMousecellular response to bacterial lipopeptide involved_inISOMIR19A (Homo sapiens)9068941 PMID:22105995ARUK-UCLPMID:22105995
Mir19aMousein utero embryonic development acts_upstream_of_or_withinIGIMGI:2676844 more ...2290270 PMID:18329372MGIPMID:18329372
Mir19aMouselong-term synaptic potentiation acts_upstream_of_or_withinIEP 2290270 PMID:25858512MGIPMID:25858512
Mir19aMouselung development acts_upstream_of_or_withinIGIMGI:2676844 more ...2290270 PMID:18329372MGIPMID:18329372
Mir19aMousemiRNA-mediated gene silencing by mRNA destabilization involved_inISOMIR19A (Homo sapiens)9068941 PMID:27098600 and PMID:29130787BHF-UCLPMID:27098600 and PMID:29130787
Mir19aMousemiRNA-mediated post-transcriptional gene silencing involved_inISOMIR19A (Homo sapiens)9068941 PMID:18728182 more ...ARUK-UCLPMID:18728182 more ...
Mir19aMousemiRNA-mediated post-transcriptional gene silencing involved_inISOMIR19A (Homo sapiens)9068941 PMID:22105995ARUK-UCLPMID:22105995
Mir19aMousenegative regulation of apoptotic process involved_inISOMIR19A (Homo sapiens)9068941 PMID:21271217ARUK-UCLPMID:21271217
Mir19aMousenegative regulation of cardiac epithelial to mesenchymal transition acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:27098600BHF-UCLPMID:27098600
Mir19aMousenegative regulation of cellular response to transforming growth factor beta stimulus involved_inISOMIR19A (Homo sapiens)9068941 PMID:27098600BHF-UCLPMID:27098600
Mir19aMousenegative regulation of extracellular matrix assembly acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:27098600BHF-UCLPMID:27098600
Mir19aMousenegative regulation of fibroblast migration acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:27098600BHF-UCLPMID:27098600
Mir19aMousenegative regulation of gene expression acts_upstream_of_or_withinISOUniProtKB:P040629068941 PMID:25584808ARUK-UCLPMID:25584808
Mir19aMousenegative regulation of inflammatory response acts_upstream_ofISOUniProtKB:O606039068941 PMID:28078022ARUK-UCLPMID:28078022
Mir19aMousenegative regulation of inflammatory response to antigenic stimulus acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:22105995ARUK-UCLPMID:22105995
Mir19aMousenegative regulation of interleukin-6 production acts_upstream_ofISOUniProtKB:O606039068941 PMID:28078022ARUK-UCLPMID:28078022
Mir19aMousenegative regulation of interleukin-6 production acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:22105995ARUK-UCLPMID:22105995
Mir19aMousenegative regulation of matrix metallopeptidase secretion acts_upstream_ofISOMIR19A (Homo sapiens)9068941 PMID:22105995ARUK-UCLPMID:22105995
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Molecular Function

  


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Reference Title
Reference Citation
1. LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN. Gao N, etal., Neuroscience. 2020 Jun 15;437:117-129. doi: 10.1016/j.neuroscience.2020.04.020. Epub 2020 Apr 24.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). Wang L, etal., Med Sci Monit. 2018 May 29;24:3591-3603. doi: 10.12659/MSM.907497.
PMID:12554860   PMID:16369549   PMID:16381832   PMID:17369397   PMID:17604727   PMID:17765889   PMID:17936263   PMID:18329372   PMID:18452032   PMID:19559694   PMID:20190740   PMID:20215419  
PMID:20413612   PMID:20708584   PMID:21037258   PMID:21267068   PMID:21338882   PMID:21371421   PMID:21660949   PMID:21892160   PMID:22095742   PMID:22187428   PMID:22511778   PMID:23174583  
PMID:23623502   PMID:23795660   PMID:23831570   PMID:24117217   PMID:24928431   PMID:25362490   PMID:25858512   PMID:26091048   PMID:26111969   PMID:26165466   PMID:26417068   PMID:26934100  
PMID:28662367   PMID:29257352   PMID:29664809   PMID:30413725   PMID:30673803   PMID:32296071   PMID:32670778   PMID:32956848   PMID:33634377   PMID:34465793   PMID:34515297   PMID:34854011  
PMID:36112239   PMID:36193848   PMID:37604350   PMID:38057885  



Mir19a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,432 - 115,281,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,000 - 115,044,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,222 - 115,443,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,568 - 113,634,649 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR19A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,891 - 91,350,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,145 - 92,003,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,145 - 90,801,226 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,850,116 - 72,850,197 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,980 - 72,599,061 (+)NCBIHuRef
CHM1_11391,971,785 - 91,971,866 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBIT2T-CHM13v2.0
Mir19a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR19A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,298 - 42,478,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,285 - 42,478,366 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,986 - 42,334,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,547 - 42,879,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,534 - 42,879,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,562,020 - 42,562,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,399 - 42,616,456 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,462 - 42,617,519 (+)NCBIUU_Cfam_GSD_1.0
MIR19A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,939 - 60,735,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,734,939 - 60,735,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,343 - 66,610,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Mir19a
9 total Variants

Predicted Targets
Summary Value
Count of predictions:23798
Count of gene targets:8954
Count of transcripts:14900
Interacting mature miRNAs:mmu-miR-19a-3p, mmu-miR-19a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined85134068119134068Mouse
12903991Opfaq4_mopen field activity QTL 4 (mouse)14111211209118699845Mouse
12792981Fbmd5_mfemoral bone mineral density 5, females only (mouse)1499838217125033054Mouse
10755523Hgb2_mhemoglobin 2 (mouse)14105884654125139656Mouse
12798541Scvg3_msubcutaneous vessel growth QTL 3 (mouse)14105544636117275989Mouse







Ensembl Acc Id: ENSMUST00000083482
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)Ensembl
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)Ensembl
RefSeq Acc Id: NR_029786
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914115,281,432 - 115,281,513 (+)NCBI
GRCm3814115,044,000 - 115,044,081 (+)ENTREZGENE
MGSCv3714115,443,222 - 115,443,303 (+)RGD
Celera14113,634,568 - 113,634,649 (+)RGD
cM Map14 ENTREZGENE
Sequence:


1 to 9 of 9 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000065416 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083482 ENTREZGENE
MGD MGI:3618743 ENTREZGENE
miRBase MI0000688 ENTREZGENE
NCBI Gene 723891 ENTREZGENE
PhenoGen Mir19a PhenoGen
RNAcentral URS000006AA40 RNACentral
  URS000006FDD4 RNACentral
  URS000075E79E RNACentral
1 to 9 of 9 rows