MIR19A (microRNA 19a) - Rat Genome Database

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Pathways
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Gene: MIR19A (microRNA 19a) Homo sapiens
Analyze
Symbol: MIR19A
Name: microRNA 19a
RGD ID: 1347994
HGNC Page HGNC:31574
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of cellular response to transforming growth factor beta stimulus; and regulation of signal transduction. Acts upstream of or within negative regulation of gene expression. Located in extracellular space and extracellular vesicle.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: C13orf25; hsa-mir-19a; miR-19a; MIR17HG; MIRH1; MIRHG1; MIRN19A; miRNA19A
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,891 - 91,350,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,145 - 92,003,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,145 - 90,801,226 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,850,116 - 72,850,197 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,980 - 72,599,061 (+)NCBIHuRef
CHM1_11391,971,785 - 91,971,866 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell activation  (IDA)
B cell apoptotic process  (ISO)
cellular response to bacterial lipopeptide  (IDA)
in utero embryonic development  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA,IMP)
negative regulation of apoptotic process  (IMP)
negative regulation of cardiac epithelial to mesenchymal transition  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (ISS)
negative regulation of cellular response to transforming growth factor beta stimulus  (IDA)
negative regulation of extracellular matrix assembly  (IDA)
negative regulation of fibroblast migration  (IDA)
negative regulation of gene expression  (IGI)
negative regulation of inflammatory response  (IGI)
negative regulation of inflammatory response to antigenic stimulus  (IDA)
negative regulation of interleukin-6 production  (IDA,IGI)
negative regulation of matrix metallopeptidase secretion  (IDA,IGI)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISS)
negative regulation of sprouting angiogenesis  (IDA)
negative regulation of toll-like receptor signaling pathway  (IMP)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA,IGI)
positive regulation of B cell receptor signaling pathway  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (IGI)
positive regulation of tyrosine phosphorylation of STAT protein  (IMP)
pre-B cell differentiation  (ISO)
regulation of cardiac conduction  (IDA)
spinal cord motor neuron differentiation  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN. Gao N, etal., Neuroscience. 2020 Jun 15;437:117-129. doi: 10.1016/j.neuroscience.2020.04.020. Epub 2020 Apr 24.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
4. MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). Wang L, etal., Med Sci Monit. 2018 May 29;24:3591-3603. doi: 10.12659/MSM.907497.
Additional References at PubMed
PMID:11679670   PMID:11914277   PMID:12554860   PMID:15126345   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18632605   PMID:18728182   PMID:19538740   PMID:20133739   PMID:20167074  
PMID:20299512   PMID:20857258   PMID:20940405   PMID:21037258   PMID:21059650   PMID:21067317   PMID:21271217   PMID:22105995   PMID:22362744   PMID:22828869   PMID:22952885   PMID:23271053  
PMID:23603256   PMID:23621248   PMID:23666757   PMID:23795660   PMID:23824915   PMID:23894411   PMID:24048714   PMID:24117217   PMID:24169826   PMID:24192448   PMID:24349422   PMID:24360091  
PMID:24378993   PMID:24416156   PMID:24427326   PMID:24460313   PMID:24675462   PMID:24740298   PMID:25107371   PMID:25137071   PMID:25220540   PMID:25308476   PMID:25362490   PMID:25383678  
PMID:25400827   PMID:25443138   PMID:25584808   PMID:25589070   PMID:25604748   PMID:25785039   PMID:25914465   PMID:25934693   PMID:25936765   PMID:25982447   PMID:25985117   PMID:25985247  
PMID:26017478   PMID:26041742   PMID:26041879   PMID:26058752   PMID:26098000   PMID:26146958   PMID:26239140   PMID:26302825   PMID:26352740   PMID:26367773   PMID:26416600   PMID:26483345  
PMID:26646931   PMID:26762410   PMID:26804172   PMID:26822694   PMID:27012708   PMID:27035427   PMID:27098600   PMID:27150195   PMID:27329239   PMID:27409728   PMID:27497158   PMID:27581787  
PMID:27666763   PMID:27779660   PMID:27830963   PMID:27835866   PMID:27991929   PMID:28078022   PMID:28081849   PMID:28177881   PMID:28214202   PMID:28257633   PMID:28276316   PMID:28364280  
PMID:28388587   PMID:28431233   PMID:28431267   PMID:28475001   PMID:28586153   PMID:28592790   PMID:28621611   PMID:28765931   PMID:28783539   PMID:28798470   PMID:28871004   PMID:28935967  
PMID:28986253   PMID:29032147   PMID:29130787   PMID:29138858   PMID:29207158   PMID:29240449   PMID:29332345   PMID:29474434   PMID:29477147   PMID:29568890   PMID:29575299   PMID:29702193  
PMID:29734189   PMID:29783075   PMID:30021351   PMID:30073755   PMID:30338791   PMID:30370628   PMID:30372881   PMID:30521783   PMID:30638858   PMID:30720178   PMID:30793479   PMID:30888082  
PMID:30996254   PMID:31128038   PMID:31247032   PMID:31248594   PMID:31266011   PMID:31424647   PMID:31513316   PMID:31646884   PMID:31682848   PMID:31729887   PMID:32004389   PMID:32096172  
PMID:32308549   PMID:32329854   PMID:32334458   PMID:32373944   PMID:32373949   PMID:32487978   PMID:32633395   PMID:32949564   PMID:33067424   PMID:33099949   PMID:33165673   PMID:33215433  
PMID:33338580   PMID:33946718   PMID:33983643   PMID:34045678   PMID:34051800   PMID:34160893   PMID:34187571   PMID:34246626   PMID:34512170   PMID:34854011   PMID:35266369   PMID:35352515  
PMID:35543855   PMID:35599631   PMID:35637792   PMID:35759451   PMID:36424716   PMID:36555437   PMID:36611927   PMID:36912590   PMID:37300685   PMID:37400667   PMID:37794714   PMID:37821504  
PMID:38149567   PMID:38250607   PMID:38583177  


Genomics

Comparative Map Data
MIR19A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,891 - 91,350,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,145 - 92,003,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,145 - 90,801,226 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,850,116 - 72,850,197 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,980 - 72,599,061 (+)NCBIHuRef
CHM1_11391,971,785 - 91,971,866 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBIT2T-CHM13v2.0
Mir19a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,432 - 115,281,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,000 - 115,044,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,222 - 115,443,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,568 - 113,634,649 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
Mir19a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR19A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,298 - 42,478,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,285 - 42,478,366 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,986 - 42,334,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,547 - 42,879,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,534 - 42,879,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,562,020 - 42,562,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,399 - 42,616,456 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,462 - 42,617,519 (+)NCBIUU_Cfam_GSD_1.0
MIR19A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,939 - 60,735,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,734,939 - 60,735,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,343 - 66,610,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 13q14.12-31.3(chr13:44967523-92738168)x1 copy number loss See cases [RCV000050891] Chr13:44967523..92738168 [GRCh38]
Chr13:45541658..93390421 [GRCh37]
Chr13:44439658..92188422 [NCBI36]
Chr13:13q14.12-31.3		 pathogenic
GRCh38/hg38 13q22.3-32.1(chr13:78349126-94701844)x1 copy number loss See cases [RCV000051379] Chr13:78349126..94701844 [GRCh38]
Chr13:78923261..95354098 [GRCh37]
Chr13:77821262..94152099 [NCBI36]
Chr13:13q22.3-32.1		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:82581008-114327173)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051380]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051380]|See cases [RCV000051380] Chr13:82581008..114327173 [GRCh38]
Chr13:83155143..115085141 [GRCh37]
Chr13:82053144..114110750 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-32.1(chr13:83947821-95128969)x1 copy number loss See cases [RCV000051414] Chr13:83947821..95128969 [GRCh38]
Chr13:84521956..95781223 [GRCh37]
Chr13:83419957..94579224 [NCBI36]
Chr13:13q31.1-32.1		 pathogenic
GRCh38/hg38 13q31.2-32.1(chr13:88260962-97285754)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051415]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051415]|See cases [RCV000051415] Chr13:88260962..97285754 [GRCh38]
Chr13:88913217..97938008 [GRCh37]
Chr13:87711218..96736009 [NCBI36]
Chr13:13q31.2-32.1		 pathogenic
GRCh38/hg38 13q31.2-32.3(chr13:88323009-98888644)x1 copy number loss See cases [RCV000051416] Chr13:88323009..98888644 [GRCh38]
Chr13:88975264..99540898 [GRCh37]
Chr13:87773265..98338899 [NCBI36]
Chr13:13q31.2-32.3		 pathogenic
GRCh38/hg38 13q31.3-32.1(chr13:89549510-96657834)x1 copy number loss See cases [RCV000051417] Chr13:89549510..96657834 [GRCh38]
Chr13:90201764..97310088 [GRCh37]
Chr13:88999765..96108089 [NCBI36]
Chr13:13q31.3-32.1		 pathogenic
GRCh38/hg38 13q31.1-33.2(chr13:82032938-106082542)x3 copy number gain See cases [RCV000051179] Chr13:82032938..106082542 [GRCh38]
Chr13:82607073..106734891 [GRCh37]
Chr13:81505074..105532892 [NCBI36]
Chr13:13q31.1-33.2		 pathogenic
GRCh38/hg38 13q31.3(chr13:90215412-91366486)x1 copy number loss See cases [RCV000051921] Chr13:90215412..91366486 [GRCh38]
Chr13:90867666..92018740 [GRCh37]
Chr13:89665667..90816741 [NCBI36]
Chr13:13q31.3		 uncertain significance
GRCh38/hg38 13q31.3(chr13:90973752-93097331)x1 copy number loss See cases [RCV000051922] Chr13:90973752..93097331 [GRCh38]
Chr13:91626006..93749584 [GRCh37]
Chr13:90424007..92547585 [NCBI36]
Chr13:13q31.3		 uncertain significance
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:43219125-114327314)x3 copy number gain See cases [RCV000053762] Chr13:43219125..114327314 [GRCh38]
Chr13:43793261..115085141 [GRCh37]
Chr13:42691261..114110891 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:44164751-114327173)x3 copy number gain See cases [RCV000053764] Chr13:44164751..114327173 [GRCh38]
Chr13:44738887..115085141 [GRCh37]
Chr13:43636887..114110750 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.12-34(chr13:44733046-114327173)x3 copy number gain See cases [RCV000053767] Chr13:44733046..114327173 [GRCh38]
Chr13:45307182..115085141 [GRCh37]
Chr13:44205182..114110750 [NCBI36]
Chr13:13q14.12-34		 pathogenic
GRCh38/hg38 13q22.1-34(chr13:74345951-114327314)x3 copy number gain See cases [RCV000053770] Chr13:74345951..114327314 [GRCh38]
Chr13:74920088..115085141 [GRCh37]
Chr13:73818089..114110891 [NCBI36]
Chr13:13q22.1-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:80628584-114327173)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053772]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053772]|See cases [RCV000053772] Chr13:80628584..114327173 [GRCh38]
Chr13:81202719..115085141 [GRCh37]
Chr13:80100720..114110750 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q31.3(chr13:90644219-92557099)x1 copy number loss See cases [RCV000234861] Chr13:90644219..92557099 [GRCh37]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q22.3-31.3(chr13:77061780-92460406)x1 copy number loss See cases [RCV000136886] Chr13:77061780..92460406 [GRCh38]
Chr13:77635915..93112659 [GRCh37]
Chr13:76533916..91910660 [NCBI36]
Chr13:13q22.3-31.3		 pathogenic
GRCh38/hg38 13q31.2-34(chr13:88937651-114327173)x3 copy number gain See cases [RCV000137102] Chr13:88937651..114327173 [GRCh38]
Chr13:89589905..115085141 [GRCh37]
Chr13:88387906..114110750 [NCBI36]
Chr13:13q31.2-34		 pathogenic
GRCh38/hg38 13q31.1-31.3(chr13:84005264-92784013)x1 copy number loss See cases [RCV000137272] Chr13:84005264..92784013 [GRCh38]
Chr13:84579399..93436266 [GRCh37]
Chr13:83477400..92234267 [NCBI36]
Chr13:13q31.1-31.3		 likely pathogenic
GRCh38/hg38 13q14.11-34(chr13:40942298-114340331)x1 copy number loss See cases [RCV000137893] Chr13:40942298..114340331 [GRCh38]
Chr13:41516434..115085141 [GRCh37]
Chr13:40414434..114123908 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:78999318-114327106)x3 copy number gain See cases [RCV000138742] Chr13:78999318..114327106 [GRCh38]
Chr13:79573453..115085141 [GRCh37]
Chr13:78471454..114110683 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:86788927-114340331)x1 copy number loss See cases [RCV000138340] Chr13:86788927..114340331 [GRCh38]
Chr13:87441182..115085141 [GRCh37]
Chr13:86239183..114123908 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q31.2-32.3(chr13:87944479-99866542)x1 copy number loss See cases [RCV000139047] Chr13:87944479..99866542 [GRCh38]
Chr13:88596734..100518796 [GRCh37]
Chr13:87394735..99316797 [NCBI36]
Chr13:13q31.2-32.3		 pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:78964223-114340331)x3 copy number gain See cases [RCV000141248] Chr13:78964223..114340331 [GRCh38]
Chr13:79538358..115085141 [GRCh37]
Chr13:78436359..114123908 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-31.3(chr13:84052824-91838339)x3 copy number gain See cases [RCV000141994] Chr13:84052824..91838339 [GRCh38]
Chr13:84626959..92490593 [GRCh37]
Chr13:83524960..91288594 [NCBI36]
Chr13:13q31.1-31.3		 uncertain significance
GRCh38/hg38 13q31.1-34(chr13:83288131-114342258)x3 copy number gain See cases [RCV000141804] Chr13:83288131..114342258 [GRCh38]
Chr13:83862266..115107733 [GRCh37]
Chr13:82760267..114125835 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q31.3(chr13:91283077-91394459)x1 copy number loss See cases [RCV000143094] Chr13:91283077..91394459 [GRCh38]
Chr13:91935331..92046713 [GRCh37]
Chr13:90733332..90844714 [NCBI36]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q31.3(chr13:91282882-91394459)x1 copy number loss See cases [RCV000143162] Chr13:91282882..91394459 [GRCh38]
Chr13:91935136..92046713 [GRCh37]
Chr13:90733137..90844714 [NCBI36]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:89796110-115083342)x1 copy number loss See cases [RCV000240161] Chr13:89796110..115083342 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.3(chr13:91209639-94704856)x3 copy number gain See cases [RCV000240035] Chr13:91209639..94704856 [GRCh37]
Chr13:13q31.3		 uncertain significance
GRCh37/hg19 13q22.1-31.3(chr13:74459395-93481294)x1 copy number loss See cases [RCV000598789] Chr13:74459395..93481294 [GRCh37]
Chr13:13q22.1-31.3		 pathogenic
GRCh37/hg19 13q14.3-33.3(chr13:53551300-109850651)x1 copy number loss See cases [RCV000449272] Chr13:53551300..109850651 [GRCh37]
Chr13:13q14.3-33.3		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61424168-115107733)x3 copy number gain See cases [RCV000449118] Chr13:61424168..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.1-31.3(chr13:86963003-93390362)x3 copy number gain See cases [RCV000446248] Chr13:86963003..93390362 [GRCh37]
Chr13:13q31.1-31.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82221361-115092569)x3 copy number gain See cases [RCV000447429] Chr13:82221361..115092569 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.1-34(chr13:56431743-115107733) copy number gain See cases [RCV000510722] Chr13:56431743..115107733 [GRCh37]
Chr13:13q21.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-33.1(chr13:81851091-102864674)x1 copy number loss See cases [RCV000448988] Chr13:81851091..102864674 [GRCh37]
Chr13:13q31.1-33.1		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:88073140-115107733)x1 copy number loss See cases [RCV000448405] Chr13:88073140..115107733 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.33-34(chr13:71871468-115107733)x4 copy number gain See cases [RCV000510281] Chr13:71871468..115107733 [GRCh37]
Chr13:13q21.33-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:80058840-115107733)x3 copy number gain See cases [RCV000510566] Chr13:80058840..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-33.3(chr13:80572498-108719528)x1 copy number loss See cases [RCV000510890] Chr13:80572498..108719528 [GRCh37]
Chr13:13q31.1-33.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:83435292-115107733)x3 copy number gain See cases [RCV000512605] Chr13:83435292..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q14.3-32.1(chr13:53932358-96586363)x3 copy number gain See cases [RCV000512571] Chr13:53932358..96586363 [GRCh37]
Chr13:13q14.3-32.1		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:85176519-115107733)x3 copy number gain See cases [RCV000512242] Chr13:85176519..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
Single allele duplication not provided [RCV000678035] Chr13:91209639..94704856 [GRCh37]
Chr13:13q31.3		 likely pathogenic
GRCh37/hg19 13q22.3-34(chr13:78590089-115107733)x3 copy number gain not provided [RCV000683571] Chr13:78590089..115107733 [GRCh37]
Chr13:13q22.3-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-31.3(chr13:85005334-92461147)x1 copy number loss not provided [RCV000738268] Chr13:85005334..92461147 [GRCh37]
Chr13:13q31.1-31.3		 pathogenic
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.1-31.3(chr13:57058434-94684615)x1 copy number loss not provided [RCV000750731] Chr13:57058434..94684615 [GRCh37]
Chr13:13q21.1-31.3		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61775567-115107733)x3 copy number gain not provided [RCV000848025] Chr13:61775567..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.3-34(chr13:53262013-115107733)x1 copy number loss not provided [RCV001006567] Chr13:53262013..115107733 [GRCh37]
Chr13:13q14.3-34		 pathogenic
GRCh37/hg19 13q31.3(chr13:91460305-92069153)x3 copy number gain not provided [RCV001006582] Chr13:91460305..92069153 [GRCh37]
Chr13:13q31.3		 likely pathogenic
GRCh37/hg19 13q31.3(chr13:91284502-92325104)x1 copy number loss See cases [RCV002285045] Chr13:91284502..92325104 [GRCh37]
Chr13:13q31.3		 pathogenic
GRCh37/hg19 13q11-34(chr13:19053605-115108528)x3 copy number gain See cases [RCV001353184] Chr13:19053605..115108528 [GRCh37]
Chr13:13q11-34		 pathogenic
NC_000013.10:g.(?_92002837)_(103343314_?)del deletion Holoprosencephaly 5 [RCV001388033] Chr13:92002837..103343314 [GRCh37]
Chr13:13q31.3-33.1		 pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878)x3 copy number gain See cases [RCV001780076] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878) copy number gain Complete trisomy 13 syndrome [RCV002280659] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733) copy number gain not specified [RCV002053036] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61424168-115107733) copy number gain not specified [RCV002053063] Chr13:61424168..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:79370012-115107733) copy number loss not specified [RCV002053072] Chr13:79370012..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q22.3-34(chr13:78514567-115107733) copy number gain not specified [RCV002053071] Chr13:78514567..115107733 [GRCh37]
Chr13:13q22.3-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:85037147-115107733) copy number gain not specified [RCV002053073] Chr13:85037147..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV001834436] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-114981726) copy number gain not specified [RCV002053035] Chr13:19436286..114981726 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.11-33.3(chr13:42504540-108206269)x3 copy number gain not provided [RCV001829235] Chr13:42504540..108206269 [GRCh37]
Chr13:13q14.11-33.3		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:88073140-115107733) copy number loss not specified [RCV002053074] Chr13:88073140..115107733 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:89490345-115062235)x3 copy number gain See cases [RCV002286354] Chr13:89490345..115062235 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19253848-115108937)x3 copy number gain not provided [RCV002291540] Chr13:19253848..115108937 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q22.1-34(chr13:75268539-115107733)x3 copy number gain not provided [RCV002472537] Chr13:75268539..115107733 [GRCh37]
Chr13:13q22.1-34		 pathogenic
GRCh37/hg19 13q31.2-33.2(chr13:89012420-106371634)x1 copy number loss not provided [RCV003483195] Chr13:89012420..106371634 [GRCh37]
Chr13:13q31.2-33.2		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82131211-115107733)x1 copy number loss not provided [RCV003483192] Chr13:82131211..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61534068-115107733)x3 copy number gain not provided [RCV003484899] Chr13:61534068..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q22.1-34(chr13:73488238-115107733)x3 copy number gain not provided [RCV003484901] Chr13:73488238..115107733 [GRCh37]
Chr13:13q22.1-34		 pathogenic
GRCh37/hg19 13q21.33-33.1(chr13:73132193-104595598)x1 copy number loss not provided [RCV003483190] Chr13:73132193..104595598 [GRCh37]
Chr13:13q21.33-33.1		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:84669397-115107733)x1 copy number loss not specified [RCV003987038] Chr13:84669397..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.1-31.3(chr13:56450978-93582180)x1 copy number loss not specified [RCV003987013] Chr13:56450978..93582180 [GRCh37]
Chr13:13q21.1-31.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82876219-115107733)x3 copy number gain not specified [RCV003987023] Chr13:82876219..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q14.2-32.2(chr13:49547974-98214905)x1 copy number loss not specified [RCV003987008] Chr13:49547974..98214905 [GRCh37]
Chr13:13q14.2-32.2		 pathogenic
GRCh37/hg19 13q21.31-33.1(chr13:64825656-103641349)x1 copy number loss not specified [RCV003987009] Chr13:64825656..103641349 [GRCh37]
Chr13:13q21.31-33.1		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CFAP43hsa-miR-19a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HOXA5hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
HOXA5hsa-miR-19a-3pMirtarbaseexternal_infoReporter assay;OtherNon-Functional MTI21271217
MECP2hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;MicroarrFunctional MTI14697198
MECP2hsa-miR-19a-3pMirtarbaseexternal_infoReporter assay;OtherNon-Functional MTI18460397
PTENhsa-miR-19a-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI18460397
PTENhsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI14697198
PTENhsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21853360
ESR1hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20080637
CCND1hsa-miR-19a-3pMirtarbaseexternal_infoflow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI20133739
ERBB4hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI19885849
ATXN1hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18758459
KAT2Bhsa-miR-19a-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayNon-Functional MTI18728182
SOCS1hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18728182
PRMT5hsa-miR-19a-3pMirtarbaseexternal_infoWestern blotFunctional MTI18694959
BCL2L11hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18728182
TGFBR2hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayNon-Functional MTI20940405
BMPR2hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI19390056
ARIH2hsa-miR-19a-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19296935
CUL5hsa-miR-19a-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22561557
TLR2hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
SUZ12hsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23451058
DPYSL2hsa-miR-19a-3pMirtarbaseexternal_infoReporter assayFunctional MTI21654684
VPS4Bhsa-miR-19a-3pMirtarbaseexternal_infoReporter assayFunctional MTI14697198
RAB14hsa-miR-19a-3pMirtarbaseexternal_infoReporter assayFunctional MTI21751348
KDELR2hsa-miR-19a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
PTENhsa-miR-19a-3pTarbaseexternal_infoReporter GenePOSITIVE
MECP2hsa-miR-19a-3pTarbaseexternal_infoReporter GeneNEGATIVE
PTENhsa-miR-19a-3pMirecordsexternal_infoNANA14697198
ATXN1hsa-miR-19a-3pMirecordsexternal_infoNANA18758459
BCL2L11hsa-miR-19a-3pMirecordsexternal_infoNANA18728182
CCN2hsa-miR-19a-3pMirecordsexternal_info{changed}NA20305691
THBS1hsa-miR-19a-3pMirecordsexternal_infoNANA20299512
ESR1hsa-miR-19a-3pMirecordsexternal_infoNANA20080637
NR4A2hsa-miR-19a-3pMirecordsexternal_infoNANA19885849
BMPR2hsa-miR-19a-3pMirecordsexternal_info{changed}NA19390056
IMPDH1hsa-miR-19a-3pOncomiRDBexternal_infoNANA22952885
CUL5hsa-miR-19a-3pOncomiRDBexternal_infoNANA22561557
CYLDhsa-miR-19a-3pOncomiRDBexternal_infoNANA22362744
MYCNhsa-miR-19a-3pOncomiRDBexternal_infoNANA21654684
TNFhsa-miR-19a-3pOncomiRDBexternal_infoNANA21271217
F3hsa-miR-19a-3pOncomiRDBexternal_infoNANA21059650
PTENhsa-miR-19a-3pOncomiRDBexternal_infoNANA20857258
BCL2L11hsa-miR-19a-3pOncomiRDBexternal_infoNANA20190740
ESR1hsa-miR-19a-3pOncomiRDBexternal_infoNANA20080637
PTENhsa-miR-19a-3pOncomiRDBexternal_infoNANA20008935
SOCS1hsa-miR-19a-3pOncomiRDBexternal_infoNANA18728182
CCND1hsa-miR-19a-3pMirecordsexternal_info{unchanged}NA20133739

Predicted Targets
Summary Value
Count of predictions:34517
Count of gene targets:10515
Count of transcripts:21524
Interacting mature miRNAs:hsa-miR-19a-3p, hsa-miR-19a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384878
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)Ensembl
RefSeq Acc Id: NR_029489
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381391,350,891 - 91,350,972 (+)NCBI
GRCh371392,003,145 - 92,003,226 (+)RGD
Celera1372,850,116 - 72,850,197 (+)RGD
HuRef1372,598,980 - 72,599,061 (+)ENTREZGENE
CHM1_11391,971,785 - 91,971,866 (+)NCBI
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31574 AgrOrtholog
COSMIC MIR19A COSMIC
Ensembl Genes ENSG00000284204 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384878 ENTREZGENE
GTEx ENSG00000284204 GTEx
HGNC ID HGNC:31574 ENTREZGENE
Human Proteome Map MIR19A Human Proteome Map
miRBase MI0000073 ENTREZGENE
NCBI Gene 406979 ENTREZGENE
OMIM 609418 OMIM
PharmGKB PA164722572 PharmGKB
RNAcentral URS000006FDD4 RNACentral
  URS00001754CF RNACentral
  URS0000539083 RNACentral