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Gene: Ick (intestinal cell kinase) Mus musculus
Symbol: Ick
Name: intestinal cell kinase
Description: Exhibits protein serine/threonine kinase activity. Involved in cilium organization and protein phosphorylation. Localizes to several cellular components, including the ciliary basal body; ciliary base; and ciliary tip. Used to study endocrine-cerebro-osteodysplasia syndrome. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome and juvenile myoclonic epilepsy 10. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human CILK1 (ciliogenesis associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210420N10Rik; AI848300; MAK-related kinase; mICK; Mrk; serine/threonine-protein kinase ICK
Homo sapiens (human) : CILK1 (ciliogenesis associated kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cilk1 (ciliogenesis associated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cilk1 (ciliogenesis associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CILK1 (ciliogenesis associated kinase 1)
Canis lupus familiaris (dog) : CILK1 (ciliogenesis associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cilk1 (ciliogenesis associated kinase 1)
Sus scrofa (pig) : CILK1 (ciliogenesis associated kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38978,109,080 - 78,172,114 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37977,956,999 - 78,019,917 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,899,093 - 77,953,626 (+)NCBImm8
Celera975,286,395 - 75,349,194 (+)NCBICelera
Cytogenetic Map9 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ick
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737218
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.