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Gene: Ick (intestinal cell kinase) Mus musculus
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Symbol: Ick
Name: intestinal cell kinase
Description: Exhibits protein serine/threonine kinase activity. Involved in cilium organization and protein phosphorylation. Localizes to several cellular components, including the ciliary basal body; ciliary base; and ciliary tip. Used to study endocrine-cerebro-osteodysplasia syndrome. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome and juvenile myoclonic epilepsy 10. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human CILK1 (ciliogenesis associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210420N10Rik; AI848300; MAK-related kinase; mICK; Mrk; serine/threonine-protein kinase ICK
Orthologs:
Homo sapiens (human) : CILK1 (ciliogenesis associated kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cilk1 (ciliogenesis associated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cilk1 (ciliogenesis associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CILK1 (ciliogenesis associated kinase 1)
Canis lupus familiaris (dog) : CILK1 (ciliogenesis associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cilk1 (ciliogenesis associated kinase 1)
Sus scrofa (pig) : CILK1 (ciliogenesis associated kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38978,109,080 - 78,172,114 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37977,956,999 - 78,019,917 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,899,093 - 77,953,626 (+)NCBImm8
Celera975,286,395 - 75,349,194 (+)NCBICelera
Cytogenetic Map9 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ick
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737218
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.