Apoa4 (apolipoprotein A-IV) - Rat Genome Database

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Gene: Apoa4 (apolipoprotein A-IV) Mus musculus
Analyze
Symbol: Apoa4
Name: apolipoprotein A-IV
RGD ID: 734420
MGI Page MGI
Description: Predicted to enable several functions, including cation binding activity; cholesterol binding activity; and cholesterol transfer activity. Involved in innate immune response in mucosa. Acts upstream of or within regulation of intestinal cholesterol absorption and response to stilbenoid. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ap; apo-AIV; Apoa-4; apoA-IV; apolipoprotein A4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39mm39
GRCm39 Ensembl946,151,994 - 46,154,757 (+)Ensembl
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBImm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
doramapimod  (EXP)
fenofibrate  (EXP)
flavonoids  (ISO)
fluconazole  (ISO)
folic acid  (EXP)
fructose  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP,ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
isoniazide  (EXP)
ketoconazole  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
metacetamol  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
rotenone  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP)
tamoxifen  (EXP)
taurocholic acid  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
triolein  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphism of the apolipoprotein A-IV gene and its significance in lipid metabolism and coronary heart disease in a Japanese population. Bai H, etal., Eur J Clin Invest. 1996 Dec;26(12):1115-24.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Identification of differentially expressed proteins in the aqueous humor of primary congenital glaucoma. Bouhenni RA, etal., Exp Eye Res. 2011 Jan;92(1):67-75. Epub 2010 Nov 13.
4. Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. Boyles JK, etal., J Biol Chem. 1990 Oct 15;265(29):17805-15.
5. Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel disease. Broedl UC, etal., Inflamm Bowel Dis. 2007 Apr;13(4):391-7.
6. Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. Carboni L, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1037-48. Epub 2010 May 23.
7. Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV. Cohen RD, etal., J Clin Invest 1997 Apr 15;99(8):1906-16.
8. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
9. Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease. Csaszar A, etal., Neurosci Lett. 1997 Jul 25;230(3):151-4.
10. Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model. Cui Y, etal., Am J Pathol. 2011 Mar;178(3):1298-308.
11. Differential cerebro spinal fluid proteome investigation of Leber hereditary optic neuropathy (LHON) and multiple sclerosis. D'Aguanno S, etal., J Neuroimmunol. 2008 Jan;193(1-2):156-60. Epub 2007 Dec 3.
12. The use of multiplexed MRM for the discovery of biomarkers to differentiate iron-deficiency anemia from anemia of inflammation. Domanski D, etal., J Proteomics. 2011 Nov 26.
13. Proteins of rat serum V: adjuvant arthritis and its modulation by nonsteroidal anti-inflammatory drugs. Ebrini I, etal., Electrophoresis. 2000 Jun;21(11):2170-9.
14. Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. Huang YC, etal., PLoS One. 2011 Jan 31;6(1):e15809.
15. Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Ito Y, etal., Science. 1990 Aug 17;249(4970):790-3.
16. No association between apolipoprotein A-IV codon 360 mutation and late-onset Alzheimer's disease in the Japanese population. Ji Y, etal., Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):473-5.
17. Proteomic analysis of the cerebrospinal fluid of patients with schizophrenia. Jiang L, etal., Amino Acids. 2003 Jul;25(1):49-57.
18. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
19. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
20. Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. Langner CA, etal., J Biol Chem. 1991 Jun 25;266(18):11955-64.
21. Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. Li TW, etal., Chin Med J (Engl). 2010 Mar 5;123(5):537-43.
22. Proteomic analysis of the cerebrospinal fluid of patients with lumbar disk herniation. Liu XD, etal., Proteomics. 2006 Feb;6(3):1019-28.
23. Chronic kidney disease-related atherosclerosis - proteomic studies of blood plasma. Luczak M, etal., Proteome Sci. 2011 May 13;9:25.
24. Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. Makino Y, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1163-9.e5.
25. Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation. McGuirk J, etal., J Hematol Oncol. 2009 Apr 20;2:17.
26. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. Papassotiropoulos A, etal., J Clin Psychiatry. 2005 Jul;66(7):940-7.
30. Effect of the inflammation, chronic hyperglycemia, or malabsorption on the apolipoprotein A-IV concentration in type 1 diabetes mellitus and in diabetes secondary to chronic pancreatitis. Quilliot D, etal., Metabolism. 2001 Sep;50(9):1019-24.
31. ApoA-IV polymorphism associated with myocardial infarction in obese NIDDM patients. The San Luis Valley Diabetes Study. Rewers M, etal., Diabetes. 1994 Dec;43(12):1485-9.
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Schonfeld G, etal., Metabolism. 1979 Oct;28(10):1001-10.
35. Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis. Shitama T, etal., Proteomics Clin Appl. 2008 Sep;2(9):1265-1280.
36. Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): proteome analysis of cerebrospinal fluid. Tumani H, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):109-12. Epub 2009 Jul 9.
37. CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis. Tumani H, etal., Neurosci Lett. 2009 Mar 13;452(2):214-7. Epub 2009 Jan 29.
38. Apolipoprotein A-IV inhibits experimental colitis. Vowinkel T, etal., J Clin Invest. 2004 Jul;114(2):260-9.
39. Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Wang CC, etal., Dev Biol 2000 Aug 15;224(2):152-67.
40. Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels. Wong WM, etal., Circ Res. 2003 May 16;92(9):969-75. Epub 2003 Apr 3.
41. Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barre syndrome. Yang YR, etal., Cell Mol Neurobiol. 2008 Aug;28(5):737-44. Epub 2008 Mar 15.
42. Differential gene expression in patients genetically predisposed to pancreatic cancer. Zervos EE, etal., J Surg Res. 2006 Oct;135(2):317-22. Epub 2006 Jun 30.
Additional References at PubMed
PMID:1648102   PMID:2575592   PMID:3796595   PMID:4000948   PMID:6099394   PMID:7592581   PMID:7798939   PMID:8020488   PMID:8354955   PMID:9186920   PMID:9300780   PMID:9323588  
PMID:9494081   PMID:9616220   PMID:9832509   PMID:10349636   PMID:10632725   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11478940   PMID:11983814   PMID:12105231   PMID:12477932  
PMID:12810823   PMID:14660441   PMID:14974682   PMID:14983036   PMID:14999024   PMID:15306172   PMID:15466464   PMID:15928313   PMID:15997185   PMID:16109169   PMID:16141072   PMID:16141073  
PMID:16497661   PMID:16498401   PMID:16602821   PMID:16929032   PMID:17086191   PMID:17222401   PMID:17363460   PMID:17641001   PMID:17916774   PMID:18188184   PMID:18617288   PMID:18678879  
PMID:19389805   PMID:19968565   PMID:21267068   PMID:21386911   PMID:21840868   PMID:21873635   PMID:22207575   PMID:22209087   PMID:22461023   PMID:22619326   PMID:23027805   PMID:23132909  
PMID:23599044   PMID:23684747   PMID:23729668   PMID:24030551   PMID:24311788   PMID:24598141   PMID:24838500   PMID:24929016   PMID:25157093   PMID:25209997   PMID:26294669   PMID:27131369  
PMID:27655915   PMID:28412351   PMID:28768657   PMID:29263093   PMID:29684311   PMID:30190457   PMID:31408538   PMID:31462513   PMID:31706944   PMID:32325033   PMID:32410861   PMID:33276196  
PMID:33444292   PMID:33513710  


Genomics

Comparative Map Data
Apoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39mm39
GRCm39 Ensembl946,151,994 - 46,154,757 (+)Ensembl
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBImm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
APOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,691,416 - 116,694,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
T2T-CHM13v2.011116,835,812 - 116,838,412 (-)NCBI
Apoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,539,083 - 46,541,464 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)Ensembl
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
Celera846,121,074 - 46,123,455 (+)NCBICelera
RH 3.4 Map8473.3RGD
Cytogenetic Map8q22NCBI
Apoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,155,801 - 18,160,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,158,095 - 18,160,636 (-)NCBIChiLan1.0ChiLan1.0
APOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,591,788 - 115,594,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,591,788 - 115,594,382 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,659,186 - 111,661,790 (-)NCBIMhudiblu_PPA_v0panPan3
APOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBI
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBI
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)Ensembl
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBI
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBI
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBI
Apoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,177,114 - 99,179,837 (-)NCBI
SpeTri2.0NW_0049365422,098,683 - 2,101,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,201,508 - 44,204,206 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,201,587 - 44,204,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,273,837 - 49,276,322 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,186,627 - 108,190,508 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,186,921 - 108,189,698 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604317,861,078 - 17,863,578 (+)NCBIVero_WHO_p1.0
Apoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:143
Interacting mature miRNAs:149
Transcripts:ENSMUST00000034585
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034585   ⟹   ENSMUSP00000034585
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,151,994 - 46,154,757 (+)Ensembl
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)Ensembl
RefSeq Acc Id: NM_007468   ⟹   NP_031494
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39946,152,142 - 46,154,756 (+)NCBI
GRCm38946,240,844 - 46,243,458 (+)ENTREZGENE
MGSCv37946,048,927 - 46,051,541 (+)RGD
Celera943,529,774 - 43,532,388 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031494   ⟸   NM_007468
- Peptide Label: precursor
- UniProtKB: P06728 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034585   ⟸   ENSMUST00000034585

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06728-F1-model_v2 AlphaFold P06728 1-395 view protein structure

Promoters
RGD ID:6844174
Promoter ID:MM_KWN:57219
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000071089
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36946,048,736 - 46,049,236 (+)MPROMDB
RGD ID:8669480
Promoter ID:EPDNEW_M12771
Type:initiation region
Name:Apoa4_2
Description:Mus musculus apolipoprotein A-IV , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12772  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38946,240,788 - 46,240,848EPDNEW
RGD ID:8669482
Promoter ID:EPDNEW_M12772
Type:multiple initiation site
Name:Apoa4_1
Description:Mus musculus apolipoprotein A-IV , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12771  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38946,241,062 - 46,241,122EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88051 AgrOrtholog
Ensembl Genes ENSMUSG00000032080 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034585 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034585 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11808 UniProtKB/Swiss-Prot
MGD MGI:88051 ENTREZGENE
NCBI Gene 11808 ENTREZGENE
Pfam Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APOA4 RGD
PhenoGen Apoa4 PhenoGen
UniProt APOA4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q810I7_MOUSE UniProtKB/TrEMBL
  Q9DBN0_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q91XF8 UniProtKB/Swiss-Prot