Hba-a1 (hemoglobin alpha, adult chain 1) - Rat Genome Database

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Gene: Hba-a1 (hemoglobin alpha, adult chain 1) Mus musculus
Analyze
Symbol: Hba-a1
Name: hemoglobin alpha, adult chain 1
RGD ID: 734079
MGI Page MGI
Description: Predicted to enable several functions, including amyloid-beta binding activity; heme binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to stilbenoid. Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Located in myelin sheath. Part of hemoglobin complex. Is expressed in several structures, including blood vessel; early conceptus; hematopoietic system; liver; and visceral pericardium. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 1 globin; alpha globin 1; alpha-globin; haemaglobin alpha 1; Hba; Hba1; Hbat1; hemoglobin alpha chain; hemoglobin subunit alpha
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: Hba-ps3  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,233,672 - 32,234,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,233,511 - 32,234,465 (+)EnsemblGRCm39 Ensembl
GRCm381132,283,672 - 32,284,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,283,511 - 32,284,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,183,672 - 32,184,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,261,880 - 32,262,699 (+)NCBIMGSCv36mm8
MGSCv361132,183,674 - 32,184,493 (+)NCBIMGSCv36mm8
Celera1134,700,973 - 34,701,816 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-diaminotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
Aroclor 1254  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
biotin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
capecitabine  (ISO)
carbon nanotube  (EXP)
cetilistat  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyanocob(III)alamin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
glucose  (ISO)
glyphosate  (EXP)
hydralazine  (ISO)
hydroquinone  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
Licochalcone B  (ISO)
maneb  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
N-(6-acetamidohexyl)acetamide  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP)
nimesulide  (ISO)
orlistat  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenylhydrazine  (ISO)
picolinic acid  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
pyrogallol  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
tamoxifen  (EXP,ISO)
tetrachloromethane  (ISO)
tremolite asbestos  (EXP)
triptonide  (EXP)
tris(picolinato)chromium  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A case series of alpha-thalassemia intermedia due to compound heterozygosity for Hb Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] with other alpha-thalassemias in Malay families. Alauddin H, etal., Hemoglobin. 2014;38(4):277-81. doi: 10.3109/03630269.2014.916720. Epub 2014 May 14.
2. Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly. Ameri A, etal., Blood. 1999 Sep 1;94(5):1825-6.
3. Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]. Baklouti F, etal., Eur J Biochem. 1988 Nov 1;177(2):307-12.
4. Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina. Deng L, etal., Hum Reprod. 2009 Jan;24(1):211-8. doi: 10.1093/humrep/den318. Epub 2008 Sep 10.
5. Interaction of hemoglobin E and several forms of alpha-thalassemia in Cambodian families. Fucharoen S, etal., Haematologica. 2003 Oct;88(10):1092-8.
6. Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant. Groff P, etal., Hemoglobin. 1989;13(5):429-36.
7. Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion. Liebhaber SA, etal., J Clin Invest. 1985 Sep;76(3):1057-64.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. An initiation codon mutation (AUG----GUG) of the human alpha 1-globin gene. Structural characterization and evidence for a mild thalassemic phenotype. Moi P, etal., J Clin Invest. 1987 Nov;80(5):1416-21.
11. alpha-Thalassaemia associated with the deletion of two nucleotides at position -2 and -3 preceding the AUG codon. Morle F, etal., EMBO J. 1985 May;4(5):1245-50.
12. The influence of alpha-thalassaemia on the haematological & clinical expression of sickle cell disease in western India. Mukherjee MB, etal., Indian J Med Res. 1998 Apr;107:178-81.
13. Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta 2]: detection and identification by in vitro biosynthesis with radioactive amino acids. Ohba Y, etal., Hemoglobin. 1987;11(6):539-56.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Initiation codon mutation as a cause of alpha thalassemia. Pirastu M, etal., J Biol Chem. 1984 Oct 25;259(20):12315-7.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia. Traeger-Synodinos J, etal., Hemoglobin. 1999 Nov;23(4):317-24.
20. Proteomic analysis of cerebral synaptosomes isolated from rat model of alzheimer's disease. Yang H, etal., Indian J Exp Biol. 2011 Feb;49(2):118-24.
Additional References at PubMed
PMID:277329   PMID:282635   PMID:519760   PMID:2444404   PMID:3032738   PMID:4611305   PMID:5340470   PMID:5345070   PMID:7092800   PMID:7357610   PMID:7518430   PMID:7550311  
PMID:7589805   PMID:7904582   PMID:7926723   PMID:8088839   PMID:8566749   PMID:8622706   PMID:8781443   PMID:8799165   PMID:8838797   PMID:8853988   PMID:8854862   PMID:8901585  
PMID:9242562   PMID:9472016   PMID:9787139   PMID:9843985   PMID:9887098   PMID:9887104   PMID:10079113   PMID:10349636   PMID:10430179   PMID:10922068   PMID:10943842   PMID:10995745  
PMID:11042159   PMID:11076861   PMID:11157800   PMID:11217851   PMID:11808628   PMID:12360531   PMID:12458204   PMID:12466851   PMID:12477932   PMID:12824305   PMID:12920035   PMID:14651853  
PMID:15034572   PMID:15215744   PMID:15555579   PMID:15649944   PMID:15745951   PMID:15798182   PMID:16002065   PMID:16141072   PMID:16141073   PMID:17086191   PMID:17535249   PMID:17634366  
PMID:17660536   PMID:18094026   PMID:18245844   PMID:18554416   PMID:18644885   PMID:18687678   PMID:19223557   PMID:19235734   PMID:19338758   PMID:19704006   PMID:19717439   PMID:19799774  
PMID:20439494   PMID:20541250   PMID:20693275   PMID:21565611   PMID:21706023   PMID:21862448   PMID:21873635   PMID:22056776   PMID:22187428   PMID:22673621   PMID:22794259   PMID:22950951  
PMID:23012479   PMID:23123858   PMID:23685348   PMID:23716600   PMID:24743017   PMID:25278292   PMID:26527618   PMID:29866654   PMID:30295646   PMID:30482269   PMID:31040226   PMID:31624071  
PMID:32020697   PMID:33539786   PMID:33830076   PMID:34671097   PMID:36302779  


Genomics

Comparative Map Data
Hba-a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,233,672 - 32,234,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,233,511 - 32,234,465 (+)EnsemblGRCm39 Ensembl
GRCm381132,283,672 - 32,284,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,283,511 - 32,284,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,183,672 - 32,184,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,261,880 - 32,262,699 (+)NCBIMGSCv36mm8
MGSCv361132,183,674 - 32,184,493 (+)NCBIMGSCv36mm8
Celera1134,700,973 - 34,701,816 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.86NCBI
HBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816176,680 - 177,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16176,680 - 177,522 (+)EnsemblGRCh38hg38GRCh38
GRCh3716226,679 - 227,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616166,679 - 167,520 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416166,678 - 167,520NCBI
Celera16426,194 - 427,035 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16144,721 - 145,562 (+)NCBIHuRef
CHM1_116226,686 - 227,527 (+)NCBICHM1_1
T2T-CHM13v2.016170,722 - 171,564 (+)NCBIT2T-CHM13v2.0
Hba-a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,841,724 - 15,842,580 (-)NCBIGRCr8
mRatBN7.21015,337,265 - 15,338,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,307,815 - 15,338,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,083,503 - 20,084,356 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,572,392 - 19,573,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,065,239 - 15,066,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,602,794 - 15,603,649 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,602,794 - 15,603,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,497,889 - 15,498,744 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,584,360 - 15,585,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,585,407 - 15,586,263 (-)NCBI
Celera1015,004,857 - 15,005,712 (-)NCBICelera
RH 3.4 Map10153.7RGD
Cytogenetic Map10q12NCBI
HBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218387,821 - 388,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,180,776 - 4,181,647 (+)NCBINHGRI_mPanPan1
PanPan1.116164,614 - 165,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16164,618 - 165,476 (+)Ensemblpanpan1.1panPan2
LOC100855540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,324,378 - 40,325,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,588,015 - 41,589,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,667,527 - 40,668,582 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1640,355,646 - 40,356,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,316,610 - 40,317,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,795,235 - 40,796,286 (-)NCBIUU_Cfam_GSD_1.0
LOC110259958
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1341,482,353 - 41,483,564 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Hba-a1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:354
Count of miRNA genes:285
Interacting mature miRNAs:301
Transcripts:ENSMUST00000093209, ENSMUST00000142555
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300607Tnbs2_mtri-nitrobenzene sulfonic acid susceptible 2 (mouse)Not determined112489805235126680Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
25394552Skmw69_mskeletal muscle weight 69, TA (mouse)112969902932329535Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
25394550Skmw71_mskeletal muscle weight 71, gastroc (mouse)113127543232745567Mouse
25394551Skmw70_mskeletal muscle weight 70, EDL (mouse)113132273732594975Mouse
25394558Skmw72_mskeletal muscle weight 72, soleus (mouse)113132943032785551Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse

Markers in Region
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381132,296,787 - 32,297,108UniSTSGRCm38
GRCm381132,283,970 - 32,284,291UniSTSGRCm38
MGSCv371132,196,787 - 32,197,108UniSTSGRCm37
MGSCv371132,183,970 - 32,184,291UniSTSGRCm37
Cytogenetic Map11A4UniSTS
cM Map1116.0UniSTS
cM Map1116.0UniSTS
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A4UniSTS
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381132,296,826 - 32,297,194UniSTSGRCm38
GRCm381132,284,009 - 32,284,377UniSTSGRCm38
MGSCv371132,184,009 - 32,184,377UniSTSGRCm37
MGSCv371132,196,826 - 32,197,194UniSTSGRCm37
Cytogenetic Map11A4UniSTS
cM Map1116.0UniSTS
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381132,296,530 - 32,297,119UniSTSGRCm38
GRCm381132,283,713 - 32,284,302UniSTSGRCm38
MGSCv371132,183,713 - 32,184,302UniSTSGRCm37
MGSCv371132,196,530 - 32,197,119UniSTSGRCm37
Cytogenetic Map11A4UniSTS
cM Map1116.0UniSTS
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381132,296,809 - 32,297,136UniSTSGRCm38
GRCm381132,283,992 - 32,284,319UniSTSGRCm38
MGSCv371132,183,992 - 32,184,319UniSTSGRCm37
MGSCv371132,196,809 - 32,197,136UniSTSGRCm37
Cytogenetic Map11A4UniSTS
cM Map1116.0UniSTS
Hba-a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK003077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY016021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L75940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000093209   ⟹   ENSMUSP00000090897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1132,233,511 - 32,234,465 (+)Ensembl
GRCm38.p6 Ensembl1132,283,511 - 32,284,465 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1132,233,811 - 32,234,438 (+)Ensembl
GRCm38.p6 Ensembl1132,283,811 - 32,284,438 (+)Ensembl
RefSeq Acc Id: NM_008218   ⟹   NP_032244
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391132,233,672 - 32,234,486 (+)NCBI
GRCm381132,283,672 - 32,284,486 (+)ENTREZGENE
MGSCv371132,183,672 - 32,184,486 (+)RGD
Celera1134,700,973 - 34,701,816 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37782 (Get FASTA)   NCBI Sequence Viewer  
  AAB59723 (Get FASTA)   NCBI Sequence Viewer  
  AAH43020 (Get FASTA)   NCBI Sequence Viewer  
  AAL32371 (Get FASTA)   NCBI Sequence Viewer  
  ABU54054 (Get FASTA)   NCBI Sequence Viewer  
  ABU63213 (Get FASTA)   NCBI Sequence Viewer  
  ABU63215 (Get FASTA)   NCBI Sequence Viewer  
  ABU63218 (Get FASTA)   NCBI Sequence Viewer  
  ABU63220 (Get FASTA)   NCBI Sequence Viewer  
  ABU63223 (Get FASTA)   NCBI Sequence Viewer  
  ABU63224 (Get FASTA)   NCBI Sequence Viewer  
  ABU63230 (Get FASTA)   NCBI Sequence Viewer  
  ABU63231 (Get FASTA)   NCBI Sequence Viewer  
  ABU63232 (Get FASTA)   NCBI Sequence Viewer  
  ABU63233 (Get FASTA)   NCBI Sequence Viewer  
  ABU63234 (Get FASTA)   NCBI Sequence Viewer  
  ABU63235 (Get FASTA)   NCBI Sequence Viewer  
  ABU63236 (Get FASTA)   NCBI Sequence Viewer  
  ABU63237 (Get FASTA)   NCBI Sequence Viewer  
  ABU63238 (Get FASTA)   NCBI Sequence Viewer  
  ABU63239 (Get FASTA)   NCBI Sequence Viewer  
  ABU63240 (Get FASTA)   NCBI Sequence Viewer  
  ABU63241 (Get FASTA)   NCBI Sequence Viewer  
  ABU63243 (Get FASTA)   NCBI Sequence Viewer  
  ABU63246 (Get FASTA)   NCBI Sequence Viewer  
  ABU63247 (Get FASTA)   NCBI Sequence Viewer  
  ABU63248 (Get FASTA)   NCBI Sequence Viewer  
  ABU63249 (Get FASTA)   NCBI Sequence Viewer  
  ABU63250 (Get FASTA)   NCBI Sequence Viewer  
  ABU63251 (Get FASTA)   NCBI Sequence Viewer  
  BAB22552 (Get FASTA)   NCBI Sequence Viewer  
  BAB27269 (Get FASTA)   NCBI Sequence Viewer  
  BAB27272 (Get FASTA)   NCBI Sequence Viewer  
  BAB27277 (Get FASTA)   NCBI Sequence Viewer  
  BAB27279 (Get FASTA)   NCBI Sequence Viewer  
  BAB27307 (Get FASTA)   NCBI Sequence Viewer  
  BAB27336 (Get FASTA)   NCBI Sequence Viewer  
  BAB27340 (Get FASTA)   NCBI Sequence Viewer  
  BAB27342 (Get FASTA)   NCBI Sequence Viewer  
  BAB27344 (Get FASTA)   NCBI Sequence Viewer  
  BAB27364 (Get FASTA)   NCBI Sequence Viewer  
  BAB27370 (Get FASTA)   NCBI Sequence Viewer  
  BAB27381 (Get FASTA)   NCBI Sequence Viewer  
  BAB28166 (Get FASTA)   NCBI Sequence Viewer  
  BAB28446 (Get FASTA)   NCBI Sequence Viewer  
  BAE42724 (Get FASTA)   NCBI Sequence Viewer  
  CAA24095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000090895.4
  ENSMUSP00000090897
  ENSMUSP00000090897.4
GenBank Protein P01942 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032244   ⟸   NM_008218
- UniProtKB: P01942 (UniProtKB/Swiss-Prot),   Q91VB8 (UniProtKB/TrEMBL),   A8DUV3 (UniProtKB/TrEMBL),   Q8BPF4 (UniProtKB/TrEMBL),   Q9CWS5 (UniProtKB/TrEMBL),   Q9CY06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000090897   ⟸   ENSMUST00000093209
Protein Domains
Globin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01942-F1-model_v2 AlphaFold P01942 1-142 view protein structure

Promoters
RGD ID:6849662
Promoter ID:EP07072
Type:single initiation site
Name:MM_HBA
Description:alpha-globin
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:adult, bone marrow, erythroid cells
Experiment Methods:Direct RNA sequencing; Nuclease protection; transfected or transformed cells
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36Un372 - 432EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96015 AgrOrtholog
Ensembl Genes ENSMUSG00000069917 UniProtKB/TrEMBL
  ENSMUSG00000069919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093207.4 UniProtKB/TrEMBL
  ENSMUST00000093209 ENTREZGENE
  ENSMUST00000093209.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin/Proto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haemoglobin_a-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haemoglobin_pi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110257 UniProtKB/TrEMBL
  mmu:15122 UniProtKB/TrEMBL
MGD MGI:96015 ENTREZGENE
NCBI Gene 15122 ENTREZGENE
PANTHER HEMOGLOBIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOGLOBIN SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hba-a1 PhenoGen
PRINTS ALPHAHAEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIHAEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8DUV3 ENTREZGENE, UniProtKB/TrEMBL
  HBA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BPF4 ENTREZGENE, UniProtKB/TrEMBL
  Q91VB8 ENTREZGENE, UniProtKB/TrEMBL
  Q9CWS5 ENTREZGENE, UniProtKB/TrEMBL
  Q9CY06 ENTREZGENE, UniProtKB/TrEMBL