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Gene: Spred2 (sprouty-related EVH1 domain containing 2) Mus musculus
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Symbol: Spred2
Name: sprouty-related EVH1 domain containing 2
Description: Exhibits protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in positive regulation of DNA damage response, signal transduction by p53 class mediator and regulation of protein modification process. Localizes to the cytoplasmic vesicle and plasma membrane. Used to study achondroplasia. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C79158; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related, EVH1 domain containing 2; sprouty-related, EVH1 domain-containing protein 2
Orthologs:
Homo sapiens (human) : SPRED2 (sprouty related EVH1 domain containing 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spred2 (sprouty-related, EVH1 domain containing 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spred2 (sprouty related EVH1 domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRED2 (sprouty related EVH1 domain containing 2)
Canis lupus familiaris (dog) : SPRED2 (sprouty related EVH1 domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spred2 (sprouty related EVH1 domain containing 2)
Sus scrofa (pig) : SPRED2 (sprouty related EVH1 domain containing 2)
Chlorocebus sabaeus (green monkey) : SPRED2 (sprouty related EVH1 domain containing 2)
Heterocephalus glaber (naked mole-rat) : Spred2 (sprouty related EVH1 domain containing 2)
more info ...
Related Pseudogenes: Gm14612  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1119,924,375 - 20,024,026 (+)Ensembl
GRCm381119,924,442 - 20,024,026 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371119,824,445 - 19,922,600 (+)NCBIGRCm37mm9NCBIm37
MGSCv361119,824,445 - 19,922,600 (+)NCBImm8
Celera1122,066,219 - 22,164,240 (+)NCBICelera
Cytogenetic Map11 A3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Spred2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319581
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.