Spred2 (sprouty-related EVH1 domain containing 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Spred2 (sprouty-related EVH1 domain containing 2) Mus musculus
Analyze
Symbol: Spred2
Name: sprouty-related EVH1 domain containing 2
RGD ID: 1319581
MGI Page MGI
Description: Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C79158; Spre; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related, EVH1 domain containing 2; sprouty-related, EVH1 domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm14612  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,874,442 - 19,974,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,874,375 - 19,974,026 (+)EnsemblGRCm39 Ensembl
GRCm381119,924,442 - 20,024,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,924,375 - 20,024,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371119,824,445 - 19,922,600 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361119,824,445 - 19,922,600 (+)NCBIMGSCv36mm8
Celera1122,066,219 - 22,164,240 (+)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
deguelin  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
inulin  (EXP)
isotretinoin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nitrofen  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11493923   PMID:12477932   PMID:12520002   PMID:12646235   PMID:12904583  
PMID:14610273   PMID:14981116   PMID:15184877   PMID:15489334   PMID:15580519   PMID:15683364   PMID:15840001   PMID:15946934   PMID:16141072   PMID:16141073   PMID:16378760   PMID:16919269  
PMID:17438136   PMID:17967808   PMID:17974561   PMID:18287559   PMID:18799693   PMID:18799725   PMID:19521500   PMID:19822672   PMID:20736167   PMID:20882678   PMID:20934536   PMID:21199868  
PMID:21267068   PMID:21873635   PMID:22868447   PMID:25275324   PMID:25576668   PMID:25690936   PMID:26075267   PMID:26362256   PMID:26496610   PMID:27869219   PMID:28070119   PMID:28489004  
PMID:28705898   PMID:28993690   PMID:29317674   PMID:29501879   PMID:29706577   PMID:30022248   PMID:30723473   PMID:30771306   PMID:31923414   PMID:32325033   PMID:32452519   PMID:32554809  
PMID:32841583   PMID:33020583   PMID:34626534   PMID:36704943   PMID:38355793   PMID:38391903   PMID:38892460  


Genomics

Comparative Map Data
Spred2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,874,442 - 19,974,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,874,375 - 19,974,026 (+)EnsemblGRCm39 Ensembl
GRCm381119,924,442 - 20,024,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,924,375 - 20,024,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371119,824,445 - 19,922,600 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361119,824,445 - 19,922,600 (+)NCBIMGSCv36mm8
Celera1122,066,219 - 22,164,240 (+)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.79NCBI
SPRED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38265,307,175 - 65,432,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl265,310,851 - 65,432,637 (-)EnsemblGRCh38hg38GRCh38
GRCh37265,537,985 - 65,659,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36265,391,489 - 65,512,815 (-)NCBINCBI36Build 36hg18NCBI36
Build 34265,449,636 - 65,570,961NCBI
Celera265,384,626 - 65,506,328 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef265,272,227 - 65,393,668 (-)NCBIHuRef
CHM1_1265,469,340 - 65,590,964 (-)NCBICHM1_1
T2T-CHM13v2.0265,316,846 - 65,442,268 (-)NCBIT2T-CHM13v2.0
Spred2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,350,577 - 98,452,143 (+)NCBIGRCr8
mRatBN7.21494,149,210 - 94,250,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,148,837 - 94,249,162 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1498,490,319 - 98,591,853 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01499,730,616 - 99,832,149 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01496,197,976 - 96,299,521 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014104,268,362 - 104,290,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,191,517 - 104,290,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014104,002,472 - 104,024,316 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414100,775,869 - 100,797,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114100,717,198 - 100,818,203 (+)NCBI
Celera1493,246,801 - 93,268,145 (+)NCBICelera
Cytogenetic Map14q22NCBI
Spred2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542419,133,568 - 19,250,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542419,133,568 - 19,250,118 (+)NCBIChiLan1.0ChiLan1.0
SPRED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21260,961,140 - 61,083,663 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A60,965,098 - 61,087,614 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A65,380,608 - 65,503,139 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A66,503,260 - 66,624,840 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A66,503,260 - 66,624,840 (-)Ensemblpanpan1.1panPan2
SPRED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11064,764,275 - 64,815,937 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1064,764,311 - 64,867,009 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1064,648,640 - 64,763,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01065,771,737 - 65,886,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1065,773,399 - 65,886,224 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11065,450,264 - 65,564,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01065,758,109 - 65,872,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01066,053,709 - 66,168,347 (-)NCBIUU_Cfam_GSD_1.0
Spred2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629218,400,544 - 18,517,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649110,053,545 - 10,170,976 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649110,053,546 - 10,170,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl376,523,589 - 76,649,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1376,527,646 - 76,649,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2380,324,906 - 80,445,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPRED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11441,574,244 - 41,699,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1441,640,758 - 41,700,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604570,192,808 - 70,318,539 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spred2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247628,109,157 - 8,240,543 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247628,109,159 - 8,240,543 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spred2
3457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1397
Count of miRNA genes:589
Interacting mature miRNAs:677
Transcripts:ENSMUST00000093298, ENSMUST00000093299, ENSMUST00000123036
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
RH126620  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,023,715 - 20,023,940UniSTSGRCm38
MGSCv371119,923,718 - 19,923,943UniSTSGRCm37
Celera1122,165,357 - 22,165,582UniSTS
Cytogenetic Map11A3.2UniSTS
Whitehead/MRC_RH11374.99UniSTS
C79158  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X50,376,134 - 50,376,294UniSTSGRCm38
GRCm381120,023,639 - 20,023,799UniSTSGRCm38
MGSCv371119,923,642 - 19,923,802UniSTSGRCm37
MGSCv37X47,729,311 - 47,729,471UniSTSGRCm37
Celera1122,165,281 - 22,165,441UniSTS
CeleraX37,809,635 - 37,809,795UniSTS
Cytogenetic Map11A3.2UniSTS
Spred2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,021,450 - 20,022,419UniSTSGRCm38
MGSCv371119,921,453 - 19,922,422UniSTSGRCm37
Celera1122,163,093 - 22,164,062UniSTS
Cytogenetic Map11A3.2UniSTS
cM Map11 UniSTS
Spred2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A3.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_033523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB063496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000093298   ⟹   ENSMUSP00000090987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,874,442 - 19,972,577 (+)Ensembl
GRCm38.p6 Ensembl1119,924,442 - 20,022,577 (+)Ensembl
Ensembl Acc Id: ENSMUST00000093299   ⟹   ENSMUSP00000090988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,874,375 - 19,974,026 (+)Ensembl
GRCm38.p6 Ensembl1119,924,375 - 20,024,026 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123036   ⟹   ENSMUSP00000115103
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,904,570 - 19,968,133 (+)Ensembl
GRCm38.p6 Ensembl1119,954,570 - 20,018,133 (+)Ensembl
Ensembl Acc Id: ENSMUST00000249881   ⟹   ENSMUSP00000159978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,929,570 - 19,974,026 (+)Ensembl
RefSeq Acc Id: NM_033523   ⟹   NP_277058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,874,442 - 19,972,597 (+)NCBI
GRCm381119,924,442 - 20,022,597 (+)NCBI
MGSCv371119,824,445 - 19,922,600 (+)RGD
Celera1122,066,219 - 22,164,240 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514456   ⟹   XP_006514519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,897,044 - 19,974,026 (+)NCBI
GRCm381119,947,045 - 20,024,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514457   ⟹   XP_006514520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,941,347 - 19,974,026 (+)NCBI
GRCm381119,991,335 - 20,024,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514458   ⟹   XP_006514521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,914,233 - 19,974,026 (+)NCBI
GRCm381119,968,235 - 20,024,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156236   ⟹   XP_036012129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,931,989 - 19,974,026 (+)NCBI
Sequence:
RefSeq Acc Id: NP_277058   ⟸   NM_033523
- UniProtKB: Q924S7 (UniProtKB/Swiss-Prot),   Q5SRF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514519   ⟸   XM_006514456
- Peptide Label: isoform X1
- UniProtKB: Q5SRF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514521   ⟸   XM_006514458
- Peptide Label: isoform X3
- UniProtKB: Q5SRF8 (UniProtKB/TrEMBL),   A0AAQ4VMS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514520   ⟸   XM_006514457
- Peptide Label: isoform X2
- UniProtKB: Q5SRF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000090988   ⟸   ENSMUST00000093299
Ensembl Acc Id: ENSMUSP00000090987   ⟸   ENSMUST00000093298
Ensembl Acc Id: ENSMUSP00000115103   ⟸   ENSMUST00000123036
RefSeq Acc Id: XP_036012129   ⟸   XM_036156236
- Peptide Label: isoform X4
- UniProtKB: Q5SRF8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000159978   ⟸   ENSMUST00000249881
Protein Domains
KBD   SPR   WH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924S7-F1-model_v2 AlphaFold Q924S7 1-410 view protein structure

Promoters
RGD ID:6822238
Promoter ID:MM_KWN:6555
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_033523,   OTTMUST00000011644,   UC007ICQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361119,824,181 - 19,824,832 (+)MPROMDB
RGD ID:6846911
Promoter ID:MM_ACW:6831
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:SPRED2.FSEP07,   SPRED2.ISEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361119,897,941 - 19,898,441 (+)MPROMDB
RGD ID:8674044
Promoter ID:EPDNEW_M15052
Type:initiation region
Name:Spred2_1
Description:Mus musculus sprouty-related, EVH1 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381119,924,417 - 19,924,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2150019 AgrOrtholog
Ensembl Genes ENSMUSG00000045671 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093298 ENTREZGENE
  ENSMUST00000093298.12 UniProtKB/Swiss-Prot
  ENSMUST00000093299.13 UniProtKB/TrEMBL
  ENSMUST00000123036.2 UniProtKB/TrEMBL
  ENSMUST00000249881 ENTREZGENE
  ENSMUST00000249881.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro KBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRE_EVH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sprouty UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:114716 UniProtKB/Swiss-Prot
MGD MGI:2150019 ENTREZGENE
NCBI Gene 114716 ENTREZGENE
PANTHER SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spred2 PhenoGen
PROSITE KBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AAQ4VMS6 ENTREZGENE, UniProtKB/TrEMBL
  Q5SRF8 ENTREZGENE, UniProtKB/TrEMBL
  Q5SRF9_MOUSE UniProtKB/TrEMBL
  Q8K2N1_MOUSE UniProtKB/TrEMBL
  Q924S7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-26 Spred2  sprouty-related EVH1 domain containing 2    sprouty-related, EVH1 domain containing 2  Symbol and/or name change 5135510 APPROVED