Agr2 (anterior gradient 2) - Rat Genome Database

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Gene: Agr2 (anterior gradient 2) Mus musculus
Analyze
Symbol: Agr2
Name: anterior gradient 2
RGD ID: 1312143
MGI Page MGI
Description: Predicted to enable dystroglycan binding activity; epidermal growth factor receptor binding activity; and protein homodimerization activity. Involved in digestive tract morphogenesis and positive regulation of developmental growth. Acts upstream of or within inflammatory response; lung goblet cell differentiation; and mucus secretion. Located in endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; gut; liver; and lung. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AG-2; Agr2h; anterior gradient 2 homolog; anterior gradient protein 2 homolog; Gob-; Gob-4; HAG-; HAG-2; mAG-; mAG-2; secreted cement gland protein XAG-2 homolog; XAG-; XAG-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391236,042,924 - 36,054,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1236,042,906 - 36,054,086 (+)EnsemblGRCm39 Ensembl
GRCm381235,992,925 - 36,004,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,992,907 - 36,004,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv371236,719,512 - 36,730,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361236,503,191 - 36,514,347 (+)NCBIMGSCv36mm8
Celera1237,446,354 - 37,457,458 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
capecitabine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroprene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
doxifluridine  (ISO)
Enterolactone  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
menadione  (ISO)
methimazole  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
octadecanoic acid  (ISO)
ozone  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sotorasib  (ISO)
sulfur dioxide  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichloroethene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
triticonazole  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients. Innes HE, etal., Br J Cancer. 2006 Apr 10;94(7):1057-65.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma. Riener MO, etal., Histol Histopathol. 2009 Sep;24(9):1121-8.
8. Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation. Sitek B, etal., J Proteome Res. 2009 Apr;8(4):1647-56.
Additional References at PubMed
PMID:9790916   PMID:10095068   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16230531   PMID:16602821   PMID:17077188  
PMID:17522155   PMID:18199544   PMID:18374910   PMID:18614015   PMID:19028979   PMID:19359471   PMID:19494835   PMID:20025862   PMID:21267068   PMID:21398290   PMID:21677750   PMID:21703447  
PMID:21791528   PMID:21873635   PMID:22403803   PMID:22675208   PMID:22784109   PMID:22819674   PMID:22945649   PMID:23209296   PMID:23213461   PMID:23392704   PMID:24274029   PMID:24920423  
PMID:25111734   PMID:25666625   PMID:25751668   PMID:27764193   PMID:27941872   PMID:28665039   PMID:30802441   PMID:31040128   PMID:31710263   PMID:31776260   PMID:33505018   PMID:33767592  
PMID:34237462   PMID:34303658   PMID:34399098   PMID:35086885   PMID:36384110  


Genomics

Comparative Map Data
Agr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391236,042,924 - 36,054,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1236,042,906 - 36,054,086 (+)EnsemblGRCm39 Ensembl
GRCm381235,992,925 - 36,004,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,992,907 - 36,004,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv371236,719,512 - 36,730,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361236,503,191 - 36,514,347 (+)NCBIMGSCv36mm8
Celera1237,446,354 - 37,457,458 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.18NCBI
AGR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38716,791,811 - 16,804,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl716,791,811 - 16,833,433 (-)EnsemblGRCh38hg38GRCh38
GRCh37716,831,435 - 16,844,623 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36716,797,960 - 16,811,133 (-)NCBINCBI36Build 36hg18NCBI36
Build 34716,604,675 - 16,617,848NCBI
Celera716,812,569 - 16,825,043 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef716,719,359 - 16,731,797 (-)NCBIHuRef
CHM1_1716,833,176 - 16,845,615 (-)NCBICHM1_1
T2T-CHM13v2.0716,921,380 - 16,934,682 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2716,885,921 - 16,898,395 (-)NCBI
Agr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8658,435,908 - 58,456,678 (+)NCBIGRCr8
mRatBN7.2652,708,602 - 52,729,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl652,708,602 - 52,729,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx652,999,619 - 53,020,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0653,314,493 - 53,335,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0652,779,800 - 52,800,569 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0655,465,782 - 55,487,087 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl655,465,782 - 55,487,714 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0665,081,213 - 65,102,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4654,695,633 - 54,716,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1654,709,609 - 54,719,927 (+)NCBI
Celera651,855,174 - 51,875,917 (+)NCBICelera
Cytogenetic Map6q16NCBI
Agr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541019,984,768 - 19,995,733 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541019,984,768 - 19,995,446 (-)NCBIChiLan1.0ChiLan1.0
AGR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2621,624,614 - 21,637,773 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1769,949,337 - 69,962,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0717,446,275 - 17,489,802 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1716,773,281 - 16,785,721 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl716,773,281 - 16,785,879 (-)Ensemblpanpan1.1panPan2
AGR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,303,784 - 31,316,752 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,305,567 - 31,316,686 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1430,825,073 - 30,838,046 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01431,224,288 - 31,237,241 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1431,226,071 - 31,237,170 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11431,326,448 - 31,339,401 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01431,038,306 - 31,051,283 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01431,351,630 - 31,364,787 (-)NCBIUU_Cfam_GSD_1.0
Agr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511875,641,522 - 75,654,857 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365463,315,543 - 3,328,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365463,316,622 - 3,328,317 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,041,369 - 86,053,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1986,042,070 - 86,053,893 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2994,843,416 - 94,855,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12141,311,250 - 41,324,806 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2141,312,415 - 41,326,663 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604263,184,604 - 63,199,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473913,428,130 - 13,442,070 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473913,428,049 - 13,440,949 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agr2
437 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:407
Count of miRNA genes:307
Interacting mature miRNAs:339
Transcripts:ENSMUST00000020898, ENSMUST00000147861
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
12879483Asp1_maudiogenic seizure prone 1 (mouse)123528549646801733Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
14696690Rfq1_mrearing frequency QTL 1, males (mouse)123604999937049999Mouse

Markers in Region
AF044262  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381236,003,897 - 36,004,030UniSTSGRCm38
MGSCv371236,730,484 - 36,730,617UniSTSGRCm37
Celera1237,457,274 - 37,457,407UniSTS
Cytogenetic Map12A3UniSTS
Whitehead/MRC_RH12327.11UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020898   ⟹   ENSMUSP00000020898
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1236,042,906 - 36,054,086 (+)Ensembl
GRCm38.p6 Ensembl1235,992,907 - 36,004,087 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1236,042,906 - 36,048,002 (+)Ensembl
GRCm38.p6 Ensembl1235,992,907 - 35,998,003 (+)Ensembl
RefSeq Acc Id: NM_011783   ⟹   NP_035913
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391236,042,924 - 36,054,080 (+)NCBI
GRCm381235,992,925 - 36,004,081 (+)ENTREZGENE
MGSCv371236,719,512 - 36,730,668 (+)RGD
Celera1237,446,354 - 37,457,458 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035913 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC72705 (Get FASTA)   NCBI Sequence Viewer  
  AAH13334 (Get FASTA)   NCBI Sequence Viewer  
  BAA32044 (Get FASTA)   NCBI Sequence Viewer  
  BAB25181 (Get FASTA)   NCBI Sequence Viewer  
  EDL36857 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020898
  ENSMUSP00000020898.6
GenBank Protein O88312 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035913   ⟸   NM_011783
- Peptide Label: precursor
- UniProtKB: A2CGA2 (UniProtKB/Swiss-Prot),   O88312 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020898   ⟸   ENSMUST00000020898

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88312-F1-model_v2 AlphaFold O88312 1-175 view protein structure

Promoters
RGD ID:8678150
Promoter ID:EPDNEW_M17106
Type:multiple initiation site
Name:Agr2_1
Description:Mus musculus anterior gradient 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381235,992,907 - 35,992,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344405 AgrOrtholog
Ensembl Genes ENSMUSG00000020581 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020898 ENTREZGENE
  ENSMUST00000020898.12 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:23795 UniProtKB/Swiss-Prot
MGD MGI:1344405 ENTREZGENE
NCBI Gene 23795 ENTREZGENE
PANTHER ANTERIOR GRADIENT PROTEIN 2 HOMOLOG UniProtKB/Swiss-Prot
  ANTERIOR GRADIENT PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam Thioredoxin_7 UniProtKB/Swiss-Prot
PhenoGen Agr2 PhenoGen
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A2CGA2 ENTREZGENE
  AGR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2CGA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-02 Agr2  anterior gradient 2    anterior gradient 2 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED