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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736849
Species: Mus musculus
RGD Object: Gene
Symbol: Cox4i1
Name: cytochrome c oxidase subunit 4I1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cox4i1increases expressionISOCox4i1 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of COX4I1 mRNAPMID:23273579
Cox4i1multiple interactionsISOCOX4I1 (Homo sapiens)6480464CTDMethylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]PMID:20348232
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