Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RBBP7 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBBP7 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Estradiol results in increased expression of RBBP7 mRNA | CTD | PMID:16514628 | 17beta-estradiol | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | Estradiol promotes the reaction [RBBP7 protein binds to ESR1 protein] | CTD | PMID:27156127 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RBBP7 mRNA | CTD | PMID:17949056 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RBBP7 mRNA | CTD | PMID:32109520 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RBBP7 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBBP7 mRNA | CTD | PMID:17942748 | 2,4,6-tribromophenol | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2-amino-14,16-dimethyloctadecan-3-ol | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | 2-amino-14 and 16-dimethyloctadecan-3-ol results in decreased expression of RBBP7 protein | CTD | PMID:32044396 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of RBBP7 protein | CTD | PMID:15798086 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of RBBP7 protein | CTD | PMID:31675489 | 3-methylcholanthrene | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter] | CTD | PMID:20348232 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of RBBP7 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of RBBP7 mRNA | CTD | PMID:36041667 | 4,4'-sulfonyldiphenol | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of RBBP7 protein | CTD | PMID:34186270 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of RBBP7 mRNA | CTD | PMID:28973697 | afimoxifene | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | afimoxifene results in decreased expression of RBBP7 mRNA | CTD | PMID:16514628 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of RBBP7 mRNA | CTD | PMID:16604517 | antirheumatic drug | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of RBBP7 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of RBBP7 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of RBBP7 mRNA | CTD | PMID:23650126 | benzo[a]pyrene | affects expression | EXP | | 6480464 | Benzo(a)pyrene affects the expression of RBBP7 mRNA | CTD | PMID:22342234 | benzo[a]pyrene | increases methylation | ISO | RBBP7 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RBBP7 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of RBBP7 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RBBP7 protein | CTD | PMID:34186270 | bisphenol A | multiple interactions | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of RBBP7 mRNA | CTD | PMID:36041667 | bisphenol A | affects expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of RBBP7 mRNA | CTD | PMID:34947998 | bisphenol A | affects expression | ISO | RBBP7 (Homo sapiens) | 6480464 | bisphenol A affects the expression of RBBP7 mRNA | CTD | PMID:30903817 | bisphenol A | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RBBP7 mRNA | CTD | PMID:29275510 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of RBBP7 promoter | CTD | PMID:27312807 | bisphenol F | multiple interactions | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of RBBP7 mRNA | CTD | PMID:36041667 | bisphenol F | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of RBBP7 protein | CTD | PMID:34186270 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RBBP7 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RBBP7 mRNA | CTD | PMID:37325564 | caffeine | increases phosphorylation | ISO | RBBP7 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of RBBP7 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of RBBP7 mRNA | CTD | PMID:25979313 | cisplatin | increases phosphorylation | EXP | | 6480464 | Cisplatin results in increased phosphorylation of RBBP7 protein | CTD | PMID:22006019 | cobalt dichloride | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of RBBP7 mRNA | CTD | PMID:19320972 and PMID:19376846 | copper atom | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RBBP7 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RBBP7 mRNA | CTD | PMID:20971185 | copper(II) sulfate | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of RBBP7 mRNA | CTD | PMID:19549813 | cortisol | affects response to substance | ISO | RBBP7 (Homo sapiens) | 6480464 | RBBP7 protein affects the susceptibility to Hydrocortisone | CTD | PMID:12767060 | cyclosporin A | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of RBBP7 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of RBBP7 protein | CTD | PMID:31675489 | dibenzofurans | decreases expression | EXP | | 6480464 | Dibenzofurans results in decreased expression of RBBP7 mRNA | CTD | PMID:34254344 | dicrotophos | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RBBP7 mRNA | CTD | PMID:28302478 | enzyme inhibitor | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBBP7 protein | CTD | PMID:23301498 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of RBBP7 mRNA | CTD | PMID:30319688 | finasteride | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of RBBP7 mRNA | CTD | PMID:24136188 | flutamide | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of RBBP7 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RBBP7 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | RBBP7 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of RBBP7 protein | CTD | PMID:37730182 | fulvestrant | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | fulvestrant results in decreased expression of RBBP7 mRNA | CTD | PMID:16514628 | furan | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | furan results in increased expression of RBBP7 mRNA | CTD | PMID:25539665 | gentamycin | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of RBBP7 mRNA | CTD | PMID:22061828 | ivermectin | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RBBP7 protein | CTD | PMID:32959892 | leflunomide | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of RBBP7 mRNA | CTD | PMID:28988120 | methoxyacetic acid | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | methoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA] | CTD | PMID:15103026 | mitomycin C | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Mitomycin results in increased expression of RBBP7 mRNA | CTD | PMID:12760830 | mono(2-ethylhexyl) phthalate | affects expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of RBBP7 mRNA | CTD | PMID:21195148 | Monobutylphthalate | affects expression | EXP | | 6480464 | monobutyl phthalate affects the expression of RBBP7 mRNA | CTD | PMID:21195148 | nefazodone | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of RBBP7 mRNA | CTD | PMID:24136188 | nickel subsulfide | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | nickel subsulfide results in increased expression of RBBP7 mRNA | CTD | PMID:21086188 | ozone | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Ozone results in increased expression of RBBP7 mRNA | CTD | PMID:23033980 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of RBBP7 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of RBBP7 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of RBBP7 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of RBBP7 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of RBBP7 mRNA | CTD | PMID:21420995 | perfluorooctanoic acid | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of RBBP7 protein | CTD | PMID:26879310 | phenobarbital | affects expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of RBBP7 mRNA | CTD | PMID:19159669 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of RBBP7 mRNA | CTD | PMID:23811191 | promegestone | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Promegestone results in increased expression of RBBP7 mRNA | CTD | PMID:15103026 | promegestone | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | methoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA] | CTD | PMID:15103026 | raloxifene | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in decreased expression of RBBP7 mRNA | CTD | PMID:16514628 | rotenone | decreases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Rotenone results in decreased expression of RBBP7 protein | CTD | PMID:35544339 | SB 431542 | multiple interactions | ISO | RBBP7 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of RBBP7 protein | CTD | PMID:37664457 | sodium dichromate | increases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | sodium bichromate results in increased expression of RBBP7 mRNA | CTD | PMID:12760830 | sulindac | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Sulindac results in increased expression of RBBP7 mRNA | CTD | PMID:24136188 | temozolomide | decreases expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of RBBP7 mRNA | CTD | PMID:31758290 | testosterone | increases expression | EXP | | 6480464 | Testosterone results in increased expression of RBBP7 mRNA | CTD | PMID:19693291 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RBBP7 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of RBBP7 mRNA | CTD | PMID:23411599 | trichloroethene | decreases expression | ISO | Rbbp7 (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of RBBP7 mRNA | CTD | PMID:33387578 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of RBBP7 mRNA | CTD | PMID:33045310 | uranium atom | affects expression | ISO | RBBP7 (Homo sapiens) | 6480464 | Uranium affects the expression of RBBP7 mRNA | CTD | PMID:15672453 | | 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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | The nucleosome remodeling and deacetylase complex in development and disease. | Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003. |
| 2. | ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. | Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1. |
| 3. | SET for life: biochemical activities and biological functions of SET domain-containing proteins. | Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20. |
| 4. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 5. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 6. | Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. | Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78. |
| 7. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 8. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 9. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 10. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 12. | Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. | Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013. |
| 13. | Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. | Yang J, etal., Genomics 2002 Oct;80(4):407-15. |
Additional References at PubMed
| PMID:7503932 | PMID:9651585 | PMID:10349636 | PMID:10920247 | PMID:10922068 | PMID:10984530 | PMID:11042159 | PMID:11076861 | PMID:11788710 | PMID:11836251 | PMID:12477932 | PMID:12520002 |
| PMID:12904583 | PMID:14609955 | PMID:14610273 | PMID:14645126 | PMID:15489334 | PMID:15782199 | PMID:15920471 | PMID:16141072 | PMID:16141073 | PMID:16428440 | PMID:16462733 | PMID:17296600 |
| PMID:18454139 | PMID:18799693 | PMID:19189660 | PMID:19521500 | PMID:19654328 | PMID:19927129 | PMID:20059953 | PMID:20064376 | PMID:20144788 | PMID:20211142 | PMID:20362541 | PMID:20548051 |
| PMID:21267068 | PMID:21490601 | PMID:21677750 | PMID:21731673 | PMID:21873635 | PMID:22083510 | PMID:22323595 | PMID:22354994 | PMID:22438827 | PMID:22560079 | PMID:22770845 | PMID:22865885 |
| PMID:22911650 | PMID:22984288 | PMID:24317350 | PMID:25330109 | PMID:25680957 | PMID:26040671 | PMID:26365490 | PMID:27113764 | PMID:27806305 | PMID:28378742 | PMID:28554894 | PMID:29078390 |
| PMID:30186101 | PMID:30196744 | PMID:30457570 | PMID:30595499 | PMID:30973865 | PMID:31162944 | PMID:31451685 | PMID:32098917 | PMID:32325033 | PMID:33798452 | PMID:33978814 | PMID:34180153 |
| PMID:34524839 | PMID:35695185 | PMID:36114006 | PMID:36414375 | PMID:37839992 | PMID:37843278 |
Genomics
Comparative Map Data
| Rbbp7 (Mus musculus - house mouse) |
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| RBBP7 (Homo sapiens - human) |
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| Rbbp7 (Rattus norvegicus - Norway rat) |
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| Rbbp7 (Chinchilla lanigera - long-tailed chinchilla) |
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| RBBP7 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| RBBP7 (Canis lupus familiaris - dog) |
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| Rbbp7 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| RBBP7 (Sus scrofa - pig) |
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| RBBP7 (Chlorocebus sabaeus - green monkey) |
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| Rbbp7 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Rbbp7
295 total Variants 
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