Rbsn (rabenosyn, RAB effector) - Rat Genome Database
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Gene: Rbsn (rabenosyn, RAB effector) Mus musculus
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Symbol: Rbsn
Name: rabenosyn, RAB effector
RGD ID: 1313405
MGI Page MGI
Description: Is expressed in central nervous system; genitourinary system; and retina outer nuclear layer. Orthologous to human RBSN (rabenosyn, RAB effector); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5330426D11Rik; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; Raben; rabenosyn-5; Zfyve2; Zfyve20; zinc finger FYVE domain-containing protein 20; zinc finger, FYVE domain containing 20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39692,163,693 - 92,191,874 (-)NCBIGRCm39mm39
GRCm39 Ensembl692,163,693 - 92,191,906 (-)Ensembl
GRCm38692,186,712 - 92,214,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl692,186,712 - 92,214,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv37692,136,706 - 92,164,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36692,152,216 - 92,180,315 (-)NCBImm8
Celera694,082,253 - 94,110,348 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18287559  
PMID:18799693   PMID:20534488   PMID:21677750   PMID:32325033  


Genomics

Comparative Map Data
Rbsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39692,163,693 - 92,191,874 (-)NCBIGRCm39mm39
GRCm39 Ensembl692,163,693 - 92,191,906 (-)Ensembl
GRCm38692,186,712 - 92,214,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl692,186,712 - 92,214,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv37692,136,706 - 92,164,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36692,152,216 - 92,180,315 (-)NCBImm8
Celera694,082,253 - 94,110,348 (-)NCBICelera
Cytogenetic Map6D1NCBI
RBSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl315,070,073 - 15,099,163 (-)EnsemblGRCh38hg38GRCh38
GRCh38315,070,069 - 15,099,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37315,111,580 - 15,140,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36315,086,584 - 15,115,659 (-)NCBINCBI36hg18NCBI36
Build 34315,090,292 - 15,112,631NCBI
Celera315,049,847 - 15,078,926 (-)NCBI
Cytogenetic Map3p25.1NCBI
HuRef315,047,226 - 15,076,297 (-)NCBIHuRef
CHM1_1315,062,528 - 15,091,574 (-)NCBICHM1_1
Rbsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24124,682,228 - 124,712,578 (-)NCBI
Rnor_6.0 Ensembl4124,052,300 - 124,080,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04124,050,559 - 124,080,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04189,180,554 - 189,211,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44126,366,759 - 126,395,365 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14126,613,791 - 126,637,337 (-)NCBI
Celera4113,601,804 - 113,630,410 (-)NCBICelera
Cytogenetic Map4q34NCBI
Rbsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,444,622 - 17,468,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,444,031 - 17,468,024 (-)NCBIChiLan1.0ChiLan1.0
RBSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1315,333,362 - 15,362,361 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl315,333,359 - 15,362,361 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0314,994,647 - 15,023,733 (-)NCBIMhudiblu_PPA_v0panPan3
RBSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl205,157,923 - 5,197,822 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1205,157,758 - 5,197,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rbsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936602586,284 - 607,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1369,404,021 - 69,434,830 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11369,403,995 - 69,434,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21376,803,675 - 76,812,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBSN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12251,004,739 - 51,031,379 (-)NCBI
ChlSab1.1 Ensembl2251,002,196 - 51,028,955 (-)Ensembl
Rbsn
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624872915,303 - 939,580 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
1301534Idd20_minsulin dependent diabetes susceptibility 20 (mouse)Not determined69203995092716697Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1453
Count of miRNA genes:715
Interacting mature miRNAs:923
Transcripts:ENSMUST00000014694, ENSMUST00000124635, ENSMUST00000138041, ENSMUST00000141332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000014694   ⟹   ENSMUSP00000014694
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,186,712 - 92,214,925 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124635   ⟹   ENSMUSP00000144749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,189,841 - 92,199,725 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138041   ⟹   ENSMUSP00000120883
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,211,596 - 92,214,569 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141332
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,190,383 - 92,201,628 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203516   ⟹   ENSMUSP00000144945
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,207,153 - 92,214,849 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204858
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl692,190,746 - 92,194,128 (-)Ensembl
RefSeq Acc Id: NM_030081   ⟹   NP_084357
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39692,163,693 - 92,191,851 (-)NCBI
GRCm38692,186,712 - 92,214,870 (-)NCBI
MGSCv37692,136,706 - 92,164,805 (-)RGD
Celera694,082,253 - 94,110,348 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506769   ⟹   XP_006506832
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39692,163,693 - 92,191,874 (-)NCBI
GRCm38692,186,715 - 92,214,894 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152400   ⟹   XP_036008293
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39692,163,693 - 92,191,874 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_084357   ⟸   NM_030081
- UniProtKB: Q80Y56 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506832   ⟸   XM_006506769
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000144945   ⟸   ENSMUST00000203516
RefSeq Acc Id: ENSMUSP00000144749   ⟸   ENSMUST00000124635
RefSeq Acc Id: ENSMUSP00000120883   ⟸   ENSMUST00000138041
RefSeq Acc Id: ENSMUSP00000014694   ⟸   ENSMUST00000014694
RefSeq Acc Id: XP_036008293   ⟸   XM_036152400
- Peptide Label: isoform X1
Protein Domains
C2H2-type   FYVE-type   UIM

Promoters
RGD ID:6840204
Promoter ID:MM_KWN:46949
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000058152
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36692,149,539 - 92,150,039 (-)MPROMDB
RGD ID:6840203
Promoter ID:MM_KWN:46951
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000058149,   OTTMUST00000058150
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36692,164,681 - 92,165,181 (-)MPROMDB
RGD ID:6890472
Promoter ID:EPDNEW_M8687
Type:initiation region
Name:Rbsn_1
Description:Mus musculus rabenosyn, RAB effector , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38692,214,870 - 92,214,930EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925537 AgrOrtholog
Ensembl Genes ENSMUSG00000014550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000014694 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000120883 UniProtKB/TrEMBL
  ENSMUSP00000144749 UniProtKB/TrEMBL
  ENSMUSP00000144945 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000014694 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000124635 UniProtKB/TrEMBL
  ENSMUST00000138041 UniProtKB/TrEMBL
  ENSMUST00000203516 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Rbsn_Rab-bd_sf UniProtKB/Swiss-Prot
  Rbsn_Rab_binding_dom UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78287 UniProtKB/Swiss-Prot
MGD MGI:1925537 ENTREZGENE
NCBI Gene 78287 ENTREZGENE
Pfam FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rbsn UniProtKB/Swiss-Prot
PhenoGen Rbsn PhenoGen
PROSITE ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF140125 UniProtKB/Swiss-Prot
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUN4_MOUSE UniProtKB/TrEMBL
  A0A0N4SV43_MOUSE UniProtKB/TrEMBL
  D3Z0E7_MOUSE UniProtKB/TrEMBL
  Q05D95_MOUSE UniProtKB/TrEMBL
  Q80Y56 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8K0L6 UniProtKB/Swiss-Prot
  Q9CTW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-30 Rbsn  rabenosyn, RAB effector  Zfyve20  zinc finger, FYVE domain containing 20  Symbol and/or name change 5135510 APPROVED