Hmga2 (high mobility group AT-hook 2) - Rat Genome Database

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Gene: Hmga2 (high mobility group AT-hook 2) Mus musculus
Analyze
Symbol: Hmga2
Name: high mobility group AT-hook 2
RGD ID: 1552855
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including endocrine system development; lung development; and positive regulation of cell population proliferation. Located in nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430083A20Rik; high mobility group AT-hook protein 2; high mobility group protein HMGI-C; high mobility group protein I; high mobility group protein I, isoform C; Hmgi; HMGI-; HMGI-C; Hmgic; MGC103393; pg; pygmy
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hmga2-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)Ensembl
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBImm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
5-azacytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
antimycin A  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP)
hypochlorous acid  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
maneb  (EXP)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IMP)
adrenal gland development  (IMP)
astrocyte differentiation  (IDA)
base-excision repair  (ISO)
cell division  (IEA)
cell proliferation in forebrain  (IMP)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
chromosome condensation  (IEA)
endodermal cell differentiation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial tube branching involved in lung morphogenesis  (IMP)
fat cell differentiation  (ISO)
fat pad development  (IGI)
fibroblast proliferation  (IMP)
heterochromatin assembly  (ISO)
intracellular signal transduction  (ISO)
lung epithelium development  (IMP)
male gonad development  (IMP)
meiotic cell cycle  (IEA)
mesenchymal cell differentiation  (ISO)
mesodermal cell differentiation  (ISO)
mesodermal-endodermal cell signaling  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte differentiation  (IDA)
negative regulation of cellular senescence  (IMP)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of double-strand break repair via nonhomologous end joining  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (IMP)
obsolete histone H2A-S139 phosphorylation  (ISO)
oncogene-induced cell senescence  (ISO)
pituitary gland development  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell proliferation in bone marrow  (IMP)
positive regulation of cellular response to X-ray  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP,ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of response to DNA damage stimulus  (ISO)
positive regulation of stem cell proliferation  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
programmed DNA elimination by chromosome breakage  (ISO)
regulation of cell cycle process  (IDA,ISO)
regulation of DNA-templated transcription  (IBA,ISO)
regulation of growth  (IEA)
regulation of growth hormone secretion  (IMP)
regulation of peptide hormone secretion  (IMP)
regulation of stem cell population maintenance  (ISO)
response to virus  (ISO)
signal transduction  (ISO)
somatic stem cell population maintenance  (IGI,IMP)
spermatogenesis  (IMP)
stem cell differentiation  (ISO)
stem cell proliferation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. In vivo modulation of Hmgic reduces obesity. Anand A and Chada K, Nat Genet. 2000 Apr;24(4):377-80.
2. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Ashar HR, etal., Cell. 1995 Jul 14;82(1):57-65.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Kazmierczak B, etal., Genomics. 1996 Dec 1;38(2):223-6.
5. HMGA2 gene is a promising target for ovarian cancer silencing therapy. Malek A, etal., Int J Cancer. 2008 Jul 15;123(2):348-56.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. Zentner MD, etal., J Biol Chem. 2001 Aug 10;276(32):29805-14. Epub 2001 Jun 4.
Additional References at PubMed
PMID:504232   PMID:1311971   PMID:1508193   PMID:1685136   PMID:1698554   PMID:1762909   PMID:1924386   PMID:1975791   PMID:2305264   PMID:5051369   PMID:7390396   PMID:7615634  
PMID:7651535   PMID:7795651   PMID:7849395   PMID:7958830   PMID:8100556   PMID:8535068   PMID:8566786   PMID:8718494   PMID:8918814   PMID:9545312   PMID:9824208   PMID:10349636  
PMID:10395190   PMID:10636877   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11181445   PMID:11427729   PMID:11438738   PMID:11555636   PMID:11801530   PMID:11805063   PMID:12032866  
PMID:12082634   PMID:12477932   PMID:12799440   PMID:13679031   PMID:14571323   PMID:14595844   PMID:14610273   PMID:14645522   PMID:14668482   PMID:14794889   PMID:15225648   PMID:15489334  
PMID:15618518   PMID:15645444   PMID:16007198   PMID:16109425   PMID:16141072   PMID:16141073   PMID:16293633   PMID:16765103   PMID:16766265   PMID:16831886   PMID:17305714   PMID:17322030  
PMID:17332316   PMID:18238902   PMID:18287559   PMID:18425117   PMID:18554416   PMID:18640244   PMID:18832382   PMID:18957199   PMID:19004856   PMID:19070572   PMID:19228596   PMID:19303107  
PMID:19320717   PMID:19521500   PMID:20007691   PMID:20059953   PMID:20123068   PMID:20412781   PMID:21267068   PMID:21417337   PMID:21460244   PMID:21873635   PMID:22639370   PMID:22726539  
PMID:22797695   PMID:22991445   PMID:23072816   PMID:23177649   PMID:23184966   PMID:23318420   PMID:23625920   PMID:23630078   PMID:23639551   PMID:23716660   PMID:23722545   PMID:23811688  
PMID:23895693   PMID:23940373   PMID:23975428   PMID:24192035   PMID:24551154   PMID:24661562   PMID:24728959   PMID:24931605   PMID:24952961   PMID:25150295   PMID:25922525   PMID:25933067  
PMID:26139524   PMID:26244988   PMID:26646104   PMID:26837766   PMID:26901496   PMID:26966068   PMID:26980276   PMID:27036552   PMID:27259253   PMID:27401346   PMID:27513632   PMID:27940362  
PMID:28415789   PMID:28502886   PMID:28637665   PMID:28790031   PMID:28851724   PMID:28963864   PMID:29033353   PMID:29296743   PMID:30228296   PMID:30478225   PMID:30654938   PMID:30728831  
PMID:30786278   PMID:31064784   PMID:31073041   PMID:31080058   PMID:31924792   PMID:32098917   PMID:32246510   PMID:32325033   PMID:32588686   PMID:32880858   PMID:33237328   PMID:33452460  
PMID:34529965   PMID:34558637   PMID:34851821   PMID:34878116   PMID:34973532   PMID:35175194  


Genomics

Comparative Map Data
Hmga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)Ensembl
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBImm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
HMGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1265,824,460 - 65,966,291 (+)EnsemblGRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
T2T-CHM13v2.01265,803,963 - 65,945,820 (+)NCBI
Hmga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)Ensembl
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Celera752,634,133 - 52,748,501 (-)NCBICelera
Cytogenetic Map7q22NCBI
Hmga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545812,493,790 - 12,624,805 (+)NCBIChiLan1.0ChiLan1.0
HMGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0panPan3
HMGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,348,101 - 8,491,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,278,957 - 8,424,016 (+)NCBI
ROS_Cfam_1.0108,459,176 - 8,604,625 (+)NCBI
ROS_Cfam_1.0 Ensembl108,459,180 - 8,601,880 (+)Ensembl
UMICH_Zoey_3.1108,335,596 - 8,480,987 (+)NCBI
UNSW_CanFamBas_1.0108,581,865 - 8,727,080 (+)NCBI
UU_Cfam_GSD_1.0108,703,471 - 8,848,741 (+)NCBI
Hmga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBI
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1530,188,521 - 30,329,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,375,397 - 33,516,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,509,114 - 61,655,633 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037184,069,350 - 184,211,090 (-)NCBIVero_WHO_p1.0
Hmga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,337,464 - 2,467,990 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248022,337,344 - 2,468,757 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126746  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810120,424,913 - 120,425,139UniSTSGRCm38
MGSCv3710119,861,969 - 119,862,195UniSTSGRCm37
Celera10122,786,666 - 122,786,892UniSTS
Cytogenetic Map10D2UniSTS
cM Map1067.5UniSTS
Whitehead/MRC_RH101262.28UniSTS
X58380  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810120,363,158 - 120,363,339UniSTSGRCm38
GRCm381176,836,973 - 176,837,154UniSTSGRCm38
MGSCv371178,767,104 - 178,767,285UniSTSGRCm37
MGSCv3710119,800,214 - 119,800,395UniSTSGRCm37
Celera10122,725,062 - 122,725,243UniSTS
Celera1183,904,932 - 183,905,113UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map1H3UniSTS
cM Map1067.5UniSTS
Whitehead/MRC_RH101262.92UniSTS
Hmga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810120,531,263 - 120,532,047UniSTSGRCm38
MGSCv3710119,968,319 - 119,969,103UniSTSGRCm37
Celera10122,893,330 - 122,894,114UniSTS
Cytogenetic Map10D2UniSTS
cM Map1067.5UniSTS
UniSTS:236475  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810120,382,463 - 120,382,662UniSTSGRCm38
MGSCv3710119,819,519 - 119,819,718UniSTSGRCm37
Celera10122,744,343 - 122,744,542UniSTS
Cytogenetic Map10D2UniSTS
cM Map1067.5UniSTS
Hmga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810120,363,192 - 120,363,534UniSTSGRCm38
GRCm381176,836,778 - 176,837,120UniSTSGRCm38
MGSCv3710119,800,248 - 119,800,590UniSTSGRCm37
MGSCv371178,766,909 - 178,767,251UniSTSGRCm37
Celera10122,725,096 - 122,725,438UniSTS
Celera1183,904,737 - 183,905,079UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map10D2UniSTS
Hmga2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381176,835,853 - 176,836,112UniSTSGRCm38
MGSCv371178,765,984 - 178,766,243UniSTSGRCm37
Cytogenetic Map1H3UniSTS
Cytogenetic Map10D2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse
27226742Metcl4_mmetatarsal-calcaneal length 4, 5 week (mouse)10118135905125435869Mouse
27226795Scvln17_msacral vertebrae length 2, 16 week (mouse)10118435905124835905Mouse
1357742Jckm1_mjuvenile cystic kidney modifier 1 (mouse)Not determined10118497164120735487Mouse
27226718Tibw3_mtibia width 3, proximal, 10 week (mouse)10118835905125435869Mouse
27095926Pglq4_mpelvic girdle length QTL 4, 5 week (mouse)10119035905124835905Mouse
26884443Sklq5_mskull length QTL 5, 5 week (mouse)10119035905124835905Mouse
27095906Scvln5_msacral vertebrae length 2, 5 week (mouse)10119035905124835905Mouse
27226736Metcl15_mmetatarsal-calcaneal length 15, 16 week (mouse)10119035905124835905Mouse
27226747Metcl10_mmetatarsal-calcaneal length 10, 10 week (mouse)10119035905124835905Mouse
27226784Tibl4_mtibia length 4, 5 week (mouse)10119035905125435869Mouse
27226791Feml8_mfemur length 8, 5 week (mouse)10119035905125735869Mouse
1301701Aggr1_maggression 1 (mouse)Not determined10119506908125575232Mouse
13801032Hwtf2_mheart weight by femur 2 (mouse)10119835905121835905Mouse
11353834Pcholq2_mplasma cholesterol QTL 2 (mouse)10120243727125515907Mouse
11353838Gluq3_mblood glucose QTL 3 (mouse)10120243727125515907Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA23318420
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA19153603
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA18403645
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA17600087
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA17437991
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA17322030
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA23318420
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA19153603
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA18403645
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA17600087
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA17437991
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA17322030
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA23318420
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA19153603
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA18403645
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA17600087
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA17437991
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA17322030
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA23318420
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA19153603
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA18403645
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA17600087
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA17437991
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA17322030
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA23318420
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA19153603
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA18403645
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA18308936
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA17600087
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA17437991
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA17322030
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA23318420
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA19153603
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA18403645
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA17600087
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA17437991
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA17322030
Mir196a-1mmu-miR-196a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19169275
Mir196a-2mmu-miR-196a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19169275
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA23318420
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA19153603
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA18403645
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA17600087
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA17437991
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA17322030
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA23318420
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA19153603
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA18403645
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA17600087
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA17437991
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA17322030
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA23318420
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA19153603
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA18403645
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA17600087
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA17437991
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA17322030
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA23318420
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA19153603
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA18403645
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA17600087
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA17437991
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA17322030

Predicted Target Of
Summary Value
Count of predictions:2301
Count of miRNA genes:600
Interacting mature miRNAs:757
Transcripts:ENSMUST00000072777, ENSMUST00000159310, ENSMUST00000159699
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY013519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ173998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX567918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072777   ⟹   ENSMUSP00000072556
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)Ensembl
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10120,306,195 - 120,312,197 (-)Ensembl
GRCm38.p6 Ensembl10120,470,290 - 120,476,292 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159699   ⟹   ENSMUSP00000123998
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)Ensembl
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)Ensembl
RefSeq Acc Id: NM_001347170   ⟹   NP_001334099
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910120,197,173 - 120,312,374 (-)NCBI
GRCm3810120,361,268 - 120,476,469 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010441   ⟹   NP_034571
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910120,197,173 - 120,312,374 (-)NCBI
GRCm3810120,361,268 - 120,476,469 (-)NCBI
MGSCv3710119,798,331 - 119,913,991 (-)RGD
Celera10122,723,179 - 122,838,757 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034571   ⟸   NM_010441
- Peptide Label: isoform 1
- UniProtKB: P52927 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001334099   ⟸   NM_001347170
- Peptide Label: isoform 2
- UniProtKB: P52927 (UniProtKB/Swiss-Prot),   Q6NSP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000123998   ⟸   ENSMUST00000159699
RefSeq Acc Id: ENSMUSP00000072556   ⟸   ENSMUST00000072777

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52927-F1-model_v2 AlphaFold P52927 1-108 view protein structure

Promoters
RGD ID:6846726
Promoter ID:MM_ACW:6197
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:HMGA2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610119,911,126 - 119,911,626 (-)MPROMDB
RGD ID:6819444
Promoter ID:MM_KWN:5770
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Kidney,   MEF_B4,   MEF_B6
Transcripts:NM_010441,   OTTMUST00000083150,   UC007HFE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610119,913,196 - 119,914,887 (-)MPROMDB
RGD ID:8673376
Promoter ID:EPDNEW_M14719
Type:initiation region
Name:Hmga2_1
Description:Mus musculus high mobility group AT-hook 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14720  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810120,476,264 - 120,476,324EPDNEW
RGD ID:8673378
Promoter ID:EPDNEW_M14720
Type:initiation region
Name:Hmga2_2
Description:Mus musculus high mobility group AT-hook 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14719  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810120,477,007 - 120,477,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101761 AgrOrtholog
Ensembl Genes ENSMUSG00000056758 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000072556 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123998 ENTREZGENE
  ENSMUSP00000123998.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072777 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000159699 ENTREZGENE
  ENSMUST00000159699.2 UniProtKB/TrEMBL
InterPro AT_hook_DNA-bd_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15364 UniProtKB/Swiss-Prot
MGD MGI:101761 ENTREZGENE
NCBI Gene 15364 ENTREZGENE
Pfam AT_hook UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmga2 PhenoGen
PRINTS ATHOOK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AT_hook UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HMGA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6NSP9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3UQW0 UniProtKB/Swiss-Prot