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Gene: Hmga2 (high mobility group AT-hook 2) Mus musculus
Symbol: Hmga2
Name: high mobility group AT-hook 2
RGD ID: 1552855
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including animal organ development; negative regulation of cellular senescence; and positive regulation of cell population proliferation. Localizes to nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2); PARTICIPATES IN Ras mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9430083A20Rik; high mobility group AT-hook protein 2; high mobility group protein HMGI-C; high mobility group protein I; high mobility group protein I, isoform C; Hmgi; HMGI-; HMGI-C; Hmgic; MGC103393; pg; pygmy
Homo sapiens (human) : HMGA2 (high mobility group AT-hook 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmga2 (high mobility group AT-hook 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmga2 (high mobility group AT-hook 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGA2 (high mobility group AT-hook 2)
Canis lupus familiaris (dog) : HMGA2 (high mobility group AT-hook 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmga2 (high mobility group AT-hook 2)
Sus scrofa (pig) : HMGA2 (high mobility group AT-hook 2)
Chlorocebus sabaeus (African green monkey) : HMGA2 (high mobility group AT-hook 2)
Heterocephalus glaber (naked mole-rat) : Hmga2 (high mobility group AT-hook 2)
more info ...
Related Pseudogenes: Hmga2-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910120,197,173 - 120,312,374 (-)NCBI
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBImm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hmga2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552855
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.